JP6059264B2 - Biological fiber composite dressing material - Google Patents
Biological fiber composite dressing material Download PDFInfo
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- JP6059264B2 JP6059264B2 JP2015025333A JP2015025333A JP6059264B2 JP 6059264 B2 JP6059264 B2 JP 6059264B2 JP 2015025333 A JP2015025333 A JP 2015025333A JP 2015025333 A JP2015025333 A JP 2015025333A JP 6059264 B2 JP6059264 B2 JP 6059264B2
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- 239000000835 fiber Substances 0.000 title claims description 202
- 239000002131 composite material Substances 0.000 title claims description 72
- 239000000463 material Substances 0.000 title claims description 66
- 239000012528 membrane Substances 0.000 claims description 90
- 239000002344 surface layer Substances 0.000 claims description 52
- 239000004744 fabric Substances 0.000 claims description 37
- 239000011176 biofiber Substances 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 11
- 239000004615 ingredient Substances 0.000 claims description 10
- 239000011229 interlayer Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 7
- 210000000988 bone and bone Anatomy 0.000 claims description 7
- 239000004745 nonwoven fabric Substances 0.000 claims description 6
- 241000032681 Gluconacetobacter Species 0.000 claims description 5
- 239000002759 woven fabric Substances 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 4
- 239000001888 Peptone Substances 0.000 claims description 4
- 108010080698 Peptones Proteins 0.000 claims description 4
- 229940041514 candida albicans extract Drugs 0.000 claims description 4
- 235000019319 peptone Nutrition 0.000 claims description 4
- 229920002994 synthetic fiber Polymers 0.000 claims description 4
- 239000012138 yeast extract Substances 0.000 claims description 4
- 229920001817 Agar Polymers 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 239000008272 agar Substances 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 3
- 210000003275 diaphysis Anatomy 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 claims description 2
- 230000037330 wrinkle prevention Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000004927 clay Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
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- 244000215068 Acacia senegal Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
本発明は生物繊維複合ドレッシング材に関し、詳しくは、皮膚に貼付する生物繊維複合ドレッシング材に関する。 The present invention relates to a biological fiber composite dressing material, and more particularly to a biological fiber composite dressing material to be applied to the skin.
現在、医療分野において、創傷治療に用いるドレッシング材の多くはカット綿またはガーゼを使用するが、それらのドレッシング材製品の抗菌性が好ましくないため、傷口の感染確率が高く、傷口にくっ付くことが起こりやすく、且つ、ドレッシング材を交換する場合は、はずし難いという欠点を有する。 Currently, in the medical field, many dressings used for wound treatment use cut cotton or gauze. However, the antibacterial properties of these dressing products are not preferred, so the probability of infection of the wound is high and it may stick to the wound. It is easy to occur and has a drawback that it is difficult to remove the dressing material.
その後、不織布ドレッシング材がガーゼ及びカット綿に取って代わったが、不織布型のドレッシング材は優れた吸液機能及び湿潤環境を提供して傷口の修復に寄与する特性を有するが、不織布が吸収する液体または水分を漸次失った後、傷口にくっ付くことが起こりやすくなる。 Later, the non-woven dressing material replaced gauze and cut cotton, but the non-woven dressing material provides excellent liquid-absorbing function and moist environment to contribute to wound repair, but the non-woven fabric absorbs After gradual loss of liquid or moisture, it tends to stick to the wound.
一方、現代人は基本的な生活での必要性のほか、さらに美容やケアを重視し、特に顔面部のケアは美容産業の訴求ポイントであるため、多くのパック製品が開発されている。現有技術のパックの種類は様々で、例えば、クレイパック、ピールオフ型パック及びシートパック等が挙げられる。 On the other hand, modern people place emphasis on beauty and care in addition to their basic needs in life. Especially, facial care is an appealing point of the beauty industry, so many pack products have been developed. There are various types of packs of the existing technology, such as clay packs, peel-off type packs, and sheet packs.
