CN109793919B - Hydrogen sulfide slow-release dressing and manufacturing method thereof - Google Patents
Hydrogen sulfide slow-release dressing and manufacturing method thereof Download PDFInfo
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Abstract
The invention discloses a hydrogen sulfide slow-release dressing and a manufacturing method thereof. The hydrogen sulfide slow release dressing comprises hydrocolloid, surfactant and sodium hydrosulfide. By adjusting the proportion of the hydrophilic polymer and the surfactant in the hydrocolloid, the hydrocolloid has different water absorption rates, and further the sodium hydrosulfide coated in the hydrocolloid has different hydrogen sulfide release rates along with the water absorption rate. The hydrogen sulfide slow-release dressing can slowly release hydrogen sulfide without generating cytotoxicity, so that the healing of chronic wounds can be effectively promoted.
Description
Technical Field
The invention relates to a hydrogen sulfide slow-release dressing and a manufacturing method thereof, in particular to a hydrogen sulfide slow-release dressing capable of slowly releasing hydrogen sulfide gas to promote chronic wound healing and a manufacturing method thereof.
Background
Hydrogen sulfide (H)2S) is the third endogenous gas phase mediator to be found following nitric oxide and carbon monoxide. In animal experiments, hydrogen sulfide gas has been proved to have the effects of relaxing blood vessels, inhibiting the proliferation of vascular smooth muscle cells, inducing the apoptosis of vascular smooth muscle cells, promoting the proliferation of microvascular endothelial cells, resisting inflammatory reaction, resisting oxidation and the like. It is known in the art that cells produce low concentrations of hydrogen sulfide gas at a slow rate, however, external hydrogen sulfide donors (donors) do not truly mimic the rate of hydrogen sulfide production in the human body.
Sodium hydrosulfide (NaHS) can generate hydrogen sulfide gas after dissolving in water, and thus can be used as a donor of hydrogen sulfide. However, since the reaction process of hydrogen sulfide evolution by the combination of hydrogen sulfide ions (HS-) in sodium hydrosulfide and hydrogen ions (H +) in water is very rapid, a high concentration of hydrogen sulfide is evolved in a short time. High concentrations of hydrogen sulfide are toxic to cells and can cause adverse reactions such as apoptosis or inflammation. Although low concentrations of hydrogen sulfide are beneficial for wound healing, high concentrations of hydrogen sulfide are toxic, thereby limiting the medical use of hydrogen sulfide.
Therefore, there is still a need for a dressing that can slowly release hydrogen sulfide without cytotoxicity and promote wound healing.
Disclosure of Invention
The invention aims to provide a novel hydrogen sulfide slow-release dressing and a manufacturing method thereof. The hydrogen sulfide slow-release dressing can slowly release hydrogen sulfide without generating cytotoxicity, and can effectively promote the healing of chronic wounds.
In order to achieve the above object, the present invention provides a hydrogen sulfide sustained release dressing comprising a hydrocolloid, a surfactant, and sodium hydrosulfide.
Preferably, the hydrocolloid is 60 to 140 parts by weight, the surfactant is 0.2 to 2 parts by weight, and the sodium hydrosulfide is 0.1 to 0.5 parts by weight.
Preferably, the surfactant is polysorbate 80, polysorbate 20, polysorbate 60 or polysorbate 40.
Preferably, the hydrocolloid comprises an elastomer, a hydrophilic polymer, a tackifier and a ductility agent.
Preferably, the elastomer is 10 to 30 parts by weight, the hydrophilic polymer is 20 to 60 parts by weight, the tackifier is 20 to 60 parts by weight, and the extender is 2 to 20 parts by weight.
Preferably, the elastomer includes at least one of the following: styrene-isoprene-styrene (SIS) copolymers, styrene-butadiene-styrene (SBS) copolymers, styrene- (ethylene-butylene) -styrene (SEBS) copolymers and styrene- (ethylene-propylene) -styrene (SEPS).
Preferably, the hydrophilic polymer includes at least one of: sodium carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, locust bean gum, collagen, and karaya gum.
Preferably, the adhesion promoter includes at least one of: rosin resins, terpene resins, C5 petroleum resins, C9 petroleum resins and high purity dicyclopentadiene (H-DCPD).
Preferably, the aforementioned extending agent comprises at least one of: mineral oil, liquid paraffin, castor oil, dibutyl phthalate, lanolin, and naphthenic oil.
