CN102600018B - Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing - Google Patents

Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing Download PDF

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CN102600018B
CN102600018B CN 201210094966 CN201210094966A CN102600018B CN 102600018 B CN102600018 B CN 102600018B CN 201210094966 CN201210094966 CN 201210094966 CN 201210094966 A CN201210094966 A CN 201210094966A CN 102600018 B CN102600018 B CN 102600018B
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layer
nanofiber
wound
nonwoven fabric
medical dressing
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CN102600018A (en
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严玉蓉
赵静宜
邱志明
洪舒寒
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华南理工大学
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Abstract

本发明公开了一种具有降温和促进伤口愈合作用的医用敷料,至少包括以下四部分:打孔无纺布层,具有梯度结构的纳米纤维层,水凝胶层和支撑层。 The present invention discloses a medical dressing having a cooling and promoting wound healing effect, comprising at least the following four parts: perforated nonwoven fabric layer, the nanofiber layer having a gradient structure, the hydrogel layer and the support layer. 本发明的医用敷料的制备方法为:将水凝胶覆盖在支撑层上,再覆上具有梯度结构的纳米纤维层,最后在纳米纤维层表面加固打孔无纺布层得到医用敷料。 The method of preparing a medical dressing of the present invention is: a hydrogel layer coated on the support, and then covered with the nanofiber layer having a gradient structure, and finally the surface of the reinforcing layer of the nanofiber layer was perforated nonwoven medical dressings. 本发明采用的纳米纤维层具有梯度结构,利于伤口液体的吸收和滞留,药物释放后可到达创面促进伤口愈合;打孔无纺布具有物理隔离作用,避免外界病菌侵入,可以吸收伤口渗出物,且易于从伤口表面去除,不粘附伤口;水凝胶层可以实现温度的调控,为伤口降温。 Nanofiber layer employed in the present invention has a gradient structure, facilitates the absorption and retention of wound fluid, the release of the drug can reach the wound to promote wound healing; punch nonwoven fabric having physical barrier effect, to avoid intrusion of external bacteria, absorb wound exudate , and easily removed from the wound surface, does not adhere to the wound; hydrogel layer can achieve regulation of the temperature, cooling the wound. 本发明综合利用纳米纤维的载药性和液体的毛细迁移性,在降温的同时促进伤口愈合。 Utilization of the present invention is a capillary carrier mobility and medicinal liquid nanofibers to promote wound healing while cooling.

Description

具有降温和促进伤口愈合作用的医用敷料及其制备方法 And having a cooling method for preparing medical dressings and wound healing promoting effect

技术领域 FIELD

[0001] 本发明属于功能性医用敷料领域,具体涉及一种具有降温和促进伤口愈合作用的医用敷料及其制备方法。 [0001] The present invention belongs to the field of functional medical dressings, and particularly relates to a cooling method for preparing medical dressings and wound healing promoting having.

背景技术 Background technique

[0002] 伤口愈合是一个极其复杂的生理过程,患者的身体素质是决定伤口愈合的内因,但医用敷料的作用更不可忽视。 [0002] Wound healing is a very complex physiological process, the patient's physical quality is determined internal wound healing, but the effect can not be ignored more medical dressings. 医用敷料是一类很重要的医用纺织品,随着科技的进步以及医疗领域的各种需求,新型的具有一定功能的医用敷料越来越受到关注。 Medical dressing is very important class of medical textiles, along with a variety of needs and medical advances in the field of science and technology, a new type of medical dressing has a certain function more and more attention. 功能性医用敷料可以针对伤口的实际情况,为伤口的愈合提供特殊的功能。 The medical dressing may be functional for the actual situation of the wound, provides special features for wound healing. 一般来说,医用敷料应该包括以下功能:(I)为伤口提供一层物理屏障,避免伤口渗出液污染其他部位;(2)控制伤口产生的流体;(3)控制伤口上产生的气味;(4)控制伤口上的细菌和微生物;(5)低黏合性,容易从伤口表面去除;(6)充填作用;(7)脱痂作用,通过控制伤口的潮湿度、pH值、温度等状态可以加快脱痂过程的进行;(8)止血作用;(9)加快伤口的愈合速度。 In general, the medical dressing should include the following features: (I) providing a physical barrier for the wound to prevent wound exudates from contaminating other parts; (2) generating a control fluid wound; (3) wound on the odor control; (4) the control of bacteria and microorganisms on the wound; (5) a low adhesion property, is easily removed from the wound surface; (6) infilling; (7) scab action by moisture degree control wounds, pH value, temperature, state scab can expedite the process; (8) hemostatic effect; (9) to accelerate the rate of healing of wounds.

[0003] 传统的伤口降温方法为用水冲洗或者医用化学冰袋,在实际操作中存在着降温温度难以控制,降温方法不便捷、更换频率高等问题。 [0003] The conventional cooling methods for the wound washed with water or ice packs of medical chemistry, there is a difficult to control the cooling temperature, cooling method is not convenient, to replace the problem of higher frequency in actual operation. 而冷敷料可以有效避免传统冷疗的缺点,目前常用的冷疗敷料以水凝胶作为基质,水凝胶中含有96%的水,水分和一些挥发性物质缓慢蒸发使局部皮肤冷却,冷却作用可长达6h。 And the cold dressing may avoid disadvantages of the conventional cold therapy, cryotherapy dressings currently used as a matrix hydrogel, the hydrogel containing 96% of water, moisture and volatiles slow evaporation of some local skin cooling, cooling effect for up to 6h. 水凝胶类的冷疗敷料在室温条件下就可以使用,同皮肤结合更紧密,与烧伤创面不粘着,易于去除,润湿伤口、无毒、无刺激。 Hydrogels cold therapy dressings can be used at room temperature, combined with more closely the skin, and burn wound does not stick, easy to remove, wetting the wound, non-toxic, non-irritating. 有研究结果显示,疼痛缓解平均温度在25〜26°C,疼痛降至轻度范围内的临界温度为28°C,II度烧伤早期应用15〜32min冷疗可以有效减轻疼痛。 Research findings show that the average temperature of pain relief at 25~26 ° C, mild pain reduced to the critical temperature range is within 28 ° C, degree of early burn II 15~32min cold therapy can effectively reduce pain.

