CN109793919A - Hydrogen sulfide is sustained dressing and its manufacturing method - Google Patents
Hydrogen sulfide is sustained dressing and its manufacturing method Download PDFInfo
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- CN109793919A CN109793919A CN201910105505.7A CN201910105505A CN109793919A CN 109793919 A CN109793919 A CN 109793919A CN 201910105505 A CN201910105505 A CN 201910105505A CN 109793919 A CN109793919 A CN 109793919A
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Abstract
The present invention discloses a kind of sustained release dressing of hydrogen sulfide and its manufacturing method.Hydrogen sulfide sustained release dressing of the invention includes hydrocolloid, interfacial agent and NaHS.By the ratio of hydrophilic macromolecule and interfacial agent in adjustment hydrocolloid, it can make hydrocolloid that there is different rate of water absorption, and the NaHS being coated in hydrocolloid is made to have different hydrogen sulfide rates of release with rate of water absorption in turn.Hydrogen sulfide sustained release dressing of the invention can slowly discharge hydrogen sulfide without generating cytotoxicity, therefore can effectively facilitate the healing of chronic wounds.
Description
Technical field
The present invention relates to a kind of sustained release dressing of hydrogen sulfide and its manufacturing method more particularly to one kind to be vulcanized with slow release
Hydrogen is to promote the hydrogen sulfide of chronic wound care to be sustained dressing and its manufacturing method.
Background technique
Hydrogen sulfide (H2It S) is the endogenous gas phase transmitting object that third is found after nitric oxide and carbon monoxide
Matter.Have been demonstrated that hydrogen sulfide gas has vasodilator, inhibits vascular smooth muscle cell proliferation, induction blood in animal experiments
Pipe Vascular Smooth Muscle Cell Apoptosis, promotion proliferation of microvascular endothelial cells, anti-inflammatory reaction and antioxidation and other effects.Existing
Known cell can be manufactured and the hydrogen sulfide gas of low concentration in technology with slow rate, however external hydrogen sulfide donor
It (donor) can not the generating rate of real simulation hydrogen sulfide in human body.
NaHS (NaHS) can produce hydrogen sulfide gas because being dissolved in after water, therefore can be used as the donor of hydrogen sulfide.However,
Because the sulphur hydrogen radical ion (HS-) in NaHS combines the reaction process for releasing hydrogen sulfide very fast with the hydrogen ion (H+) in water
Speed, therefore the hydrogen sulfide of high concentration can be released in a short time.The hydrogen sulfide of high concentration is toxic to cell, can cause cell and wither
It dies or the adverse reactions such as inflammation.Although the hydrogen sulfide of low concentration facilitates the effect of wound healing, but because of the hydrogen sulfide of high concentration
It is toxic, therefore hydrogen sulfide is limited in application medically.
Therefore, it is still necessary to which one kind with slow release hydrogen sulfide and can will not generate cytotoxicity, can promote wound healing
Dressing.
Summary of the invention
The purpose of the present invention is to provide a kind of novel hydrogen sulfide sustained release dressing and its manufacturing methods.Vulcanization of the invention
Hydrogen sustained release dressing can slowly discharge hydrogen sulfide without generating cytotoxicity, can effectively facilitate the healing of chronic wounds.
In order to achieve the above objectives, the present invention provides a kind of hydrogen sulfide to be sustained dressing, and it includes hydrocolloids, interfacial agent
And NaHS.
Preferably, aforementioned hydrocolloid is 60 to 140 parts by weight, foregoing interface activating agent is 0.2 to 2 parts by weight, and aforementioned
NaHS is 0.1 to 0.5 parts by weight.
Preferably, foregoing interface activating agent is polysorbate80, polysorbate20, polysorbate60 or poly- sorb
Alcohol ester 40.
Preferably, aforementioned hydrocolloid includes elastomer, hydrophilic macromolecule, tackifier and extension agent.
Preferably, foregoing elastomers are 10 to 30 parts by weight, aforementioned hydrophilic macromolecule is 20 to 60 parts by weight, aforementioned increasing
Glutinous agent is 20 to 60 parts by weight, and aforementioned extension agent is 2 to 20 parts by weight.