Preferably, the hydrocolloid further comprises 0.2 to 2 parts by weight of an antioxidant.
Preferably, the antioxidant is a hindered phenol, thiosynergists (thiosynergists), secondary aromatic amines (secondary aromatic amines), or phosphites.
The invention also provides a manufacturing method of the hydrogen sulfide slow-release dressing, which comprises the following steps: (a) heating and stirring the hydrocolloid material; (b) adding a surfactant and sodium hydrosulfide into the hydrocolloid material; and (c) injecting the hydrocolloid material containing the surfactant and the sodium hydrosulfide into a forming die for hot-press forming to form the hydrogen sulfide slow-release dressing.
Preferably, the hydrocolloid material is 60 to 140 parts by weight, the surfactant is 0.2 to 2 parts by weight, and the sodium hydrosulfide is 0.1 to 0.5 parts by weight.
Preferably, the heating temperature in the step (a) is between 100 ℃ and 200 ℃.
Preferably, the heating time in the step (a) is between 1 hour and 1.5 hours.
Preferably, the step (b) further comprises: and heating the hydrocolloid material containing the surfactant and the sodium hydrosulfide at a temperature of between 100 and 150 ℃.
Preferably, the heating time in the step (b) is between 15 minutes and 45 minutes.
Compared with the prior art, the invention provides a novel hydrogen sulfide slow-release dressing and a manufacturing method thereof. The hydrogen sulfide slow release dressing comprises hydrocolloid, surfactant and sodium hydrosulfide. The hydrocolloid comprises an elastomer, a hydrophilic polymer, a tackifier and a ductility agent. By adjusting the proportion of the hydrophilic polymer and the surfactant in the hydrocolloid, the hydrocolloid has different water absorption rates, and further the sodium hydrosulfide coated in the hydrocolloid has different hydrogen sulfide release rates along with the water absorption rate. The hydrogen sulfide slow-release dressing can slowly release hydrogen sulfide without generating cytotoxicity, so that the healing of chronic wounds can be effectively promoted.
Detailed Description
In order to further understand the objects, structures, features and functions of the present invention, the following embodiments are described in detail.
In order to make the description of the present disclosure more complete and complete, the following illustrative description is set forth in connection with the embodiments of the present invention; it is not intended to be the only form in which the embodiments of the invention may be practiced or utilized. The embodiments disclosed below may be combined with or substituted for one another where appropriate, and other embodiments may be added to the embodiments without further recitation or description.
The invention aims to provide a hydrogen sulfide slow-release dressing which comprises a hydrocolloid, a surfactant and sodium hydrosulfide. The hydrogen sulfide slow-release dressing can avoid the problem of cytotoxicity caused by releasing high-concentration hydrogen sulfide in a short time, so that the hydrogen sulfide slow-release dressing can be effectively applied to promoting the healing of chronic wounds. In the process of releasing the hydrogen sulfide slow release dressing, the concentration of the hydrogen sulfide can be less than 1300 μ M, preferably between 1 and 1000 μ M, and more preferably between 1 and 500 μ M.
In an embodiment of the hydrogen sulfide sustained release dressing of the present invention, the hydrocolloid may be 60 to 140 parts by weight, the surfactant may be 0.2 to 2 parts by weight, and the sodium hydrosulfide may be 0.1 to 0.5 parts by weight. When the amount of sodium hydrosulfide added is too large, the concentration of the released hydrogen sulfide gas may become too high, which may cause cytotoxicity. When the amount of sodium hydrosulfide added is too small, the concentration of the released hydrogen sulfide gas may be too low to effectively promote wound healing.
Suitable hydrocolloids may be Hydrocolloid (hydrocolloids) compositions known to be useful as dressings. Hydrocolloids have the ability to absorb wound exudate. After absorbing the exudate, the hydrophilic materials in the hydrocolloid can form a semisolid substance similar to gel, and the semisolid substance is attached to the base of a wound to provide and maintain a wet environment which is beneficial to wound healing. In addition, because of its adhesive properties, hydrocolloids form an occlusive (occlusive) wound surface to promote the proliferation of microvasculature and the formation of granulation tissue, thereby accelerating wound healing. The hydrocolloid dressing can provide a closed environment, is beneficial to macrophage to remove necrotic tissues, and has a debridement function. In an embodiment of the present invention, the hydrocolloid may comprise an elastomer, a hydrophilic polymer, a tackifier, and a ductility agent.
