CN106177901B - A kind of private parts facial mask - Google Patents

A kind of private parts facial mask Download PDF

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Publication number
CN106177901B
CN106177901B CN201610795789.3A CN201610795789A CN106177901B CN 106177901 B CN106177901 B CN 106177901B CN 201610795789 A CN201610795789 A CN 201610795789A CN 106177901 B CN106177901 B CN 106177901B
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parts
facial mask
private
bifidobacterium
extract
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CN106177901A (en
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邱明世
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Harbin Tianmei Pharmaceutical Co ltd
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Harbin OT Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/05Chlorophycota or chlorophyta (green algae), e.g. Chlorella
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
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    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212Face masks
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/34Alcohols
    • A61K8/347Phenols
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    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
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    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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    • AHUMAN NECESSITIES
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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Abstract

The present invention relates to a kind of private parts facial masks, and it includes non-woven fabric layer, the non-woven fabric layer is impregnated with facial mask liquid;The facial mask liquid contains each component of following parts by weight: 5-10 parts of aurantialba extract, 6-8 parts of chlorella extract, 1-5 parts of radish powder, 1-8 parts of rose extract, 8-10 parts of arbutin, 1-5 parts of echidnotoxin peptide, 2-5 parts of avocado oil, 1-3 parts of cocoa seed extracts, 1-3 parts of Sodium Hyaluronate, 2-5 parts of Rosemary Oil, 1-3 parts of grape seed oil, 1-3 parts of lactic acid, 3-5 parts of sodium lactate, 1-5 parts of eugenol, 2-5 parts of tea oil, 1-4 parts of hazel extract, 1-2 parts of Bifidobacterium composition, 5-15 parts and deionized water 40-78 parts of glycerol.By application private parts facial mask provided by the invention, sterilization and anti-inflammatory can be played the role of, it is non-stimulated to skin, while private parts can also be made to achieve the effect that whitening, moisturizing and smoothing wrinkle.

Description

A kind of private parts facial mask
Technical field
The present invention relates to health care technology fields, and in particular to a kind of facial mask more particularly to a kind of private parts facial mask.
Background technique
Facial mask is temporarily isolating extraneous air and pollution, improves skin mainly using the of short duration time for being covered on skin Temperature expands the pore of skin, promotes sweat gland secretion and metabolism, increase the oxygen content of skin, is conducive to skin row Except the product of epidermal cell metabolism and the oil substances of accumulation, the moisture in facial mask penetrates into the cuticula of skin epidermis, Skin becomes soft, and skin is naturally bright flexible.
According to the form of facial mask, it is generally classified as diaphragm type and emulsion-type two major classes.Diaphragm type facial mask is with plastics system Make, and is coated with drug, can be wrinkle resistant, dirt is removed, keeps skin vigorous;Emulsion-type facial mask is in paste, is eluted with water after painting, energy Play the role of extra-nutrition, skin care.According to the effect of facial mask, it is classified as moisturizing facial mask, nourishing pack, anti-drawn grain Film, curative effect facial mask etc..Whitening mask and mask for acne in curative effect facial mask are that different component is added for yellowish-brown class and acne Traditional Chinese medicinal components be made.Result of study shows: improving skin in appearance, curative effect facial mask is than general cosmetics and medicine Object therapeutic effect is big, quick.
The facial mask occurred in the market at present is mainly to be applied to face or skin of neck, and pass through such face of application Film is mainly used for achieving the effect that beauty.So far, it and has no facial mask applied to private parts, also has no through private parts facial mask To realize the report for carrying out sterilization and anti-inflammatory to private parts.However, the use of some suppositorys can bring all due in actual therapeutic Mostly inconvenient, operation is also relative complex, in addition, it is heavy that private parts can generate a large amount of pigment due to inherent cause, hormone secretion etc. , and there is the phenomenon that cutis laxa, to influence the skin beauty of human body.
It therefore, will be big as can researching and developing a kind of mask product for applying to private parts for realizing sterilization and anti-inflammatory to private parts Facilitate daily use greatly, operates simpler, conveniently;And by the application private parts facial mask, as can alleviate pigmentation and Cutis laxa, it will help meet the greater demand of women.
Summary of the invention
In view of problems of the prior art, the purpose of the present invention is to provide a kind of facial masks, in particular, provide one Kind private parts facial mask can play the role of carrying out private parts sterilization and anti-inflammatory by the application private parts facial mask, stingless to skin Swash, while private parts can also be made to achieve the effect that whitening, moisturizing and smoothing wrinkle.
For this purpose, the invention adopts the following technical scheme:
The present invention provides a kind of private parts facial masks, and it includes non-woven fabric layer, the non-woven fabric layer is impregnated with face Film liquid;The facial mask liquid contains each component of following parts by weight:
5-10 parts of aurantialba extract, 6-8 parts of chlorella extract, 1-5 parts of radish powder, 1-8 parts of rose extract, black bearberry 8-10 parts of glycosides, 1-5 parts of echidnotoxin peptide, 2-5 parts of avocado oil, 1-3 parts of cocoa seed extracts, 1-3 parts of Sodium Hyaluronate, fan change 2-5 parts of essential oil, 1-3 parts of grape seed oil, 1-3 parts of lactic acid, 3-5 parts of sodium lactate, 1-5 parts of eugenol, 2-5 parts of tea oil, gold thread 1-4 parts of plum extracting solution, 1-2 parts of Bifidobacterium composition, 5-15 parts of glycerol and 40-78 parts of deionized water.
The present invention can play synergistic work by the way that each component of facial mask liquid is carried out reasonable disposition between each component With can realize the effect for carrying out sterilization and anti-inflammatory to private parts well, while also private parts can be made to reach whitening, moisturizing and smoothing wrinkle Effect.
According to the present invention, content (weight) of the aurantialba extract in facial mask liquid is 5-10 parts, such as can be 5 It is specific between part, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts and above-mentioned numerical value Point value, as space is limited and for concise consideration, the specific point value that range described in the present invention no longer exclusive list includes.The present invention Described in the content of aurantialba extract be preferably 6-8 parts, further preferably 6 parts.
According to the present invention, term " aurantialba extract ", which refers to, is extracted by any mode well known in the art from Jin Erzhong The golden fungus polysaccharides containing effective component extract, such as can be obtained by extraction process.
According to the present invention, content (weight) of the chlorella extract in facial mask liquid is 6-8 parts, such as can be 6 Part, 6.5 parts, 7 parts, 7.5 parts or the specific point value between 8 parts and above-mentioned numerical value, as space is limited and for concise consideration, The specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described chlorella extract is preferably 7-8 parts, further preferably 8 parts.
According to the present invention, term " chlorella extract " refers to is mentioned from chlorella by any mode well known in the art The extract containing effective component taken out, can also be by being commercially available.Illustratively, it such as can be obtained by following technique : chlorella (chlorella pyrenoidosa) frond 10g is put into butanediol 100mL, agitating and heating, 100 DEG C of heating 2h, is removed not Molten object obtains freeze-dried powder after liquid is concentrated.
According to the present invention, content (weight) of the radish powder in facial mask liquid be 1-5 parts, such as can be 1 part, Specific point value between 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts and above-mentioned numerical value, as space is limited And for concise consideration, specific point value that range described in the present invention no longer exclusive list includes.Heretofore described radish The content of powder is preferably 2-5 parts, and further preferably 3 parts.
According to the present invention, term " radish powder ", which refers to, processes powdering for radish by any mode well known in the art Object.Illustratively, it such as can be obtained by following technique: first that fresh radish (carrot tassel powder or green turnip tassel) is clear After washing, draining surface moisture under room temperature, heated-air drying at 50 DEG C makes moisture content≤7%, is crushed with medicinal herb grinder, mistake 200-300 mesh obtains radish powder.
According to the present invention, content (weight) of the rose extract in facial mask liquid be 1-8 parts, such as can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts or 8 parts, Yi Jishang The specific point value between numerical value is stated, as space is limited and for concise consideration, range described in the present invention no longer exclusive list includes Specific point value.The content of heretofore described rose extract is preferably 3-6 parts, and further preferably 5 parts.
According to the present invention, term " rose extract " can be prepared by mode commercially available or well known in the art.Show Example property, such as the 1.1.1 low cost vegetable plant water extract part being referred in document " researchs of Flos Rosae Rugosae extract anti-aging effects " (" researchs of Flos Rosae Rugosae extract anti-aging effects ", Shao Wei etc., " Nankai University's journal ", the 3rd phase of volume 41, in June, 2008).
According to the present invention, content (weight) of the arbutin in facial mask liquid is 8-10 parts, such as can be 8 parts, 8.5 Part, 9 parts, 9.5 parts or the specific point value between 10 parts and above-mentioned numerical value, as space is limited and for concise consideration, the present invention The no longer specific point value that includes of range described in exclusive list.The content of heretofore described arbutin is preferably 9-10 parts, into one Preferably 10 parts of step.
According to the present invention, No. CAS of term " arbutin " is 497-76-7, primarily serves whitening function.
According to the present invention, content (weight) of the echidnotoxin peptide in facial mask liquid be 1-5 parts, such as can be 1 part, Specific point value between 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts and above-mentioned numerical value, as space is limited And for concise consideration, specific point value that range described in the present invention no longer exclusive list includes.Heretofore described snake venom egg The content of white peptide is preferably 2-5 parts, into one preferably 3 parts.
According to the present invention, term " echidnotoxin peptide ", also referred to as " calmette's serum protein peptides " can pass through commercially available or sheet Mode well known to field is prepared.Illustratively, it such as can be obtained by following technique:
(1) thick poison is produced;
(2) DEAE-Sephadex A-50 is applied, gradient elution is carried out with the buffer containing NaCl, separates snake venom;
(3) the thick poison isolated is used in the Tris-HCl buffer of pH7.5 on 100000rpm refrigerated centrifuge, acquirement Clear liquid.
(4) above-mentioned supernatant is chromatographed with Sephadex G-75 column, is 240nm in absorbance, protein peak is collected, through ultrafiltration Concentration, freeze-drying obtain echidnotoxin.
According to the present invention, content (weight) of the avocado oil in facial mask liquid be 2-5 parts, such as can be 2 parts, Specific point value between 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts and above-mentioned numerical value, as space is limited and for simplicity The considerations of, specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described avocado oil is excellent 2-4 parts are selected as, into one preferably 2 parts.