Preferably, foregoing elastomers include at least one of following: styrene-isoprene-phenylethene (SIS) copolymerization
Object, s-B-S (SBS) copolymer, styrene-(Ethylene/Butylene)-styrene (SEBS) copolymer and
Styrene-(ethylene-propylene)-styrene (SEPS).
Preferably, aforementioned hydrophilic macromolecule includes at least one of following: sodium carboxymethylcellulose, hydroxy ethyl fiber
Element, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, locust bean gum, collagen and karaya gum.
Preferably, aforementioned tackifier includes at least one of following: rosin resin, terpene resin, C5 Petropols, C9 stone
Oleoresin and high-purity bicyclopentadiene (H-DCPD).
Preferably, aforementioned extension agent includes at least one of following: mineral oil, atoleine, castor oil, phthalic acid
Dibutyl ester, lanolin and naphthenic oil.
Preferably, aforementioned hydrocolloid also includes the antioxidant of 0.2 to 2 parts by weight.
Preferably, aforementioned antioxidant is hindered phenol, sulfur synergist (thiosynergists), second level aromatic amine
(secondary aromatic amines) or phosphite ester (phosphites).
The present invention also provides a kind of manufacturing methods of hydrogen sulfide sustained release dressing, and step includes: (a) heating stirring glue
Body material；(b) interfacial agent and NaHS are added in aforementioned hydrocolloid material；And it will (c) contain foregoing interface
It is hot-forming to form hydrogen sulfide sustained release dressing in the hydrocolloid material injection moulding mold of activating agent and aforementioned NaHS.
Preferably, aforementioned hydrocolloid material is 60 to 140 parts by weight, foregoing interface activating agent is 0.2 to 2 parts by weight, and
Aforementioned NaHS is 0.1 to 0.5 parts by weight.
Preferably, in the heating temperature in abovementioned steps (a) between 100 DEG C to 200 DEG C.
Preferably, in the heating time in abovementioned steps (a) between 1 hour to 1.5 hours.
Preferably, also including in abovementioned steps (b): to the hydrocolloid containing the interfacial agent and the NaHS
Material is heated, and heating temperature is between 100 DEG C to 150 DEG C.
Preferably, the heating time in abovementioned steps (b) is between 15 minutes to 45 minutes.
Compared with the prior art, the present invention provides a kind of novel hydrogen sulfide sustained release dressing and its manufacturing method.The present invention
Hydrogen sulfide sustained release dressing include hydrocolloid, interfacial agent and NaHS.Hydrocolloid includes elastomer, hydrophily high score
Son, tackifier and extension agent.By the ratio of hydrophilic macromolecule and interfacial agent in adjustment hydrocolloid, glue can be made
Body has different rate of water absorption, and the NaHS being coated in hydrocolloid is made to have different vulcanizations with rate of water absorption in turn
Hydrogen rate of release.Hydrogen sulfide sustained release dressing of the invention can slowly discharge hydrogen sulfide without generating cytotoxicity, therefore can
Effectively facilitate the healing of chronic wounds.
Specific embodiment
To make to have further understanding to the purpose of the present invention, construction, feature and its function, hereby cooperate embodiment detailed
It is described as follows.
In order to keep the narration of the disclosure of invention more detailed with it is complete, below for the embodiment of the present invention proposition
Illustrative description；But this not implements or uses the unique forms of the specific embodiment of the invention.Each reality as disclosed below
Example is applied, can be combined with each other or replace in the case of beneficial, other embodiments can also be added in embodiment, and need not be into one
The record or explanation of step.
The object of the present invention is to provide a kind of hydrogen sulfide to be sustained dressing, and it includes hydrocolloid, interfacial agent and sulphur hydrogen
Change sodium.Hydrogen sulfide sustained release dressing of the invention can avoid releasing high-concentration hydrogen sulfide in a short time and then generate cytotoxicity
The problem of, therefore can be effectively applied to the healing for promoting chronic wounds.Hydrogen sulfide sustained release dressing of the invention is during release, sulphur
The concentration for changing hydrogen is smaller than 1300 μM, preferably between 1-1000 μM, more preferably between 1-500 μM.
