CN107583098A - One kind hemostasis polypropylene non-woven fabric and preparation method thereof - Google Patents
One kind hemostasis polypropylene non-woven fabric and preparation method thereof Download PDFInfo
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Abstract
The invention discloses one kind hemostasis polypropylene non-woven fabric and preparation method thereof, the non-woven fabrics includes 26~50 parts of polypropylene non-woven fabric, 16~25 parts of chitosan, 13~28 parts of polyvinyl alcohol, 12~25 parts of lavo-ofloxacin, 12~19 parts of acetic acid, 8~22 parts of sodium carbonate, 12~18 parts of SSS, 2~7 parts of 2 pyrrolidones of N vinyl, 3~8 parts of acrylamide, 1~8 part of acrylic acid, 23~48 parts of deionized water.Hemostasis polypropylene non-woven fabric aperture of the present invention is homogeneous, and uniform load antibacterials lavo-ofloxacins；Hemostasis polypropylene non-woven fabric of the present invention can stablize release antibacterials under different vitros；Hemostasis polypropylene non-woven fabric of the present invention has preferable sustained release performance, can be used as wound dressing and hemostatic material.
Description
Technical field
The invention belongs to technical field of material chemistry, is related to a kind of functional non-woven fabric material, is specially a kind of hemostasis polypropylene
Non-woven fabrics and preparation method thereof.
Background technology
Chitosan (chitosan, CS) is a kind of abundant natural alkaline polysaccharide, is that nature is only second to the 2nd of cellulose
Big living resources, there is good biocompatibility, biodegradability, human body affinity, antibacterial, hemostasis and promote wound to be cured
The excellent properties such as conjunction.Chitosan nano fiber membrane is in fields such as dressing for skin, hemostatic material, tissue engineering bracket and insoluble drug releases
Have wide practical use.
Polyvinyl alcohol (PVA) is a kind of water soluble polymer with biodegradability and bioaffinity, to human body
Nonhazardous, it is a kind of good bio-medical material.In view of the mechanical performance of pure chitosan fiber is poor, as medical fibre
Using being restricted, thus polyvinyl alcohol and chitosan blend are used herein.Due to 2 kinds of intermolecular hydrogen bond actions and well
Compatibility, the two solution blending is prepared into electrospinning fibre, it is expected to reach 2 kinds of material physiological function Synergistics and make the machine of fiber
Tool performance is improved.
Ofloxacin (ofloxacin, OFX) is the 3rd generation fluoroquinolone antibacterial agent, has has a broad antifungal spectrum, efficient, low toxicity
The characteristics of, by acting on the A subunits of DNA of bacteria helicase, suppress DNA synthesis and duplication and cause bacterial death, it is main
It is used to treat reproduction caused by sensitive bacteria, breathing, digestive system；The acute and chronic bacterium sense such as bone and joint, skin soft tissue
Dye, it can also be used to the treatment of the patient such as typhoid fever, septicemia.In recent years, chitosan and Ofloxacin are in research drug controlled release
Application in system, it is always the focus of medical domain research.Peng and Shen Hongliang etc. per capita using Ofloxacin as model drug,
The external sustained release behavior with glutaraldehyde cross-linking and emulsification and cross linked chitosan drug-loading microballoon is have studied respectively.
In the prior art, use electrical spinning method to prepare chitosan/polyvinyl alcohol and non-woven fabrics is blended as pharmaceutical carrier, prepare tool
There is Ofloxacin/chitosan/polyvinyl alcohol blending non-woven fabrics of anti-microbial property.But above-mentioned non-woven fabrics is in the body of different pH values
Insoluble drug release is unstable in external environment, and fibre diameter is uneven, causes Drug loadings heterogeneity.
The content of the invention
Present invention solves the technical problem that：The defects of in order to overcome prior art, obtaining one kind can be in different external ring
Stable release antibacterials under the conditions of border, and itself aperture is homogeneous, the non-woven fabrics hemostatic material of good permeability, the invention provides
One kind hemostasis polypropylene non-woven fabric and preparation method thereof.
Technical scheme：One kind hemostasis polypropylene non-woven fabric, by weight, the non-woven fabrics includes polypropylene non-woven fabric 26
~50 parts, 16~25 parts of chitosan, 13~28 parts of polyvinyl alcohol, 12~25 parts of lavo-ofloxacin, 12~19 parts of acetic acid, sodium carbonate
8~22 parts, 12~18 parts of SSS, 2~7 parts of NVP, 3~8 parts of acrylamide, acrylic acid 1
~8 parts, 23~48 parts of deionized water.
