CN109316621A - A kind of preparation method of aerogel dressing - Google Patents
A kind of preparation method of aerogel dressing Download PDFInfo
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- CN109316621A CN109316621A CN201811196748.8A CN201811196748A CN109316621A CN 109316621 A CN109316621 A CN 109316621A CN 201811196748 A CN201811196748 A CN 201811196748A CN 109316621 A CN109316621 A CN 109316621A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
- C08F283/065—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals on to unsaturated polyethers, polyoxymethylenes or polyacetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
A kind of preparation method of aerogel dressing, belongs to skin ultrastructure technical field of material.Step: first the monomer matched in parts by weight, crosslinking agent, photoinitiator and thickener investment are furnished in the container of agitating device and stirred evenly, hydrogel solution is obtained after cooling, hydrogel solution is coated on substrate again and is shaped through ultraviolet lighting, be supported hydrogel layer, uses remaining hydrogel solution as stand-by liquid；Antibacterial heal-promoting conjunction monomer is added into the stand-by liquid and control promoting healing monomer is added to the additional amount in stand-by liquid, is stirred evenly, obtains functional layer pre-gel solution；Obtained functional layer pre-gel solution is coated on the support hydrogel layer, then be crosslinked through ultraviolet lighting, obtains aerogel dressing.Processing step is brief and without relying on harsh equipment；The excellent effect to wound sustained release such as antibacterial, promoting healing effective component can be played；It embodies to the covering of wound good physics and moistening effect, and wound exudate can be absorbed well.
Description
Technical field
The invention belongs to skin ultrastructure technical field of material, and in particular to a kind of preparation side of aerogel dressing
Method.
Background technique
Skin is the maximum organ of human body, plays a part of to protect and supports body, once its integrality is destroyed,
It will lead to body water, electrolyte largely loses, while the injury vulnerable to bacterium and external environment.Traditional skin wound dressing
(i.e. wound dressing) is commonly the natural plant fiber materials such as gauze, cotton pad, and is directly covered on the surface of a wound and is mentioned for wound
For protection.But stemness environment is unfavorable for wound healing, and dressing need to be replaced within a certain period of time, when replacement wound easily with apply
Expect adhesion, causes secondary injury, be unfavorable for the healing of wound.
Since the sixties in last century British scientist George doctor Winter has found that wet environment is conducive to wound and is cured
Merge since proposing moisture treatment, various functional aquagel dressing are widely applied.Water based on wet union theory
There is gel dressing preferably ventilative, moisture-inhibiting, barrier bacterium, control to absorb the performances such as wound exudate, can keep wound moist, inhale
It receives extra sepage and creates the environment for being more advantageous to wound healing.In addition, the stickiness of hydrogel and wound is good, when more change dressings not
It will cause wound secondary injury.
But since the aerogel dressing function in prior art is relatively single, for infected wound, extremely it is difficult to be cured
It is often helpless to close wound.Therefore, if aerogel dressing antibacterial can be assigned, promote the functions such as healing, for wound
The application of nursing field has positive effect.