In the embodiment of hydrogen sulfide sustained release dressing of the invention, hydrocolloid can be 60 to 140 parts by weight, interfacial agent
It can be 0.2 to 2 parts by weight, and NaHS can be 0.1 to 0.5 parts by weight.It may make when the additive amount of NaHS is excessive
The sulfureted hydrogen gas concentration released is too fast and causes cytotoxicity.It then may be because of institute when the additive amount of NaHS is very few
The sulfureted hydrogen gas concentration released is too low and can not effectively facilitate wound healing.
Suitable hydrocolloid can be known hydrocolloid (Hydrocolloid) composition that can be used as dressing.Hydrocolloid tool
There is the ability for absorbing wound exudate.After absorbing sepage, the hydrophilic material in hydrocolloid can form the semisolid object of similar gels
Matter is attached to wound base portion, provides and maintain to be conducive to the wet environment of wound healing.In addition, because hydrocolloid has stickiness,
Closed (occlusive) surface of a wound can be formed, to promote the formation of the hyperplasia and granulation tissue of capilary, so that wound be accelerated to be cured
It closes.Because bearing hydrocolloid dressing can provide closed environment, is conducive to macrophage and removes necrotic tissue, therefore hydrocolloid also has debridement function
Energy.In an embodiment of the present invention, hydrocolloid may include elastomer, hydrophilic macromolecule, tackifier and extension agent.
The effect of elastomer mainly forms and provides stickiness and flexibility etc..Because elastomer is hydrophobic structure, by bullet
Property body coat NaHS, can avoid NaHS directly contacts with water, therefore can slow down and regulate and control the rate of release of hydrogen sulfide.It is suitable
The elastomer of conjunction may, for example, be styrene-isoprene-phenylethene (SIS) copolymer, s-B-S
(SBS) copolymer, styrene-(Ethylene/Butylene)-styrene (SEBS) copolymer, styrene-(ethylene-propylene)-styrene
(SEPS) any of or a combination of copolymer, but not limited to this.
Hydrophilic macromolecule has the ability for absorbing liquid, and will not dissolve after absorbing sepage due to cross-linked structure
But be swollen, therefore can be used to provide water imbibition.Workable hydrophilic macromolecule may include natural, semi-synthetic or synthesis
Hydrophilic macromolecule.Natural hydrophilic macromolecule can for example including polysaccharide macromolecule for example pectin, Arabic gum, guar gum,
Agar, starch, xanthan gum, glucan etc.；With protein or polypeptide macromolecule such as gelatin, albumin, casein etc..It is semi-synthetic
Hydrophilic macromolecule can be for example including carboxymethyl cellulose, sodium carboxymethylcellulose, methylcellulose, ethyl cellulose, hydroxyl
Ethyl cellulose, hydroxypropyl cellulose, methylhydroxypropylcellulose, sodium alginate, carboxymethyl starch etc..The hydrophily of synthesis is high
Molecule can be for example including acrylic polymer (such as polyacrylic acid and polyacrylamide), polyvinyl alcohol, polyvinylpyrrolidone
Ketone, polyethylene glycol, polyvinyl methyl ether etc..In the preferred embodiment, hydrophilic macromolecule can be carboxymethyl
Sodium cellulosate, hydroxyethyl cellulose, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, locust bean gum, collagen
At least one of albumen and karaya gum or combinations thereof, but not limited to this.When the additive amount of hydrophilic macromolecule is excessive
The rate of water absorption of hydrocolloid may be made excessively high thus keep the rate of release of hydrogen sulfide gas too fast and cause cytotoxicity.When hydrophilic
Property high molecular additive amount it is very few when then may make the rate of release mistake of hydrogen sulfide gas because the rate of water absorption of hydrocolloid is excessively slow
It is low and wound healing can not be effectively facilitated.
Tackifier can be used to further adjust the stickiness of hydrocolloid.Suitable tackifier can be rosin resin, terpenes tree
At least one of rouge, C5 Petropols, C9 Petropols and high-purity bicyclopentadiene (H-DCPD) or combinations thereof.