[0004] 医用敷料是一种用量巨大的一次性医疗用品,使用后的医用敷料含有患者的体液、血液或者分泌物,一般直接焚烧处理,对环境造成很大的影响。 [0004] The medical dressing is a huge amount of disposable medical supplies, medical dressings containing the patient's bodily fluids, secretions or blood, typically direct incineration, a great impact on the environment. 因此对敷料产品进行减量化控制其污染的有效途径,对医用敷料进行减量化处理一个重要方面是敷料新产品的设计和敷料的性能。 Therefore, an effective way to dressing product of its pollution reduction control, reduction of medical dressings be an important aspect of treatment is dressing performance of new product design and dressing. 新型医用敷料在向着材料高效性、产品的高效性、护理的高效性方向发展。 New medical dressings in the direction toward efficiency material efficiency, efficiency of the product, care development. 目前针对吸收伤口渗出物,保持伤口湿润,抗菌消炎等方面开发出了一系列医用敷料产品。 Currently absorb wound exudate for material, keep the wound moist, anti-bacterial anti-inflammatory and other aspects of the development of a series of medical dressing products. 在复合医用敷料方面,为了提高敷料同创面的亲和性、抗菌性以及生物可降解性等,将天然高分子如壳聚糖、胶原、海藻酸钠等以纤维或者薄膜的形式加入敷料的无纺布层的专利较多,也有专利报道了将含有甲壳质的水刺无纺布用于烫伤烧伤等领域。 In terms of the composite medical dressing, the dressing with the wound in order to improve the affinity, antibacterial and biodegradability, etc., natural polymer such as chitosan, collagen, sodium alginate was added in the form of fibers or dressing film more nonwoven layers patents, patent also reported that chitin-containing spunlace nonwoven fabric used in the field scald burns. 而有关冷疗的敷料大多采用水、冰袋来做降温物质,有专利将降温和给药结合制备出了具有降温和给药作用的眼贴,降温部边缘和给药部用工业胶水粘合,但该眼贴只能降低眼部的温度,功能和冰袋类似。 For cold therapy and mostly used dressings water, ice cooling to do material, and cooling the patent administration is prepared by combining an eye having a cooling effect and administration paste, cooling and dosing edge portion binder industrial glue, However, the eye patch can only reduce the temperature of the eye, similar functions and ice packs. 开发出兼具降温和药物释放功能的敷料是冷疗敷料的发展方向。 The development of both cooling and drug release function of dressing is the development direction of cold therapy dressing.

发明内容 SUMMARY

[0005] 本发明的目的在于针对上述现有技术的缺陷,主要从高效性、便捷性和舒适性方面考虑,提供一种具有降温和促进伤口愈合作用的医用敷料及其制备方法,本发明的医用敷料兼具隔离伤口、吸收伤口渗出物、促进伤口愈合以及给伤口降温的作用,其中给药部采用同皮肤亲和性好的纳米纤维载药系统,药物的释放效率更高。 [0005] The object of the present invention is the defects of the prior art, mainly from the efficiency, convenience and comfort in view, there is provided a medical dressing and cooling and preparation method for promoting wound healing has, according to the present invention isolating both medical dressing the wound, absorb wound exudate, a wound to promote wound healing and cooling effect, wherein the administration unit employed more efficient release of the skin with good affinity for the nanofiber system drug, a drug.

[0006] 为了达到上述目的,本发明采用了以下技术方案: [0006] To achieve the above object, the present invention employs the following technical solution:

[0007] —种具有降温和促进伤口愈合作用的医用敷料,至少由以下四层结构依次组成:打孔无纺布层,纳米纤维层,水凝胶层和支撑层;所述纳米纤维层为梯度结构,具有促进伤口愈合的作用;所述水凝胶层具有为伤口降温的作用;所述支撑层具有或者不具有打孔,具有支撑作用;所述支撑层的材料与打孔无纺布层的材料相同。 [0007] - species has a cooling effect and promoting wound healing medical dressing, at least four of the following structural order: the perforated nonwoven fabric layer, the nanofiber layer, the hydrogel layer and the support layer; the nanofiber layer gradient structure, has the effect of promoting wound healing; said hydrogel layer having a cooling effect to the wound; the support layer with or without puncturing, having a supporting role; material punching the nonwoven fabric of the support layer the same material layer.

