CN111905142A - Oxygen-releasing hydrogel dressing and preparation method thereof - Google Patents
Oxygen-releasing hydrogel dressing and preparation method thereof Download PDFInfo
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
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- C08J3/075—Macromolecular gels
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
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Abstract
The invention provides an oxygen-releasing hydrogel dressing which is characterized by comprising a first dressing and a second dressing, wherein the first dressing is prepared from a hydrogel dressing, glucose, an oxygen-releasing catalyst and a polyester mesh sheet with a pore structure, the second dressing comprises the hydrogel dressing and glucose oxidase, and the first dressing and the second dressing are matched for use; the oxygen release hydrogel material has good water vapor permeability and water absorption performance, and a final product can release oxygen, iodine simple substance and water after contacting air, so that the oxygen release hydrogel material serving as a novel functional material can be used for various acute and chronic wound surfaces, can automatically remove exudate of damaged tissues, guarantees the moist wound surface environment, simultaneously improves the local oxygen concentration, releases the anti-inflammatory iodine simple substance, and plays roles in relieving pain of the wound surface and accelerating the healing speed of the damaged tissues.
Description
Technical Field
The invention relates to the field of medical high polymer materials, in particular to an oxygen release hydrogel material and a preparation method thereof.
Background
According to statistical data, the worldwide cost for wound treatment reaches $ 130- $ 150 million each year. In China, tens of millions of human skins cause skin wounds due to accidents and operations every year. Chronic difficult-to-heal wound surfaces become a difficult problem in the field of wound care and have the characteristics of large patient base, high healing difficulty, high treatment cost and the like.
The theory for wound therapy is also continually updated, and the Winter doctor at university of london in 1962 indicates that the rate of wound healing in the wet environment is twice as fast as the rate of healing in the dry environment. In the eighties, the first-generation moisture-retention hydrocolloid dressing emerged, and along with the improvement of material science and technology, the novel hydrogel dressing becomes an important branch of medical dressings, replaces the function of damaged skin in the using process and acts on wound healing and skin damage healing all the time.
Adequate oxygen supply is an important prerequisite for ensuring proper wound healing when the tissue partial Pressure of Oxygen (PO) is present2) Below a certain level, the risk of chronic wounds increases. Therefore, in order to more effectively realize oxygenation intervention of wound tissues, reduce cost, reduce complexity of equipment and improve use experience of patients, equipment applied clinically develops for several generations, and mainly comprises a high-pressure chamber, a local oxygen perfusion device, oxygen diffusion enhanced hemoglobin, an oxygen release dressing and the like. The oxygen release dressing can directionally and effectively provide oxygen for a wound part, promotes wound healing, and can solve the problems that collagen dressings are easy to damage due to water absorption, film dressings are frequently replaced due to impermeability of water, and sodium alginate dressings react with water to generate gelatin and skin adhesion are not easy to separate. Several types of oxygen-containing dressings have been marketed in succession abroad, but their mechanical properties are still to be improved, and oxygen-containing dressings with excellent properties are still under constant investigation.
In view of the above, the inventors of the present invention found an oxygen-releasing hydrogel material with excellent performance after extensive research, and the oxygen-releasing hydrogel material has the characteristics of definite preparation process, controllable hydrogel performance, good stability, simple use method, wide application range and the like when being applied to medical dressings.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a hydrogel dressing which has excellent mechanical property, moderate gelation speed, anti-inflammatory component content and oxygen release function and a preparation method thereof.
In order to achieve the above object, the first aspect of the present invention provides an oxygen-releasing hydrogel dressing, comprising a first dressing and a second dressing, wherein the first dressing is prepared from a hydrogel dressing, glucose, an oxygen-releasing catalyst and a polyester mesh having a pore structure, the second dressing comprises a hydrogel dressing and glucose oxidase, and the first dressing and the second dressing are used in combination; the hydrogel dressing is prepared from the following components in parts by weight: 30-90 parts of water, 5-50 parts of acrylamide and derivatives thereof, 1-5 parts of cross-linking agent and 2-5 parts of initiator.
Preferably, the hydrogel dressing according to claim 1, wherein the acrylamide derivative is selected from one or more of polyacrylamide, acrylamide carboxylic acid, acrylamide sulfonic acid, acrylamide carboxylate, acrylamide sulfonate, enamide carboxylate or acrylamide sulfonate.
