CN115075043B - Preparation method of kapok-based dressing - Google Patents
Preparation method of kapok-based dressing Download PDFInfo
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- CN115075043B CN115075043B CN202210677762.XA CN202210677762A CN115075043B CN 115075043 B CN115075043 B CN 115075043B CN 202210677762 A CN202210677762 A CN 202210677762A CN 115075043 B CN115075043 B CN 115075043B
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- kapok
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H11/00—Pulp or paper, comprising cellulose or lignocellulose fibres of natural origin only
- D21H11/12—Pulp from non-woody plants or crops, e.g. cotton, flax, straw, bagasse
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21B—FIBROUS RAW MATERIALS OR THEIR MECHANICAL TREATMENT
- D21B1/00—Fibrous raw materials or their mechanical treatment
- D21B1/04—Fibrous raw materials or their mechanical treatment by dividing raw materials into small particles, e.g. fibres
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21C—PRODUCTION OF CELLULOSE BY REMOVING NON-CELLULOSE SUBSTANCES FROM CELLULOSE-CONTAINING MATERIALS; REGENERATION OF PULPING LIQUORS; APPARATUS THEREFOR
- D21C1/00—Pretreatment of the finely-divided materials before digesting
- D21C1/06—Pretreatment of the finely-divided materials before digesting with alkaline reacting compounds
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21F—PAPER-MAKING MACHINES; METHODS OF PRODUCING PAPER THEREON
- D21F13/00—Making discontinuous sheets of paper, pulpboard or cardboard, or of wet web, for fibreboard production
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/24—Polysaccharides
- D21H17/25—Cellulose
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- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/20—Macromolecular organic compounds
- D21H17/21—Macromolecular organic compounds of natural origin; Derivatives thereof
- D21H17/24—Polysaccharides
- D21H17/28—Starch
- D21H17/29—Starch cationic
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a preparation method of a kapok-based dressing, which comprises the following steps: physically modifying kapok fibers; heating the obtained kapok fiber in NaOH solution under the water bath condition; mixing the obtained kapok fiber with an adhesive, and homogenizing by using a homogenizer; preparing the obtained mixture into a fiber web by utilizing a wet papermaking process; placing the hydrogel on a fiber net to obtain the composite kapok-based dressing. The preparation method is simple in process operation, not only effectively realizes the preparation of the biomass fiber dressing, but also has excellent antibacterial property and hydrophilic and oleophilic properties, can be applied to the field of medical cosmetology postoperative repair, and has a wide application prospect.
Description
Technical Field
The invention relates to a preparation method of a kapok-based dressing, and belongs to the field of composite biological materials.
Background
Since the 70 s of the 20 th century, medical cosmetology has become one of the fastest growing, closest commercialized industries in the medical field. Medical cosmetology inevitably damages the barrier function of the skin, causing postoperative complications such as skin pigmentation, contact dermatitis, superficial ulcers, and other skin diseases. To address the above-described skin problems, repairing such damaged skin with a post-operative repair dressing is one of the most widespread and common methods. However, the existing biomass cellulose-based postoperative repair dressing has a single structure, and is high in cost and complex in process.
Kapok fiber is a biomass fiber, is the thinnest and lightest fiber in natural fibers, has a hollow rate of more than 86%, and is the highest hollow rate in natural fibers. Kapok fibers have a large number of surface micropores and a large specific surface area. Due to these physicochemical properties, it has excellent hygroscopicity and breathability. In addition, kapok fibers have good biocompatibility, biodegradability and natural antibacterial properties. Early research shows that the log cotton fiber has excellent natural antibacterial performance and the antibacterial rate reaches more than 91.9%. These properties of kapok fibers make it of great potential for application in medical dressings.