According to the present invention, term " avocado oil ", also referred to as " Butyrospermum parkii oil ", can be public by commercially available or this field The mode known is prepared.
According to the present invention, content (weight) of the cocoa seed extracts in facial mask liquid is 1-3 parts, such as can be 1 Part, 1.5 parts, 2 parts, 2.5 parts or the specific point value between 3 parts and above-mentioned numerical value, as space is limited and for concise consideration, The specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described cocoa seed extracts is preferably 1-2 parts, further preferably 1 part.
According to the present invention, term " cocoa seed extracts " refers to is extracted from cocoa by any mode well known in the art The extract containing effective component out can also pass through commercially available acquisition.
According to the present invention, content (weight) of the Sodium Hyaluronate in facial mask liquid be 1-3 parts, such as can be 1 part, Specific point value between 1.5 parts, 2 parts, 2.5 parts or 3 parts and above-mentioned numerical value, as space is limited and for concise consideration, this hair The specific point value that range described in bright no longer exclusive list includes.The content of heretofore described Sodium Hyaluronate is preferably 1-2 parts, Further preferably 1 part.
According to the present invention, content (weight) of the Rosemary Oil in facial mask liquid be 2-5 parts, such as can be 2 parts, Specific point value between 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts and above-mentioned numerical value, as space is limited and for simplicity The considerations of, specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described Rosemary Oil Preferably 3-5 parts, further preferably 4 parts.
According to the present invention, content (weight) of the grape seed oil in facial mask liquid be 1-3 parts, such as can be 1 part, Specific point value between 1.5 parts, 2 parts, 2.5 parts or 3 parts and above-mentioned numerical value, as space is limited and for concise consideration, this hair The specific point value that range described in bright no longer exclusive list includes.The content of heretofore described grape seed oil is preferably 1-2 parts, into One step is preferably 2 parts.
According to the present invention, content (weight) of the lactic acid in facial mask liquid be 1-3 parts, such as can be 1 part, 1.5 parts, Specific point value between 2 parts, 2.5 parts or 3 parts and above-mentioned numerical value, as space is limited and for concise consideration, the present invention is no longer The specific point value that range described in exclusive list includes.The content of heretofore described lactic acid is preferably 1-2 parts, further preferably 1 part.
According to the present invention, content (weight) of the sodium lactate in facial mask liquid is 3-5 parts, such as can be 3 parts, 3.5 Part, 4 parts, 4.5 parts or the specific point value between 5 parts and above-mentioned numerical value, as space is limited and for concise consideration, the present invention The no longer specific point value that includes of range described in exclusive list.The content of heretofore described sodium lactate is preferably 4-5 parts, further Preferably 4 parts.
According to the present invention, content (weight) of the eugenol in facial mask liquid is 1-5 parts, such as can be 1 part, 1.5 Part, 2 parts, 2.5 parts, 3 parts, 4 parts or the specific point value between 5 parts and above-mentioned numerical value being examined as space is limited and for concise Consider, the specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described eugenol is preferably 2-5 Part, further preferably 3 parts.
According to the present invention, content (weight) of the tea oil in facial mask liquid is 2-5 parts, such as can be 2 parts, 2.5 Part, 3 parts, 3.5 parts, 4 parts, 4.5 parts or the specific point value between 5 parts and above-mentioned numerical value being examined as space is limited and for concise Consider, the specific point value that range described in the present invention no longer exclusive list includes.The content of heretofore described tea oil is preferably 3-5 Part, further preferably 4 parts.
According to the present invention, content (weight) of the hazel extract in facial mask liquid is 1-4 parts, such as can be 1 Part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts or the specific point value between 4 parts and above-mentioned numerical value, as space is limited and for letter Bright consideration, the specific point value that range described in the present invention no longer exclusive list includes.Heretofore described hazel extract Content is preferably 2-4 parts, and further preferably 3 parts.
According to the present invention, term " Sodium Hyaluronate ", " Rosemary Oil ", " grape seed oil ", " lactic acid ", " sodium lactate ", " eugenol ", " tea oil " and " hazel extract " is each meant to be contained by what any mode well known in the art extracted The extract of ingredient or the product of commercially available acquisition are imitated, particular determination is not done to its specific preparation method.
According to the present invention, content (weight) of the Bifidobacterium composition in facial mask liquid is 1-2 parts, such as be can be 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts or 2 parts and above-mentioned numerical value it Between specific point value, as space is limited and for concise consideration, range described in the present invention no longer exclusive list includes specific Value.The content that heretofore described Bifidobacterium group is combined into is preferably 1-1.5 parts, and further preferably 1.5 parts.
According to the present invention, the Bifidobacterium composition is preferably using following combination: by bifidobacterium lactis (Bifidobacterium lactis), animal bifidobacteria (Bifidobacterium animalis) and bifidobacterium bifidum (Bifidobacterium bifidum) composition;Wherein, the weight ratio between above-mentioned each Bifidobacterium is (according to above-mentioned each bifid The sequence of bacillus) it is specially (3-5): (1-3): (2-7), such as can be 3:1:2,4:1:5,5:1:3,4:2:7,5:1:6,4: 1:5 or 5:1:7, preferably 5:1:3.
