CN108478468B - Medical bacterial cellulose/non-woven fabric composite hydrogel mask and preparation method thereof - Google Patents
Medical bacterial cellulose/non-woven fabric composite hydrogel mask and preparation method thereof Download PDFInfo
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- CN108478468B CN108478468B CN201810256972.5A CN201810256972A CN108478468B CN 108478468 B CN108478468 B CN 108478468B CN 201810256972 A CN201810256972 A CN 201810256972A CN 108478468 B CN108478468 B CN 108478468B
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a preparation method of a medical bacterial cellulose/non-woven fabric composite hydrogel mask. The invention also provides the medical bacterial cellulose/non-woven fabric composite hydrogel mask prepared by the method. The medical bacterial cellulose/non-woven fabric composite hydrogel mask disclosed by the invention is easy to spread, has high water content and high-efficiency adsorption/diffusion dual functions, and can effectively adsorb skin care essence. When in use, the composite hydrogel facial mask can efficiently release skin care ingredients and keep good wettability.
Description
Technical Field
The invention relates to the field of masks, and particularly relates to a medical bacterial cellulose/non-woven fabric composite hydrogel mask and a preparation method thereof.
Background
The facial mask is a carrier of beauty care products and is divided into powder blending type and facial mask paper (cloth) made of various fabric materials. The basic function of the facial mask is to achieve the maintenance functions of deep cleaning, moisture retention, whitening and the like by expanding pores and promoting skin metabolism. The facial mask paper plays a role by adsorbing essence, and different materials of the facial mask paper have great influence on the functions of the facial mask. At present, the better mask paper is a biological fiber class, and then the better mask paper is silk mask paper and blended non-woven fabrics.
The bacterial cellulose is cellulose hydrogel prepared by microbial fermentation, has a fine nanofiber 3D structure, endows the material with various excellent properties such as extremely high water content, strong adsorption and diffusion dual functions, good elasticity, excellent mechanical property and high biological safety, and is used for efficient moist healing wound dressings. Similarly, the excellent carrier performance of the bacterial cellulose makes the bacterial cellulose become a high-grade facial mask paper carrier with very good performance, and belongs to biological cellulose. However, the pure bacterial cellulose hydrogel mask is not easy to spread due to its soft texture, and is inconvenient to use.
Disclosure of Invention
In order to overcome the defects and shortcomings of the prior art, the invention aims to provide the medical bacterial cellulose/non-woven fabric composite hydrogel mask which is easy to spread, has high water content and high-efficiency adsorption/diffusion dual functions, can effectively adsorb skin care essence, can efficiently release skin care ingredients when in use, and keeps good wettability.
The purpose of the invention is realized by the following technical scheme:
a preparation method of a medical bacterial cellulose/non-woven fabric composite hydrogel mask comprises the following steps:
(1) preparing medical bacterial cellulose by adopting acetobacter xylinum fermentation;
(2) inoculating acetobacter xylinum strain into the seed culture solution, wherein the temperature is 25-32 ℃, the stirring speed is 150-;
(3) inoculating seed liquid with volume of 8-12% of the culture liquid into the culture liquid, and mixing uniformly for later use to obtain fermentation liquid;
(4) injecting the fermentation liquor into a culture vessel filled with non-woven fabric facial mask paper, bundling, standing and culturing for 2-5 days at 25-32 ℃, wherein the bacterial cellulose grows into the fibers of the non-woven fabric facial mask paper in the fermentation process to form a staggered interpenetrating network with the fibers, so that the bacterial cellulose and the non-woven fabric composite hydrogel facial mask are tightly compounded to obtain the medical bacterial cellulose/non-woven fabric composite hydrogel facial mask;
(5) rinsing the medical bacterial cellulose/non-woven fabric composite culture product with deionized water, removing residual culture solution, soaking with deionized water until colorless, leaching with 0.05-0.5M sodium hydroxide solution for 1-2 times, and rinsing with deionized water until neutral.
The non-woven fabric mask paper is pure cotton non-woven fabric, silk mask paper, jute mask paper or fiber-forming mask cloth.
The synthetic fiber is acrylic acid, nylon, polyethylene, polypropylene, polyester or viscose fiber.
The culture vessel filled with the non-woven fabric facial mask paper in the step (4) is a sterilized culture vessel with the non-woven fabric facial mask paper, and the specific sterilization process is as follows:
placing the non-woven fabric facial mask paper in a culture vessel, bundling, sterilizing at the high temperature of 115-121 ℃ and 0.07-0.101MPa for 20-30min, and drying at 30-80 ℃ for later use.
A medical bacterial cellulose/non-woven fabric composite hydrogel mask comprises a medical bacterial cellulose hydrogel layer and a non-woven fabric layer, wherein fibers of the bacterial cellulose hydrogel layer grow into the non-woven fabric to form a staggered interpenetrating network.
The thickness of the bacterial cellulose hydrogel layer is 0.2-5 mm.
The fiber gap range of the non-woven fabric layer is 50-200 mu m.