Extension agent can provide wetting action and/or viscosity control.Suitable extension agent can be mineral oil, atoleine,
At least one of castor oil, dibutyl phthalate, lanolin and naphthenic oil or combinations thereof.
In an embodiment of the present invention, the elastomer of hydrocolloid can be 10 to 30 parts by weight, and hydrophilic macromolecule can be 20
To 60 parts by weight, tackifier can be 20 to 60 parts by weight, and extension agent can be 2 to 20 parts by weight.
In another embodiment of the invention, hydrocolloid is also selectively included the antioxidant of 0.2 to 2 parts by weight,
Characteristic changing is caused to avoid elastomer degradation.Suitable antioxidant can be hindered phenol, sulfur synergist
(thiosynergists), phosphite ester (phosphites) or second level aromatic amine (secondary aromatic amines).
Hydrophilic macromolecule is scattered in elastomer, and by addition interfacial agent, water-wet side can make hydrocolloid surface
It is infiltrated after meeting water, enable hydrophilic macromolecule Peng Run and absorbs sepage, and hydrone is promoted to penetrate into hydrophobic elastomer
In.Therefore by the ratio of adjustment hydrophilic macromolecule and interfacial agent, it can make hydrocolloid that there is different rate of water absorption,
And the NaHS being coated in hydrocolloid is set to have different hydrogen sulfide rates of release with rate of water absorption in turn.Of the invention
In embodiment, interfacial agent can be polysorbate80, polysorbate20, polysorbate60 or polysorbate40.
It may make the rate of liquid aspiration of hydrocolloid too fast when the additive amount of interfacial agent is excessive and make the release concentration mistake of hydrogen sulfide
It is high.It may then make the rate of liquid aspiration of hydrocolloid excessively slow when the additive amount of interfacial agent is very few and influence the release of hydrogen sulfide
Speed.
Another embodiment of the present invention is to provide a kind of manufacturing method of hydrogen sulfide sustained release dressing, and step may include but not
It is limited to following step.
Firstly, in step (a), heating stirring hydrocolloid material.In the embodiment of the manufacturing method of the present invention, glue
Body material can be 60 to 140 parts by weight, hydrocolloid material can for example it is aforementioned comprising elastomer, hydrophilic macromolecule, tackifier with
And extension agent.In the preferred embodiment of the manufacturing method of the present invention, the heating temperature in step (a) can be between 100 DEG C extremely
Between 200 DEG C, heating time can be between 1 hour to 1.5 hours.
Then, in step (b), interfacial agent and NaHS are added in hydrocolloid material.Interfacial agent
Additive amount can be 0.2 to 2 parts by weight, and the additive amount of NaHS can be 0.1 to 0.5 parts by weight.In manufacture of the invention
In the preferred embodiment of method, it can further include and be heated in step (b), heating temperature can be between 100 DEG C to 150 DEG C
Between, heating time can be between 15 minutes to 45 minutes.
Finally, in step (c), by the hydrocolloid material injection moulding mold containing interfacial agent and NaHS
In it is hot-forming with formed hydrogen sulfide sustained release dressing.Hot pressing temperature can be for example between 50 DEG C to 100 DEG C.
Following embodiments are for further illustrating the present invention, but the present invention is not intended to be limited thereto.
Embodiment
Embodiment 1
Take 15.4 grams styrene-isoprene-phenylethene (SIS) copolymer (Kraton D1161, be purchased from Kraton,
The U.S.), 36.55 grams of C9 modification resin (Wingtack 86 is purchased from CRAY VALLEY, the U.S.), 6.4 grams of mineral oil
(Kaydol white mineral oil is purchased from Sonneborn, the U.S.) and 1 gram of (3, the 5- di-t-butyl -4- of hindered phenol four
Hydroxyl) benzenpropanoic acid pentaerythritol ester (Chinox 1010 is purchased from double bond chemical industry, Taiwan) in 180 DEG C stirs 60 in a nitrogen environment
Minute, after being then cooled to 120 DEG C, be added 40 grams of sodium carboxymethylcellulose, 0.5 gram of interfacial agent Tween 80 and
Hot-forming at 90 DEG C in mold, formation hydrogen sulfide sustained release dressing is poured into 0.15 gram of NaHS, stirring after ten minutes.
