CN1352974A - Nerve receptor excitomotor - Google Patents
Nerve receptor excitomotor Download PDFInfo
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- CN1352974A CN1352974A CN 00133435 CN00133435A CN1352974A CN 1352974 A CN1352974 A CN 1352974A CN 00133435 CN00133435 CN 00133435 CN 00133435 A CN00133435 A CN 00133435A CN 1352974 A CN1352974 A CN 1352974A
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- nerve receptor
- nerve
- part radix
- excitomotor
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Abstract
A nerve receptor excitant for treating infantile cerebroplegia, brain injury sequela and lumbar intervertebral disk protrusion by exciting human factors is prepared from 9 Chinese medicinal materials including lycopodium, Chinese angelica root, red peony root, astragalus root, red sage root, etc.. Its advantages include high curative effect, quickly taking its effect, low cost and little by-effect.
Description
The present invention relates to a kind of medicine for external use for the treatment of function of nervous system, particularly nerve receptor excitomotor.
The problem of neuroreceptor aspect is that many in the world medical experts and scholars want the difficult medical problem of capturing.Existing neurological disease such as cerebral palsy, cerebral trauma sequela, prolapse of lumbar intervertebral disc, rheumatoid etc.Disease is more thorny on existing traditional therapy medically at present, and for example children's's cerebral palsy makes to occur central paralysis in the infancy stage, can be unusual with mental retardation, convulsions, epilepsy, dystropy, disturbance of perception and other.At present above-mentioned disease is not still had effective Therapeutic Method, on medical literature, also do not have the record of Therapeutic Method.Prolapse of lumbar intervertebral disc and for example, general just massage treatment is to alleviate the state of an illness at that time, but the state of an illness there is not benefit from long-range, have both allow to the treatment, cost that patient spent and risk are all than higher, can treat by performing the operation as prolapse of lumbar intervertebral disc, but the treatment difficulty is that very large therapeutic process is also very painful, cure rate is lower, in addition, general treatment all is to utilize external factor to cure the disease, as has an injection, massages, takes medicine, but have an injection, taking medicine has side effect to human body.
The purpose of this invention is to provide a kind of medicine for external use for the treatment of function of nervous system is nerve receptor excitomotor, receptor refers generally to some the special part on postsynaptic membrane or the effector lymphocyte, its chemical nature belongs to protein, some drugs both can with receptors bind, can excite the function of receptor again, be called receptor stimulating agent.The difficulty that it exists in the time of solving the above-mentioned disease of treatment, it can utilize the human body self factor to cure the disease, from human external with efficacy of a drug osmosis to the inside of human body site of disease, it is enhanced vigour the human body factor excitement of site of disease, low, the instant effect of its treatment difficulty, treatment cost is low, and patient is subjected to or suffer not less during treatment, and the treatment risk is little.
The objective of the invention is to realize by following technical scheme.
Nerve receptor excitomotor of the present invention is made of by weight proportion following component:
Lycopodium clavatum 20-26 part Radix Angelicae Sinensis 22-26 part Radix Paeoniae Rubra 22-26 part
Radix Astragali 22-26 part Herba speranskiae tuberculatae 22-26 part Radix Clematidis 22-26 part
Radix Salviae Miltiorrhizae 20-26 part Radix Polygoni Multiflori 8-14 part nicotine 0.020-0.03 part
In said components, with Lycopodium clavatum, nicotine is key component, be equipped with other component for auxiliary, wherein the main component of Lycopodium clavatum is a choline, and effect is to make the neurotransmitter excitement, the material of transmission, nicotine produces excitation to the neuroreceptor of the neural joint of skeletal muscle, promotes the transmission of impulsion, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, has promoting blood circulation to remove blood stasis regulating menstruation blood and acts on bitterly, the Radix Astragali, Radix Polygoni Multiflori have QI invigorating invigorating the liver and kidney effect, and Radix Clematidis, Herba speranskiae tuberculatae have the effect of the removing dampness of dispeling the wind dredge the meridian passage.The present invention spreads on the illing skin outside outward with each set of dispense integrator, and by the drug osmotic effect, the messenger drug masterpiece is used the affected part.Mainly act on preceding fiber of sympathetic nerve and parasympathetic ganglion and skeletal muscle movement nerve, it both can discharge acetylcholine by excited parasympathetic nervous, also can exciting sympathetic nerves discharge norepinephrine.The receptor acting of this agonist and disease sites, make the calcium channel that links with receptor open, cause calcium ion to enter in the cell, cause that cell discharges multiple neurotransmitter, the performance physiological effect, cell activity enhancing, the irritability of raising human nerve, muscle, the function of each organ of raising human body, thereby raising organism ability, and promote diseased cells to recover homergy, and reparative regeneration, thus reach the effect of curing the disease.
This therapy is by percutaneous drug delivery, safety, reliable, no pain, is easy to grasp, and patient part is had stronger affinity interaction.
The method for production of agonist of the present invention is:
1, gets the raw materials ready.Nicotine is got ready, other each raw material is screened, remove impurity, by prescription
The regulation share is got ready.
2, water is carried.With in the raw material except that nicotine, be added in the water by prescription requirements, press decocting method decoction
Three times, boil the back at every turn and kept 30 minutes, the elimination slag concentrates medicinal liquid and sinks to the bottom.
3, freezing, concentrated solution is freezing, and then, pour out supernatant with 2/3 thawing of freezing liquid top
And adding nicotine, stir, be required medicinal liquid.