クレイパックはケア成分またはミネラルを含有するが、パックを使用した後は洗い流す必要があり、ケア成分が完全に皮膚に吸収されるのは困難であり、且つ、多くのミネラルを含むため、より多くの防腐剤を添加して細菌が湿潤なクレイで繁殖することを防止する必要がある。ピールオフ型パックの主要成分は、ポリマーゲル、水及びアルコールであり、表皮温度を上昇させることにより、皮膚の血液循環を促すが、ピールオフ型パックはパックが乾燥してから剥がさなければならないため、剥がす過程は敏感肌に損傷を与える恐れがあり、また当該ピールオフ型パックは乾燥を求めるため、保湿成分が添加されていないので、乾燥肌には向かない。また、シートパックは主に効果を有するエッセンスを吸着した単層シートであり、成分を調整することで各種の肌質をケアすることができ、使用後に洗い流す必要はないが、洗浄効果を有しない。上記シートパックでは、多くは単層の不織布で作ったものを使用している。使用者がエッセンスを吸着した不織布を使用する場合、通常、不織布の中の水分が速やかに揮発することを考量して、濃度が高いエッセンスを使用することから、浪費に繋がるのみならず、水分が揮発する問題も解決できない。 Clay packs contain care ingredients or minerals, but they need to be washed away after using the pack, it is difficult for the care ingredients to be completely absorbed into the skin, and contain more minerals, so more It is necessary to add a preservative to prevent bacteria from growing on wet clay. The main components of the peel-off pack are polymer gel, water and alcohol, which promotes blood circulation in the skin by raising the epidermis temperature, but the peel-off pack must be peeled off after the pack has dried The process may damage sensitive skin, and the peel-off pack is not suitable for dry skin because it does not contain moisturizing ingredients because it requires dryness. In addition, the sheet pack is a single-layer sheet that absorbs the essence that has the main effect, and it can care for various skin qualities by adjusting the ingredients, and it does not need to be washed away after use, but has no cleaning effect . Many of the above-mentioned sheet packs are made of a single layer non-woven fabric. When a user uses a nonwoven fabric that has adsorbed essence, the moisture content in the nonwoven fabric is usually taken into consideration, and the essence with a high concentration is used. The problem of volatilization cannot be solved.
そのため、業界ではパック製品として生物繊維膜が開発され、また、生物繊維膜は優れた保湿性を有するが、全体の付着及び快適性が好ましくなく、且つ、それを使用してエッセンスを吸着した後、一枚の生物繊維膜パックを展開し難い。そのため、新たなドレッシング材製品を開発する必要がある。 Therefore, the biofiber membrane has been developed as a packed product in the industry, and the biofiber membrane has excellent moisture retention, but the overall adhesion and comfort are not favorable, and after using it to adsorb the essence It is difficult to deploy one biological fiber membrane pack. Therefore, it is necessary to develop a new dressing product.
上記公知技術の欠陥に鑑みて、本発明は、対向する第一の表層と第二の表層を有し、布膜繊維を有する布膜と、グルコンアセトバクター属（Ｇｌｕｃｏｎａｃｅｔｏｂａｃｔｅｒ）の菌により形成され、対向する第三の表層及び第一の表層上に結合する第四の表層を有し、第四の表層には布膜繊維に絡め合って結合する複数の生物繊維が伸びている生物繊維膜と、を含む生物繊維複合ドレッシング材を提供する。 In view of the defects of the above-mentioned known technology, the present invention has a first surface layer and a second surface layer facing each other, and is formed by a cloth film having cloth film fibers, and a bacterium of the genus Gluconacetobacter. A biological fiber membrane having a third surface layer facing and a fourth surface layer bonded on the first surface layer, wherein the fourth surface layer is extended with a plurality of biological fibers entangled and bonded to the fabric membrane fiber; A biological fiber composite dressing material is provided.
一つ具体的な実施例において、生物繊維膜は、第三の表層と第四の表層の間に結合する立体網状構造をさらに有し、立体網状構造の密度は第三の表層と第四の表層の密度より小さく、立体網状構造は、第四の表層から布膜における第一の表層内まで伸び、立体網状構造は複数の生物繊維からなる。 In one specific embodiment, the biofiber membrane further has a three-dimensional network structure bonded between the third surface layer and the fourth surface layer, and the density of the three-dimensional network structure is the third surface layer and the fourth surface layer. The three-dimensional network structure is smaller than the density of the surface layer and extends from the fourth surface layer to the first surface layer of the cloth film, and the three-dimensional network structure is composed of a plurality of biological fibers.
なお、立体網状構造は、互いに平行する複数の骨幹繊維及び隣接する任意の二つの骨幹繊維に織り合わされる複数の層間繊維を有し、複数の骨幹繊維及び層間繊維はいずれも生物繊維であり、且つ、複数の骨幹繊維の直径は複数の層間繊維の直径以上である。また、複数の骨幹繊維は生物繊維膜の長さ方向または幅方向に伸びる。 The three-dimensional network structure has a plurality of interlayer fibers interwoven with a plurality of bone shaft fibers parallel to each other and any two adjacent bone shaft fibers, each of the plurality of bone shaft fibers and the interlayer fibers is a biological fiber, And the diameter of a plurality of diaphysis fibers is more than the diameter of a plurality of interlayer fibers. In addition, the plurality of bone shaft fibers extend in the length direction or the width direction of the biological fiber membrane.
さらに、一つ具体的な実施例において、生物繊維複合ドレッシング材は、第二の表層上に設けられるもう一つの生物繊維膜をさらに含む。 Further, in one specific embodiment, the biofiber composite dressing further includes another biofiber membrane provided on the second surface layer.
もう一つ具体的な実施例において、もう一つの生物繊維膜は複数の布膜繊維に絡め合って結合する生物繊維を有する。 In another specific embodiment, the other biological fiber membrane comprises biological fibers that are intertwined with and bonded to a plurality of fabric membrane fibers.
本発明の生物繊維複合ドレッシング材は布膜及び生物繊維膜を有し、生物繊維膜でより多くの水分または活性成分を吸収し、且つ、生物繊維膜の孔隙が布膜より細いため、透気性を有すると同時に、水分が速やかに布膜から蒸発することを回避し、ドレッシング材の保湿性を上昇させる。そのため、本発明の生物繊維複合ドレッシング材を使用して皮膚に貼付し、例えばパックとして使用した場合、過剰な量の活性成分を吸い取る必要がなく、末端使用者にとって大幅な消費コストを節約することができる。 The biological fiber composite dressing material of the present invention has a cloth membrane and a biological fiber membrane, absorbs more moisture or active ingredients in the biological fiber membrane, and the pores of the biological fiber membrane are narrower than the fabric membrane. At the same time, the moisture is prevented from quickly evaporating from the fabric film, and the moisture retention of the dressing material is increased. Therefore, when it is applied to the skin using the biological fiber composite dressing material of the present invention and used as a pack, for example, it is not necessary to absorb an excessive amount of the active ingredient, thereby saving a significant consumption cost for the end user. Can do.
以下、特定の具体的な実施例で本発明の実施形態を説明し、当業者は本明細書が開示する内容から本発明の他の利点及び効果を容易に理解できる。 The embodiments of the present invention will be described below with specific specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in the present specification.
本明細書が図面で示す構造、割合、大きさ等は、いずれも明細書が開示する内容に合わせて、当業者の理解に供するものであり、本発明の実施できる限定条件を限定するものではなく、技術上の実質的な意味を有さず、本発明が奏しうる効果及び達成できる目的に影響しない限り、任意の構造の修正、割合関係の改変、または大きさの調整は、いずれも本発明が開示する技術内容の範囲内である。同時に、本明細書が記載する「第一」、「第二」、「第三」、「第四」、「上」及び「一」等の用語は、単に記載の便宜上用いるものに過ぎず、本発明の実施できる範囲を限定するものではなく、その相対関係の改変または調整は、実質的に技術内容を変更しない限り、本発明の実施できる範疇内である。 The structures, ratios, sizes, and the like shown in the drawings in this specification are all for the understanding of those skilled in the art in accordance with the contents disclosed in the specification, and are not intended to limit the limiting conditions in which the present invention can be implemented. Any modification of the structure, modification of the proportion, or adjustment of the size of the present invention is not required unless it has a technical meaning and does not affect the effects that the present invention can achieve and the purpose that can be achieved. It is within the scope of the technical content disclosed by the invention. At the same time, terms such as “first”, “second”, “third”, “fourth”, “upper” and “one” described in this specification are merely used for convenience of description, The scope in which the present invention can be practiced is not limited, and the modification or adjustment of the relative relationship is within the scope in which the present invention can be practiced unless the technical contents are substantially changed.
本明細書における技術用語である「平行」とは、複数の骨幹繊維が同じ方向、例えば、長さ方向または幅方向で伸びる形態である。 The term “parallel” as a technical term in the present specification is a form in which a plurality of diaphyseal fibers extend in the same direction, for example, a length direction or a width direction.
本発明は、対向する第一の表層及び第二の表層を有し、布膜繊維を有する布膜と、グルコンアセトバクター属の菌により形成され、対向する第三の表層及び前記第一の表層上に結合する第四の表層を有し、前記第四の表層には前記布膜繊維に絡め合って結合する複数の生物繊維が伸びている生物繊維膜と、を含むことを特徴とする生物繊維複合ドレッシング材を提供する。 The present invention has a first surface layer and a second surface layer that face each other, and is formed by a cloth film having cloth film fibers and a bacterium belonging to the genus Gluconacetobacter, and the third surface layer and the first surface layer that face each other. A biological fiber membrane having a fourth surface layer bonded thereon, wherein the fourth surface layer includes a biological fiber membrane extending from a plurality of biological fibers entangled with and bonded to the fabric membrane fiber. A fiber composite dressing is provided.
前記布膜は織布または不織布である。通常、織布とは、紡績技術により織り成すものである。織布は人造繊維または天然繊維から織り成すことができ、あるいは人造繊維と天然繊維を混紡して織り成すことができる。具体的実施例において、人造繊維はポリエステル、アクリルまたはナイロンである。天然繊維は絹糸またはコットンである。 The fabric film is a woven fabric or a non-woven fabric. Usually, the woven fabric is woven by a spinning technique. The woven fabric can be woven from man-made fibers or natural fibers, or can be woven by blending man-made fibers and natural fibers. In a specific embodiment, the artificial fiber is polyester, acrylic or nylon. Natural fibers are silk or cotton.