Curcumin is a natural compound with good anti-inflammatory and anticancer properties. Curcumin is a diketone compound extracted from rhizomes of some plants in the families of zingiberaceae and Araceae. Recent studies have found that curcumin has a wide range of pharmacological activities such as anti-inflammatory, antioxidant, lipid-regulating, antiviral, anti-infective, antitumor, anticoagulant, anti-hepatic fibrosis, etc., and has low toxicity and little adverse reaction. It is not only curcumin as a non-steroidal anti-inflammatory drug that attracts researchers, but because of its chemopreventive properties, curcumin has a broad preventive property against diseases. In view of the fact that the modern medical research discovers that the occurrence of a plurality of diseases of human bodies is related to the participation of free radical formation and inflammatory reaction, the antioxidant activity and the anti-inflammatory effect of curcumin have attracted extensive attention of domestic and foreign scholars.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: provides a preparation method of a composite kapok-based dressing.
In order to solve the technical problems, the invention provides a preparation method of a kapok-based dressing, which comprises the following steps:
step 1): physically modifying kapok fibers;
step 2): heating kapok fibers obtained in the step 1) in NaOH solution under the water bath condition;
step 3): mixing the kapok fibers obtained in the step 2) with an adhesive, and homogenizing by using a homogenizer;
step 4): preparing the mixture obtained in the step 3) into a fiber web by utilizing a wet papermaking process;
step 5): placing the hydrogel on a fiber net to obtain the composite kapok-based dressing.
Preferably, the physical modification in step 1) includes at least one of beating, pulverizing, and microfibrillating. Crushing refers to controlling the fiber size to 100-500 μm.
Preferably, the mass concentration of the NaOH solution in the step 2) is 2-20%, the temperature of the water bath is 70-99 ℃, and the bath ratio is 1g:1-20mL, and the treatment time is 2-6h.
Preferably, the binder in step 3) comprises carboxymethyl cellulose and cationic starch, and the mechanical properties of the fiber web are enhanced in a binary system.
More preferably, the mass ratio of the carboxymethyl cellulose to the cationic starch is 1:2.
preferably, in the step 3), the mass ratio of kapok fiber to binder is 300-500:1, the homogenizing rotating speed is 4500-6000r/s, and the homogenizing time is 15-30min.
Preferably, the grammage of the web obtained in step 4) is between 35 and 75g/m 2 。
Preferably, the preparation method of the hydrogel in the step 5) comprises the following steps: dissolving collagen and curcumin in acetic acid, stirring with a magnetic stirrer, sealing in a dialysis bag after stirring uniformly, dialyzing in deionized water, and drying.
More preferably, the mass ratio of the collagen to the curcumin is 1-20:1, a step of; the ratio of the collagen to the acetic acid is 1:50g-100mL.
More preferably, the dialysis is for a period of time of: ending dialysis when the pH value inside and outside the dialysis bag reaches balance; the drying conditions are as follows: 70 ℃ for 6h.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses a preparation method of a kapok-based dressing for medical cosmetology postoperative repair, which is simple in process operation, not only effectively realizes the preparation of a biomass fiber dressing, but also has excellent antibacterial performance and excellent hydrophilic and oleophilic performance, can be applied to the field of medical cosmetology postoperative repair, and has wide application prospect and higher practicability.
Detailed Description
In order to make the present invention more comprehensible, preferred embodiments accompanied with the present invention are described in detail below.
Example 1
A method for preparing a kapok-based dressing, comprising the steps of:
1. physical modification of kapok fibers: mechanically crushing kapok fibers, wherein the length of the kapok fibers is controlled by using a 300-325 mesh screen, and the length interval of the obtained fibers is 0.04-0.06mm;
2. chemical treatment of kapok fibers: 2wt% NaOH solution, kapok fiber to solution bath ratio of 1g:10mL, boiling in a water bath kettle at 70 ℃ for 6h;
3. weighing 0.2g of sodium carboxymethyl cellulose and 0.1g of cationic starch, dissolving in 10mL of deionized water, magnetically stirring, mixing with 10g of absolute dry modified kapok fiber after stirring completely, and placing into a homogenizer, wherein the bath ratio of the fiber to water is controlled to be 1g:400mL, the rotating speed is 4500r/s, and the treatment time is 30min;
4. pouring the uniformly mixed solute and solution into a homemade sheet making machine, forming a three-dimensional fiber net by utilizing a wet papermaking process, and transferring the fiber net into a 15cm glass culture dish;
5. weighing 1g of collagen powder and 0.6g of curcumin, dissolving in 50mL of acetic acid solution with pH of 2.7, adding deionized water to 100mL, uniformly stirring by a magnetic stirrer, placing the mixed solution in a dialysis bag after uniform stirring, sealing, placing the dialysis bag in deionized water, after the pH value inside and outside the dialysis bag reaches equilibrium, dialyzing, transferring into a glass culture dish, and drying to obtain the composite kapok-based dressing.