Can be no lack of the technical information for being seen in the preparation method about aerogel dressing in disclosed Chinese patent literature, such as
A kind of antibacterial hydrogel material and preparation method thereof for being used to prepare medical wound dressing of CN102319448A(),
A kind of antibacterial medical aerogel dressing of CN104353103B(and preparation method thereof) and a kind of recombinant collagen egg of CN108273122A(
White hydrogel wound dressing and its preparation method and application), etc..Typical such as CN103232611B recommends " a kind of novel
The preparation method of hydrogel medical dressing ", formula meter: 20-40 parts of water soluble polymer, functional monomer 4-20
Part, 40-120 parts of dehydrating agent, 0-0.2 parts of polymerization inhibitor, 0.2-1.5 parts of catalyst, hydrogel monomer weight 0.5-1% initiation
The water of agent and 1.5-4 times of hydrogel monomer weight；The preparation method of the patent see the 0032nd to 0036 section of specification and
Embodiment 1 to 3.The CN103232611B is due to needing to be heated to reflux during the preparation process and need to add after long-time flows back
Initiator high-temperature baking plastic, thus energy consumption is high, causes preparation cost high, is unfavorable for industrial amplification production.For another example
" a kind of aerogel dressing and preparation method thereof " that CN101337086B is provided, aerogel dressing is made of upper layer and lower layer, up and down
Radiation method and the preparation of freeze thawing radiation method is respectively adopted in layer, and upper layer and lower layer hydrogel all has water-soluble polymer and solvent, wherein
Polyvinyl alcohol is contained in lower layer；The patent during the preparation process, since lower layer's hydrogel needs the multiple circulating frozen of low temperature, and upper water
Gel needs cross-linking radiation, thus preparation time is long and energy consumption is high, due to after water-setting composes with infusion method carrying medicament, thus
It is not good enough for protide macromolecular drug adsorption effect and adsorbance is limited, due to continue charging irradiation after needing multiple circulating frozen
Molding, thus other than preparation time above-mentioned is long, technique is cumbersome, is unfavorable for industrial amplification production.
Summary of the invention
Task of the invention lies in a kind of preparation method of aerogel dressing is provided, this method preparation process is terse, prepares
Energy consumption in the process is small, is satisfied industrial amplification production requirement, and both can be right by aerogel dressing prepared by this method
Wound plays physics covering, moisture-keeping function, but can effectively to wound sustained release such as antibacterial, promoting healing effective component and
With good gas permeability and to the good absorbability of wound exudate.
The task of the present invention is in this way to complete, a kind of preparation method of aerogel dressing, comprising the following steps:
A) preparation support hydrogel layer first matches the monomer matched in parts by weight, crosslinking agent, photoinitiator and thickener investment
Have in the container of agitating device and stir evenly, obtains hydrogel solution after cooling, then hydrogel solution is coated on substrate and is passed through
Ultraviolet lighting forming, be supported hydrogel layer, wherein uses remaining hydrogel solution as stand-by liquid；
B functional layer pre-gel solution) is prepared, antibacterial heal-promoting is added into stand-by liquid described in step A) and closes monomer and controls
Promoting healing monomer is added to the additional amount in stand-by liquid, is stirred evenly, and functional layer pre-gel solution is obtained；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is coated on to the support hydrogel obtained by step A)
It on layer, then is crosslinked through ultraviolet lighting, obtains aerogel dressing.
In a specific embodiment of the invention, step A) described in the parts by weight of monomer be 10-80 parts, it is described
The parts by weight of crosslinking agent are 0.01-1 parts, and the parts by weight of the photoinitiator are 0.01-0.2 parts；The weight of the thickener
Measuring number is 10-50 parts.
In another specific embodiment of the invention, step A) described in stirring be that magnetic agitation or machinery stir
It mixes；The cooling temperature of the cooling is 5~-20 DEG C.
In another specific embodiment of the invention, the monomer is ionic comonomer and/or non-ionic list
Body.
In another specific embodiment of the invention, the ionic comonomer is to be able to crosslink reaction generation
The double bond containing 2- acrylamide-2-methyl propane sulfonic of hydrogel, acrylic acid, methacrylic acid and (3- acrylamide propyl)
Any one in trimethyl ammonium chloride or several combinations；The nonionic monomers be so that cross-linking reaction generate
The double bond containing methacrylate of hydrogel, acrylamide, N- vinyl acetamide, n-vinyl pyrrolidone, methyl-prop
Olefin(e) acid hydroxyl ethyl ester and N, the combination of one or more of N- dimethacrylamide.
Of the invention there are one in specific embodiment, the crosslinking agent can be crosslinked the monomer and contain
The esters or amide substance of unsaturated double-bond, the Ester are ethylene glycol dimethacrylate, polyethylene glycol two
Any one in acrylate and tripropylene glycol diacrylate or several combinations, the amide substance are methene
Bisacrylamide.
In a still more specific embodiment of the invention, the photoinitiator is 1173, I184, I127, I379
And one of TPU.