本発明の生物繊維膜は微生物の培養から得るものである。本発明は、グルコンアセトバクター属の菌により、マンニトール、ペプトン（ｐｅｐｔｏｎｅ）、酵母エキストラクト（ｙｅａｓｔ ｅｘｔｒａｃｔ）及び寒天を有する培養液の中で形成される生物繊維膜は、複数の布膜繊維に絡め合って結合する生物繊維を有することを見出した。 The biological fiber membrane of the present invention is obtained from culturing microorganisms. In the present invention, a biofiber membrane formed in a culture solution containing mannitol, peptone, yeast extract and agar by a bacterium of the genus Gluconacetobacter is entangled with a plurality of fabric membrane fibers. It was found to have biological fibers that bind together.
生物繊維膜を生産する具体的な実施例においては、菌種の発酵培養から始まり、まず、培養液を提供し、培養液を容器に置き、且つ、培養液の成分はゼラチン、アラビアゴム、寒天等の公知組成から選ばれるものを含み、培養液はさらに炭素源（例えばマンニトール、またはグルコース等）、他の成分（例えばペプトン及び酵母エキストラクト）を有し、且つ、炭素源、ペプトン及び酵母エキストラクトの重量部割合は５：１：１〜４：１：１の間であってもよい。次に、培養液を酸性、例えばｐＨ値０．５〜６の間に調整し、且つ、開始微生物濃度範囲は１０２〜１０５菌数／ｍｌに調整し、２５〜２８℃で２４〜９６時間静置培養した後、前記の布膜を容器中の培養液内に平らに敷き、２４〜４８時間で取り出し、複合ドレッシング材、即ち、本発明の生物繊維複合ドレッシング材を得た。 In a specific embodiment for producing a biological fiber membrane, starting from a fermentation culture of bacterial species, first, a culture solution is provided, the culture solution is placed in a container, and the components of the culture solution are gelatin, gum arabic, agar The culture solution further contains a carbon source (for example, mannitol or glucose), other components (for example, peptone and yeast extract), and the carbon source, peptone and yeast extract. The weight part ratio of the cut may be between 5: 1: 1 and 4: 1: 1. Next, the culture solution is adjusted to acidity, for example, between pH values 0.5 to 6, and the starting microorganism concentration range is adjusted to 10 2 to 10 5 bacteria / ml, and 24 to 96 at 25 to 28 ° C. After the stationary culture for a period of time, the cloth membrane was laid flat in the culture solution in the container and taken out in 24 to 48 hours to obtain a composite dressing material, that is, the biological fiber composite dressing material of the present invention.
検出したところ、本発明の生物繊維複合ドレッシング材における生物繊維膜は複数の生物繊維を有し、且つ、単位面積ごとの生物繊維量は０．００５〜０．００８ｇ／ｃｍ２であり、生物繊維の直径は２０〜１００ｎｍである。 As detected, the biological fiber membrane in the biological fiber composite dressing material of the present invention has a plurality of biological fibers, and the biological fiber amount per unit area is 0.005 to 0.008 g / cm 2 , The diameter is 20 to 100 nm.
また、本発明の生物繊維複合ドレッシング材を乾燥した後、再び水または活性成分を吸収し、少なくとも５０％の再水和率、少なくとも６０％の再水和率、少なくとも７０％の再水和率、さらには９１％まで達する再水和率を有する。一方、生物繊維複合ドレッシング材における生物繊維膜の厚さは少なくとも２０μｍ、例えば２０〜３０μｍ、または例えば２０〜２６μｍまたは２４〜２６μｍである。 In addition, after the biological fiber composite dressing of the present invention is dried, water or the active ingredient is absorbed again, and at least 50% rehydration rate, at least 60% rehydration rate, at least 70% rehydration rate. And a rehydration rate of up to 91%. On the other hand, the thickness of the biological fiber membrane in the biological fiber composite dressing material is at least 20 μm, such as 20 to 30 μm, or such as 20 to 26 μm or 24 to 26 μm.
図１に示すように、本発明の生物繊維複合ドレッシング材１は、対向する第一の表層１０ａと第二の表層１０ｂを有する布膜１０、及び第一の表層１０ａに設置した生物繊維膜１２を含む。生物繊維膜１２は、対向する第三の表層１２ａと第四の表層１２ｂを有し、第四の表層１２ｂは第一の表層１０ａ上に結合する。 As shown in FIG. 1, the biological fiber composite dressing material 1 of the present invention includes a fabric film 10 having a first surface layer 10a and a second surface layer 10b facing each other, and a biological fiber film 12 installed on the first surface layer 10a. including. The biological fiber membrane 12 has a third surface layer 12a and a fourth surface layer 12b facing each other, and the fourth surface layer 12b is bonded onto the first surface layer 10a.
また、図２Ａを参照し、生物繊維膜１２における第四の表層１２ｂには複数の布膜繊維１０１に絡め合って結合する生物繊維が伸びている。 2A, the fourth surface layer 12b of the biological fiber membrane 12 is extended with biological fibers that are entangled with and bonded to the plurality of fabric membrane fibers 101.
図に示すように、生物繊維膜１２は立体網状構造１２１を有し、第四の表層１２ｂから布膜１０之第一の表層１０ａ内まで伸び、且つ、立体網状構造１２１は複数の生物繊維からなる。具体的には、立体網状構造１２１は、複数の互いに平行する骨幹繊維１２１ａ及び隣接する任意の二つの骨幹繊維１２１ａに織り合わされる複数の層間繊維１２１ｂを有することで、水平方向及び垂直方向で隣接する任意の二つの骨幹繊維１２１ａを連接し、三次元立体網状構造１２１を形成する。骨幹繊維１２１ａ及び層間繊維１２１ｂはいずれも生物繊維であり、且つ、図面が示すように、骨幹繊維１２１ａの直径は層間繊維１２１ｂの直径以上。さらに、骨幹繊維１２１ａの直径は布膜繊維１０１より小さいことを確認できる。 As shown in the figure, the biological fiber membrane 12 has a three-dimensional network structure 121, extends from the fourth surface layer 12b to the first surface layer 10a of the cloth membrane 10, and the three-dimensional network structure 121 includes a plurality of biological fibers. Become. Specifically, the three-dimensional network structure 121 includes a plurality of mutually parallel diaphysical fibers 121a and a plurality of interlayer fibers 121b interwoven with any two adjacent diaphyseal fibers 121a, thereby adjoining in the horizontal direction and the vertical direction. Two arbitrary diaphyseal fibers 121a are connected to form a three-dimensional three-dimensional network structure 121. The diaphyseal fiber 121a and the interlayer fiber 121b are both biological fibers, and as shown in the drawing, the diameter of the diaphyseal fiber 121a is equal to or greater than the diameter of the interlayer fiber 121b. Further, it can be confirmed that the diameter of the diaphysis fiber 121a is smaller than the cloth membrane fiber 101.
図２Ｂは生物繊維膜１２の側面写真を示し、生物繊維膜１２は複数の互いに平行するまたは生物繊維膜１２の長さ方向あるいは幅方向に伸びる骨幹繊維１２１ａ、及び骨幹繊維１２１ａに織り合わされる層間繊維１２１ｂを有する。また、立体網状構造は生物繊維膜１２の両表層の間に結合し、且つ、立体網状構造の密度は、両表層の密度、例えば、第三の表層と第四の表層の密度より小さい。この実施例において、生物繊維複合ドレッシング材における生物繊維膜の厚さは２０〜３０μｍである。 FIG. 2B shows a side view photograph of the biofibrous membrane 12, wherein the biofibrous membrane 12 is a plurality of bone shaft fibers 121a extending parallel to each other or extending in the length direction or width direction of the biofiber membrane 12, and the layers interwoven with the bone shaft fibers 121a. It has a fiber 121b. The three-dimensional network structure is bonded between both surface layers of the biological fiber membrane 12, and the density of the three-dimensional network structure is smaller than the density of both surface layers, for example, the density of the third surface layer and the fourth surface layer. In this example, the thickness of the biological fiber membrane in the biological fiber composite dressing material is 20 to 30 μm.
図３Ａ及び図３Ｂは、それぞれ、本発明の生物繊維複合ドレッシング材の生物繊維膜側の５００倍で拡大したＳＥＭ写真及び従来生物繊維膜の５００倍で拡大したＳＥＭ写真を示す。 FIG. 3A and FIG. 3B respectively show an SEM photograph magnified by 500 times on the biological fiber membrane side of the biological fiber composite dressing material of the present invention and an SEM photograph magnified by 500 times of the conventional biological fiber membrane.
図３Ａに示すように、本発明の生物繊維複合ドレッシング材の生物繊維膜側は平坦であり、図面で示す條状物は生物繊維膜下方の布膜繊維であり、本発明の生物繊維複合ドレッシング材の生物繊維膜側は非常に平坦である。しかし、図３Ｂが示す従来生物繊維膜の表面は多くのしわを有する。そのため、生物繊維膜と皮膚の付着性がよくないため、感触に影響し、薬物または活性成分の吸収がよくないという問題を起こす。 As shown in FIG. 3A, the biological fiber membrane side of the biological fiber composite dressing material of the present invention is flat, and the cage shown in the drawing is a fabric membrane fiber below the biological fiber membrane. The biofiber membrane side of the material is very flat. However, the surface of the conventional biological fiber membrane shown in FIG. 3B has many wrinkles. Therefore, the adhesion between the biofiber membrane and the skin is not good, which affects the touch and causes the problem of poor absorption of drugs or active ingredients.
図４に示すように、培養過程において布膜２０の容器に置く時間が長く、または布膜２０をひっくり返すと、布膜２０における第二の表層２０ｂ上に、さらにもう一つの生物繊維膜２２’が形成されるため、この実施例において、生物繊維複合ドレッシング材２は、第一の表層２０ａ上に形成する生物繊維膜２２以外に、さらにもう一つの生物繊維膜２２’を含む。 As shown in FIG. 4, when the cloth membrane 20 is placed in the container for a long time in the culturing process, or when the fabric film 20 is turned over, another biological fiber membrane 22 ′ is formed on the second surface layer 20b of the fabric film 20. Therefore, in this embodiment, the biological fiber composite dressing 2 further includes another biological fiber film 22 ′ in addition to the biological fiber film 22 formed on the first surface layer 20a.