Embodiment 2
The step of embodiment 2 and material are same as embodiment 1, replace 36.55 grams in addition to using 36.5 grams of C9 to modify resin
C9 modification resin and replace 0.15 gram of NaHS with 0.2 gram of NaHS.
Embodiment 3
The step of embodiment 3 and material are same as embodiment 1, the styrene-isoprene-phenylethene in addition to using 15.3 grams
(SIS) copolymer replaces 15.4 grams styrene-isoprene-phenylethene (SIS) copolymer, modifies resin with 36.3 grams of C9
Replace 36.55 grams of C9 modification resin and replaces 0.15 gram of NaHS with 0.5 gram of NaHS.
Embodiment 4
The step of embodiment 4 and material are same as embodiment 1, styrene-isoprene-benzene second in addition to using 17.93 grams
Alkene (SIS) copolymer is replaced 15.4 grams styrene-isoprene-phenylethene (SIS) copolymer, is modified with 42.59 grams of C9
Resin replaces 36.55 grams of C9 modification resin, replaced with 30 grams of sodium carboxymethylcellulose 40 grams of sodium carboxymethylcellulose with
And with the NaHS of 0.5 gram of 0.15 gram of NaHS substitution.
Comparative example 1
The step of comparative example 1 and material are same as embodiment 1, the styrene-isoprene-phenylethene in addition to using 15.2 grams
(SIS) copolymer is replaced 15.4 grams styrene-isoprene-phenylethene (SIS) copolymer, is taken with 36 grams of C9 modification resin
The C9 in 36.55 grams of generation is modified resin and is replaced 0.15 gram of NaHS with 1 gram of NaHS.
The hydrogen sulfide rate of release of the hydrogen sulfide sustained release dressing of embodiment 1-4 and comparative example 1 is measured with methylene blue laws.
Firstly, preparing the standard items of known concentration, calibration curve is made.Calibration curve making step is as follows, and first configuration contains
500 μ L phosphate buffer solutions (pH=7.4) of 0.04mg/mL NaHS, and serial dilution is the standard items of each concentration, and quasi-
The standby phosphate buffer solution for not containing NaHS.Take the 1.0wt% zinc acetate of each 100 μ L of standard items and 100 μ L water-soluble respectively
After liquid mixing, the N, N- dimethyl-Isosorbide-5-Nitrae-phenylenediamine sulphate (N, N- for being 20mM containing concentration of 20 μ L is added
Dimethyl-p-phenylenediamine sulfate) and concentration be 7.2N hydrochloride aqueous solution, with containing for 20 μ L
Concentration is the iron chloride (FeCl of 30mM3) and concentration be 1.2N hydrochloride aqueous solution after, react 10 minutes.Because iron chloride is made
For oxidant, it can be catalyzed N, product hydrogen sulfide of the N- dimethyl-after Isosorbide-5-Nitrae-phenylenediamine sulphate is dissolved in water with NaHS reacts
Methylene blue is generated, therefore measures absorption intensity of the methylene blue of each standard items at wavelength 670nm, calibration curve can be established,
And calibration curve it can push back concentration of hydrogen sulfide according to this.Then, the dressing of embodiment 1-4 and comparative example 1 is placed in the phosphorus of 1500 μ L
In acid buffering solution, 2 hours, 4 hours, 6 hours, 8 hours, 18 hours, 24 hours, 42 hours and 48 hours are stood respectively
Afterwards, 100 μ L are taken out and impregnated the phosphate buffer solution of dressing, add zinc acetate aqueous solution that 100 μ L concentration are 1.0wt%,
The N, N- dimethyl -1,4- phenylenediamine sulphate (N, N-dimethyl-p- for being 20mM containing concentration of 20 μ L
Phenylenediamine sulfate) and concentration be the hydrochloride aqueous solution of 7.2N, containing concentration be 30mM with 20 μ L
Iron chloride (FeCl3) and concentration be 1.2N hydrochloride aqueous solution, react 20 minutes.The methylene of each solution is measured later
Absorption intensity of the indigo plant at wavelength 670nm, it is dense with hydrogen sulfide of the anti-each dressing for pushing away Examples and Comparative Examples under different time
Degree.Shown in list that test result is as follows 1.