Present invention employs increase on the basis of various extracts Bifidobacterium composition as facial mask liquid it is active at Point, which create synergistic functions, can balance each flora in vagina well, have wide spectrum for treatment vaginitis Property simultaneously can fundamentally prevent and treat vaginitis disease.
Inventor is it was unexpectedly observed that the present invention is used cooperatively by using by three kinds of Bifidobacteriums, compared to using single One component can be further improved the effective percentage of the prevention and treatment to various vaginitis diseases, wherein it is for colpomycosis and drop The treated effect of worm property vaginitis can be improved to 99.5%, for the treated effect of cervical erosion and bacterial vaginitis It can reach 99.1% or more.
According to the present invention, content (weight) of the glycerol in facial mask liquid is 5-15 parts, such as can be 5 parts, 6 parts, 7 Part, 7.5 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or the specific point value between 15 parts and above-mentioned numerical value, limit In length and for concise consideration, specific point value that range described in the present invention no longer exclusive list includes.It is heretofore described The content of glycerol is preferably 5-10 parts, and further preferably 8 parts.
According to the present invention, content (weight) of the deionized water in facial mask liquid is 40-78 parts, such as can be 40 Part, 41 parts, 45 parts, 48 parts, 50 parts, 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 63 parts, 65 parts, 68 parts, 70 parts, 72 parts, 73 Part, 75 parts or the specific point value between 78 parts and above-mentioned numerical value, as space is limited and for concise consideration, the present invention is no longer The specific point value that range described in exclusive list includes.The content of deionized water of the present invention is preferably 42-75 parts, further excellent It is selected as 51 parts.
According to the present invention, the private parts facial mask, preferably comprises each component of following parts by weight:
6-8 parts of aurantialba extract, 7-8 parts of chlorella extract, 2-5 parts of radish powder, 3-6 parts of rose extract, black bearberry 9-10 parts of glycosides, 2-5 parts of echidnotoxin peptide, 2-4 parts of avocado oil, 1-2 parts of cocoa seed extracts, 1-2 parts of Sodium Hyaluronate, fan change 3-5 parts of essential oil, 1-2 parts of grape seed oil, 1-2 parts of lactic acid, 4-5 parts of sodium lactate, 2-5 parts of eugenol, 3-5 parts of tea oil, gold thread 2-4 parts of plum extracting solution, 1-1.5 parts of Bifidobacterium composition, 5-10 parts of glycerol and 42-75 parts of deionized water.
It is further preferred that the facial mask liquid is grouped as by each group of following parts by weight:
6 parts of aurantialba extract, 8 parts of chlorella extract, 3 parts of radish powder, 5 parts of rose extract, 10 parts of arbutin, snake 3 parts of toxalbumin peptide, avocado oily 2 parts, 1 part of cocoa seed extracts, 1 part of Sodium Hyaluronate, 4 parts of Rosemary Oil, grape seed oil 2 Part, 1 part of lactic acid, 4 parts of sodium lactate, 3 parts of eugenol, 4 parts of tea oil, 3 parts of hazel extract, 1.5 parts of Bifidobacterium composition, 8 parts and 51 parts of deionized water of glycerol.
According to the present invention, the non-woven fabric layer is the substrate for being impregnated with the facial mask of facial mask liquid.Non-woven fabric layer does not have Have and particularly limit, precondition is made of it by supatex fabric commonly used in the art.For the leaching for being conducive to facial mask liquid Stain, the supatex fabric comprising hydrophilic fibre are preferred.The hydrophilic fibre can be selected from following objects to be at least one Matter: mulberry silk, cotton, paper pulp, nylon, cellulose, etc..
In the present invention, the non-woven fabric layer also may include the polymer of such as polyester (PET), easy to handle to ensure Property, processability, etc..
The complex nonwoven fabric layer being made of hydrophilic fibre and polymer can be non-woven comprising artificial silk and PET Tissue layer.In this case, the weight ratio of artificial silk and PET can be at (7-8): (5-3), preferably (7-8): (8-2), more preferably For 7:8.
Non-woven fabric layer according to supatex fabric manufacturing process can for meltblown nonwoven fabric, spunbonded non-woven fabrics, Hydroentangled nonwoven fabrics, etc., however, the present invention is not limited thereto.
As used herein, the term " supatex fabric " be include random orientation plurality of fibers web.Here, this A little fibers can be staple fiber or continuous filaments.
Total weight of the content of non-woven fabric layer based on facial mask can be in the range of 96.5 weight % to 99 weight %. The thickness of non-woven fabric layer is not particularly limited, but can be in the range of 0.32mm to 0.38mm.Non-woven fabric layer The quality of per unit area is not particularly limited, but can be in the range of 45gsm to 55gsm.
According to the present invention, the private parts facial mask also contains layers of nanofibers, is adhered on the non-woven fabric layer;It is excellent Selection of land, by adhesive phase, fusible films plus heat or ultrasonic between the layers of nanofibers and the non-woven fabric layer Any one mode is bonded.
In the present invention, the layers of nanofibers is used as the adhesive surface of skin.Non-woven fabric layer is present in relatively In on the apparent surface of the facial mask of the adhesive surface of skin, if any, described adhesive layer is clipped between the two.
Layers of nanofibers since the Kong Zhongke that nanofiber can be easily accessible skin shows excellent skin adhesion, and Nanoscale fiber enhances the reservation of liquid side film liquid in which can dramatically.