The elastomer is mainly used for molding and providing viscosity, flexibility and the like. Because the elastomer is of a hydrophobic structure, the sodium hydrosulfide is coated by the elastomer, so that the sodium hydrosulfide can be prevented from directly contacting with water, and the release rate of the hydrogen sulfide can be slowed down and regulated. Suitable elastomers may be, for example, any one of or a combination of styrene-isoprene-styrene (SIS) copolymer, styrene-butadiene-styrene (SBS) copolymer, styrene- (ethylene-butylene) -styrene (SEBS) copolymer, styrene- (ethylene-propylene) -styrene (SEPS) copolymer, but are not limited thereto.
The hydrophilic polymer has a liquid-absorbing ability and has a crosslinked structure so that it does not dissolve but swells after absorbing an exudate, and thus can provide water-absorbing properties. The hydrophilic polymer that may be used may include natural, semisynthetic, or synthetic hydrophilic polymers. Natural hydrophilic polymers may include, for example, polysaccharide polymers such as pectin, gum arabic, guar gum, agar, starch, xanthan gum, dextran, and the like; and protein or polypeptide polymers such as gelatin, albumin, casein, etc. Semi-synthetic hydrophilic polymers may include, for example, carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylhydroxypropylcellulose, sodium alginate, carboxymethyl starch, and the like. Synthetic hydrophilic polymers may include, for example, acrylic polymers (e.g., polyacrylic acid and polyacrylamide), polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polyvinyl methyl ether, and the like. In a preferred embodiment of the present invention, the hydrophilic polymer may be at least one of sodium carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, locust bean gum, collagen, and karaya gum, or a combination thereof, but is not limited thereto. When the hydrophilic polymer is added in an excessive amount, the water absorption rate of the hydrocolloid may become too high, and the release rate of hydrogen sulfide gas may become too high, resulting in cytotoxicity. When the amount of the hydrophilic polymer added is too small, the rate of release of hydrogen sulfide gas may be too low due to too low water absorption rate of the hydrocolloid, and wound healing may not be effectively promoted.
The tackifier can be used to further adjust the viscosity of the hydrocolloid. Suitable tackifiers may be at least one of rosin resins, terpene resins, C5 petroleum resins, C9 petroleum resins, and high purity dicyclopentadiene (H-DCPD) or a combination thereof.
The extender may provide wetting and/or viscosity control. Suitable extending agents may be at least one of mineral oil, liquid paraffin, castor oil, dibutyl phthalate, lanolin, and naphthenic oil, or combinations thereof.
In the embodiment of the present invention, the elastomer of the hydrocolloid may be 10 to 30 parts by weight, the hydrophilic polymer may be 20 to 60 parts by weight, the tackifier may be 20 to 60 parts by weight, and the extender may be 2 to 20 parts by weight.
In another embodiment of the present invention, the hydrocolloid may optionally further comprise 0.2 to 2 parts by weight of an antioxidant to avoid changes in properties caused by aging of the elastomer. Suitable antioxidants may be hindered phenols, thiosynergists (thiosynergists), phosphites or secondary aromatic amines (secondary aromatic amines).
The hydrophilic polymer is dispersed in the elastomer, and by adding the surfactant, the hydrophilic end of the hydrophilic polymer can enable the surface of the hydrocolloid to be soaked after meeting water, so that the hydrophilic polymer can swell and absorb seepage, and water molecules are promoted to permeate into the hydrophobic elastomer. Therefore, by adjusting the proportion of the hydrophilic polymer and the surfactant, the hydrocolloid can have different water absorption rates, and further the sodium hydrosulfide coated in the hydrocolloid has different hydrogen sulfide release rates according to the water absorption rate. In an embodiment of the present invention, the surfactant may be polysorbate 80, polysorbate 20, polysorbate 60 or polysorbate 40. When the amount of the surfactant added is too large, the absorption rate of the hydrocolloid may be too high and the release concentration of hydrogen sulfide may be too high. When the amount of the surfactant added is too small, the absorption rate of the hydrocolloid may be too slow, and the release rate of hydrogen sulfide may be affected.
Another embodiment of the present invention is to provide a method for manufacturing a hydrogen sulfide sustained release dressing, which includes, but is not limited to, the following steps.