本発明の生物繊維複合ドレッシング材は皮膚上に貼付し、特にパックとして使用できるため、生物繊維複合ドレッシング材はさらに活性成分または薬物を含んでもよい。活性成分の実例は、保湿剤、美白成分、しわ防止成分、角質除去成分、成長因子（ｇｒｏｗｔｈ ｆａｃｔｏｒｓ）または酵素（ｅｎｚｙｍｅｓ）が含まれる。異なる活性成分を添加することで、本発明の生物繊維複合ドレッシング材がさらにストレス解消と体表マッサージの効果を有する。 Since the biofiber composite dressing of the present invention is applied on the skin and can be used in particular as a pack, the biofiber composite dressing may further contain an active ingredient or a drug. Examples of active ingredients include humectants, whitening ingredients, anti-wrinkle ingredients, exfoliating ingredients, growth factors or enzymes. By adding different active ingredients, the biological fiber composite dressing material of the present invention further has the effects of stress relief and body massage.
本発明の生物繊維複合ドレッシング材の引張強度試験
本発明の生物繊維複合ドレッシング材を、１５ｍｍｘ１５ｍｍのサイズに切断し、三枚の試験シートを引張強度試験に行って、得られた結果は、それぞれ２１１３．７０ｇ／１５ｍｍ、２１４５．００ｇ／１５ｍｍ、１９５１．９０ｇ／１５ｍｍであり、平均引張強度は２０７０．２０ｇ／１５ｍｍである。
Tensile strength test of the biological fiber composite dressing material of the present invention The biological fiber composite dressing material of the present invention was cut into a size of 15 mm x 15 mm, and three test sheets were subjected to a tensile strength test. .70 g / 15 mm, 2145.00 g / 15 mm, 1951.90 g / 15 mm, and the average tensile strength is 2070.20 g / 15 mm.
従来生物繊維膜に同じ試験を行ったところ、その引張強度は、２６０７．３３ｇ／１５ｍｍまで達した。このことから、本発明の生物繊維複合ドレッシング材の柔軟性は従来生物繊維膜より好ましいことが分かる。 When the same test was performed on a conventional biological fiber membrane, the tensile strength reached 2607.33 g / 15 mm. From this, it can be seen that the flexibility of the biological fiber composite dressing material of the present invention is more preferable than the conventional biological fiber membrane.
本発明の生物繊維複合ドレッシング材の伸長率試験
また、本発明の生物繊維複合ドレッシング材を、伸長率の試験に行って、得られた結果は、それぞれ２１．００％、１６．２０％、及び１６．６０％であり、平均伸長率は１７．９３％である。従来生物繊維膜に同じ試験を行ったところ、その伸長率は５．６６％にとどまる。このことから、本発明の生物繊維複合ドレッシング材の伸長率は顕著に好ましく、より大きい面積に伸びて貼付くことができることが分かる。
Elongation rate test of the biological fiber composite dressing material of the present invention The biological fiber composite dressing material of the present invention was also subjected to the elongation rate test, and the results obtained were 21.00%, 16.20%, and It is 16.60% and the average elongation is 17.93%. When the same test was performed on a conventional biological fiber membrane, the elongation rate was only 5.66%. From this, it can be seen that the elongation rate of the biological fiber composite dressing material of the present invention is remarkably preferable, and it can be stretched and attached to a larger area.
本発明の生物繊維複合ドレッシング材の吸水性試験
サイズが１００ｍｍｘ１５ｍｍである三枚の試験シート、皿に脱イオン水を注入し、水温を２３±１℃に保持し、次に、試験シートを水面に接触させ、１分間の吸水高さを測る。
Water absorption test of biological fiber composite dressing material of the present invention Three test sheets having a size of 100 mm x 15 mm, deionized water was poured into a dish, the water temperature was maintained at 23 ± 1 ° C, and then the test sheet was placed on the water surface. Contact and measure the water absorption height for 1 minute.
測った結果、本発明の生物繊維複合ドレッシング材の平均吸水高さは４０ｍｍであり、従来生物繊維膜の平均吸水高さは１ｍｍに過ぎなかった。このことから、本発明の生物繊維複合ドレッシング材はより好ましい吸水性を有することが分かる。 As a result of measurement, the average water absorption height of the biological fiber composite dressing material of the present invention was 40 mm, and the average water absorption height of the conventional biological fiber membrane was only 1 mm. This shows that the biological fiber composite dressing material of the present invention has more preferable water absorption.