Layers of nanofibers in the present invention includes hydrophilic polymer, is used as the adhesive surface of skin.It can be used Hydrophilic polymer in the present invention can be selected from following substance: polyacrylonitrile (PAN), hydrophilic polyurethane to be at least one (PU), polyvinyl alcohol (PVA), nylon (nylon 6), hydrophily polyvinylidene fluoride (PVDF), hydrophilic polyethersulfone (PES) and poly- Etherimide (PEI), etc..The layers of nanofibers also may include thermoplastic polyurethane (TPU), be adhered to skin with enhancing When flexibility and prevent due to outer friction or contact (for example, scratch or fracture) damage to the layers of nanofibers.
Total weight of the content of the layers of nanofibers based on the facial mask can be in 0.7 weight % to 2.8 weight %'s In range, and the quality of the per unit area of the layers of nanofibers can be in the range of 0.4gsm to 2gsm according to gas permeability It is interior.
To ensure more preferably skin adhesion in the use process of facial mask and liquid make-up preparation to the good of skin Infiltration, the pore size of the layers of nanofibers can be in the range of 0.8 μm to 3 μm, and the diameter of single nanofiber can be In the range of 100nm to 300nm.The thickness of layers of nanofibers non-specifically limits, but it can be in 0.5 μm to 2 μm of range.
In the present invention, the layers of nanofibers is bonded to non-woven fabric layer.Non-woven fabric layer and the nanofiber Bonding between layer is formed using selected from following one or more of modes: adhesive phase, adds thermally or ultrasonically fusible films Wave.For example, the layers of nanofibers by acquisitions such as electrostatic spinnings can be adhered using adhesive to non-woven fabric layer, alternatively, receiving Rice fiber can be on the non-woven fabric layer that coats to adhesive of electrostatic spinning.
Private parts facial mask of the invention may include that at least one being placed between non-woven fabric layer and layers of nanofibers is added Layer, can be adhesive layer.At least one adhesive can be used as adhesive phase.
Workable adhesive phase can be by acryloid cement, polyurethane binder, polyester binder, silicon oxygen in the present invention Alkane adhesive or combinations thereof is made.The use of acryloid cement, polyurethane binder and polyester binder is preferred.
Described adhesive can prevent nanofiber to be layered and the minimum without skin irritatin uses.In general, Total weight of the content of described adhesive layer based on the facial mask can be in the range of 0.05 weight % to 0.5 weight %.
Utilize method generally known in the art, such as coating method, evaporation (deposition) method etc., described adhesive layer It can be formed on non-woven fabric layer.
The supatex fabric of nanofiber coating is subjected to post-processing generally known in the art (calendering process) to prepare Facial mask of the invention.
According to the present invention, the layers of nanofibers contains the fibroblast factor and human serum albumins, can play Continue the effect of whitening and smoothing wrinkle.
The present invention also provides foregoing private parts facial masks to dispel the purposes in private parts wrinkle and/or moisturizing, can also For private parts whitening.
Compared with prior art, the present invention at least has the advantages that
(1) present invention can play synergy between each component by the way that each component of facial mask liquid is carried out reasonable disposition Effect, each flora in vagina can be balanced well, having for treatment vaginitis broad spectrum activity and can fundamentally prevent Control vaginitis disease;It can be improved to 99.5% the treated effect of colpomycosis and trichomonas vaginitis, right It can reach 99.1% or more in the treated effect of cervical erosion and bacterial vaginitis;
(2) by application private parts facial mask provided by the invention, can not only play the role of sterilization and anti-inflammatory, to skin without Stimulation, while private parts can also be made to achieve the effect that lasting whitening, moisturizing and smoothing wrinkle.
Specific embodiment
Of the invention for ease of understanding, it is as follows that the present invention enumerates embodiment.Those skilled in the art are it will be clearly understood that the implementation Example is only to aid in the understanding present invention, should not be regarded as a specific limitation of the invention.
Embodiment 1
(1) raw material is weighed according to following weight, is uniformly mixed, prepare facial mask liquid:
Aurantialba extract 6g, chlorella extract 8g, radish powder 3g, rose extract 5g, arbutin 10g, snake venom egg White peptide 3g, avocado oil 2g, cocoa seed extracts 1g, Sodium Hyaluronate 1g, Rosemary Oil 4g, grape seed oil 2g, lactic acid 1g, Sodium lactate 4g, eugenol 3g, tea oil 4g, hazel extract 3g, Bifidobacterium composition 1.5g, glycerol 8g and deionized water 51g;
Wherein the weight ratio of the bifidobacterium lactis in Bifidobacterium composition, animal bifidobacteria and bifidobacterium bifidum is 5:1:3;
(2) preparation of mulberry silk nourishing pack spunlace non-woven cloth: the mulberry silk 100kg after choosing removal of impurities is removed through F108 Miscellaneous carding machine combing, removes impurity and short flannel, obtains 92kg fine work mulberry silk fiber;Combing, networking through spun lacing production line, water Thorn;Through with 80g/m2Plain weave terylene non-woven fabric wrapped up roller dryer (drum temperature be 70 DEG C, speed of production 18 M/min, finished product weight is 60g/m2) drying;It batches and cuts into 25cm breadth to get 75kg nourishing pack patch mulberry silk spun lacing is arrived Non-woven fabrics base fabric, the active sericin content of the cloth is up to 5% or more;
(3) after mulberry silk nourishing pack to be cut into the facial mask size for needing size with spunlace non-woven cloth, it is immersed in step (1) in facial mask liquid;Mulberry silk nourishing pack spunlace non-woven cloth and the mass volume ratio of facial mask liquid are 1g:20mL, when immersion Between be 30min, be made private parts facial mask.