Preferably, the cross-linking agent is selected from one or more of N, N' -methylene bisacrylamide, ethylene glycol and derivatives thereof, riboflavin or guar gum.
Preferably, the initiator is a free radical generating active substance selected from the group consisting of per 2-hydroxy-4- (2-hydroxyethoxy) -2-methylpropiophenone and 1-hydroxycyclohexyl phenyl methanone.
According to the invention, acrylamide and derivatives thereof react with a cross-linking agent under the action of an initiator to form a three-dimensional hydrogel material with good mechanical properties, so that the three-dimensional hydrogel material has certain tensile strength when applied to the surface of a wound surface, and fully plays a role of a physical barrier. Meanwhile, the product is colorless and odorless, is transparent and is convenient for observing the condition of the wound surface.
Preferably, the oxygen evolution catalyst is potassium iodide.
Preferably, the size of the holes of the polyester mesh sheet with the hole structure is 1-9 mm2。
In a second aspect of the present invention, there is provided a method for preparing the above-mentioned oxygen-releasing hydrogel dressing, comprising the steps of:
(1) preparing to obtain a hydrogel dressing;
(2) pouring the hydrogel dressing into a prefabricated quartz mold, standing for a period of time, and freeze-drying to obtain a dry hydrogel dressing;
(3) preparing a mixed solution of anhydrous glucose and potassium iodide, adding the dry hydrogel dressing into the mixed solution of anhydrous glucose and potassium iodide, standing, covering on a polyester mesh with a hole structure, drying in a vacuum drying oven, and independently packaging to obtain the first dressing;
(4) preparing a glucose oxidase aqueous solution, adding the hydrogel dressing into the glucose oxidase aqueous solution, and performing independent sealing packaging by using a vacuum bottle or a binary spray bottle to obtain the second dressing;
(5) packaging the first dressing and second dressing in combination to obtain the oxygen-releasing hydrogel dressing.
Further, the preparation process of the hydrogel dressing in the step (1) specifically comprises the following steps:
1) adding acrylamide and derivatives thereof into deionized water, stirring, heating and dissolving to obtain a first solution;
2) adding a cross-linking agent into the first solution, and fully stirring until the cross-linking agent is dissolved to obtain a second solution;
3) adding an initiator into a proper amount of deionized water, fixing the volume, accelerating the stirring, and filtering to obtain a third solution;
4) and uniformly mixing the second solution and the third solution to obtain a fourth solution, and placing the fourth solution in an ultraviolet crosslinking instrument for UV crosslinking to obtain the hydrogel dressing.
Preferably, in the step 1), the temperature for stirring and heating is 20-50 ℃, the stirring speed is 100-300r/min, and the stirring time is 0.5-3 h.
Preferably, in the step 3), the accelerated stirring speed is 300-500 r/min.
Preferably, the irradiation wavelength of the ultraviolet crosslinking instrument is 365nm, and the irradiation intensity is 100mw/cm2The irradiation time is 10-60 s.
Preferably, the dimensions of the prefabricated quartz mold are as follows: 5cm × 5cm × 1mm, 5cm × 5cm × 1.5mm, 15cm × 15cm × 1mm, or 15cm × 15cm × 1.5 mm.
Preferably, the freeze-drying condition is-30 ℃ and 0.5-3 h.
The application method of the oxygen-releasing hydrogel dressing prepared according to the preparation method comprises the following steps: after the package of the first dressing is removed, the first dressing is attached to the wound, wrinkles are prevented from appearing, the second dressing is sprayed onto the first dressing through a binary spray bottle or a vacuum bottle, and the second dressing can be sprayed repeatedly at intervals for improving the treatment effect. The wound surface can be effectively kept moist by a scheme of combining application and spraying, a certain oxygen concentration can be maintained for a long time, and the wound surface healing effect is improved.
The action mechanism of the oxygen-releasing hydrogel dressing is as follows:
(1) glucose generates gluconic acid and hydrogen peroxide under the action of glucose oxidase and aerobic condition;
(2) the hydrogen peroxide and the potassium iodide react to generate oxygen, water and iodine simple substance.
The hydrogel has the following functions: physical barrier of wound, absorption of wound exudate, maintenance of moist environment.