The thickness of the non-woven fabric layer is 0.1-1.5 mm.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the medical bacterial cellulose/non-woven fabric composite hydrogel mask can fully utilize the dual functions of quick adsorption and diffusion of bacterial cellulose to adsorb essence, and can quickly diffuse to the surface of skin when in use.
(2) The medical bacterial cellulose/non-woven fabric composite hydrogel mask disclosed by the invention has the advantages that the bacterial cellulose hydrogel film is good in elasticity and good in fitting property, the mask can be completely attached to the face, the effective contact area of the mask on the skin is increased, and the effective action of essence is promoted.
(3) According to the medical bacterial cellulose/non-woven fabric composite hydrogel mask, the non-woven fabric base effectively improves the spreading performance of the bacterial cellulose film, and the use convenience is greatly improved.
Drawings
Fig. 1 is a scanning electron microscope image of the medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel mask in example 1 of the present invention.
Fig. 2 is a scanning electron microscope image of the medical bacterial cellulose/polypropylene non-woven fabric composite hydrogel mask in example 2 of the present invention.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1
The preparation method of the medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel mask comprises the following steps:
(1) disinfection preparation of culture vessels
Placing the pure cotton non-woven fabric facial mask paper in a disc-shaped culture vessel, bundling, sterilizing at high temperature and high pressure (115 ℃, 30min), and drying at low temperature for later use (30 ℃, 24 hours);
(2) seed liquid preparation
Inoculating acetobacter xylinum strain into the seed culture solution, and culturing at the temperature of 25 ℃ and the stirring speed of 150 rpm for 24 hours;
(3) preparation of fermentation broth
Inoculating the seed liquid into the culture solution according to the proportion of 10%, and uniformly mixing for later use.
(4) In-situ fermentation of bacterial cellulose
Injecting 200ml of fermentation liquor into a culture vessel, bundling, and standing and culturing at 25 ℃ for 4 days;
(5) purification of medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel mask
Rinsing the medical bacterial cellulose/pure cotton non-woven fabric composite culture product with deionized water, removing residual culture solution, soaking with deionized water until colorless, leaching with 0.1M sodium hydroxide solution for 1 time, and rinsing with deionized water until neutral.
The medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel mask is prepared, wherein the thickness of the bacterial cellulose hydrogel layer is 2.0mm, and the microstructure (figure 1) in the composite mask is observed by a scanning electron microscope, so that the cotton fibers (marked by an arrow A in figure 1) are covered by the bacterial cellulose nanofibers (marked by an arrow B in figure 1), as shown in figure 1.
The essential fluid absorption and release, the fitting rate and the spreading performance of the prepared medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel mask are described in table 1.
Example 2
The preparation method of the medical bacterial cellulose/polypropylene non-woven fabric composite hydrogel mask comprises the following steps:
(1) disinfection preparation of culture vessels
Placing polypropylene non-woven fabric facial mask paper in a disc-shaped culture vessel, bundling, sterilizing at high temperature and high pressure (121 ℃, 0.101MPa, 20min), and drying at low temperature for later use (80 ℃, 12 hours);
(2) seed liquid preparation
Inoculating acetobacter xylinum strain into the seed culture solution, wherein the temperature is 30 ℃, the stirring speed is 180 r/min, and the culture time is 16-24 hours;
(3) preparation of fermentation broth
Inoculating the seed liquid into the culture solution according to the proportion of 10%, and uniformly mixing for later use.
(4) In-situ fermentation of bacterial cellulose
300ml of fermentation liquor is injected into a culture vessel, wrapped and kept stand for culture for 4 days at 30 ℃;
(5) purification of medical bacterial cellulose/polypropylene non-woven fabric composite hydrogel mask
Rinsing the medical bacterial cellulose/polypropylene non-woven fabric composite culture product with deionized water, removing residual culture solution, soaking with deionized water until colorless, leaching with 0.5M sodium hydroxide solution for 2 times, and rinsing with deionized water until neutral.
The prepared medical bacterial cellulose/polypropylene non-woven fabric composite hydrogel mask has the thickness of a bacterial cellulose hydrogel layer of 3.5 mm. The microscopic structure (fig. 2) inside the composite facial mask observed by a scanning electron microscope shows that the polypropylene fiber (marked by arrow a in fig. 2) and the bacterial cellulose nanofiber network (marked by arrow B in fig. 2) form an interpenetrating network structure, which indicates that the polypropylene fiber and the bacterial cellulose nanofiber network are tightly compounded.
The essential liquid absorption and release, the fitting rate and the spreading performance of the prepared medical bacterial cellulose/polypropylene composite hydrogel mask are described in table 1.
The medical bacterial cellulose/pure cotton non-woven fabric composite hydrogel (BC/pure cotton) prepared in the embodiment 1, the medical bacterial cellulose/polypropylene non-woven fabric composite hydrogel (BC/polypropylene) prepared in the embodiment 2, the pure cotton non-woven fabric, the polypropylene non-woven fabric and the medical pure bacterial cellulose (pure BC) are respectively subjected to essence absorption rate and release rate detection, joint rate evaluation and spreading performance evaluation.