本発明の生物繊維複合ドレッシング材の単位面積ごとの生物繊維量試験
本発明の生物繊維複合ドレッシング材を、５ｃｍｘ５ｃｍのサイズに切断し、全部で１６片のサンプルを作った後、６０℃で１０分間ベーク乾燥し、ベーク乾燥したサンプルの乾燥重量を測り、布膜の乾燥重量を除いた後の各サンプル乾燥重量をサンプル面積で割って、得られた単位面積ごとの生物繊維量は０．００５〜０．００８ｇ／ｃｍ２である。
Biological fiber amount test for each unit area of the biological fiber composite dressing material of the present invention The biological fiber composite dressing material of the present invention was cut into a size of 5 cm x 5 cm to make a total of 16 pieces of samples, and then at 60 ° C for 10 minutes. Bake-dry, measure the dry weight of the baked sample, divide each sample dry weight after removing the dry weight of the cloth film by the sample area, the amount of biological fiber per unit area obtained is 0.005 0.008 g / cm 2 .
それに対して、市販の従来生物繊維膜の単位面積ごとの生物繊維量は、通常０．００１ｇ／ｃｍ２にとどまる。 On the other hand, the amount of biological fibers per unit area of a commercially available conventional biological fiber membrane is usually only 0.001 g / cm 2 .
本発明の生物繊維複合ドレッシング材の再水和率試験
本発明の生物繊維複合ドレッシング材、及び市販従来生物繊維膜を取り、その湿重量を測り、次に、２０℃で３０分間ベーク乾燥し、ドレッシング材及び生物繊維膜が曲がって白色糸状維になった後、その乾燥重量を測った。次に、改めてドレッシング材及び生物繊維膜を水に３０分間接触し、その再水和後の重量を記録し、再水和後の重量を湿重量と乾燥重量との重量差で割ることで、再水和率を得た。
Rehydration rate test of the biological fiber composite dressing material of the present invention Take the biological fiber composite dressing material of the present invention and the commercially available conventional biological fiber membrane, weigh its wet weight, then bake dry at 20 ° C for 30 minutes, After the dressing material and the biological fiber membrane were bent into white filaments, the dry weight was measured. Next, contact the dressing material and the biofiber membrane again with water for 30 minutes, record the weight after rehydration, and divide the weight after rehydration by the weight difference between the wet weight and the dry weight, A rehydration rate was obtained.
検出したところ、本発明の生物繊維複合ドレッシング材は少なくとも５０％、最も高くは９１％まで達する再水和率を有することが分かり、市販の従来生物繊維膜が吸水できない原因は、市販の従来生物繊維膜の単位面積繊維量が０．００１ｇ／ｃｍ２だけであるためと考えられ、本発明の生物繊維複合ドレッシング材における生物繊維膜之の単位面積ごとの生物繊維量は０．００５〜０．００８ｇ／ｃｍ２まで達するため、優れた再水和率を有する。 As a result, it was found that the biological fiber composite dressing material of the present invention has a rehydration rate of at least 50%, the highest reaching 91%. It is considered that the amount of fiber per unit area of the fiber membrane is only 0.001 g / cm 2 , and the amount of biological fiber per unit area of the biological fiber membrane in the biological fiber composite dressing of the present invention is 0.005 to 0.00. Since it reaches 008 g / cm 2, it has an excellent rehydration rate.
本発明の生物繊維複合ドレッシング材の浸透性試験
本発明の生物繊維複合ドレッシング材及び市販の従来生物繊維膜を、それぞれ底材の上に設置し、次に、本発明の生物繊維複合ドレッシング材及び市販の従来生物繊維膜に、等量の染色されたエッセンスを滴下し、１０秒後、底材の浸透状況を目視で観察した。
Penetration test of the biological fiber composite dressing material of the present invention The biological fiber composite dressing material of the present invention and a commercially available conventional biological fiber membrane were respectively installed on the bottom material, and then the biological fiber composite dressing material of the present invention and An equal amount of the dyed essence was dropped on a commercially available conventional biological fiber membrane, and after 10 seconds, the penetration of the bottom material was visually observed.
図５に示すように、図５（ａ）は本発明の生物繊維複合ドレッシング材の試験結果であり、図５（ｂ）は市販の従来生物繊維膜の試験結果であり、その中、市販の従来生物繊維膜は、剛滴加エッセンス時、そのエッセンスの拡散効果は良くなく、１０秒後はエッセンスを底材まで自然に効果的に浸透させることができず、それに対して、本発明の生物繊維複合ドレッシング材は顕著的なエッセンス拡散性及び浸透性を有する。 As shown in FIG. 5, FIG. 5 (a) is a test result of the biological fiber composite dressing material of the present invention, and FIG. 5 (b) is a test result of a commercially available conventional biological fiber membrane, among which a commercially available The conventional biological fiber membrane does not have a good effect of diffusing the essence at the time of the sessile essence, and after 10 seconds, the essence cannot be effectively penetrated to the bottom material. The fiber composite dressing has significant essence diffusibility and permeability.