The oxygen has the functions of: improving the oxygen concentration of the wound surface, increasing the oxygen partial pressure of the tissue, promoting the healing of the wound surface and preventing the formation of scars.
The iodine simple substance has the functions of: and (5) sterilizing and disinfecting.
The invention has the beneficial effects that:
(1) according to the invention, acrylamide and derivatives thereof react with a cross-linking agent under the action of an initiator to form a three-dimensional hydrogel material with good mechanical properties, so that the three-dimensional hydrogel material has certain tensile strength when applied to the surface of a wound surface, and fully plays a role of a physical barrier. Meanwhile, the product is colorless, tasteless and transparent, and is convenient for observing the condition of the wound surface;
(2) the invention utilizes the reaction of glucose and glucose oxidase in the air to release hydrogen peroxide, the hydrogen peroxide further generates oxygen and water under the action of potassium iodide or manganese dioxide catalyst, and simultaneously iodide ions are oxidized into iodine simple substances. The oxygen concentration of the wound surface is improved while a moist environment is provided for the wound surface, and simultaneously iodine simple substance with anti-inflammatory effect is formed, so that the pain of the wound surface is relieved, and the healing is promoted.
(3) The hydrogel provided by the invention can completely maintain the internal pore structure through the freeze drying operation process, has good forming capability, can fully absorb glucose, glucose oxidase and potassium iodide, and improves the content of effective components of the product.
(4) When the first dressing and the second dressing are used in a matched mode, the first dressing is attached to a wound to ensure that no wrinkles occur, the second dressing is sprayed onto the first dressing through a binary spray bottle or a vacuum bottle, and the second dressing can be sprayed repeatedly at intervals in order to improve the treatment effect. The wound surface can be effectively kept moist by a scheme of combining application and spraying, a certain oxygen concentration can be maintained for a long time, and the wound surface healing effect is improved.
(5) The preparation method is simple, convenient to operate, easy to obtain raw materials, clear in reaction mechanism, mild in preparation conditions, easy to control and high in efficiency.
Detailed Description
The technical solution of the present invention is further described in detail below, but the scope of the present invention is not limited thereto.
In order to achieve the above object, in a first aspect of the present embodiment, there is provided an oxygen-releasing hydrogel dressing, including a first dressing and a second dressing, wherein the first dressing is prepared from a hydrogel dressing, glucose, an oxygen-releasing catalyst and a polyester mesh having a pore structure, the second dressing includes a hydrogel dressing and glucose oxidase, and the first dressing and the second dressing are used in combination; the hydrogel dressing is prepared from the following components in parts by weight: 30-90 parts of water, 5-50 parts of acrylamide and derivatives thereof, 1-5 parts of cross-linking agent and 2-5 parts of initiator.
As a preferred embodiment of the present invention, the water may be 30 parts, 40 parts, 50 parts, 60 parts, 65 parts, 70 parts, 80 parts or 90 parts by weight; acrylamide and its derivatives are one or more of polyacrylamide, acrylamide carboxylic acid, acrylamide sulfonic acid, acrylamide carboxylate, acrylamide sulfonate, poly-2-methyl-2-acrylamide sulfonic acid, and specifically, may be acrylamide carboxylic acid, or a combination of acrylamide sulfonic acid and poly-2-methyl-2-acrylamide sulfonic acid, or a combination of polyacrylamide and poly-2-methyl-2-acrylamide sulfonic acid, or a combination of acrylamide carboxylate and poly-2-methyl-2-acrylamide sulfonic acid, or a combination of acrylamide sulfonate and poly-2-methyl-2-acrylamide sulfonic acid, the parts by weight of acrylamide and its derivatives are preferably 5 parts, 10 parts, 20 parts, 30 parts, 40 parts or 50 parts. In the embodiment of the invention, the cross-linking agent is selected from N, N' -methylene bisacrylamide, glycol and derivatives thereof, riboflavin or guar gum, and the weight part of the cross-linking agent is 1 part, 2 parts, 3 parts, 4 parts or 5 parts. The initiator is 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone or 1-hydroxycyclohexyl phenyl ketone, and the weight parts of the initiator are 2 parts, 3 parts, 4 parts or 5 parts.