In an of the invention and then specific embodiment, the thickener be glycerol, sorbierite, propylene glycol and
The combination of one or more of polyethylene glycol.
Step B in yet a further embodiment of the present invention) described in control antibacterial heal-promoting close monomer add
Entering to the additional amount in the stand-by liquid is that the additional amount that antibacterial heal-promoting is closed monomer controls as the weight of the stand-by liquid
0.1-1%, it is chitosan, silver ion, nano silver, caffeic acid, Win-41464, recombinant human serum that the antibacterial heal-promoting, which closes monomer,
The combination of one or more of albumin and rhGM-CSF.
Of the invention again and then in a specific embodiment, step A) and step C) described in ultraviolet lighting it is ultraviolet
Light wave a length of 240-480nm, light intensity 20-200mw/cm2, the time of ultraviolet lighting is 10-80s, the support hydrogel
Layer with a thickness of 0.01-5mm；The substrate is non-woven fabrics or gauze, and the non-woven fabrics is polyurethane non-woven fabrics.
Of the invention also and then in a specific embodiment, step C) described in the coating of functional layer pre-gel solution
In it is described support hydrogel layer on a thickness of 0.01-5mm.
One of the technical effect of technical solution provided by the invention, since the processing step of preparation is brief and is not necessarily to rely on
Harsh equipment, thus the energy consumption in preparation process can have not only been saved, but also be able to satisfy industrial amplification production requirement；Two, due to
Contain antibacterial heal-promoting in functional layer pre-gel solution and close monomer, thus works as and functional layer pre-gel solution is coated on support hydrogel
After layer surface, the excellent effect to wound sustained release such as antibacterial, promoting healing effective component can be played；Three, due to by water
Gel solution is configured to support hydrogel layer through ultraviolet lighting after being coated on substrate, and due to applying functional layer pre-gel solution
It is crosslinked, thus can both embody to the covering of wound good physics and moisturizing effect through ultraviolet lighting again after being distributed on support hydrogel layer
Fruit, and wound exudate can be absorbed well.
Specific embodiment
Embodiment 1:
A) preparation support hydrogel layer, first will 45 parts of 2- acrylamide-2-methyl propane sulfonic weighed in parts by weight, can be crosslinked
Aforementioned 2- acrylamide-2-methyl propane sulfonic and 0.3 part of the ethylene glycol dimethacrylate containing unsaturated double-bond, poly- second
0.3 part of omega-diol diacrylate, 0.4 part of tripropylene glycol diacrylate, 1,184 0.01 parts of photoinitiator, 10 parts of glycerol, sorb
10 parts of alcohol, 10 parts of propylene glycol investments equipped in the container of agitating device by magnetic agitation to uniform, then through cold at a temperature of -20 DEG C
But, hydrogel solution is obtained, then hydrogel solution is coated on polyurethane non-woven fabrics, is formed on polyurethane non-woven fabrics thick
Degree is the coating of 5mm, then shapes through ultraviolet lighting, and the ultraviolet light wave length of ultraviolet lighting is 480nm, and the light intensity of ultraviolet light is
20mw/cm2, the time of ultraviolet lighting is 10s, and be supported hydrogel layer, wherein is made in this step with remaining hydrogel solution
For stand-by liquid；
B functional layer pre-gel solution) is prepared, is added into the stand-by liquid obtained by step A) and accounts for stand-by liquid weight
0.03% nano silver, 0.03% recombination human serum albumin and 0.04% chitosan, then stirred evenly, it is pre- to obtain functional layer
Gel solution；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is first coated on to the support water-setting obtained by step A)
On glue-line, the coating with a thickness of 5mm is formed on the surface of support hydrogel layer, then be crosslinked through ultraviolet lighting, the purple of ultraviolet lighting
The outer a length of 480nm of light wave, the light intensity of ultraviolet light are 20mw/cm2, the time of ultraviolet lighting is 10s, obtains aerogel dressing.