6. The prepared kapok-based dressing has a double-layer composite structure, has hydrophilic performance (water contact angle is 36.7 degrees), oleophilic performance (oil contact angle is 45.7 degrees) and certain antibacterial performance. The bactericidal activity of kapok fiber on staphylococcus aureus ATCC 6538P is 1.7, and the value of the antibacterial activity is 0.6; the bactericidal activity value for the escherichia coli NBRC 3301 is 2.6, and the bacteriostatic activity value is 6.0. The mite-repellent rate reaches 87.54 percent.
Example 2
1. Physical modification of kapok fibers: mechanically crushing kapok fibers, wherein the length of the fibers is controlled by using a 60-80 mesh screen, and the length interval of the fibers is 0.2-0.3mm;
2. chemical treatment of kapok fibers: 4wt% NaOH solution, kapok fiber to solution bath ratio of 1g:10mL, boiling in a water bath kettle at 70 ℃ for 6h;
3. weighing 0.2g of sodium carboxymethyl cellulose and 0.1g of cationic starch, dissolving in 10mL of deionized water, magnetically stirring, mixing with 10g of absolute dry modified kapok fiber after stirring completely, and placing into a homogenizer, wherein the bath ratio of the fiber to water is controlled to be 1g:400mL, the rotating speed is 4500r/s, and the treatment time is 30min;
4. pouring the uniformly mixed solute and solution into a homemade sheet making machine, forming a three-dimensional fiber net by utilizing a wet papermaking process, and transferring the fiber net into a 15cm glass culture dish;
5. weighing 1g of collagen powder and 0.6g of curcumin, dissolving in 50mL of acetic acid solution with pH of 2.7, adding deionized water to 100mL, uniformly stirring by a magnetic stirrer, placing the mixed solution in a dialysis bag after uniform stirring, sealing, placing the dialysis bag in deionized water, after the pH value inside and outside the dialysis bag reaches equilibrium, dialyzing, transferring into a glass culture dish, and drying to obtain the composite kapok-based dressing.
6. The prepared kapok-based dressing has a double-layer composite structure, has hydrophilic performance (water contact angle is 36.2 degrees), oleophilic performance (oil contact angle is 44.7 degrees) and certain antibacterial performance. The bactericidal activity of kapok fiber on staphylococcus aureus ATCC 6538P is 1.7, and the value of the antibacterial activity is 0.6; the bactericidal activity value for the escherichia coli NBRC 3301 is 2.6, and the bacteriostatic activity value is 6.0. The mite-repellent rate reaches 87.54 percent.
Example 3
1. Physical modification of kapok fibers: mechanically crushing kapok fibers, wherein the length of the fibers is controlled by using a 60-80 mesh screen, and the length interval of the fibers is 0.2-0.3mm;
2. chemical treatment of kapok fibers: 4wt% NaOH solution, kapok fiber to solution bath ratio of 1g:10mL, boiling in a water bath kettle at 70 ℃ for 6h;
3. weighing 0.1g of sodium carboxymethyl cellulose and 0.1g of cationic starch, dissolving in 10mL of deionized water, magnetically stirring, mixing with 10g of absolute dry modified kapok fiber after stirring completely, and placing into a homogenizer, wherein the bath ratio of the fiber to water is controlled to be 1g:500mL, the rotating speed is 4500r/s, and the treatment time is 30min;
4. pouring the uniformly mixed solute and solution into a homemade sheet making machine, forming a three-dimensional fiber net by utilizing a wet papermaking process, and transferring the fiber net into a 15cm glass culture dish;
5. weighing 2g of collagen powder and 1g of curcumin, dissolving in 100mL of acetic acid solution with pH of 2.7, adding deionized water to 200mL, uniformly stirring by a magnetic stirrer, placing the mixed solution into a dialysis bag after uniform stirring, sealing, placing the dialysis bag into deionized water, after the pH value inside and outside the dialysis bag reaches equilibrium, dialyzing, transferring into a glass culture dish, and drying to obtain the composite kapok-based dressing.