The weight portion of the glucose in this embodiment is 1 to 6 portions, and specifically may be 1 portion, 2 portions, 3 portions, 4 portions, 5 portions, or 6 portions; the glucose oxidase of the embodiment of the invention is 0.5-2 parts by weight, specifically 0.5 part, 1 part or 2 parts by weight; the weight portion of the oxygen releasing catalyst is 0.5-2 parts, and specifically can be 0.5 part, 1 part or 2 parts.
The oxygen evolution catalyst described in this example was potassium iodide.
In the embodiment, acrylamide and derivatives thereof react with a cross-linking agent under the action of an initiator to form a three-dimensional hydrogel material with good mechanical properties, so that the three-dimensional hydrogel material has certain tensile strength when applied to the surface of a wound surface, and fully plays a role of a physical barrier. Meanwhile, the product is colorless and odorless, is transparent and is convenient for observing the condition of the wound surface.
As a preferred embodiment of the invention, the size of the holes of the polyester mesh with the hole structure is 1-9 mm2。
In a second aspect of the embodiments of the present invention, there is provided a method for preparing the oxygen-releasing hydrogel dressing, including the steps of:
(1) preparing to obtain a hydrogel dressing;
(2) pouring the hydrogel dressing into a prefabricated quartz mold, standing for a period of time, and freeze-drying to obtain a dry hydrogel dressing;
(3) preparing a mixed solution of anhydrous glucose and potassium iodide, adding the dry hydrogel dressing into the mixed solution of anhydrous glucose and potassium iodide, standing, covering on a polyester mesh with a hole structure, drying in a vacuum drying oven, and independently packaging to obtain the first dressing;
(4) preparing a glucose oxidase aqueous solution, adding the hydrogel dressing into the glucose oxidase aqueous solution, and performing independent sealing packaging by using a vacuum bottle or a binary spray bottle to obtain the second dressing;
(5) packaging the first dressing and second dressing in combination to obtain the oxygen-releasing hydrogel dressing.
Further, the preparation process of the hydrogel dressing in the step (1) specifically comprises the following steps:
1) adding acrylamide and derivatives thereof into deionized water, stirring, heating and dissolving to obtain a first solution;
2) adding a cross-linking agent into the first solution, and fully stirring until the cross-linking agent is dissolved to obtain a second solution;
3) adding an initiator into a proper amount of deionized water, fixing the volume, accelerating the stirring, and filtering to obtain a third solution;
4) and uniformly mixing the second solution and the third solution to obtain a fourth solution, and placing the fourth solution in an ultraviolet crosslinking instrument for UV crosslinking to obtain the hydrogel dressing.
As a preferred embodiment of the invention, in the step 1), the temperature of the stirring and heating is 20-50 ℃, the stirring speed is 100-300r/min, and the stirring time is 0.5-3 h.
As a preferred embodiment of the present invention, in the step 3), the accelerated stirring rate is 300-500 r/min.
In a preferred embodiment of the present invention, the irradiation wavelength of the UV crosslinking apparatus is 365nm, the irradiation intensity is 100mw/cm2, and the irradiation time is 10 to 60 s.
As a preferred embodiment of the present invention, the dimensions of the prefabricated quartz mold are as follows: 5cm × 5cm × 1mm, 5cm × 5cm × 1.5mm, 15cm × 15cm × 1mm, or 15cm × 15cm × 1.5 mm.
As a preferred embodiment of the present invention, the freeze-drying conditions are-30 ℃ for 0.5-3 h.
While the invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not to be limited to the disclosed embodiments, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.
Claims (13)
1. The oxygen release hydrogel dressing is characterized by comprising a first dressing and a second dressing, wherein the first dressing is prepared from a hydrogel dressing, glucose, an oxygen release catalyst and a polyester mesh with a hole structure, the second dressing comprises the hydrogel dressing and glucose oxidase, and the first dressing and the second dressing are matched for use; the hydrogel dressing is prepared from the following components in parts by weight: 30-90 parts of water, 5-50 parts of acrylamide and derivatives thereof, 1-5 parts of cross-linking agent and 2-5 parts of initiator.
2. The hydrogel dressing of claim 1, wherein the acrylamide derivative is selected from one or more of polyacrylamide, acrylamide carboxylic acid, acrylamide sulfonic acid, acrylamide carboxylate, acrylamide sulfonate, enamine carboxylate, or acrylamide sulfonate.