Preferably, by weight, the non-woven fabrics includes 45 parts of polypropylene non-woven fabric, 22 parts of chitosan, polyvinyl alcohol
23 parts, 20 parts of lavo-ofloxacin, 16 parts of acetic acid, 18 parts of sodium carbonate, 15 parts of SSS, NVP 5
Part, 6 parts of acrylamide, 6 parts of acrylic acid, 42 parts of deionized water.
A kind of preparation method for the polypropylene non-woven fabric that stops blooding, methods described comprise the steps of：
(1) polypropylene non-woven fabric is cut to 10cm × 10cm sample, 18~35 DEG C of conditions after being cleaned with absolute ethyl alcohol
Lower drying, and around glass bar be rolled into it is cylindric after tie up；
Under the conditions of (2) 18~35 DEG C, by SSS, NVP, acrylamide be dissolved in from
In sub- water, acrylic acid is added dropwise thereto, being placed in 4 DEG C after well mixed is sealed；
(3) polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred to spoke
In looking after, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, enters under the conditions of 15~25 DEG C
Row irradiation；
(4) polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric heating air blast
In drying box, dried under the conditions of 18~35 DEG C to constant weight；
(5) dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, will be poly- after step (4) processing
Propylene non-woven fabrics submerges wherein, is reacted 12~18 hours under the conditions of 18~36 DEG C；
(6) polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in levofloxacin
In the aqueous solution of star, reacted 12~18 hours under the conditions of 18~36 DEG C, be then washed with deionized water only, be made after vacuum drying.
Preferably, polypropylene non-woven fabric is cut to 10cm × 10cm sample, after being cleaned with absolute ethyl alcohol in step (1)
Dried under the conditions of 28 DEG C, and around glass bar be rolled into it is cylindric after tie up.
Preferably, in step (2) under the conditions of 28 DEG C, by SSS, NVP, acryloyl
Amine is dissolved in deionized water, and acrylic acid is added dropwise thereto, and being placed in 4 DEG C after well mixed is sealed.
Preferably, the polypropylene non-woven fabric after step (1) is tied up in step (3) is immersed in the solution of step (2) acquisition
In, and be transferred in irradiation tube, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, 18
Irradiated under the conditions of DEG C.
Preferably, the polypropylene non-woven fabric after irradiation is taken out in step (4), soaks simultaneously supersound washing with deionized water, so
After be placed in electric drying oven with forced convection, dried under the conditions of 27 DEG C to constant weight.
Preferably, dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, by step in step (5)
(4) the polypropylene non-woven fabric submergence after handling is reacted 16 hours under the conditions of 33 DEG C wherein.
Preferably, the polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in left oxygen
In the aqueous solution of Flucloxacillin, reacted 15 hours under the conditions of 32 DEG C, be then washed with deionized water only, be made after vacuum drying.
Beneficial effect：(1) hemostasis polypropylene non-woven fabric aperture of the present invention is homogeneous, and uniform load antibacterials are left
Ofloxacin；(2) hemostasis polypropylene non-woven fabric of the present invention can stablize release antibacterials under different vitros；
(3) hemostasis polypropylene non-woven fabric of the present invention has preferable sustained release performance, can be used as wound dressing and hemostatic material.
Embodiment
Embodiment 1
One kind hemostasis polypropylene non-woven fabric, by weight, the non-woven fabrics includes 26 parts of polypropylene non-woven fabric, chitosan
16 parts, 13 parts of polyvinyl alcohol, 12 parts of lavo-ofloxacin, 12 parts of acetic acid, 8 parts of sodium carbonate, 12 parts of SSS, N- ethene
2 parts of base -2-Pyrrolidone, 3 parts of acrylamide, 1 part of acrylic acid, 23 parts of deionized water.
A kind of preparation method for the polypropylene non-woven fabric that stops blooding, methods described comprise the steps of：
(1) polypropylene non-woven fabric is cut to 10cm × 10cm sample, dried after being cleaned with absolute ethyl alcohol under the conditions of 18 DEG C
It is dry, and around glass bar be rolled into it is cylindric after tie up；
Under the conditions of (2) 18 DEG C, SSS, NVP, acrylamide are dissolved in deionized water
In, acrylic acid is added dropwise thereto, being placed in 4 DEG C after well mixed is sealed；
(3) polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred to spoke
In looking after, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, spoke is carried out under the conditions of 15 DEG C
According to；
(4) polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric heating air blast
In drying box, dried under the conditions of 18 DEG C to constant weight；
(5) dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, will be poly- after step (4) processing
Propylene non-woven fabrics submerges wherein, is reacted 12 hours under the conditions of 18 DEG C；
(6) polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in levofloxacin
In the aqueous solution of star, reacted 12 hours under the conditions of 18 DEG C, be then washed with deionized water only, be made after vacuum drying.