First, in step (a), the hydrocolloid material is heated and agitated. In an embodiment of the manufacturing method of the present invention, the hydrocolloid material may be 60 to 140 parts by weight, and the hydrocolloid material may include an elastomer, a hydrophilic polymer, a tackifier, and a ductility agent, for example, as described above. In a preferred embodiment of the manufacturing method of the present invention, the heating temperature in step (a) may be between 100 ℃ and 200 ℃, and the heating time may be between 1 hour and 1.5 hours.
Next, in step (b), a surfactant is added to the hydrocolloid material along with the sodium hydrosulfide. The surfactant may be added in an amount of 0.2 to 2 parts by weight, and the sodium hydrosulfide may be added in an amount of 0.1 to 0.5 parts by weight. In a preferred embodiment of the manufacturing method of the present invention, the step (b) may further comprise performing a heating process, wherein the heating temperature may be between 100 ℃ and 150 ℃, and the heating time may be between 15 minutes and 45 minutes.
Finally, in the step (c), the hydrocolloid material containing the surfactant and the sodium hydrosulfide is injected into a forming die to be hot-pressed and formed to form the hydrogen sulfide slow-release dressing. The hot pressing temperature may be, for example, between 50 ℃ and 100 ℃.
The following examples are intended to further illustrate the invention, but the invention is not limited thereto.
Examples
Example 1
15.4 g of styrene-isoprene-styrene (SIS) copolymer (Kraton D1161, available from Kraton, USA), 36.55 g of C9 modified resin (Wingtack 86, available from CRAY VALLEY, USA), 6.4 g of mineral oil (Kaydol white mineral oil, available from Sonneborn, USA) and 1 g of hindered phenol tetra (3, 5-di-tert-butyl-4-hydroxy) pentaerythritol phenylpropionate (Chinox 1010, available from double bond chemical industry, Taiwan) are stirred at 180 ℃ for 60 minutes in a nitrogen environment, then cooled to 120 ℃, 40 g of sodium carboxymethylcellulose, 0.5 g of surfactant Tween 80 and 0.15 g of sodium hydrosulfide are added, stirred for 10 minutes and poured into a mold for hot-press molding at 90 ℃ to form the hydrogen sulfide slow-release dressing.
Example 2
The procedure and materials of example 2 were the same as example 1 except that 36.55 grams of the C9 modified resin was replaced with 36.5 grams of the C9 modified resin and 0.15 grams of sodium hydrosulfide was replaced with 0.2 grams of sodium hydrosulfide.
Example 3
The procedure and materials of example 3 were the same as in example 1 except that 15.3 grams of styrene-isoprene-styrene (SIS) copolymer was used in place of 15.4 grams of styrene-isoprene-styrene (SIS) copolymer, 36.3 grams of C9 modified resin was used in place of 36.55 grams of C9 modified resin, and 0.5 grams of sodium hydrosulfide was used in place of 0.15 grams of sodium hydrosulfide.
Example 4
The procedure and materials of example 4 were the same as in example 1 except that 17.93 grams of styrene-isoprene-styrene (SIS) copolymer was used in place of 15.4 grams of styrene-isoprene-styrene (SIS) copolymer, 42.59 grams of C9 modified resin was used in place of 36.55 grams of C9 modified resin, 30 grams of sodium carboxymethylcellulose was used in place of 40 grams of sodium carboxymethylcellulose, and 0.5 grams of sodium hydrosulfide was used in place of 0.15 grams of sodium hydrosulfide.
Comparative example 1
The procedure and materials of comparative example 1 were the same as in example 1 except that 15.2 g of styrene-isoprene-styrene (SIS) copolymer was used instead of 15.4 g of styrene-isoprene-styrene (SIS) copolymer, 36 g of C9 modified resin was used instead of 36.55 g of C9 modified resin, and 1 g of sodium hydrosulfide was used instead of 0.15 g of sodium hydrosulfide.
The hydrogen sulfide release rates of the hydrogen sulfide sustained-release dressings of examples 1 to 4 and comparative example 1 were measured by the methylene blue method.
