CN114045681A - Preparation method of hydrogel gauze for preventing blood adhesion - Google Patents
Preparation method of hydrogel gauze for preventing blood adhesion Download PDFInfo
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- CN114045681A CN114045681A CN202111467950.1A CN202111467950A CN114045681A CN 114045681 A CN114045681 A CN 114045681A CN 202111467950 A CN202111467950 A CN 202111467950A CN 114045681 A CN114045681 A CN 114045681A
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- gauze
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- adhesion
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/19—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
- D06M15/21—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D06M15/356—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of other unsaturated compounds containing nitrogen, sulfur, silicon or phosphorus atoms
- D06M15/3568—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of other unsaturated compounds containing nitrogen, sulfur, silicon or phosphorus atoms containing silicon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/04—Vegetal fibres
- D06M2101/06—Vegetal fibres cellulosic
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides hydrogel gauze for preventing blood adhesion, which belongs to the technical field of biochemical engineering, and the preparation method comprises the following steps: s1, adding a monomer and hydroxyl silicone oil into a solvent, and fully stirring and emulsifying to obtain a uniform emulsified solution; adding a photoinitiator and N-aminoethyl-3-aminopropylmethyldimethoxysilane, and fully stirring and mixing to obtain a gel precursor solution; the monomer is composed of a first monomer and a second monomer, wherein the first monomer comprises acrylamide, and the second monomer comprises a double-bond-containing silane coupling agent; s2, soaking gauze in the gel precursor solution, and carrying out photocuring treatment on the soaked gauze to obtain the blood adhesion prevention hydrogel gauze; the hydrogel gauze keeps the softness and the air permeability of the original gauze and has good anti-adhesion effect on water, protein, blood and other solutions.
Description
Technical Field
The invention relates to the technical field of biochemical engineering, in particular to a preparation method of hydrogel gauze for preventing blood adhesion.
Background
The traditional medical gauze is made by plain weaving cotton yarn, bleaching, degreasing, has sparse structure, is sterilized strictly at high temperature and high pressure, and is suitable for being used as a base material for medical bandaging, dressing, and the like. When the gauze is used for treating a wound, pressure is usually applied, and the method inevitably absorbs blood, so that the gauze is stuck on the wound, and if the gauze is forcedly torn, the wound is often torn, pain is caused, and even secondary bleeding is caused.
The textile coating is a high molecular compound uniformly coated on the surface of the fabric, and forms one or more layers of films on the surface of the fabric through the adhesion effect, so that the appearance and style of the fabric can be improved, the functions of the fabric can be enhanced, and the fabric has special functions of water resistance, water pressure resistance, ventilation and moisture permeability, flame retardance, stain resistance, shading, reflection and the like. Hydrogel is a high molecular material with a large amount of water bound by a polymer network, and the high water content of the hydrogel determines that the hydrogel has the characteristic of low modulus to a certain extent and is similar to a human body. Therefore, the composite material can be made into a composite material with gauze, and the softness of the gauze is not influenced, and the human body discomfort is not caused.
The blood is a red opaque viscous liquid flowing in human blood vessels and heart, and consists of blood plasma and blood cells, wherein one liter of the blood plasma contains 900-910 g of water, 65-85 g of protein and 20 g of low molecular substances. Because the structure of the protein is complex and contains various functional groups, the protein can form physical actions such as hydrogen bonds and the like with various substrates, and further cause wound adhesion. Therefore, prevention of blood adhesion is a major problem in the medical field at present.
Disclosure of Invention
Aiming at the problems, the invention provides hydrogel gauze for preventing blood adhesion and a preparation method thereof.
The purpose of the invention is realized by adopting the following technical scheme:
a preparation method of hydrogel gauze for preventing blood adhesion comprises the following steps:
s1, adding a monomer and hydroxyl silicone oil into a solvent, and fully stirring and emulsifying to obtain a uniform emulsified solution; adding a photoinitiator and N-aminoethyl-3-aminopropylmethyldimethoxysilane, and fully stirring and mixing to obtain a gel precursor solution;
the monomer is composed of a first monomer and a second monomer, wherein the first monomer comprises acrylamide, and the second monomer comprises a double-bond-containing silane coupling agent;
s2, soaking gauze in the gel precursor solution, and carrying out photocuring treatment on the soaked gauze to obtain the blood adhesion prevention hydrogel gauze.