Embodiment 2:
A) preparation support hydrogel layer, first will 2 parts of acrylic acid weighed in parts by weight, 2 parts of methacrylic acid, (3- acryloyl
Amine propyl) 6 parts of trimethyl ammonium chloride, aforementioned acrylic acid, methacrylic acid, (3- acrylamide propyl) trimethyl ammonia chloride can be crosslinked
Ammonium and 1,173 0.03 parts of 0.01 part of ethylene glycol dimethacrylate, photoinitiator, polyethylene glycol containing unsaturated double-bond
10 parts of investments equipped in the container of agitating device by mechanical stirring to uniform, then through cooling at a temperature of 5 DEG C, obtain water-setting peptization
Hydrogel solution is then coated on gauze by liquid, on gauze formed with a thickness of 0.01mm coating, then through ultraviolet lighting at
Shape, the wavelength of ultraviolet lighting are 400nm, and the light intensity of ultraviolet lighting is 200mw/cm2, the time of ultraviolet lighting is 30s, is propped up
Support hydrogel layer, wherein use remaining hydrogel solution as stand-by liquid in this step；
B functional layer pre-gel solution) is prepared, addition accounts for the 0.1% of stand-by liquid weight into the stand-by liquid obtained by step A)
Nano silver, 0.2% Win-41464, then stirred evenly, obtain functional layer pre-gel solution；
C finished product) is prepared, is first coated on the functional gel obtained by step B) on the support hydrogel layer obtained by step A),
The coating with a thickness of 0.01mm is formed on the surface of support hydrogel layer, then is crosslinked through ultraviolet lighting, the ultraviolet light of ultraviolet lighting
Wavelength is 400nm, and the light intensity of ultraviolet light is 200mw/cm2, the time of ultraviolet lighting is 30s, obtains aerogel dressing.
Embodiment 3:
A) preparation support hydrogel layer, first by 80 parts of acrylic acid weighed in parts by weight, can be crosslinked aforementioned acrylic acid and
0.015 part of 0.015 part of polyethyleneglycol diacrylate, tripropylene glycol diacrylate, photoinitiator containing unsaturated double-bond
1379 0.2 parts, 50 parts of propylene glycol investments equipped in the container of agitating device by magnetic agitation to uniform, then through at a temperature of 0 DEG C
It is cooling, hydrogel solution is obtained, then hydrogel solution is coated on gauze, forms the painting with a thickness of 0.08mm on gauze
Layer, then shaped through ultraviolet lighting, the wavelength of the ultraviolet light of ultraviolet lighting is 240nm, and the light intensity of ultraviolet light is 60mw/cm2, ultraviolet
The time of illumination is 80s, and be supported hydrogel layer, wherein uses remaining hydrogel solution as stand-by liquid in this step；
B functional layer pre-gel solution) is prepared, 1% weight for accounting for stand-by liquid weight is added into the stand-by liquid obtained by step A)
Group human growth factor, then stirred evenly, obtain functional layer gel solution；
C finished product) is prepared, is first coated on the functional gel obtained by step B) on the support hydrogel layer obtained by step A),
The coating with a thickness of 0.08mm is formed on the surface of support hydrogel layer, then is crosslinked through ultraviolet lighting, the ultraviolet light of ultraviolet lighting
Wavelength is 240nm, and the light intensity of ultraviolet light is 60mw/cm2, the time of ultraviolet lighting is 80s, obtains aerogel dressing.