[0008] 所述纳米纤维层为载有药物的纳米纤维,纤维直径为2(Tl000nm ;所述纳米纤维层具有梯度结构,由打孔无纺布层向水凝胶层逐渐由细到粗;所述纳米纤维为可降解高分子材料,包括聚乳酸、聚己内酯、聚乙醇酸一聚乳酸共聚物、明胶、甲壳素及其衍生物、壳聚糖及其衍生物或海藻酸盐;所述药物为消炎药物、抗菌药物、治疗药物或纳米银中的一种或两种以上;所述药物的分布方式为:在纳米纤维的表面或者内部均匀分散;所述纳米纤维层的克重为0.f 5g/m2。 [0008] The nanofiber layer is a drug-loaded nano-fiber, fiber diameter 2 (Tl000nm; the nanofiber layer has a gradient structure, perforated nonwoven fabric layer to the hydrogel layer gradually from fine to coarse; the biodegradable polymer nanofiber materials, including polylactic acid, polycaprolactone, polyglycolic acid, a polylactic acid copolymer, gelatin, chitin and derivatives thereof, chitosan and its derivatives, or alginic acid; the drug is anti-inflammatory drugs, antibiotics, therapeutic drugs, one or nano silver or more than two; the drug is distributed manner: the inside surface or uniformly dispersed nanofibers; said nanofiber layer basis weight It is 0.f 5g / m2.

[0009] 所述水凝胶层的基体材料为聚丙烯酸类、聚乙二醇、聚乙烯醇、海藻酸盐类或聚乙烯基吡咯烷酮,并且可以在上述基体材料中分散降冰片烯或薄荷油;所述水凝胶层的克重为80〜300g/m2。 [0009] The hydrogel layer base material is polyacrylic, polyethylene glycol, polyvinyl alcohol, alginic acid salts, or polyvinyl pyrrolidone, and may be dispersed norbornene or peppermint oil in the base material ; grammage of the hydrogel layer is 80~300g / m2. [0010] 所述支撑层为织物层、薄膜层或无纺布层;所述支撑层的克重为l(T60g/m2 ;所述支撑层的材料为聚乳酸、聚丙烯、聚己内酯、聚对苯二甲酸乙二醇酯、聚对苯二甲酸丁二醇酯、聚对苯二甲酸丙二醇酯、聚乙烯一醋酸乙烯共聚物、聚烯烃共聚物或热酸性弹性体Vistamaxx中的一种或两种以上。 [0010] The supporting layer is a textile layer, a film layer or a nonwoven fabric layer; g of the support layer has a weight of l (T60g / m2; of the support layer material is polylactic acid, polypropylene, polycaprolactone , polyethylene terephthalate, polybutylene terephthalate, polyethylene terephthalate, polyethylene, a vinyl acetate copolymers, polyolefin copolymers or thermal acid Vistamaxx elastomer in a or two or more species.

[0011] 所述打孔无纺布层同皮肤直接接触;当纳米纤维层的材料为聚乳酸时,则纳米纤维层同皮肤直接接触。 [0011] The nonwoven fabric layer is in direct contact with the punctured skin; nanofiber layer when the material is polylactic acid, the fiber layer is in direct contact with the skin nm.

[0012] 所述打孔无纺布层的材料为聚乳酸、聚丙烯或聚己内酯;所述打孔无纺布层的克重为f20g/m2,孔径为0.5〜lmm,具有均匀分散的圆形、菱形或十字形孔。 [0012] The perforated nonwoven fabric layer material is polylactic acid, polypropylene or polycaprolactone; puncturing the basis weight of the nonwoven fabric layer f20g / m2, a pore diameter of 0.5~lmm, having uniformly dispersed circular, cross-shaped or diamond-shaped holes.

[0013] 本发明还提供所述的医用敷料的制备方法,主要包括以下步骤: [0013] The present invention further provides a medical dressing according to the preparation method includes the following steps:

[0014] (I)配制质量浓度为2〜16%的水凝胶溶液,并将其均匀覆盖在支撑层上得到水凝胶层和支撑层的双层复合物: [0014] (I) is formulated at a concentration of 2~16% by mass aqueous gel solution obtained was uniformly covering the hydrogel layer and a support layer on a support layer of two-layer composite:

[0015] (2)制备具有梯度纤维直径分布的纳米纤维层; [0015] (2) Preparation of nanofiber layer having a gradient of fiber diameter distribution;

[0016] (3)在步骤(I)制备的双层复合物的水凝胶层表面覆上步骤(2)制备的纳米纤维层得到三层复合物; [0016] (3) at step (I) the hydrogel layer composite double surface covered prepared in step (2) Preparation of the nanofiber layer to give a three-layer composite;

[0017] (4)在步骤(3)制备的三层复合物的纳米纤维层表面加固打孔无纺布层。 [0017] (4) in step (3) three perforated surface of the nonwoven fabric layer composite reinforcement prepared nanofiber layer.

[0018] 所述支撑层的成型方法为水刺、纺粘、热风、热轧、针织、编织、淋膜、吹膜或熔喷;所述纳米纤维层的成型方法为拉伸法、模板合成、自组装、微相分离或静电纺丝;所述打孔无纺布层的成型方法为纺粘或者水刺加工。 [0018] The method of forming the support layer as spunlace, spunbond, hot air, hot rolling, knitting, weaving, lamination, blown film or meltblown; The method of forming the nanofiber layer is stretched, template synthesis , self-assembly, electrostatic spinning, or micro-phase separation; the method of forming perforated or a spunbonded nonwoven fabric layer is a spunlace processing.

[0019] 所述水凝胶层与支撑层的结合方法为刮涂、喷涂或复合。 [0019] The method of binding the hydrogel layer and the support layer is knife coating, spray coating or composite.

[0020] 所述纳米纤维的直径优选为5(T800nm。 Diameter [0020] The nanofiber is preferably 5 (T800nm.