In some embodiments, the double bond-containing silane coupling agent is vinyltris (2-methoxyethoxy) silane and/or 3- (acryloyloxy) propyltrimethoxysilane.
In some embodiments, the mass ratio of the first monomer to the second monomer in the monomers is (9-6): (1-4).
In some embodiments, the N-aminoethyl-3-aminopropylmethyldimethoxysilane is added in an amount of 3% to 20% by weight of the monomer.
In some embodiments, the amount of the hydroxyl silicone oil added is 0% to 20% of the mass of the monomer;
further preferably, the adding amount of the hydroxyl silicone oil is 6-20% of the mass of the monomer;
when the mass of the hydroxyl silicone oil is 0, the hydrogel gauze has the effects of dewatering and dredging blood, but the blood is obviously adhered to the gauze line.
In some embodiments, the solvent is water or a mixed solvent with glycerol, wherein the mixing mass ratio of the water to the glycerol is (10-5): (0-5).
In some embodiments, the proportion of the solvent in the emulsified solution is 10% to 30% by mass.
In some embodiments, the photoinitiator is added in an amount of 0.1% to 1% by mass of the monomers.
The invention also aims to provide the hydrogel gauze for preventing blood adhesion, which is prepared by the preparation method.
The invention has the beneficial effects that:
(1) the invention provides hydrogel gauze, in particular to a layer of hydrogel adsorbed and wrapped on cotton threads of common gauze, which not only keeps the porous structure of the gauze, but also does not influence the air permeability of the gauze; due to the low modulus of the hydrogel, the softness of the hydrogel gauze is also retained, and the hydrogel gauze does not cause discomfort when applied to a wound.
(2) Ordinary medical gauze is super hydrophilic, and blood can be inevitable adsorbs on the gauze in the in-service use in-process, can tear the wound when the gauze is peeled off, causes the secondary injury. The hydrogel gauze disclosed by the invention is modified, the contact angle of water reaches 130 degrees, the hydrogel gauze is in a hydrophobic state, and the contact angle of 2% Bovine Serum Albumin (BSA) solution and blood (pig) also reaches about 130 degrees, so that the hydrogel gauze has a good anti-adhesion effect on the liquids; meanwhile, due to the super-hydrophilic characteristic of the common gauze, the breakthrough pressure of the common gauze on blood is almost 0, and the blood at the wound directly flows out through the gauze in the actual use process, so that the hemostasis of the wound is not facilitated; the hydrogel gauze disclosed by the invention is modified, so that the breakthrough pressure of the hydrogel gauze on blood reaches 228Pa, and the hydrogel gauze has an excellent anti-permeability hemostatic effect.
Drawings
The invention is further illustrated by means of the attached drawings, but the embodiments in the drawings do not constitute any limitation to the invention, and for a person skilled in the art, other drawings can be obtained on the basis of the following drawings without inventive effort.
FIG. 1 is a structural diagram of a fiber of a common medical gauze before hydrogel wrapping;
FIG. 2 is a fiber structure diagram of a hydrogel gauze according to the present invention;
FIG. 3 is a graph of contact angles of several different solutions on hydrogel gauze described in example 1 (water, 2% BSA solution, blood, from left to right);
FIG. 4 is a graph comparing contact angle data for several different solutions on hydrogel gauze described in example 1;
fig. 5 is a graph of the blood breakthrough pressure measurement result of the ordinary medical gauze before hydrogel wrapping:
FIG. 6 is a graph of the blood breakthrough pressure measurements for the hydrogel gauze described in example 1:
FIG. 7 is a solution state of blood on a common medical gauze before hydrogel wrapping in an inclined position;
FIG. 8 is a solution of blood on a beveled hydrogel gauze as described in example 1.
Detailed Description
The invention is further described with reference to the following examples.
Example 1
The embodiment relates to hydrogel gauze for preventing blood adhesion, and a preparation method of the hydrogel gauze comprises the following steps:
s1, weighing 0.06g of photoinitiator, adding the photoinitiator into 2mL of ethanol, and uniformly stirring to obtain a photoinitiator solution;
s2, 2.4g of acrylamide, 0.6g of vinyltris (2-methoxyethoxy) silane and 0.2g of hydroxysilicone oil were weighed out, and added to 9g of a solvent (m)Water (W)：mGlycerolStirring fully for 30-60 min in the ratio of 7:3), adding 300 mu L of the photoinitiator solution obtained in the step S1, and continuing stirring for 10 min;
s3, 0.3g N-aminoethyl-3-aminopropylmethyldimethoxysilane is weighed and added into the solution obtained in the step S2, and the mixture is stirred uniformly;
s4, pouring the solution obtained in the step S3 into a culture dish, cutting medical gauze into a proper size, and soaking the medical gauze in the culture dish for 30 min;
s5, taking out the soaked gauze, and placing the gauze into an ultraviolet curing machine for irradiation for 5min to obtain the hydrogel gauze.