Embodiment 4:
A) preparation support hydrogel layer, first will 65 parts of methacrylate weighed in parts by weight, aforementioned methyl-prop can be crosslinked
Olefin(e) acid ester and 1,127 0.06 parts of 0.8 part of polyethyleneglycol diacrylate, photoinitiator, sorbierite containing unsaturated double-bond
20 parts, 20 parts of propylene glycol investments equipped with cooling to uniform, then at a temperature of -5 DEG C of warp by magnetic agitation in the container of agitating device,
Hydrogel solution is obtained, then hydrogel solution is coated on polyurethane non-woven fabrics, forms thickness on polyurethane non-woven fabrics
It for the coating of 0.15mm, then shapes through ultraviolet lighting, a length of 300nm of the ultraviolet light wave of ultraviolet lighting, the light intensity of ultraviolet light is
100mw/cm2, the time of ultraviolet lighting is 60s, and be supported hydrogel layer, wherein with remaining hydrogel solution in this step
As stand-by liquid；
B functional layer pre-gel solution) is prepared, addition accounts for the 0.8% of stand-by liquid weight into the stand-by liquid obtained by step A)
Caffeic acid, then stirred evenly, obtain functional layer pre-gel solution；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is first coated on to the support water-setting obtained by step A)
On glue-line, the coating with a thickness of 0.15mm is formed on the surface of support hydrogel layer, then be crosslinked through ultraviolet lighting, ultraviolet lighting
The a length of 300nm of ultraviolet light wave, the light intensity of ultraviolet light are 100mw/cm2, the time of ultraviolet lighting is 60s, obtains aerogel dressing.
Embodiment 5:
A) preparation support hydrogel layer, first will 20 parts of acrylamide weighed in parts by weight, 20 parts of N- vinyl acetamide, first
15 parts of base hydroxy-ethyl acrylate, can be crosslinked foregoing acryloyl amine, N- vinyl acetamide, hydroxyethyl methacrylate and contain
20 parts of 0.16 part of 0.06 part of ethylene glycol dimethacrylate, photoinitiator TPU, glycerol investments of unsaturated double-bond, which are furnished with, to be stirred
Mix in the container of device by magnetic agitation to uniform, then at a temperature of -15 DEG C of warp it is cooling, hydrogel solution is obtained, then by water
Gel solution is coated on polyurethane non-woven fabrics, the coating with a thickness of 2mm is formed on polyurethane non-woven fabrics, then through ultraviolet lighting
Forming, the wavelength of the ultraviolet light of ultraviolet lighting are 430nm, and the light intensity of ultraviolet light is 170mw/cm2, the time of ultraviolet lighting is
40s, be supported hydrogel layer, wherein uses remaining hydrogel solution as stand-by liquid in this step；
B functional layer pre-gel solution) is prepared, addition accounts for the 0.2% of stand-by liquid weight into the stand-by liquid obtained by step A)
Chitosan, then stirred evenly, obtain functional layer pre-gel solution；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is first coated on to the support water-setting obtained by step A)
On glue-line, the coating with a thickness of 2mm is formed on the surface of support hydrogel layer, then be crosslinked through ultraviolet lighting, the purple of ultraviolet lighting
The outer a length of 430nm of light wave, the light intensity of ultraviolet light are 170mw/cm2, the time of ultraviolet lighting is 40s, obtains aerogel dressing.
Embodiment 6:
A) preparation support hydrogel layer, first will 11 parts of 2- acrylamide-2-methyl propane sulfonic weighed in parts by weight, N- second
11 parts of alkenyl pyrrolidone, can be crosslinked aforementioned 2- acrylamide-2-methyl propane sulfonic, N- vinyl pyrrolidone and containing not
45 parts of 0.12 part of 0.6 part of methylene diacrylamide, photoinitiator TPU, glycerol investments for being saturated double bond are furnished with the appearance of agitating device
By magnetic agitation to uniform in device, then at a temperature of -10 DEG C of warp it is cooling, obtain hydrogel solution, then apply hydrogel solution
It is distributed on gauze, forms the coating with a thickness of 3.5mm on gauze, then shape through ultraviolet lighting, the ultraviolet light wave of ultraviolet lighting
A length of 320nm, the light intensity of ultraviolet light are 140mw/cm2, the time of ultraviolet lighting is 50s, and be supported hydrogel layer, wherein
Use remaining hydrogel solution as stand-by liquid in this step；
B functional layer pre-gel solution) is prepared, addition accounts for the 0.6% of stand-by liquid weight into the stand-by liquid obtained by step A)
Nano silver, then stirred evenly, obtain functional layer pre-gel solution；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is first coated with to the support hydrogel obtained by step A)
On layer, the coating with a thickness of 3.5mm is formed on the surface of support hydrogel layer, then be crosslinked through ultraviolet lighting, the purple of ultraviolet lighting
The outer a length of 320nm of light wave, the light intensity of ultraviolet light are 140mw/cm2, the time of ultraviolet lighting is 50s, obtains aerogel dressing.