3. The hydrogel dressing of claim 1, wherein the cross-linking agent is selected from one or more of N, N' -methylenebisacrylamide, ethylene glycol and derivatives thereof, riboflavin, or guar gum.
4. The hydrogel dressing of claim 1, wherein the initiator is a free radical generating active selected from the group consisting of per 2-hydroxy-4- (2-hydroxyethoxy) -2-methylpropiophenone and 1-hydroxycyclohexyl phenyl methanone.
5. The hydrogel dressing of claim 1, wherein the oxygen-releasing catalyst is potassium iodide.
6. The hydrogel dressing of claim 1, wherein the pore size of the porous structured polyester mesh is 1-9 mm2。
7. The method of producing an oxygen-releasing hydrogel dressing as claimed in any one of claims 1 to 6, comprising the steps of:
(1) preparing to obtain a hydrogel dressing;
(2) pouring the hydrogel dressing into a prefabricated quartz mold, standing for a period of time, and freeze-drying to obtain a dry hydrogel dressing;
(3) preparing a mixed solution of anhydrous glucose and potassium iodide, adding the dry hydrogel dressing into the mixed solution of anhydrous glucose and potassium iodide, standing, covering on a polyester mesh with a hole structure, drying in a vacuum drying oven, and independently packaging to obtain the first dressing;
(4) preparing a glucose oxidase aqueous solution, adding the hydrogel dressing into the glucose oxidase aqueous solution, and performing independent sealing packaging by using a vacuum bottle or a binary spray bottle to obtain the second dressing;
(5) packaging the first dressing and second dressing in combination to obtain the oxygen-releasing hydrogel dressing.
8. The method according to claim 7, wherein the hydrogel dressing in step (1) is prepared by a process comprising the steps of:
1) adding acrylamide and derivatives thereof into deionized water, stirring, heating and dissolving to obtain a first solution;
2) adding a cross-linking agent into the first solution, and fully stirring until the cross-linking agent is dissolved to obtain a second solution;
3) adding an initiator into a proper amount of deionized water, fixing the volume, accelerating the stirring, and filtering to obtain a third solution;
4) and uniformly mixing the second solution and the third solution to obtain a fourth solution, and placing the fourth solution in an ultraviolet crosslinking instrument for UV crosslinking to obtain the hydrogel dressing.
9. The method as claimed in claim 8, wherein the temperature of the stirring and heating in step 1) is 20-50 ℃, the stirring rate is 100-300r/min, and the stirring time is 0.5-3 h.
10. The method as claimed in claim 8, wherein the accelerated stirring speed in step 3) is 300-500 r/min.
11. The method according to claim 8, wherein the UV crosslinking apparatus has an irradiation wavelength of 365nm and an irradiation intensity of 100mw/cm2The irradiation time is 10-60 s.
12. The method according to claim 7, wherein the pre-fabricated quartz mold has dimensions of: 5cm × 5cm × 1mm, 5cm × 5cm × 1.5mm, 15cm × 15cm × 1mm, or 15cm × 15cm × 1.5 mm.
13. The method according to claim 7, wherein the freeze-drying is carried out at-30 ℃ for 0.5 to 3 hours.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113101053A (en) * | 2021-03-30 | 2021-07-13 | 上海健康医学院 | Wound dressing capable of releasing nitric oxide |
| CN113679874A (en) * | 2021-09-03 | 2021-11-23 | 明基材料有限公司 | Multi-segment release dressing |
| CN114470297A (en) * | 2021-12-20 | 2022-05-13 | 山西医科大学 | Sugar-triggered response type wound quick-healing dressing and preparation method thereof |
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| CN107823691A (en) * | 2017-11-06 | 2018-03-23 | 河南汇博医疗股份有限公司 | A kind of oxygen-containing dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113101053A (en) * | 2021-03-30 | 2021-07-13 | 上海健康医学院 | Wound dressing capable of releasing nitric oxide |
| CN113679874A (en) * | 2021-09-03 | 2021-11-23 | 明基材料有限公司 | Multi-segment release dressing |
| CN114470297A (en) * | 2021-12-20 | 2022-05-13 | 山西医科大学 | Sugar-triggered response type wound quick-healing dressing and preparation method thereof |
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