Embodiment 2
One kind hemostasis polypropylene non-woven fabric, by weight, the non-woven fabrics includes 45 parts of polypropylene non-woven fabric, chitosan
22 parts, 23 parts of polyvinyl alcohol, 20 parts of lavo-ofloxacin, 16 parts of acetic acid, 18 parts of sodium carbonate, 15 parts of SSS, N- ethene
5 parts of base -2-Pyrrolidone, 6 parts of acrylamide, 6 parts of acrylic acid, 42 parts of deionized water.
A kind of preparation method for the polypropylene non-woven fabric that stops blooding, methods described comprise the steps of：
(1) polypropylene non-woven fabric is cut to 10cm × 10cm sample, dried after being cleaned with absolute ethyl alcohol under the conditions of 28 DEG C
It is dry, and around glass bar be rolled into it is cylindric after tie up；
Under the conditions of (2) 28 DEG C, SSS, NVP, acrylamide are dissolved in deionized water
In, acrylic acid is added dropwise thereto, being placed in 4 DEG C after well mixed is sealed；
(3) polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred to spoke
In looking after, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, spoke is carried out under the conditions of 18 DEG C
According to；
(4) polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric heating air blast
In drying box, dried under the conditions of 27 DEG C to constant weight；
(5) dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, will be poly- after step (4) processing
Propylene non-woven fabrics submerges wherein, is reacted 16 hours under the conditions of 33 DEG C；
(6) polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in lavo-ofloxacin
The aqueous solution in, reacted 15 hours under the conditions of 32 DEG C, be then washed with deionized water net, be made after vacuum drying.
Embodiment 3
One kind hemostasis polypropylene non-woven fabric, by weight, the non-woven fabrics includes 50 parts of polypropylene non-woven fabric, chitosan
25 parts, 28 parts of polyvinyl alcohol, 25 parts of lavo-ofloxacin, 19 parts of acetic acid, 22 parts of sodium carbonate, 18 parts of SSS, N- ethene
7 parts of base -2-Pyrrolidone, 8 parts of acrylamide, 8 parts of acrylic acid, 48 parts of deionized water.
A kind of preparation method for the polypropylene non-woven fabric that stops blooding, methods described comprise the steps of：
(1) polypropylene non-woven fabric is cut to 10cm × 10cm sample, dried after being cleaned with absolute ethyl alcohol under the conditions of 35 DEG C
It is dry, and around glass bar be rolled into it is cylindric after tie up；
Under the conditions of (2) 35 DEG C, SSS, NVP, acrylamide are dissolved in deionized water
In, acrylic acid is added dropwise thereto, being placed in 4 DEG C after well mixed is sealed；
(3) polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred to spoke
In looking after, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, spoke is carried out under the conditions of 25 DEG C
According to；
(4) polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric heating air blast
In drying box, dried under the conditions of 35 DEG C to constant weight；
(5) dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, will be poly- after step (4) processing
Propylene non-woven fabrics submerges wherein, is reacted 18 hours under the conditions of 36 DEG C；
(6) polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in levofloxacin
In the aqueous solution of star, reacted 18 hours under the conditions of 36 DEG C, be then washed with deionized water only, be made after vacuum drying.
The hemostasis polypropylene non-woven fabric prepared to embodiment 1~3 carries out performance test, as a result as shown in the table：
Claims (9)
1. one kind hemostasis polypropylene non-woven fabric, it is characterised in that by weight, the non-woven fabrics includes polypropylene non-woven fabric 26
~50 parts, 16~25 parts of chitosan, 13~28 parts of polyvinyl alcohol, 12~25 parts of lavo-ofloxacin, 12~19 parts of acetic acid, sodium carbonate
8~22 parts, 12~18 parts of SSS, 2~7 parts of NVP, 3~8 parts of acrylamide, acrylic acid 1
~8 parts, 23~48 parts of deionized water.