[0021] 本发明与现有技术相比,具有以下优点和有益效果: [0021] Compared with the prior art the present invention has the following advantages and benefits:

[0022] (I)本发明采用载药的纳米纤维层,药物释放后可到达创面促进伤口愈合,并且纳米纤维层为具有梯度纤维直径分布的结构,与打孔无纺布层相配合,形成由细到粗的结构,更利于伤口液体的吸收和滞留,从而提供相对干爽的伤口愈合环境;[0023] (2)本发明将打孔无纺布固定在纳米纤维层表面,打孔无纺布具有物理隔离作用,避免外界病菌侵入,且易于从伤口表面去除,不粘附伤口; [0022] (I) of the present invention employs drug nanofiber layer, the drug release to reach the wound to promote wound healing, and the nanofiber layer having a gradient of fiber diameter distribution structure, nonwoven fabric layer cooperates with the punch, is formed from fine to coarse structure is more conducive to the absorption and retention of wound fluid, thereby providing a relatively dry wound environment; [0023] (2) the nonwoven fabric of the present invention is fixed to the surface perforated nanofiber layer, the nonwoven perforation fabric has physical isolation effect, to avoid intrusion of external bacteria, and easily removed from the wound surface, does not adhere to the wound;

[0024] (3)本发明利用水凝胶层实现温度的调控,达到为伤口降温的目的; [0024] (3) the use of the hydrogel layer of the present invention to achieve temperature-controlled, for the purpose of cooling the wound;

[0025] (4)本发明综合利用纳米纤维的载药性和液体的毛细迁移性,从而达到有效控制伤口微循环的目的。 [0025] (4) a capillary carrier mobility and liquid medicinal utilization nanofibers of the present invention, so as to achieve effective control of wound microcirculation.

附图说明 BRIEF DESCRIPTION

[0026] 图1为本发明的医用敷料的结构示意图,其中,I为打孔无纺布层,2为纳米纤维层,3为水凝胶层,4为支撑层。 [0026] FIG. 1 is a schematic configuration of the medical dressings of the present invention, wherein, I is perforated nonwoven fabric layer, 2 is a nanofiber layer, a hydrogel layer 3, 4 of the support layer.

具体实施方式 Detailed ways

[0027] 下面结合实施例对本发明作进一步说明,但是本发明要求保护的范围并不局限于此。 [0027] The following embodiments in conjunction with embodiments of the present invention will be further described, but the scope of the claimed invention is not limited thereto.

[0028] 实施例1 [0028] Example 1

[0029] 将8g聚丙烯酸溶于去离子水中,制备质量浓度为8%的聚丙烯酸水凝胶;采用刮涂法将聚丙烯酸水凝胶涂覆在克重为10g/m2的聚乳酸水刺无纺布支撑层上,其中水凝胶的克重为80 g/m2 ;将静电纺丝法制备的载有20% (wt.)诺氟沙星的聚乳酸纳米纤维层覆在聚丙烯酸水凝胶表面,并采用聚乳酸打孔无纺布固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0029] 8g of polyacrylic acid was dissolved in deionized water to prepare a concentration of 8% by mass of polyacrylic hydrogels; doctor blade method polyacrylic hydrogels coated grammage of polylactic acid hydroentangled 10g / m2 of non-woven fabric support layer, wherein the hydrogel grammage of 80 g / m2; prepared contained the electrostatic spinning method norfloxacin 20% polylactic acid nanofiber layer overlying Acrylic acid (wt.) gel surface, and using polylactic acid nonwoven fabric is fixed punch, obtain medical dressing having a cooling effect, and promote wound healing. 其中打孔无纺布层克重为1 0 g/m2,具有平均孔径为0.8mm的圆形孔;纳米纤维层的纤维直径为5(T200nm,克重为0.2^0.4g/m2。 Wherein puncturing grammage of the nonwoven fabric layer 1 0 g / m2, having an average pore diameter of the circular hole 0.8mm; fiber diameter of the nanofiber layer is 5 (T200nm, grammage 0.2 ^ 0.4g / m2.

[0030] 如图1所示,本发明的伤口敷料包括打孔无纺布层I,纳米纤维层2,水凝胶层3和支撑层4,由上至下依次结合。 [0030] 1, the wound dressing according to the present invention comprises a perforated nonwoven fabric layer I, 2 nanofiber layer, the hydrogel layer 3 and supporting layer 4, from top to bottom in combination.

[0031] 该伤口敷料可将伤口温度降至15〜25°C。 [0031] The wound dressing can be wound down to a temperature of 15~25 ° C.

[0032] 实施例2 [0032] Example 2

[0033] 将6g海藻酸钠溶于去离子水中,制备质量浓度为6%的海藻酸钠水溶液,加入5%(wt.)氯化钙溶液并快速搅拌形成海藻酸钙钠凝胶;将海藻酸钙钠凝胶刮涂在克重为60 g/m2的热塑性弹性体Vistamaxx纺粘无纺布支撑层表面,得到水凝胶层和支撑层的双层复合物;将利用静电纺丝技术制备的甲壳素纳米纤维层覆在双层复合物的壳聚糖凝胶层表面;用聚丙烯打孔无纺布固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0033] The 6g sodium alginate dissolved in deionized water to prepare a concentration of 6 mass% sodium alginate aqueous solution, 5% calcium chloride solution was added with rapid stirring and the formed sodium calcium alginate gel (wt.); Seaweed sodium calcium gel knife in a grammage of 60 g / m2 spunbond nonwoven fabric supporting surface Vistamaxx layer of a thermoplastic elastomer, to give the hydrogel layer and the support layer of two-layer composite; prepared by using electrospinning techniques chitin nanofiber layer overlying the surface of the bilayer composite chitosan gel layer; polypropylene nonwoven fixing punched to obtain medical dressing having a cooling effect, and promote wound healing. 其中纳米纤维层的克重为1.0 g/m2',纤维直径20(T700nm ;打孔无纺布层具有孔径0.5mm的十字形孔,克重为15 g/m2' ;支撑层的克重为30 g/m2。 Wherein the basis weight of the nanofiber layer was 1.0 g / m2 ', a fiber diameter of 20 (T700nm; punch nonwoven fabric layer having a cross-shaped hole diameter of 0.5mm, basis weight of 15 g / m2'; gram weight of the support layer 30 g / m2.

[0034] 该伤口敷料使伤口温度保持在1Γ25 °C。 [0034] The wound dressing at a wound temperature was maintained 1Γ25 ° C.

[0035] 实施例3 [0035] Example 3

[0036] 制备质量浓度为10%的壳聚糖溶液,按质量分数1.2%向溶液中加入25% (wt.)戊二醛溶液,快速搅拌分散使得壳聚糖部分交联得到壳聚糖凝胶;将壳聚糖凝胶采用旋涂法覆在聚对苯二甲酸丙二醇酯织物制成的支撑层表面得到水凝胶层和支撑层的双层复合物,该支撑层克重为60 g/m2 ;以10%浓度的明胶水溶液为原材料,采用微相分离法制备载有诺氟沙星的明胶纳米纤维层,并将其转移于双层复合物的壳聚糖凝胶层表面;用聚乳酸打孔无纺布层将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0036] Preparation of a 10% concentration of chitosan solution, mass fraction of 1.2% was added 25% (wt.) Glutaraldehyde was added to the solution, such that the chitosan dispersion with rapid stirring to give a partially crosslinked chitosan condensate plastic; chitosan gel by spin coating on the surface of the support layer of polyethylene terephthalate fabric obtained hydrogel layer and the support layer bilayer composite, the support layer basis weight of 60 g / m2; in a concentration of 10% aqueous gelatin solution as a raw material, chitosan gel layer surface of the micro phase separation Preparation of gelatin containing norfloxacin nanofiber layer, and transferred to a bilayer complex; with the polylactic acid nonwoven fabric layer perforated bilayer composite and the nanofiber layer is fixed, and cooling to obtain medical dressing having a wound healing effect. 其中聚乳酸打孔无纺布的克重为30 g/m2,孔为菱形,孔径lmm;纳米纤维层的纤维直径为50〜400nm,克重为4 g/m2。 Wherein puncturing the polylactic acid nonwoven fabric basis weight of 30 g / m2, a rhombus hole, aperture LMM; fiber diameter of the nanofiber layer is 50~400nm, weight of 4 g / m2.

[0037] 该伤口敷料使伤口温度降低至12〜25°C。 [0037] The wound dressing to the wound to reduce the temperature of 12~25 ° C.

[0038] 实施例4 [0038] Example 4

[0039] 将16g聚丙烯酸溶于去离子水中,制备质量浓度为16%的聚丙烯酸水凝胶;按质量分数1.0%在其中均匀分散降冰片烯;采用刮涂法将聚丙烯酸水凝胶涂覆在支撑层表面得到水凝胶层和支撑层的双层复合物;将采用拉伸法制备的聚己内酯纳米纤维层覆在双层复合物的丙烯酸凝胶层表面;最后用聚己内酯打孔无纺布将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0039] 16g of polyacrylic acid was dissolved in deionized water to prepare a concentration of 16 mass% polyacrylic acid hydrogel; mass fraction of 1.0% uniformly dispersed therein norbornene; doctor blade coating method polyacrylic hydrogels layer was coated on the support surface of the hydrogel layer and the support layer bilayer composite; the use of polycaprolactone nanofiber layer overlying a tensile Preparation of acrylic surface of the gel layer of the bilayer composite; Finally polycaprolactone lactone punch nonwoven fabric bilayer composite and the nanofiber layer is fixed, and cooling to obtain medical dressing having a wound healing effect. 其中支撑层为聚烯烃共聚物薄膜层,克重为15 g/m2 ;打孔无纺布层克重为15 g/m2,具有孔径为0.5mm的菱形孔;纳米纤维层的纤维直径为300~600nm,克重为5 g/m2。 Wherein the support layer is a layer of a polyolefin copolymer film, a grammage of 15 g / m2; punch nonwoven fabric layer grammage of 15 g / m2, having a pore size of 0.5mm diamond hole; fiber diameter of the nanofiber layer was 300 ~ 600nm, a grammage of 5 g / m2.

[0040] 该伤口敷料使伤口温度降低至10~20°C。 [0040] The wound dressing a wound temperature was lowered to 10 ~ 20 ° C.