Table 1: the test result of embodiment 1 to 4 and comparative example 1
The hydrogen sulfide as obtained by embodiment 1 to 4 be sustained dressing, can in 24 hours effective slow release stink damp
Body and be less than safe handling concentration, especially the hydrogen sulfide of embodiment 2 and embodiment 3 sustained release dressing more can the extended release time extremely
48 hours.And concentration of hydrogen sulfide of hydrogen sulfide sustained release dressing during release of comparative example 1 is higher than 1300 μM, though also can be long when
Between discharge hydrogen sulfide gas but be more than hydrogen sulfide safe handling concentration.In conclusion the present invention provides a kind of novel
Hydrogen sulfide is sustained dressing and its manufacturing method, and it includes hydrocolloid, interfacial agent and NaHS that hydrogen sulfide, which is sustained dressing,.Water
Colloid includes elastomer, hydrophilic macromolecule, tackifier and extension agent.By adjustment hydrocolloid in hydrophilic macromolecule and
The ratio of interfacial agent can make hydrocolloid have different rate of water absorption, and in turn hydrogenate the sulphur being coated in hydrocolloid
Sodium has different hydrogen sulfide rates of release with rate of water absorption, so as to slowly discharge hydrogen sulfide without generating cell toxicant
Property, therefore the healing of chronic wounds can be effectively facilitated.
By the above detailed description of preferred embodiments, it is intended to more clearly describe feature and spirit of the invention,
And not protection scope of the present invention is limited with above-mentioned disclosed preferred embodiment.On the contrary, its purpose
It is intended to cover various changes and has being arranged in the scope of protection of the claims of the invention to be applied of equality.Cause
This, scope of protection of the claims of the invention should illustrate the most wide explanation of work according to above-mentioned, to cause it to cover institute
Possible change and the arrangement of tool equality.
Claims (15)
1. a kind of hydrogen sulfide is sustained dressing, which is characterized in that hydrogen sulfide sustained release dressing includes:
Hydrocolloid；
Interfacial agent；And
NaHS.
2. hydrogen sulfide as described in claim 1 is sustained dressing, which is characterized in that hydrocolloid is 60 to 140 parts by weight, the interface
Activating agent is 0.2 to 2 parts by weight, and the NaHS is 0.1 to 0.5 parts by weight.
3. hydrogen sulfide as described in claim 1 is sustained dressing, which is characterized in that the interfacial agent be polysorbate80,
Polysorbate20, polysorbate60 or polysorbate40.
4. hydrogen sulfide as described in claim 1 is sustained dressing, which is characterized in that the hydrocolloid includes:
Elastomer；
Hydrophilic macromolecule；
Tackifier；And
Extension agent.
5. hydrogen sulfide as claimed in claim 4 is sustained dressing, which is characterized in that the elastomer is 10 to 30 parts by weight, the parent
Aqueous high molecular is 20 to 60 parts by weight, which is 20 to 60 parts by weight, and the extension agent is 2 to 20 parts by weight.
6. hydrogen sulfide as claimed in claim 4 is sustained dressing, which is characterized in that the elastomer includes at least one of following:
Styrene-isoprene-phenylethene (SIS) copolymer, s-B-S (SBS) copolymer, styrene-(second
Alkene-butylene)-styrene (SEBS) copolymer and styrene-(ethylene-propylene)-styrene (SEPS) copolymer.
7. hydrogen sulfide as claimed in claim 4 is sustained dressing, which is characterized in that the hydrophilic macromolecule include it is below at least
One of: sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium alginate, gelatin, pectin, carboxymethyl chitosan, guar gum, thorn
Locust bean gum, collagen and karaya gum.
8. hydrogen sulfide as claimed in claim 4 is sustained dressing, which is characterized in that the tackifier includes at least one of following:
Rosin resin, terpene resin, C5 Petropols, C9 Petropols and high-purity bicyclopentadiene (H-DCPD).
9. hydrogen sulfide as claimed in claim 4 is sustained dressing, which is characterized in that the extension agent includes at least one of following:
Mineral oil, atoleine, castor oil, dibutyl phthalate, lanolin and naphthenic oil.