A kind of 2. hemostasis polypropylene non-woven fabric according to claim 1, it is characterised in that by weight, the nonwoven
Cloth includes 45 parts of polypropylene non-woven fabric, 22 parts of chitosan, 23 parts of polyvinyl alcohol, 20 parts of lavo-ofloxacin, 16 parts of acetic acid, sodium carbonate
18 parts, 15 parts of SSS, 5 parts of NVP, 6 parts of acrylamide, 6 parts of acrylic acid, deionized water 42
Part.
A kind of 3. preparation method of hemostasis polypropylene non-woven fabric described in claim 1, it is characterised in that methods described include with
Lower step：
(1) polypropylene non-woven fabric is cut to 10cm × 10cm sample, dried after being cleaned with absolute ethyl alcohol under the conditions of 18~35 DEG C
It is dry, and around glass bar be rolled into it is cylindric after tie up；
Under the conditions of (2) 18~35 DEG C, SSS, NVP, acrylamide are dissolved in deionized water
In, acrylic acid is added dropwise thereto, being placed in 4 DEG C after well mixed is sealed；
(3) polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred to irradiation tube
In, test tube is irradiated with sealing after nitrogen charging deoxygenation wait vacuumizing, is placed in ultraviolet radioactive room, spoke is carried out under the conditions of 15~25 DEG C
According to；
(4) polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric heating forced air drying
In case, dried under the conditions of 18~35 DEG C to constant weight；
(5) dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, by the polypropylene after step (4) processing
Non-woven fabrics submerges wherein, is reacted 12~18 hours under the conditions of 18~36 DEG C；
(6) polypropylene non-woven fabric after step (5) processing is rinsed with aqueous sodium carbonate, is then submerged in lavo-ofloxacin
In the aqueous solution, reacted 12~18 hours under the conditions of 18~36 DEG C, be then washed with deionized water only, be made after vacuum drying.
4. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that in step (1)
Polypropylene non-woven fabric is cut to 10cm × 10cm sample, dried after being cleaned with absolute ethyl alcohol under the conditions of 28 DEG C, and surround glass
Glass rod be rolled into it is cylindric after tie up.
5. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that in step (2)
Under the conditions of 28 DEG C, SSS, NVP, acrylamide are dissolved in deionized water, dripped thereto
Add acrylic acid, being placed in 4 DEG C after well mixed is sealed.
6. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that in step (3)
Polypropylene non-woven fabric after step (1) is tied up is immersed in the solution of step (2) acquisition, and is transferred in irradiation tube, waits to take out
Sealing irradiation test tube, is placed in ultraviolet radioactive room, is irradiated under the conditions of 18 DEG C after vacuum and nitrogen charging deoxygenation.
7. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that in step (4)
The polypropylene non-woven fabric after irradiation is taken out, with deionized water immersion and supersound washing, is subsequently placed in electric drying oven with forced convection, 27
Dried under the conditions of DEG C to constant weight.
8. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that in step (5)
Dissolve the chitosan in acetic acid, then mixed with polyvinyl alcohol water solution, the polypropylene non-woven fabric after step (4) processing is soaked
Not wherein, react 16 hours under the conditions of 33 DEG C.
9. the preparation method of a kind of polypropylene non-woven fabric that stops blooding according to claim 3, it is characterised in that by step (5)
Polypropylene non-woven fabric after processing is rinsed with aqueous sodium carbonate, is then submerged in the aqueous solution of lavo-ofloxacin, 32 DEG C of bars
Reacted 15 hours under part, be then washed with deionized water only, be made after vacuum drying.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108642714A (en) * | 2018-07-13 | 2018-10-12 | 合肥洁诺医疗用品有限公司 | A kind of disposable medical sheet non-woven fabrics |
| CN109056097A (en) * | 2018-07-27 | 2018-12-21 | 望江汇通纺织有限公司 | A kind of medical non-woven fabrics modified polypropylene fiber |
| CN109235042A (en) * | 2018-07-27 | 2019-01-18 | 铜陵熙成塑料制品有限公司 | A kind of non-woven fabrics and preparation method thereof that corrosion resistance is good |
| CN109316621A (en) * | 2018-10-15 | 2019-02-12 | 苏州汇涵医用科技发展有限公司 | A kind of preparation method of aerogel dressing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108642714A (en) * | 2018-07-13 | 2018-10-12 | 合肥洁诺医疗用品有限公司 | A kind of disposable medical sheet non-woven fabrics |
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| CN109316621A (en) * | 2018-10-15 | 2019-02-12 | 苏州汇涵医用科技发展有限公司 | A kind of preparation method of aerogel dressing |
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