There is good biocompatibility and water imbibition by the aerogel dressing that above-described embodiment 1 to 6 obtains, convenient for keeping
The Moist healing environment of wound simultaneously absorbs extra sepage.It is easy to remove from wound and wound will not be caused after gel water suction simultaneously
Secondary injury.Aerogel dressing prepared by the present invention can also load antibacterial or rush other than having the advantages that conventional gel dressing
The functional component of healing simultaneously is allowed to can effectively reduce the therapeutic efficiency of the frequency upgrading wound of more change dressings in wound sustained release
Reduce treatment cost.
Embodiment described above is only that preferred embodiments of the present invention will be described, not to the scope of the present invention
It is defined, the various changes and improvements that technical solution of the present invention is made without departing from the spirit of the design of the present invention
It should all fall within the scope of protection of the present invention.
Claims (10)
1. a kind of preparation method of aerogel dressing, it is characterised in that the following steps are included:
A) preparation support hydrogel layer first matches the monomer matched in parts by weight, crosslinking agent, photoinitiator and thickener investment
Have in the container of agitating device and stir evenly, obtains hydrogel solution after cooling, then hydrogel solution is coated on substrate and is passed through
Ultraviolet lighting forming, be supported hydrogel layer, wherein uses remaining hydrogel solution as stand-by liquid；
B functional layer pre-gel solution) is prepared, antibacterial heal-promoting is added into stand-by liquid described in step A) and closes monomer and controls
Promoting healing monomer is added to the additional amount in stand-by liquid, is stirred evenly, and functional layer pre-gel solution is obtained；
C finished product) is prepared, the functional layer pre-gel solution obtained by step B) is coated on to the support hydrogel obtained by step A)
It on layer, then is crosslinked through ultraviolet lighting, obtains aerogel dressing.
2. a kind of preparation method of aerogel dressing according to claim 1, it is characterised in that step A) described in monomer
Parts by weight be 10-80 part, the parts by weight of the crosslinking agent are 0.01-1 parts, and the parts by weight of the photoinitiator are
0.01-0.2 parts；The parts by weight of the thickener are 10-50 parts.
3. a kind of preparation method of aerogel dressing according to claim 1, it is characterised in that step A) described in stir
It mixes as magnetic agitation or mechanical stirring；The cooling temperature of the cooling is 5~-20 DEG C.
4. a kind of preparation method of aerogel dressing according to claim 1 or 2, it is characterised in that the monomer be from
Subtype monomer and/or nonionic monomers.
5. a kind of preparation method of aerogel dressing according to claim 4, it is characterised in that the ionic comonomer
To be able to crosslink double bond containing 2- acrylamide-2-methyl propane sulfonic, the acrylic acid, metering system of reaction generation hydrogel
Any one in acid and (3- acrylamide propyl) trimethyl ammonium chloride or several combinations；The non-ionic list
Body be so that cross-linking reaction generate hydrogel double bond containing methacrylate, acrylamide, N- vinyl acetamide, N-
Vinyl pyrrolidone, hydroxyethyl methacrylate and N, the combination of one or more of N- dimethacrylamide.
6. a kind of preparation method of aerogel dressing according to claim 1 or 2, it is characterised in that the crosslinking agent is
Esters or the amide substance monomer and containing unsaturated double-bond can be crosslinked, the Ester is glycol dinitrate
Any one in base acrylate, polyethyleneglycol diacrylate and tripropylene glycol diacrylate or several combinations,
The amide substance is methylene diacrylamide.
7. a kind of preparation method of aerogel dressing according to claim 1 or 2, it is characterised in that the photoinitiator
For one of 1173, I184, I127, I379 and TPU.
8. a kind of preparation method of aerogel dressing according to claim 1 or 2, it is characterised in that the thickener is
The combination of one or more of glycerol, sorbierite, propylene glycol and polyethylene glycol.