1) Essence absorption rate detection
30ml of collagen essence is respectively injected into the beakers, and the weighing mass is recorded as M1Soaking the sample (10cm × 10cm), taking out the sample after 5min, and detecting the quality of the beaker and the rest essence as M2. Calculating the absorption rate V of the essence according to the formula 1Absorption ofEach sample was set to 3 replicates and the average was taken.
VAbsorption of＝(M1-M2)/100(g/cm2) (formula 1)
2) Method for detecting release rate of essence
The sample (10cm × 10cm) soaked with the essence is weighed and recorded as M3Attaching to the arm of a tester, taking down the sample to be tested after 15min, and weighing and recording the mass as M4. Calculating the essence absorption rate V according to the formula 2ReleasingEach sample was set to 3 replicates and the average was taken.
VReleasing＝(M3-M4)/15×100(g/min·cm2) (formula 2)
3) Meanwhile, please evaluate the fit rate and spreadability of various mask samples, and the test results are shown in table 1.
TABLE 1 Properties of various facial mask pastes
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (8)
1. A preparation method of a medical bacterial cellulose/non-woven fabric composite hydrogel mask is characterized by comprising the following steps:
(1) preparing medical bacterial cellulose by adopting acetobacter xylinum fermentation;
(2) inoculating acetobacter xylinum strain into the seed culture solution, wherein the temperature is 25-32 ℃, the stirring speed is 150-;
(3) inoculating seed liquid with volume of 8-12% of the culture liquid into the culture liquid, and mixing uniformly for later use to obtain fermentation liquid;
(4) injecting the fermentation liquor into a culture vessel filled with non-woven fabric facial mask paper, bundling, standing and culturing for 2-5 days at 25-32 ℃, wherein the bacterial cellulose grows into the fibers of the non-woven fabric facial mask paper in the fermentation process to form a staggered interpenetrating network with the fibers, so that the bacterial cellulose and the non-woven fabric composite hydrogel facial mask are tightly compounded to obtain the medical bacterial cellulose/non-woven fabric composite hydrogel facial mask;
(5) rinsing the medical bacterial cellulose/non-woven fabric composite culture product with deionized water, removing residual culture solution, soaking with deionized water until colorless, leaching with 0.05-0.5mol/L sodium hydroxide solution for 1-2 times, and rinsing with deionized water until neutral.
2. The method for preparing the medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 1, wherein the non-woven fabric mask paper is a pure cotton non-woven fabric, silk mask paper, jute mask paper or synthetic fiber mask cloth.
3. The method for preparing the medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 2, wherein the synthetic fibers are acrylic, nylon, polyethylene, polypropylene, polyester or viscose fibers.
4. The method for preparing the medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 1, wherein the culture vessel containing the non-woven fabric mask paper in the step (4) is a sterilized culture vessel containing the non-woven fabric mask paper, and the specific sterilization process comprises the following steps:
placing the non-woven fabric facial mask paper in a culture vessel, bundling, sterilizing at the temperature of 121 ℃ of 115 ℃ and the pressure of 0.07-0.101MPa for 20-30min, and drying at the temperature of 30-80 ℃ for later use.
5. The medical bacterial cellulose/non-woven fabric composite hydrogel mask prepared by the method of any one of claims 1 to 4, which is characterized by comprising two layers, namely a medical bacterial cellulose hydrogel layer and a non-woven fabric layer, wherein fibers of the bacterial cellulose hydrogel layer grow into the non-woven fabric to form a staggered interpenetrating network.
6. The medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 5, wherein the thickness of the bacterial cellulose hydrogel layer is 0.2-5 mm.
7. The medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 5, wherein the fiber gap of the non-woven fabric layer is in the range of 50-200 μm.
8. The medical bacterial cellulose/non-woven fabric composite hydrogel mask as claimed in claim 5, wherein the thickness of the non-woven fabric layer is 0.1-1.5 mm.
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| KR20200035899A (en) * | 2018-09-27 | 2020-04-06 | 주식회사 엘지화학 | A biocellulose sheet and a method for preparing thereof |
| CN111437221A (en) * | 2019-01-16 | 2020-07-24 | 北京大学 | Mite-removing free radical hydrogel mask |
| CN109736097A (en) * | 2019-01-28 | 2019-05-10 | 陕西科技大学 | A kind of bacteria cellulose composite ultrafine fiber synthetic leather and preparation method thereof |
| CN110158311A (en) * | 2019-05-31 | 2019-08-23 | 盐城工业职业技术学院 | A kind of boron nitride nanosheet is modified to carbonize bacteria cellulose/carbon fibre fabric based composites and preparation method thereof |
| CN112323494B (en) * | 2020-11-06 | 2022-06-03 | 南京林业大学 | Efficient preparation method of bacterial cellulose/non-woven fiber composite mask base cloth |
| CN114028311A (en) * | 2021-12-09 | 2022-02-11 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of hydrogel mask, product and application thereof |
| CN114191415A (en) * | 2021-12-27 | 2022-03-18 | 福建长源纺织有限公司 | Eye protection film and preparation method thereof |
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