Embodiment 2
(1) raw material is weighed according to each component in embodiment 1, be uniformly mixed, prepare facial mask liquid;
(2) the artificial silk PET of viscose rayon and PET (weight ratio 8:2) (Nanyang Textile Co., Ltd.) will be included Spun lacing (60gsm) is prepared as supatex fabric;Polyurethane binder (0.3g) is coated on the supatex fabric poly- to be formed The artificial silk PET water non-woven fabric of urethane adhesive coating;By PAN (6.30g), parent in dimethyl acetamide (89.5g) The solution of aqueous PU (3.15g), heat fusing PU (1.04g) and pigment (0.01g) is applied to the adhesive by electrospinning process On the supatex fabric of coating, to complete the supatex fabric of nanofiber coating;At this point, the per unit of the layers of nanofibers The Mass adjust- ment of area is 1gsm;Wherein, the 1.5g fibroblast factor and 1.2g human seralbumin egg are contained in layers of nanofibers It is white;
(3) after the supatex fabric that nanofiber coats being cut into the facial mask size for needing size, it is immersed in step (1) Facial mask liquid in;The supatex fabric of nanofiber coating and the mass volume ratio of facial mask liquid are 1g:20mL, and soaking time is Private parts facial mask is made in 30min.
Embodiment 3
Compared with Example 1, other same as Example 1 in addition to the component of facial mask liquid and its content are different.
Raw material is weighed according to following weight, is uniformly mixed, facial mask liquid is prepared:
Aurantialba extract 8g, chlorella extract 7g, radish powder 5g, rose extract 3g, arbutin 9g, echidnotoxin Peptide 2g, avocado oil 4g, cocoa seed extracts 2g, Sodium Hyaluronate 2g, Rosemary Oil 5g, grape seed oil 1g, lactic acid 2g, cream Sour sodium 5g, eugenol 2g, tea oil 3g, hazel extract 4g, Bifidobacterium composition 1g, glycerol 5g and deionized water 65g;
Wherein the weight ratio of the bifidobacterium lactis in Bifidobacterium composition, animal bifidobacteria and bifidobacterium bifidum is 5:1:3。
Embodiment 4
Compared with Example 1, other same as Example 1 in addition to the component of facial mask liquid and its content are different.
Raw material is weighed according to following weight, is uniformly mixed, facial mask liquid: aurantialba extract 10g, chlorella extract is prepared 6g, radish powder 1g, rose extract 2g, arbutin 8g, echidnotoxin peptide 2g, avocado oil 2g, cocoa seed extracts 3g, thoroughly Bright matter acid sodium 1g, Rosemary Oil 2g, grape seed oil 1g, lactic acid 1g, sodium lactate 3g, eugenol 1g, tea oil 2g, witch hazel mention Take liquid 1g, Bifidobacterium composition 2g, glycerol 10g and deionized water 45g;
Wherein the weight ratio of the bifidobacterium lactis in Bifidobacterium composition, animal bifidobacteria and bifidobacterium bifidum is 5:1:3。
Embodiment 5
Compared with Example 1, other with 1 phase of embodiment in addition to the weight ratio of ingredient each in Bifidobacterium composition is different Together.
The weight ratio of bifidobacterium lactis, animal bifidobacteria and bifidobacterium bifidum in Bifidobacterium composition is 3:1: 7。
Embodiment 6
Compared with Example 1, other same as Example 1 in addition to the weight ratio of each ingredient of Bifidobacterium composition is different.
The weight ratio of bifidobacterium lactis, animal bifidobacteria and bifidobacterium bifidum in Bifidobacterium composition is 4:3: 5。
Embodiment 7
Compared with Example 1, other same as Example 1 in addition to mulberry silk nourishing pack is replaced with cotton.
Comparative example 1
Compared with Example 1, other same as Example 1 in addition to being added without Bifidobacterium composition.
Comparative example 2
Compared with Example 1, except bifidobacterium lactis, animal bifidobacteria and bifidobacterium bifidum in Bifidobacterium composition Weight ratio be 1:4:1 outside, it is other same as Example 1.
Comparative example 3
Compared with Example 1, except bifidobacterium lactis, animal bifidobacteria and bifidobacterium bifidum in Bifidobacterium composition Weight ratio be 6:1:8 outside, it is other same as Example 1.
Comparative example 4
Compared with Example 1, in addition to Bifidobacterium composition is using the single Bifidobacterium of bifidobacterium lactis, other and implementation Example 1 is identical.
Comparative example 5
Compared with Example 1, except Bifidobacterium composition is using in addition to the single Bifidobacterium of animal bifidobacteria, it is other with it is real It is identical to apply example 1.