10. hydrogen sulfide as described in claim 1 is sustained dressing, which is characterized in that the hydrocolloid also includes 0.2 to 2 parts by weight
Antioxidant.
11. hydrogen sulfide as claimed in claim 10 is sustained dressing, which is characterized in that the antioxidant is hindered phenol, sulphur synergy
Agent (thiosynergists), phosphite ester (phosphites) or second level aromatic amine (secondary aromatic
amines)。
12. a kind of manufacturing method of hydrogen sulfide sustained release dressing, which is characterized in that this method includes:
(a) heating stirring hydrocolloid material；
(b) interfacial agent and NaHS are added in the hydrocolloid material；And
(c) by the hydrocolloid material injection moulding mold containing the interfacial agent and the NaHS it is hot-forming with
It forms hydrogen sulfide and is sustained dressing.
13. manufacturing method as claimed in claim 12, which is characterized in that the hydrocolloid material is 60 to 140 parts by weight, the boundary
Face activating agent is 0.2 to 2 parts by weight, and the NaHS is 0.1 to 0.5 parts by weight.
14. manufacturing method as claimed in claim 12, which is characterized in that the heating temperature in the step (a) between 100 DEG C extremely
Between 200 DEG C, and heating time is between 1 hour to 1.5 hours.
15. manufacturing method as claimed in claim 12, which is characterized in that also include in the step (b): to living containing the interface
The hydrocolloid material of property agent and the NaHS is heated, wherein heating temperature between 100 DEG C to 150 DEG C it
Between, heating time is between 15 minutes to 45 minutes.
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| CN113679874A (en) * | 2021-09-03 | 2021-11-23 | 明基材料有限公司 | Multi-segment release dressing |
| TWI752666B (en) * | 2020-10-05 | 2022-01-11 | 明基材料股份有限公司 | Composition for promoting wound healing and manufacturing method thereof |
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| JPWO2020262054A1 (en) * | 2019-06-28 | 2020-12-30 | ||
| JP7262065B2 (en) | 2019-06-28 | 2023-04-21 | 国立研究開発法人物質・材料研究機構 | Skin wound prevention and/or skin wound healing composition |
| CN114072156A (en) * | 2019-06-28 | 2022-02-18 | 国立研究开发法人物质·材料研究机构 | Construct for preventing and/or treating skin wound |
| CN112263777A (en) * | 2020-08-04 | 2021-01-26 | 北京工业大学 | Hydrogen molecule slow-release composite dressing and preparation method thereof |
| US11583503B2 (en) | 2020-10-05 | 2023-02-21 | Benq Materials Corporation | Composition for promoting wound healing and preparing method thereof |
| TWI752666B (en) * | 2020-10-05 | 2022-01-11 | 明基材料股份有限公司 | Composition for promoting wound healing and manufacturing method thereof |
| CN112516367A (en) * | 2020-10-27 | 2021-03-19 | 明基材料（芜湖）有限公司 | Composition for promoting wound healing and preparation method thereof |
| CN112274531A (en) * | 2020-11-19 | 2021-01-29 | 徐州医科大学 | Preparation method of hydrogen sulfide sustained-release gel and application of hydrogen sulfide sustained-release gel in preparation of medicine for treating diabetic skin ulcer |
| CN112274531B (en) * | 2020-11-19 | 2022-04-15 | 徐州医科大学 | Preparation method of hydrogen sulfide sustained-release gel and application of hydrogen sulfide sustained-release gel in preparation of medicine for treating diabetic skin ulcer |
| CN113679874B (en) * | 2021-09-03 | 2022-07-22 | 明基材料有限公司 | Multi-segment release dressing |
| CN113679874A (en) * | 2021-09-03 | 2021-11-23 | 明基材料有限公司 | Multi-segment release dressing |
| CN114099419A (en) * | 2021-11-19 | 2022-03-01 | 苏州大学 | Sodium hydrosulfide-loaded injectable nano-fibrosis hydrogel and preparation method and application thereof |
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| CN109793919B (en) | 2022-01-14 |
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