6. The prepared kapok-based dressing has a double-layer composite structure, has hydrophilic performance (water contact angle of 37.2 degrees), lipophilic performance (oil contact angle of 46.7 degrees) and certain antibacterial performance. The bactericidal activity of kapok fiber on staphylococcus aureus ATCC 6538P is 1.7, and the value of the antibacterial activity is 0.6; the bactericidal activity value for the escherichia coli NBRC 3301 is 2.6, and the bacteriostatic activity value is 6.0. The mite-repellent rate reaches 87.54 percent.
Claims (4)
1. A method for preparing a kapok-based dressing, which is characterized by comprising the following steps:
step 1): physically modifying kapok fibers; the physical modification includes at least one of beating, pulverizing, and fibrillating;
step 2): heating kapok fibers obtained in the step 1) in NaOH solution under the water bath condition; step 3): mixing the kapok fibers obtained in the step 2) with an adhesive, and homogenizing by using a homogenizer; the mass concentration of the NaOH solution is 2-20%, the temperature of the water bath is 70-99 ℃, and the bath ratio is 1g:1-20mL, and the treatment time is 2-6h; the binder comprises carboxymethyl cellulose and cationic starch; the mass ratio of the carboxymethyl cellulose to the cationic starch is 1:2;
step 4): preparing the mixture obtained in the step 3) into a fiber web by utilizing a wet papermaking process;
step 5): placing the hydrogel on a fiber net to obtain a composite kapok-based dressing; the preparation method of the gel comprises the following steps: dissolving collagen and curcumin in acetic acid solution, stirring with a magnetic stirrer, placing in a dialysis bag for sealing after stirring uniformly, placing in deionized water for dialysis, and drying; the mass ratio of the collagen to the curcumin is 1-20:1, a step of; the ratio of the collagen to the acetic acid is 1g:50-100mL; the dialysis time is as follows: and (5) ending the dialysis when the pH value inside and outside the dialysis bag reaches balance.
2. The method for preparing a kapok-based dressing according to claim 1, wherein the mass ratio of kapok fibers to binder in the step 3) is 300-500:1, the homogenizing rotating speed is 4500-6000r/s, and the homogenizing time is 15-30min.
3. The method of preparing a kapok-based dressing according to claim 1, wherein the web obtained in step 4) has a grammage of 35-75g/m 2 。
4. The method of making a kapok-based dressing according to claim 1, wherein the drying conditions are: 70 ℃ for 6h.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102600018B (en) * | 2012-03-31 | 2013-07-03 | 华南理工大学 | Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing |
| CN107126576A (en) * | 2017-04-21 | 2017-09-05 | 芜湖扬展新材料科技服务有限公司 | A kind of composite regenerated cellulosic wound dressings of kapok and preparation method thereof |
| CN108837176A (en) * | 2018-06-26 | 2018-11-20 | 东莞市联洲知识产权运营管理有限公司 | A kind of MULTILAYER COMPOSITE medical dressing and preparation method thereof |
| CN113069403A (en) * | 2021-04-02 | 2021-07-06 | 陕西科技大学 | Konjac kapok fiber traditional Chinese medicine mask and preparation method thereof |
| CN113813443B (en) * | 2021-10-19 | 2022-08-26 | 蓝科医美科学技术(吉林)有限公司 | Glucan-based hydrogel dressing and preparation method thereof |
| CN114059378B (en) * | 2021-11-19 | 2022-11-25 | 东华大学 | Preparation method of high-porosity material with heat insulation and warm keeping functions |
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