Comparative example 6
Compared with Example 1, except Bifidobacterium composition is using in addition to the single Bifidobacterium of bifidobacterium bifidum, it is other with it is real It is identical to apply example 1.
Comparative example 7
Compared with Example 2, other in addition to not containing the fibroblast factor and human serum albumins in layers of nanofibers It is same as Example 2.
Comparative example 8
Compared with Example 2, in addition to containing human serum albumins in layers of nanofibers and not containing the fibroblast factor, It is other same as Example 2.
Comparative example 9
Compared with Example 2, in addition to containing the fibroblast factor in layers of nanofibers and not containing human serum albumins, It is other same as Example 2.
Comparative example 10
Compared with Example 1, except being added without Sodium Hyaluronate, Rosemary Oil, grape seed oil, lactic acid, sodium lactate, cloves These are organized exceptionally for phenol, tea oil and hazel extract, other same as Example 1.
Comparative example 11
Compared with Example 1, except being added without aurantialba extract, chlorella extract, radish powder, rose extract, bear These are organized exceptionally for fruit glycosides, echidnotoxin peptide, avocado oil and cocoa seed extracts, other same as Example 1.
Clinical test
One, research method
Research approach is referring to related " the gynemetrics's genital inflammation of Ministry of Health of the People's Republic of China's new drug clinical guidance principle The clinical verification of local application " content and formulate.
1. test case: accepting patient totally 150 for medical treatment, make a definite diagnosis bacterial vaginitis patient 50 through gynecologial examination, beads Bacterium property vulvovaginal patient 53;Trichomonas vaginitis patient 47, the age between 21-60 years old, excludes gestation and feeds Newborn phase patient;
2. diagnostic criteria:
Symptom: pruritus vulvue, cusalgia, or with frequent micturition, urgent urination, urodynia;
Gynecologial examination: bacterial vaginitis secretory substance is even, thin, has a fish like smell;Vulvovaginal candidiasis, have compared with More white bean dregs sample leukorrhea;Trichomonas vaginitis secretion is in yellow foam;
Laboratory checks: bacterial vaginitis can discover a clue under microscope cell in secretion, monilial vulva Vaginopathy, smear detect, and look for pseudohypha under microscope, positive rate is up to 60%;Trichomonas vaginitis vaginal fluid microscope Under visible trichomonad;
3. grouping and application vagina facial mask: by 51 cervical erosion, being randomly divided into treatment group 29 and control group 22;It will 50 bacterial vaginitis are randomly divided into treatment group 29 and control group 21;By 53 vulvovaginal candidiasis patients, It is randomly divided into treatment group 33 and control group 20;By 47 trichomonas vaginitis patients, it is randomly divided into treatment group 25 and right According to group 22;The vagina facial mask of application embodiment 1-7 and comparative example 1-11 are given by the above treatment group, and a daily patch, 7 days are one The course for the treatment of;
4. observation item
4.1 therapeutic observations
(1) symptom;
(2) gynecologial examination: including vulva, vagina, uterine neck and vaginal fluid inspection;
(3) laboratory check: to vaginal fluid inspection, including under mirror, smear;
(4) Bacteria Culture;
4.2 safety observations
(1) general physical examination project;
(2) blood, urine, feces routine test;
(3) heart, Liver and kidney function inspection;
4.3 adverse reactions observation
Any abnormal symptom occurred during medication, sign, laboratory checks, all answers serious analysis, carefully identifies;
4.4 skin irritatins test
5. efficacy assessment standard:
Recovery from illness: symptom disappears, and gynecologial examination and laboratory check normally;
Effective: symptom is substantially reduced, and gynecologial examination and laboratory check and be clearly better;
Effective: symptom is mitigated, and gynecologial examination and laboratory check and improved;
It is invalid: unchanged before relatively being treated after treatment;
6. treatment results: after patient's 4 courses for the treatment of of equal application, therapeutic effect is as shown in table 1.
Table 1
It can be seen from Table 1 that embodiment 1 is by addition Bifidobacterium composition and adopts compared with comparative example 1 and 4-6 The facial mask liquid constituted is compounded with by bifidobacterium lactis, animal bifidobacteria and bifidobacterium bifidum, compared to using individually a kind of double Discrimination bacillus or the case where do not add, for colpomycosis and trichomonas vaginitis and cervical erosion and bacterial vaginosis Scorching treated effect is improved, and illustrates that this these three Bifidobacterium produces synergistic function;With comparative example 2-3 phase Than embodiment 1 can greatly improve private parts by using the facial mask liquid for setting the weight ratio of three kinds of Bifidobacteriums to 5:1:3 Therapeutic effect of the facial mask to various vaginitis;Compared with comparative example 7-9, embodiment 2 in layers of nanofibers by being added into fibre Cell factor and human serum albumins component are tieed up, private parts facial mask is can aid in and cures various vaginitis, the fibroblast factor There is synergistic function between human serum albumins both components, improve treated effect;With comparative example 10-11 phase Than embodiment 1 has synergistic function by using the sum of these components to each other, controls various vaginitis are improved Therapeutic effect has obvious effect.