[0041] 实施例5 [0041] Example 5

[0042] 将2g海藻酸钠溶于去离子水中,制备质量浓度为2%的海藻酸钠水溶液,加入3%(wt.)氯化钙溶液和1% (wt.)薄荷油快速搅拌形成海藻酸钙钠凝胶;将该凝胶刮涂在支撑层表面得到水凝胶层和支撑层的双层复合物;将壳聚糖载纳米银纳米纤维层覆在双层复合物的海藻酸钙凝胶层表面;最后用聚己内酯打孔无纺布将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0042] 2g of sodium alginate dissolved in deionized water to prepare a concentration of 2 mass% sodium alginate aqueous solution, was added 3% (wt.) Calcium chloride solution and 1% (wt.) With rapid stirring peppermint formed seaweed sodium calcium gel; gels the blade supporting surface of the hydrogel layer and the support layer was a double layer composite; chitosan nano silver contained in the nanofiber layer coated bilayer composite alginate surface of the gel layer; polycaprolactone finally punching the bilayer nonwoven composite nanofiber layer and fixed, and cooling to obtain medical dressing having a wound healing effect. 其中支撑层为聚对苯二甲酸丁二醇酯薄膜层,克重为40 g/m2;打孔无纺布层为聚丙烯纺粘无纺布,其克重为20 g/m2,具有孔径为 Wherein the support layer is a polyethylene terephthalate film layer, a grammage of 40 g / m2; polypropylene spunbonded nonwoven fabric layer perforated nonwoven fabric of weight 20 g / m2, having an aperture for

0.5mm的圆形孔;纳米纤维层的纤维直径为50nnT600nm,克重为5 g/m2。 A circular hole 0.5mm; fiber diameter of the nanofiber layer is 50nnT600nm, a grammage of 5 g / m2.

[0043] 该伤口敷料使伤口温度降低至15〜25°C。 [0043] The wound dressing to the wound to reduce the temperature of 15~25 ° C.

[0044] 实施例6 [0044] Example 6

[0045] 配制质量浓度为10%的聚乙烯吡咯烷酮凝胶,在其中按质量分数0.6%添加降冰片烯;采用旋涂法将聚乙烯吡咯烷酮凝胶覆在支撑层表面得到水凝胶层和支撑层的双层复合物;将载有诺氟沙星的利用静电纺丝技术制备的PGLA纳米纤维层置于双层复合物的聚乙烯吡咯烷酮凝胶层表面;用聚丙烯打孔无纺布将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0045] The formulation of the mass concentration of 10% polyvinylpyrrolidone gel, in which the mass fraction of 0.6% was added norbornene; spin coating method polyvinylpyrrolidone gel coated surface of the support layer and the hydrogel layer to give support bilayer composite layer; preparation will contain electrospinning nanofiber layer utilized PGLA norfloxacin placed polyvinyl pyrrolidone surface of the gel layer of the bilayer composite; polypropylene nonwoven fabric perforated to bilayer composite and the nanofiber layer is fixed, and cooling to obtain medical dressing having a wound healing effect. 其中支撑层为聚己内酯薄膜层,克重30 g/m2;聚丙烯打孔无纺布层的克重为10 g/m2,具有直径0.8mm的十字形孔;纳米纤维层的纤维直径为40(T800nm,克重为1.5 g/m2。 Wherein the support layer is a polycaprolactone film layer, weight 30 g / m2; polypropylene punctured weight of the nonwoven fabric layer 10 g / m2, a cross-shaped aperture having a diameter of 0.8mm; fiber diameter of the nanofiber layer It is 40 (T800nm, weight of 1.5 g / m2.

[0046] 该伤口敷料可保持伤口温度在10〜20 ℃。 [0046] The wound dressing may be kept at a wound temperature of 10~20 ℃.

[0047] 实施例7 [0047] Example 7

[0048] 将8gPEG和聚丙烯酸的混合物(二者比例为1:4)溶于去离子水中,制备质量浓度为8%的PEG/聚丙烯酸水凝胶;采用刮涂法将该共混水凝胶涂覆在支撑层表面得到水凝胶层和支撑层的双层复合物;将静电纺丝法制备的载有纳米银的海藻酸钠纳米纤维层覆在双层复合物的壳聚糖凝胶层表面;用聚丙烯打孔无纺布将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0048] The mixture 8gPEG and polyacrylic acid (ratio between the two is 1: 4) dissolved in deionized water to prepare a concentration of 8% PEG / polyacrylic hydrogels; doctor blade method using the hydrogel blend to give the hydrogel layer resist coating and the supporting surface of the support layer is a double layer composite; to be prepared by the electrostatic spinning method of the nano silver alginate nanofiber layer overlying bilayer composite chitosan condensate subbing layer surface; punch nonwoven polypropylene bilayer composite and the nanofiber layer is fixed, and cooling to obtain medical dressing having a wound healing effect. 其中支撑层为聚乳酸薄膜层,克重20 g/m2;聚丙烯打孔无纺布层的克重为10 g/m2,具有直径0.8mm的圆形字形孔;纳米纤维层的纤维直径为200-400nm,克重为0.5 g/m2。 Wherein the support layer is a polylactic acid film layer, weight 20 g / m2; polypropylene punctured weight of the nonwoven fabric layer 10 g / m2, a circular-shaped holes having a diameter of 0.8mm; fiber diameter of the nanofiber layer 200-400nm, basis weight of 0.5 g / m2.