Referring to fig. 3-4, the hydrogel gauze of this example is hydrophobic, and has a contact angle of 130 ° with water, and a contact angle of about 130 ° with 2% BSA solution and blood (pig); referring to fig. 5-6, the ordinary medical gauze is in a hydrophilic state, and the breakthrough pressure of the ordinary medical gauze on blood is almost 0, while the breakthrough pressure of the hydrogel gauze in the embodiment on blood reaches 228 Pa; referring to fig. 7-8, the result that the common medical gauze absorbs blood quickly when contacting blood, and the hydrogel gauze of the present embodiment rolls off quickly when blood drops and is not absorbed by the gauze shows that the hydrogel gauze has good anti-adhesion and anti-permeability effects on the liquids, and can achieve better effects through multiple layers in the practical application process.
Example 2
This example relates to a hydrogel gauze, which is prepared according to the same method as that of example 1, except that the double bond-containing silane coupling agent is different in type and unchanged in molar weight, and the specific conditions are as follows:
examples 3 to 6
This example relates to a hydrogel gauze, which is prepared according to the same method as in example 1, except that N-aminoethyl-3-aminopropylmethyldimethoxysilane is replaced with other silane coupling agents, but the molar weight is unchanged, and the specific conditions are as follows:
finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. A preparation method of hydrogel gauze for preventing blood adhesion is characterized by comprising the following steps:
s1, adding a monomer and hydroxyl silicone oil into a solvent, and fully stirring and emulsifying to obtain a uniform emulsified solution; adding a photoinitiator and N-aminoethyl-3-aminopropylmethyldimethoxysilane, and fully stirring and mixing to obtain a gel precursor solution;
the monomer is composed of a first monomer and a second monomer, wherein the first monomer comprises acrylamide, and the second monomer comprises a double-bond-containing silane coupling agent;
s2, soaking gauze in the gel precursor solution, and carrying out photocuring treatment on the soaked gauze to obtain the blood adhesion prevention hydrogel gauze.
2. The method for preparing a blood adhesion-preventing hydrogel gauze according to claim 1, wherein the double bond-containing silane coupling agent is vinyltris (2-methoxyethoxy) silane and/or 3- (acryloyloxy) propyltrimethoxysilane.
3. The preparation method of the blood adhesion preventing hydrogel gauze as claimed in claim 1, wherein the mass ratio of the first monomer to the second monomer in the monomers is (9-6): (1-4).
4. The method for preparing the hydrogel gauze for preventing blood adhesion according to claim 1, wherein the amount of N-aminoethyl-3-aminopropylmethyldimethoxysilane added is 3-20% by mass of the monomer.
5. The method for preparing the blood adhesion preventing hydrogel gauze as recited in claim 1, wherein the amount of the hydroxyl silicone oil added is 6-20% of the mass of the monomer.
6. The method for preparing the blood adhesion preventing hydrogel gauze as claimed in claim 1, wherein the solvent is water or a mixed solvent of water and glycerol, and the mixing mass ratio of the water to the glycerol is (10-5): (0-5).
7. The method for preparing the blood adhesion preventing hydrogel gauze as claimed in claim 1, wherein the solvent is present in the emulsified solution in a proportion of 10-30% by mass.
8. The method for preparing the blood adhesion preventing hydrogel gauze as recited in claim 1, wherein the amount of the photoinitiator added is 0.1-1% of the mass of the monomer.
9. An anti-blood-adhesion hydrogel gauze prepared by the preparation method of any one of claims 1 to 8.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114601978A (en) * | 2022-03-11 | 2022-06-10 | 广州大学 | Preparation and application of medical hydrogel coating for preventing blood adhesion |
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2021
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114601978A (en) * | 2022-03-11 | 2022-06-10 | 广州大学 | Preparation and application of medical hydrogel coating for preventing blood adhesion |
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