First, a standard substance having a known concentration is prepared, and a calibration curve is prepared. The calibration curve was prepared by preparing 500. mu.L of a phosphate buffer solution (pH 7.4) containing 0.04mg/mL of sodium hydrosulfideThe sequence was diluted to standards of each concentration, and a phosphate buffer solution containing no sodium hydrosulfide was prepared. After mixing 100. mu.L and 100. mu.L of 1.0 wt% zinc acetate aqueous solutions of each standard, 20. mu.L of an aqueous solution containing 20mM N, N-dimethyl-1, 4-phenylenediamine sulfate and 7.2N hydrogen chloride and 20. mu.L of an aqueous solution containing 30mM ferric chloride (FeCl)3) And a 1.2N aqueous hydrogen chloride solution, and then reacted for 10 minutes. Because ferric chloride is used as an oxidant, N-dimethyl-1, 4-phenylenediamine sulfate and hydrogen sulfide which is a product of sodium hydrosulfide dissolved in water can be catalyzed to react to generate methylene blue, the absorption intensity of the methylene blue of each standard product under the wavelength of 670nm can be measured, a detection line can be established, and the concentration of the hydrogen sulfide can be deduced back according to the detection line. Next, the dressings of examples 1 to 4 and comparative example 1 were placed in 1500. mu.L of phosphoric acid buffer solution, and left for 2 hours, 4 hours, 6 hours, 8 hours, 18 hours, 24 hours, 42 hours and 48 hours, respectively, and then 100. mu.L of the phosphoric acid buffer solution having been soaked in the dressing was taken out, and 100. mu.L of a 1.0 wt% aqueous solution of zinc acetate, 20. mu.L of a 20mM aqueous solution of N, N-dimethyl-1, 4-phenylenediamine sulfate and 7.2N aqueous solution of hydrogen chloride, and 20. mu.L of a 30mM aqueous solution of FeCl (FeCl) were added3) And a 1.2N aqueous solution of hydrogen chloride, and reacted for 20 minutes. The absorption intensity of methylene blue at a wavelength of 670nm was then measured for each solution to extrapolate the hydrogen sulfide concentration at different times for each dressing of the examples and comparative examples. The test results are shown in table 1 below.
Table 1: test results of examples 1 to 4 and comparative example 1
The hydrogen sulfide slow-release dressings prepared in examples 1 to 4 can effectively and slowly release hydrogen sulfide gas within 24 hours without exceeding the safe use concentration, and particularly, the hydrogen sulfide slow-release dressings prepared in examples 2 and 3 can prolong the release time to 48 hours. The concentration of hydrogen sulfide in the release process of the hydrogen sulfide slow-release dressing of comparative example 1 is higher than 1300 μ M, and although hydrogen sulfide gas can be released for a long time, the hydrogen sulfide gas exceeds the safe use concentration of hydrogen sulfide. In summary, the present invention provides a novel hydrogen sulfide slow-release dressing and a manufacturing method thereof, wherein the hydrogen sulfide slow-release dressing comprises a hydrocolloid, a surfactant and sodium hydrosulfide. The hydrocolloid comprises an elastomer, a hydrophilic polymer, a tackifier and a ductility agent. By adjusting the proportion of the hydrophilic polymer and the surfactant in the hydrocolloid, the hydrocolloid has different water absorption rates, and the sodium hydrosulfide coated in the hydrocolloid has different hydrogen sulfide release rates along with the water absorption rates, so that the hydrogen sulfide can be slowly released without generating cytotoxicity, and the healing of the chronic wound can be effectively promoted.
The above detailed description of the preferred embodiments is intended to more clearly illustrate the features and spirit of the present invention, and is not intended to limit the scope of the present invention by the preferred embodiments disclosed above. On the contrary, it is intended to cover various modifications and equivalent arrangements included within the scope of the appended claims. The scope of the invention is therefore to be accorded the broadest interpretation so as to encompass all such modifications and equivalent arrangements as is within the scope of the appended claims.
Claims (10)
1. A hydrogen sulfide slow release dressing, comprising:
the hydrocolloid comprises an elastomer, a hydrophilic macromolecule, a tackifier and a ductility agent;
a surfactant; and
sodium hydrosulfide;
wherein the elastomer comprises at least one of: styrene-isoprene-styrene (SIS) copolymers, styrene-butadiene-styrene (SBS) copolymers, styrene- (ethylene-butylene) -styrene (SEBS) copolymers, and styrene- (ethylene-propylene) -styrene (SEPS) copolymers;
60 to 140 parts of hydrocolloid, 0.2 to 2 parts of surfactant and 0.1 to 0.5 part of sodium hydrosulfide;
10 to 30 parts of elastomer, 20 to 60 parts of hydrophilic polymer, 20 to 60 parts of tackifier and 2 to 20 parts of extender.
2. The hydrogen sulfide sustained release dressing of claim 1, wherein the surfactant is polysorbate 80, polysorbate 20, polysorbate 60 or polysorbate 40.