以上のように、本発明の生物繊維複合ドレッシング材は布膜及び生物繊維膜を有し、生物繊維膜によりより多くの水分または活性成分を吸収すると共に、生物繊維膜の孔隙が布膜より細いため、透気性を有する同時に、水分が速やかに布膜から蒸発することを回避し、ドレッシング材の保湿性を上昇させる。一方、生物繊維複合ドレッシング材の片側が布膜である場合、同時に付着快適性と長い保湿性効果を有することができる。そのため、本発明の生物繊維複合ドレッシング材を使用して皮膚に貼付し、例えばパックとして使用する場合、過剰な量の活性成分を吸い取る必要がなく、末端使用者にとって大幅な消費コストを節約することができる。 As described above, the biological fiber composite dressing material of the present invention has a cloth film and a biological fiber film, absorbs more moisture or active ingredients by the biological fiber film, and the pores of the biological fiber film are narrower than the cloth film. Therefore, it has air permeability, and at the same time, it avoids moisture from quickly evaporating from the cloth film, and increases the moisture retention of the dressing material. On the other hand, when one side of the biological fiber composite dressing material is a fabric film, it can have adhesion comfort and a long moisturizing effect at the same time. Therefore, when applied to the skin using the biological fiber composite dressing material of the present invention, for example, as a pack, it is not necessary to absorb an excessive amount of the active ingredient, and it saves a significant cost of consumption for the end user. Can do.
上記実施例は例示的に本発明の原理及びその効果を説明するためのものであり、本発明を制限するものではない。当業者は本発明の主旨及び範疇に違反しない限り、上記実施例を改変できる。本発明の権利保護範囲は、特許請求の範囲の通りである。 The above-described embodiments are for illustrative purposes only and are not intended to limit the present invention. Those skilled in the art can modify the above-described embodiments without violating the spirit and scope of the present invention. The scope of rights protection of the present invention is as set forth in the claims.
１、２ 生物繊維複合ドレッシング材
１０、２０ 布膜
１０１ 布膜繊維
１０ａ、２０ａ 第一の表層
１０ｂ、２０ｂ 第二の表層
１２、２２ 生物繊維膜
１２ａ 第三の表層
１２ｂ 第四の表層
１２１ 立体網状構造
１２１ａ 骨幹繊維
１２１ｂ 層間繊維
２２’ もう一つの生物繊維膜
1, 2 Biological fiber composite dressing material 10, 20 Fabric membrane 101 Fabric membrane fibers 10a, 20a First surface layer 10b, 20b Second surface layer 12, 22 Biological fiber membrane 12a Third surface layer 12b Fourth surface layer 121 Three-dimensional network Structure 121a Skeletal fiber 121b Interlayer fiber 22 'Another biological fiber membrane
Claims (18)
グルコンアセトバクター属の菌により形成され、対向する第三の表層及び前記第一の表層上に結合する第四の表層を有し、前記第四の表層には前記布膜繊維に絡め合って結合する複数の生物繊維が伸びている生物繊維膜と、
を含む生物繊維複合ドレッシング材であって、
前記生物繊維膜は、前記第三の表層と前記第四の表層の間に結合する立体網状構造をさらに有し、前記立体網状構造の密度は前記第三の表層と前記第四の表層の密度より小さく、前記立体網状構造は前記第四の表層から前記布膜における第一の表層内まで伸びており、
前記立体網状構造は、骨幹繊維及び層間繊維を有し、
前記骨幹繊維は、複数で存在して、互いに平行し、
前記層間繊維は、複数で存在して、隣接する任意の二つの前記骨幹繊維に織り合わされ、
前記生物繊維膜は、複数の生物繊維を有し、且つ、単位面積ごとの前記生物繊維量は０．００５〜０．００８ｇ／ｃｍ ２ であることを特徴とする、生物繊維複合ドレッシング材。 A fabric membrane having opposing first and second surface layers and having fabric membrane fibers;
It is formed by a bacterium of the genus Gluconacetobacter, and has a third surface layer facing and a fourth surface layer bonded to the first surface layer, and the fourth surface layer is entangled with the fabric membrane fiber and bonded. A biological fiber membrane in which a plurality of biological fibers are stretched,
A biological fiber composite dressing including,
The biological fiber membrane further has a three-dimensional network structure bonded between the third surface layer and the fourth surface layer, and the density of the three-dimensional network structure is the density of the third surface layer and the fourth surface layer. Smaller, the three-dimensional network structure extends from the fourth surface layer into the first surface layer of the fabric film,
The three-dimensional network structure has skeletal fibers and interlayer fibers,
The diaphyseal fiber is present in a plurality, parallel to each other,
A plurality of the interlayer fibers are interwoven with any two adjacent diaphyseal fibers,
The biological fiber composite dressing material, wherein the biological fiber membrane has a plurality of biological fibers, and the amount of the biological fibers per unit area is 0.005 to 0.008 g / cm 2 .
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