9. a kind of preparation method of aerogel dressing according to claim 1, it is characterised in that step B) described in control
It is that the additional amount that antibacterial heal-promoting is closed monomer controls as institute that antibacterial heal-promoting processed, which closes the additional amount that monomer is added in the stand-by liquid,
The 0.1-1% of the weight of stand-by liquid is stated, it is chitosan, silver ion, nano silver, caffeic acid, Losec that the antibacterial heal-promoting, which closes monomer,
The too combination of one or more of pyridine, recombination human serum albumin and rhGM-CSF.
10. a kind of preparation method of aerogel dressing according to claim 1, it is characterised in that step A) and step C) in
The ultraviolet light wave of the ultraviolet lighting a length of 240-480nm, light intensity 20-200mw/cm2, the time of ultraviolet lighting is 10-
80s, the described support hydrogel layer with a thickness of 0.01-5mm；The substrate is non-woven fabrics or gauze, the non-woven fabrics
For polyurethane non-woven fabrics；Step C) described in functional layer pre-gel solution be coated on it is described support hydrogel layer on a thickness of
0.01-5mm。
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| CN110229286A (en) * | 2019-05-10 | 2019-09-13 | 台州学院 | A kind of method preparing dissymmetrical structure hydrogel using one step of differences in viscosity and products thereof and application |
| CN111729123A (en) * | 2020-06-29 | 2020-10-02 | 苏州凝智新材料发展有限公司 | Suture-free hydrogel adhesive plaster for tissue wound closure and preparation method thereof |
| CN111905142A (en) * | 2019-05-10 | 2020-11-10 | 陕西佰傲再生医学有限公司 | Oxygen-releasing hydrogel dressing and preparation method thereof |
| CN112587723A (en) * | 2020-11-19 | 2021-04-02 | 南京医科大学 | In-situ rapid-forming magnetic hydrogel for repairing urinary system and preparation method thereof |
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| CN109939066A (en) * | 2019-03-06 | 2019-06-28 | 华南理工大学 | Stimuli responsive hydrogel and its preparation method and application based on functionalization dual network |
| CN110229286A (en) * | 2019-05-10 | 2019-09-13 | 台州学院 | A kind of method preparing dissymmetrical structure hydrogel using one step of differences in viscosity and products thereof and application |
| CN111905142A (en) * | 2019-05-10 | 2020-11-10 | 陕西佰傲再生医学有限公司 | Oxygen-releasing hydrogel dressing and preparation method thereof |
| CN110229286B (en) * | 2019-05-10 | 2021-07-13 | 台州学院 | Method for preparing hydrogel with asymmetric structure in one step by using viscosity difference, product and application thereof |
| CN111729123A (en) * | 2020-06-29 | 2020-10-02 | 苏州凝智新材料发展有限公司 | Suture-free hydrogel adhesive plaster for tissue wound closure and preparation method thereof |
| CN113354839A (en) * | 2020-08-26 | 2021-09-07 | 兰州大学 | Collagen-silver nanoparticle composite gel, preparation method and application |
| WO2022072394A1 (en) * | 2020-09-30 | 2022-04-07 | Green Theme Technologies, Inc. | Curable coating compositions and antimicrobial/antiviral coatings made by curing such coating compositions |
| CN112587723A (en) * | 2020-11-19 | 2021-04-02 | 南京医科大学 | In-situ rapid-forming magnetic hydrogel for repairing urinary system and preparation method thereof |
| CN114045681A (en) * | 2021-12-03 | 2022-02-15 | 广州大学 | Preparation method of hydrogel gauze for preventing blood adhesion |
| CN114045681B (en) * | 2021-12-03 | 2023-05-23 | 广州大学 | Preparation method of hydrogel gauze capable of preventing blood adhesion |
| CN115340630A (en) * | 2022-09-02 | 2022-11-15 | 东莞市中森新材料有限公司 | Gel with good heat dissipation effect and rapid cooling and manufacturing process |
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