[0049] 该伤口敷料使伤口温度降低至12〜20°C。 [0049] The wound dressing to the wound to reduce the temperature of 12~20 ° C. [0050] 实施例8 [0050] Example 8

[0051] 制备浓度为9%的聚乙烯醇水凝胶,并在其中按质量分数1%分散降冰片烯;采用旋涂法将聚乙烯醇水凝胶涂覆到聚对苯二甲酸乙二醇酯支撑层表面,得到水凝胶层和支撑层的双层复合物;将静电纺丝法制备的载有四环素的聚乳酸纳米纤维层覆在双层复合的聚乙烯醇凝胶层表面,得到具有降温和促进伤口愈合作用的医用敷料。 [0051] Preparation of a concentration of 9% polyvinyl alcohol hydrogel, and wherein the mass fraction of 1% dispersion norbornene; spin coating method using a polyvinyl alcohol hydrogel coating onto a polyethylene terephthalate alcohol esters supporting surface layer, the hydrogel layer to give bilayer composite and the support layer; prepared by the electrostatic spinning method of the polylactic acid containing the tetracycline nanofiber layer overlying the surface of the gel layer composite polyvinyl alcohol layer, and cooling to obtain medical dressing having a wound healing effect. 其中水凝胶层克重为200 g/m2 ;支撑层克重为40 g/m2 ;纳米纤维层纤维直径为10(T600nm,克重为2.0 g/m2。 Wherein the hydrogel layer weight of 200 g / m2; support layer grammage of 40 g / m2; fiber diameter of nanofiber layer 10 (T600nm, weight of 2.0 g / m2.

[0052] 该敷料使伤口温度降至10〜15°C。 [0052] The temperature was lowered to a wound dressing 10~15 ° C.

[0053] 实施例9 [0053] Example 9

[0054] 制备浓度为16%的聚乙烯吡咯烷酮水凝胶,并在其中按质量分数0.5%添加薄荷油;采用旋涂法将聚乙烯吡咯烷酮水凝胶涂覆到聚乙烯一醋酸乙烯共聚物支撑层表面,得到水凝胶层和支撑层的双层复合物;将静电纺丝法制备的载有诺氟沙星的明胶纳米纤维层覆在双层复合的聚乙烯吡咯烷酮凝胶层表面;采用聚乳酸打孔无纺布将双层复合物和纳米纤维层固定,得到具有降温和促进伤口愈合作用的医用敷料。 [0054] Preparation of a concentration of 16% polyvinylpyrrolidone hydrogels, and the mass fraction of 0.5% peppermint oil added thereto; spin coating method polyvinylpyrrolidone hydrogel coated to a polyethylene vinyl acetate copolymer support a surface layer, to give the hydrogel layer and the support layer of the bilayer composite; to be prepared by the electrostatic spinning method has norfloxacin gelatin nanofiber layer overlying the gel layer on the surface layer composite polyvinylpyrrolidone; and using the polylactic acid nonwoven fabric perforated bilayer composite and the nanofiber layer is fixed, and cooling to obtain medical dressing having a wound healing effect. 其中水凝胶层克重为100 g/m2 ;支撑层克重为60 g/m2 ;纳米纤维层纤维直径为5(T200nm,克重为1.0 g/m2 ;打孔无纺布层的克重为20 g/ m2',孔径为0.8mm的圆形孔。 Wherein the hydrogel layer grammage of 100 g / m2; support layer grammage of 60 g / m2; nanofiber layer fiber diameter of 5 (T200nm, weight of 1.0 g / m2; weight perforated nonwoven fabric layer of 20 g / m2 ', a pore size of 0.8mm circular holes.

[0055] 该敷料使伤口温度降至12〜20°C。 [0055] The temperature was lowered to a wound dressing 12~20 ° C.

Claims (9)