3. The hydrogen sulfide sustained release dressing of claim 1, wherein the hydrophilic polymer comprises at least one of: sodium carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, locust bean gum, collagen, and karaya gum.
4. The hydrogen sulfide slow release dressing of claim 1, wherein the adhesion promoter comprises at least one of: rosin resins, terpene resins, C5 petroleum resins, C9 petroleum resins and high purity dicyclopentadiene (H-DCPD).
5. The hydrogen sulfide slow release dressing of claim 1, wherein the extending agent comprises at least one of: mineral oil, liquid paraffin, castor oil, dibutyl phthalate, lanolin, and naphthenic oil.
6. The hydrogen sulfide extended release dressing of claim 1, wherein the hydrocolloid further comprises 0.2 to 2 parts by weight of an antioxidant.
7. The hydrogen sulfide sustained release dressing of claim 6, wherein the antioxidant is a hindered phenol, thiosynergists (thiosynergists), phosphites or secondary aromatic amines (secondary aromatic amines).
8. A method of manufacturing a hydrogen sulfide slow release dressing, the method comprising:
(a) heating and stirring a hydrocolloid material, wherein the hydrocolloid material comprises an elastomer, a hydrophilic polymer, a tackifier and a ductility agent;
(b) adding a surfactant and sodium hydrosulfide to the hydrocolloid material; and
(c) injecting the hydrocolloid material containing the surfactant and the sodium hydrosulfide into a forming die for hot-press forming to form the hydrogen sulfide slow-release dressing;
wherein the elastomer comprises at least one of: styrene-isoprene-styrene (SIS) copolymers, styrene-butadiene-styrene (SBS) copolymers, styrene- (ethylene-butylene) -styrene (SEBS) copolymers, and styrene- (ethylene-propylene) -styrene (SEPS) copolymers;
60 to 140 parts of hydrocolloid, 0.2 to 2 parts of surfactant and 0.1 to 0.5 part of sodium hydrosulfide;
10 to 30 parts of elastomer, 20 to 60 parts of hydrophilic polymer, 20 to 60 parts of tackifier and 2 to 20 parts of extender.
9. The method of claim 8, wherein the heating temperature in step (a) is between 100 ℃ and 200 ℃ and the heating time is between 1 hour and 1.5 hours.
10. The method of claim 8, wherein step (b) further comprises: and heating the hydrocolloid material containing the surfactant and the sodium hydrosulfide at 100-150 ℃ for 15-45 minutes.
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| US20220354885A1 (en) * | 2019-06-28 | 2022-11-10 | National Institute For Materials Science | Constituent for preventing and/or treating skin wounds |
| CN112263777B (en) * | 2020-08-04 | 2023-05-05 | 北京工业大学 | Hydrogen molecule slow-release composite dressing and preparation method thereof |
| TWI752666B (en) * | 2020-10-05 | 2022-01-11 | 明基材料股份有限公司 | Composition for promoting wound healing and manufacturing method thereof |
| CN112516367B (en) * | 2020-10-27 | 2022-06-17 | 明基材料（芜湖）有限公司 | Composition for promoting wound healing and preparation method thereof |
| CN112274531B (en) * | 2020-11-19 | 2022-04-15 | 徐州医科大学 | Preparation method of hydrogen sulfide sustained-release gel and application of hydrogen sulfide sustained-release gel in preparation of medicine for treating diabetic skin ulcer |
| CN113679874B (en) * | 2021-09-03 | 2022-07-22 | 明基材料有限公司 | Multi-segment release dressing |
| CN114099419B (en) * | 2021-11-19 | 2023-03-24 | 苏州大学 | Sodium hydrosulfide-loaded injectable nano-fibrosis hydrogel and preparation method and application thereof |
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| EP3579888B1 (en) * | 2017-02-09 | 2023-09-27 | Noxsano Inc. | Electrochemical gasotransmitter generating compositions and methods of using same and dressings and treatment systems incorporating same |
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| CN1297363A (en) * | 1998-03-12 | 2001-05-30 | 卫生与营养实验室 | Hydrocolloid adhesive mass useful for medical purpose |
| CN1418114A (en) * | 2000-03-22 | 2003-05-14 | 卫生及营养实验室 | Antiseptic compress |
| CN101678146A (en) * | 2007-05-25 | 2010-03-24 | 于尔戈实验室 | The novel agent of release of active agent in the dressing that contains at least a fatty material |
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