The private parts film sample prepared in embodiment 1-7 is applied to 30min on the genital skin surface of 20 people, and is seen The presence of skin irritatin (for example, itch, inflammation) is examined, and compares the whitening skin degree and guarantor before application and after application Wet degree.Test result is shown, does not find skin irritatin phenomenon in 20 people, illustrates that the private parts facial mask pacifies application on human skin very much Entirely;In addition to this, it was found that the trend that there is the private parts after application pigment to shoal illustrates that it makees with a degree of whitening With;In addition, also having certain moisturizing and smoothing wrinkle effect after application.
It in summary it can be seen, private parts facial mask provided by the invention, for controlling for colpomycosis and trichomonas vaginitis Treating effective percentage can be improved to 99.5%, can reach 99.1% for the treated effect of cervical erosion and bacterial vaginitis More than;Moreover, can not only play the role of sterilization and anti-inflammatory, while can also by application private parts facial mask provided by the invention Private parts is set to achieve the effect that lasting whitening, moisturizing and smoothing wrinkle.
The Applicant declares that the present invention is explained by the above embodiments detailed process equipment and process flow of the invention, But the present invention is not limited to the above detailed process equipment and process flow, that is, it is above-mentioned detailed not mean that the present invention must rely on Process equipment and process flow could be implemented.It should be clear to those skilled in the art, any improvement in the present invention, Addition, selection of concrete mode of equivalence replacement and helper component to each raw material of product of the present invention etc., all fall within of the invention Within protection scope and the open scope.

Claims (11)

1. a kind of private parts facial mask, which is characterized in that it includes non-woven fabric layer, the non-woven fabric layer is impregnated with facial mask Liquid;The facial mask liquid contains each component of following parts by weight:
5-10 parts of aurantialba extract, 6-8 parts of chlorella extract, 1-5 parts of radish powder, 1-8 parts of rose extract, arbutin 8- 10 parts, 1-5 parts of echidnotoxin peptide, 2-5 parts of avocado oil, 1-3 parts of cocoa seed extracts, 1-3 parts of Sodium Hyaluronate, rosemary essence 2-5 parts oily, 1-3 parts of grape seed oil, 1-3 parts of lactic acid, 3-5 parts of sodium lactate, 1-5 parts of eugenol, 2-5 parts of tea oil, witch hazel mention Take 1-4 parts of liquid, 1-2 parts of Bifidobacterium composition, 5-15 parts of glycerol and 40-78 parts of deionized water.
2. private parts facial mask as described in claim 1, which is characterized in that the facial mask liquid contains each component of following parts by weight:
6-8 parts of aurantialba extract, 7-8 parts of chlorella extract, 2-5 parts of radish powder, 3-6 parts of rose extract, arbutin 9- 10 parts, 2-5 parts of echidnotoxin peptide, 2-4 parts of avocado oil, 1-2 parts of cocoa seed extracts, 1-2 parts of Sodium Hyaluronate, rosemary essence 3-5 parts oily, 1-2 parts of grape seed oil, 1-2 parts of lactic acid, 4-5 parts of sodium lactate, 2-5 parts of eugenol, 3-5 parts of tea oil, witch hazel mention Take 2-4 parts of liquid, 1-1.5 parts of Bifidobacterium composition, 5-10 parts of glycerol and 42-75 parts of deionized water.
3. private parts facial mask as claimed in claim 1 or 2, which is characterized in that the facial mask liquid by following parts by weight each component Composition:
6 parts of aurantialba extract, 8 parts of chlorella extract, 3 parts of radish powder, 5 parts of rose extract, 10 parts of arbutin, snake venom egg 3 parts of white peptide, avocado oil 2 parts, 1 part of cocoa seed extracts, 1 part of Sodium Hyaluronate, 4 parts of Rosemary Oil, 2 parts of grape seed oil, It is 1 part of lactic acid, 4 parts of sodium lactate, 3 parts of eugenol, 4 parts of tea oil, 3 parts of hazel extract, 1.5 parts of Bifidobacterium composition, sweet 8 parts and 51 parts of deionized water of oil.
4. private parts facial mask as described in claim 1, which is characterized in that the Bifidobacterium composition is by bifidobacterium lactis, dynamic Object Bifidobacterium and bifidobacterium bifidum composition.
5. private parts facial mask as claimed in claim 4, which is characterized in that bifidobacterium lactis in the Bifidobacterium composition, The weight ratio of animal bifidobacteria and bifidobacterium bifidum is (3-5): (1-3): (2-7).
6. private parts facial mask as claimed in claim 4, which is characterized in that bifidobacterium lactis in the Bifidobacterium composition, The weight ratio of animal bifidobacteria and bifidobacterium bifidum is 5:1:3.
7. private parts facial mask as described in claim 1, which is characterized in that the non-woven fabric layer be cotton, mulberry silk, paper pulp, In nylon or cellulose any one or at least two mixture.
8. private parts facial mask as described in claim 1, which is characterized in that the non-woven fabric layer is cotton and/or mulberry silk.
9. private parts facial mask as described in claim 1, which is characterized in that the private parts facial mask also contains layers of nanofibers, glues It is connected on the non-woven fabric layer.
10. private parts facial mask as claimed in claim 9, which is characterized in that the layers of nanofibers and the non-woven fabric layer Between by adhesive phase, fusible films, plus heat or ultrasonic in any one mode be bonded.
11. private parts facial mask as claimed in claim 9, which is characterized in that the layers of nanofibers contains the fibroblast factor And human serum albumins.
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