1.一种具有降温和促进伤口愈合作用的医用敷料,其特征在于,至少由以下四层结构依次组成:打孔无纺布层,纳米纤维层,水凝胶层和支撑层;所述纳米纤维层为梯度结构,用于促进伤口愈合;所述水凝胶层用于为伤口降温;所述支撑层具有或者不具有打孔,具有支撑作用;所述支撑层的材料与打孔无纺布层的材料相同。 A medical dressing having a cooling and to promote wound healing effect, characterized in that at least four of the following structural order: the perforated nonwoven fabric layer, the nanofiber layer, the hydrogel layer and the support layer; the nano a gradient layer is a fiber structure, for promoting wound healing; said hydrogel layer is used to cool the wound; the support layer with or without puncturing, having a supporting role; puncturing the support layer material is a nonwoven fabric layer of the same material.
2.根据权利要求1所述的医用敷料,其特征在于,所述纳米纤维层为载有药物的纳米纤维,纤维直径为20〜IOOOnm ;所述纳米纤维层具有梯度结构,由打孔无纺布层向水凝胶层逐渐由细到粗;所述纳米纤维为可降解高分子材料,包括聚乳酸、聚己内酯、聚乙醇酸一聚乳酸共聚物、明胶、甲壳素及其衍生物、壳聚糖及其衍生物或海藻酸盐;所述药物为消炎药物、抗菌药物、治疗药物或纳米银中的一种或两种以上;所述药物的分布方式为:在纳米纤维的表面或者内部均匀分散;所述纳米纤维层的克重为0.1〜5g/m2。 The medical dressing according to claim 1, wherein said nanofiber layer is a drug-loaded nano-fiber, fiber diameter 20~IOOOnm; the nanofiber layer has a gradient structure, a perforated nonwoven fabric layer to the hydrogel layer gradually from fine to coarse; the biodegradable polymer nanofiber materials, including polylactic acid, polycaprolactone, polyglycolic acid, a polylactic acid copolymer, gelatin, chitin and its derivatives , alginate or chitosan and its derivatives; the drug is anti-inflammatory drugs, antibiotics, therapeutic or nano silver of one or more; the drug is distributed manner: the surface of the nanofiber or an internal uniform dispersion; said nanofiber layer basis weight of 0.1~5g / m2.
3.根据权利要求2所述的医用敷料,其特征在于,所述水凝胶层的基体材料为聚丙烯酸类、聚乙二醇、聚乙烯醇、海藻酸盐类或聚乙烯基吡咯烷酮,并且在上述基体材料中分散降冰片烯或薄荷油;所述水凝胶层的克重为80〜300g/m2。 3. The medical dressing according to claim 2, characterized in that said hydrogel layer base material is polyacrylic, polyethylene glycol, polyvinyl alcohol, alginic acid salts or polyvinylpyrrolidone, and in the matrix material dispersed norbornene or peppermint oil; gram weight of the hydrogel layer is 80~300g / m2.
4.根据权利要求3所述的医用敷料,其特征在于,所述支撑层为织物层、薄膜层或无纺布层;所述支撑层的克重为10〜60g/m2 ;所述支撑层的材料为聚乳酸、聚丙烯、聚己内酯、聚对苯二甲酸乙二醇酯、聚对苯二甲酸丁二醇酯、聚对苯二甲酸丙二醇酯、聚乙烯一醋酸乙烯共聚物、聚烯烃共聚物或热酸性弹性体Vistamaxx中的一种或两种以上。 4. The medical dressing of claim 3, wherein said support layer is a textile layer, a film layer or a nonwoven fabric layer; g of the support layer has a weight of 10~60g / m2; the support layer material is polylactic acid, polypropylene, polycaprolactone, polyethylene terephthalate, polybutylene terephthalate, polyethylene terephthalate, polyethylene-vinyl acetate copolymer, polyolefin copolymers or thermal acid Vistamaxx elastomer is one or two or more kinds.
5.根据权利要求4所述的医用敷料,其特征在于,所述打孔无纺布层同皮肤直接接触;当纳米纤维层的材料为聚乳酸时,则纳米纤维层会接触到皮肤。 A medical dressing according to claim 4, characterized in that the perforated nonwoven fabric layer in direct contact with the skin; nanofiber layer when the material is polylactic acid, the nanofiber layer may contact with the skin.
6.根据权利要求5所述的医用敷料,其特征在于,所述打孔无纺布层的材料为聚乳酸、聚丙烯或聚己内酯;所述打孔无纺布层的克重为I〜20g/m2,孔径为0.5〜Imm,具有均勻分散的圆形、菱形或十字形孔。 The medical dressing according to claim 5, characterized in that the material layer is perforated nonwoven fabric of polylactic acid, polypropylene or polycaprolactone; g puncturing the weight of the nonwoven fabric layer I~20g / m2, a pore diameter of 0.5~Imm, having uniformly dispersed circular, diamond or a cross hole.
7.权利要求1〜6之一所述的医用敷料的制备方法,其特征在于,主要包括以下步骤: (1)配制水凝胶层的基体材料质量浓度为2〜16%的水凝胶溶液,并将其均匀覆盖在支撑层上得到水凝胶层和支撑层的双层复合物: (2)制备具有梯度纤维直径分布的纳米纤维层; (3)在步骤(I)制备的双层复合物的水凝胶层表面覆上步骤(2)制备的纳米纤维层得到三层复合物; (4)在步骤(3)制备的三层复合物的纳米纤维层表面加固打孔无纺布层。 A method of preparing a medical dressing according to one of claim 1~6, wherein, includes the following steps: (1) preparation of the hydrogel layer base material mass concentration of 2~16% aqueous gel solution of preparation of double layer (3) at step (I); and (2) preparation nanofiber layer having a gradient of fiber diameter distribution: and uniformly coated on the support layer to give bilayer composite hydrogel layer and the support layer hydrogel layer covered surface of the composite of step (2) preparation of the nanofiber layer to give a three-layer composite; reinforcement perforated non-woven surface of the three-layer composite prepared nanofiber layer (4) in step (3) Floor.
8.根据权利要求7所述的制备方法,其特征在于,所述支撑层的成型方法为水刺、纺粘、热风、热轧、针织、编织、淋膜、吹膜或熔喷;所述纳米纤维层的成型方法为拉伸法、模板合成、自组装、微相分离或静电纺丝;所述打孔无纺布层的成型方法为纺粘或者水刺加工。 8. The production method according to claim 7, characterized in that the support layer forming method as spunlace, spunbond, hot air, hot rolling, knitting, weaving, lamination, blown film or meltblown; the the method of forming the nanofiber layer stretching method, template synthesis, self-assembly, electrostatic spinning, or micro-phase separation; the method of forming perforated or a spunbonded nonwoven fabric layer is a spunlace processing.
9.根据权利要求8所述的制备方法,其特征在于,所述水凝胶层与支撑层的结合方法为刮涂、喷涂或复合。 9. A method of preparation according to claim 8, characterized in that said hydrogel layer and the bonding method of the support layer knife coating, spray coating or composite.
CN 201210094966 2012-03-31 2012-03-31 Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing CN102600018B (en)

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CN104189942A (en) * 2014-09-09 2014-12-10 东华大学 Antibacterial wound dressing and preparation method thereof
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CN104784740B (en) * 2015-04-15 2017-10-27 中国科学院化学研究所 One kind of bi-layer composite moisturizing antimicrobial medical dressing and preparation method
CN105769442A (en) * 2016-02-29 2016-07-20 广州市电纺生物科技有限公司 Wound dressing and preparation method thereof
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