4, fill.With medicinal liquid bottling sealing, the autoclave sterilization sterilization medicament that gets product.This medicament makes
Time spent smears it on the affected part surface skin, passes through percutaneous drug delivery.
In sum, the present invention adopts nicotine, Lycopodium clavatum and other blood circulation promoting and blood stasis dispelling, wind-expelling pain-stopping, invigorating the liver and kidney medicine to be mixed with can reach therapeutic purposes to the human nerve receptor activation, and its treatment is simple and convenient, expense is low, and patient is painful few, and risk is little.The present invention mainly produces following effect clinically: make nerve, skeletal muscle, smooth muscle excitement, glandular secretion increases, and myocardial contraction, little vasoconstriction power are strengthened.Can treat spastic cerebral palsy, mental retardation, cerebral trauma sequela, nervous vascular Headache, neurosis, prolapse of lumbar intervertebral disc, femur head necrosis, various nerves, muscle disease etc.
Specifically introduce the present invention with embodiment below.
The present invention was the clinical use of preparation name with the cerebral palsy liniment once, and the treatment children cerebral palsy is respond well.
Embodiment:
One, prescription
Lycopodium clavatum 2.4kg Radix Angelicae Sinensis 2.3kg Radix Paeoniae Rubra 2.3kg
Radix Astragali 2.5kg Herba speranskiae tuberculatae 2.6kg Radix Clematidis 2.6kg
Radix Salviae Miltiorrhizae 2.6kg Radix Polygoni Multiflori 1kg nicotine 2.3g
Two, method for production:
1, gets the raw materials ready.By prescription nicotine is got ready, with other each component raw material screening, clean, removal
Impurity.
2, water is carried.In each component of raw material, remove other outer component of nicotine also with 25kg water logging bubble
Boil three times, kept 30 minutes at every turn, the elimination slag concentrates medicinal liquid, precipitate.
3, freezing, concentrated solution is freezing, then freezing liquid top 2/3 is melted, pour out supernatant,
Add nicotine in containing 0.25 milligram of nicotine ratio in every milliliter of supernatant, stir, promptly
Be required liquid preparation.
4, fill.With liquid preparation bottling sealing, the autoclave sterilization sterilization medicament that gets product.
Medicament of the present invention is through animal experiment, and conclusion is: smearing nerve receptor excitomotor of the present invention at mouse skin, is maximum dose level 60ml/kg, observes 7 days, and no dead mouse is so its LD50 affirms that this dosage is higher 120 times than clinical consumption 0.5ml/kg greater than 60ml/kg.
Nerve fires agent of the present invention was once accepted CP children 238 examples, total effective rate 98.55%, obvious effective rate 64.25%, effective percentage 34.3% with preparation cerebral palsy liniment by name for medical treatment in Beijing and Shijiazhuang altogether.Illustrate that nerve receptor excitomotor of the present invention is that clinical effectiveness is better, and is especially more remarkable to spasm type patient treatment effect at a kind of new medicine of treatment cerebral palsy pathomechanism.Nerve fires agent of the present invention also can be treated diseases such as cerebral trauma sequela, nervous headache, prolapse of lumbar intervertebral disc, femur head necrosis, rheumatoid, soft tissue injury according to its treatment pathology, now just studies in the enforcement.
Claims (3)
1, nerve receptor excitomotor is characterized in that: it is made of by weight proportion following component:
Lycopodium clavatum 20-26 part Radix Angelicae Sinensis 22-26 part Radix Paeoniae Rubra 22-26 part
Radix Astragali 22-26 part Herba speranskiae tuberculatae 22-26 part Radix Clematidis 22-26 part
Radix Salviae Miltiorrhizae 20-26 part Radix Polygoni Multiflori 8-14 part nicotine 0.020-0.03 part
2, nerve receptor excitomotor according to claim 1 is characterized in that: described nerve receptor excitomotor is a water preparation.
3, nerve receptor excitomotor according to claim 2 is characterized in that: described nerve receptor excitomotor is used for the treatment of children cerebral palsy disease through skin external application administration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00133435 CN1352974A (en) | 2000-11-06 | 2000-11-06 | Nerve receptor excitomotor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00133435 CN1352974A (en) | 2000-11-06 | 2000-11-06 | Nerve receptor excitomotor |
Publications (1)
Publication Number | Publication Date |
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CN1352974A true CN1352974A (en) | 2002-06-12 |
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ID=4595714
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CN 00133435 Pending CN1352974A (en) | 2000-11-06 | 2000-11-06 | Nerve receptor excitomotor |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1889906B (en) * | 2003-12-10 | 2010-12-01 | 金伯利-克拉克环球有限公司 | Interlabial absorbent article with improved flushability characteristics |
CN108567855A (en) * | 2018-07-09 | 2018-09-25 | 张春枝 | Treat the Chinese medicine of brain paralysis |
CN111317769A (en) * | 2020-04-20 | 2020-06-23 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in treatment of postoperative complications of arthroscopic surgery |
-
2000
- 2000-11-06 CN CN 00133435 patent/CN1352974A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1889906B (en) * | 2003-12-10 | 2010-12-01 | 金伯利-克拉克环球有限公司 | Interlabial absorbent article with improved flushability characteristics |
CN108567855A (en) * | 2018-07-09 | 2018-09-25 | 张春枝 | Treat the Chinese medicine of brain paralysis |
CN111317769A (en) * | 2020-04-20 | 2020-06-23 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in treatment of postoperative complications of arthroscopic surgery |
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PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |