CN1108809C - Medicine for treating leukoderma and preparing process thereof - Google Patents
Medicine for treating leukoderma and preparing process thereof Download PDFInfo
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- CN1108809C CN1108809C CN 99101473 CN99101473A CN1108809C CN 1108809 C CN1108809 C CN 1108809C CN 99101473 CN99101473 CN 99101473 CN 99101473 A CN99101473 A CN 99101473A CN 1108809 C CN1108809 C CN 1108809C
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Abstract
The present invention relates to a new medicine for treating vitiligo. Red sage root, psoralea and white puncturevine are used as raw materials; the red sage root, the psoralea and the white puncturevine are decocted in water for three times, and the decoction times are respectively 2 hours, 1 hour and 1 hour; decocted liquid is combined and is concentrated to the ratio of 2: 1; ethanol is added for precipitating the decocted liquid twice, wherein the alcohol content is 75% in the first time and is 85% in the second time, and the decocted liquid is refrigerated and statically placed for 24 hours in each time; next, the decocted liquid is filtered to recover the alcohol, and injecting water is added for the fine filtration of the decocted liquid until the decocted liquid is clear; finally, the decocted liquid is subpackaged and sterilized. The medicine for treating vitiligo has the advantages of activating blood circulation, dissipating blood stasis, nourishing the liver and the kidney, promoting blood circulation, removing diseases, regulating breath and blood, and promoting the growth of melanin histiocyte. The total effective rate of the medicine reaches 98% through clinical application.
Description
The present invention relates to the leukodermic medicine of a kind of treatment, specifically is the injection agent of raw material through the extraction preparation with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Vitiligo is a kind of common hypopigmentation's dermatoses, and is more with the teenager sickness rate.The cause of disease of primary disease is comparatively complicated, and the traditional Chinese medical science is thought at present: because the rheumatism heresy is gone into fur, ailment said due to cold or exposure is attacked skin, and is qi-blood disharmony, skin losing its nutrition and due to.Doctor trained in Western medicine is then thought: trace element deficiency, reduce as copper, zinc, ferrum plasma.Perhaps endocrine disturbance, hypophysis cerebri divides must melanocyte to stimulate and is controlled.Perhaps inherited genetic factors and immunologic function degression produce antibody to the melanin system.Also have neural factor, as the thin dysfunction of god, nerve does not divide slightly and must destroy melanocyte by chemokines, controls the activity that melanin produced or disturbed cheese ammonia enzyme.Another is that modern environment pollutes, as the influence of harmful substances such as phenolate to human body.
Vitiligo is sent out in the exposure portion that is rubbed well, is common in head, face amount, cervical region, trunk, extremity, macule and mostly is white, and the form size is flat one, and the upright or symmetry of arc distributes no conscious sympton, no infectiousness.
On therapy of vitiligo, encounter a difficulty at present, adopt Western medicine " BAILING PIAN " treatment, this medicine contains the hormone composition, and side effect is big, unsuitable life-time service.And do not have pure Chinese medicinal preparation to treat leukoderma on the existing market.
The purpose of this invention is to provide a kind of Chinese medicine injection, adopt blood circulation promoting and blood stasis dispelling, nourishing liver and kidney, expelling wind and clearing away heat, promote QI and blood to be in harmonious proportion, liver and kidney tonifying strengthens the growth of melanin histiocyte.
Another object of the present invention provides the preparation method of this therapy of vitiligo medicine.
Solution of the present invention is a utilization motherland theory of medicine, with strengthening the body resistance, QI and blood regulating, liver and kidney tonifying, the growth of enhancing melanin histiocyte, recovers the medicine of normal skin color.
Medicine of the present invention is made (consumption is a weight portion) by following component:
Radix Salviae Miltiorrhizae 10-3 part Fructus Psoraleae 20-60 part Fructus Atriplicis Sibiricae 20-60 part
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Radix Salviae Miltiorrhizae 15-25 part Fructus Psoraleae 30-50 part Fructus Atriplicis Sibiricae 30-50 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 40 parts of Fructus Atriplicis Sibiricaees of 20 parts of Fructus Psoraleaes of Radix Salviae Miltiorrhizae
The present invention treats leukodermic medicine, and its said medicament is an injection.
Above-mentioned each component is made medicine production method of the present invention is:
Radix Salviae Miltiorrhizae 150 gram Fructus Psoraleaes 300 gram Fructus Atriplicis Sibiricaees 300 grams
Get above-mentioned three flavor medical materials, add 1500 milliliters in water, decocted 2 hours, get decocting liquid, add water again and decocted 1 hour for 1500 milliliters, get decocting liquid, add water again and decocted 1 hour for 1500 milliliters, get decocting liquid, merge three times decocting liquid, be condensed into 2: 1, use the ethanol precipitation secondary, contain for the first time alcohol amount 75%, contain alcohol amount 85% for the second time, after each all cold preservation standing over night, filter, reclaim ethanol, add injection water to 1000 milliliter, fine straining is to clear and bright, and packing is sterilized.
In the raw material of the present invention, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; Fructus Psoraleae, nourishing liver and kidney; Fructus Atriplicis Sibiricae, promoting blood circulation by removing wind, three have share interaction, promote QI and blood to be in harmonious proportion, liver and kidney tonifying, blood circulation promoting and blood stasis dispelling strengthens the growth of melanin histiocyte.
Medicine of the present invention is observed through 207 routine patient treatments, male's 101 examples wherein, women's 106 examples, 3 years old to 59 years old age, the course of disease 1 month to 30 years.Occupation: workman 58 people, peasant 23 people, cadre 33 people, commercial 8 people, student 65 people, teacher 3 people, soldier 5 people, child 12 people.
Medicine of the present invention is to the Therapeutic Method of patients with vitiligo, get this injection and use intramuscular injection, 1-2 time on the one, one time 2 milliliters.20 is a course of treatment, has a rest ten, carries out second course of therapy again.Criterion of therapeutical effect: complete, local pigment recovers fully, and white macula all disappears; Produce effects, the area that recovers for pigment surpasses 50%; Effectively, for part skin lesion pigment recovers, but do not surpass 40%; Invalid, be local no change, the white macula diffusion.Therapeutic outcome, in 207 routine patients, complete more 84 examples of treatment, produce effects 81 examples, effective 41 examples, invalid 1 example, total effective rate reaches 98%, treat effective patient and treating 2 months with the interior pigment that occurs mostly, patient's curative effect of course of disease weak point is remarkable relatively, does not see other side effect during the injection.
The present invention adds and uses strengthening the body resistance on the basis of general treatment by Chinese herbs rule, blood circulation promoting and blood stasis dispelling, and QI and blood regulating strengthens the Drug therapy vitiligo that the melanin histiocyte is grown.
The present invention prepares embodiment;
Take by weighing raw material by following proportioning:
Radix Salviae Miltiorrhizae 150 gram Fructus Psoraleaes 300 gram Fructus Atriplicis Sibiricaees 300 grams
Production method is as follows:
Get above three flavor medicines, adding water with each 1: 2 is that the every gram of medicine adds 2 milliliters in water, decocts three times, be respectively 2: 1: 1 hours, collecting decoction was condensed into 2: 1, with ethanol precipitation 2 times, contain alcohol amount 75% for the first time, be 85% for the second time, each all cold preservation standing over night filter, and reclaim ethanol, add injection water to 1000 milliliter, fine straining is clear and bright, packing (making injection), sterilization.This product is the conventional injection preparation technology of water extract-alcohol precipitation, because decocting liquid contains tannin, resin, pigment, glycoside unit, high dense ethanol precipitation is removed impurity, comes out but fat-soluble composition is also precipitated, should not repeatedly precipitate, to guarantee the medicine active ingredient.
Claims (5)
1, the leukodermic medicine of a kind of treatment is characterized in that it is the medicament of being made by the following weight proportion raw material
Radix Salviae Miltiorrhizae 10-30 part Fructus Psoraleae 20-60 part Fructus Atriplicis Sibiricae 20-60 part.
2, the leukodermic medicine of treatment as claimed in claim 1, wherein the weight proportion of each raw material is
Radix Salviae Miltiorrhizae 15-25 part Fructus Psoraleae 30-50 part Fructus Atriplicis Sibiricae 30-50 part.
3, the leukodermic medicine of treatment as claimed in claim 1, wherein the weight proportion of each raw material is
40 parts of 40 parts of Fructus Atriplicis Sibiricaees of 20 parts of Fructus Psoraleaes of Radix Salviae Miltiorrhizae.
4, as claim 1 or the leukodermic medicine of 2 or 3 described treatments, it is characterized in that said medicament is an injection.
5, the leukodermic process for preparing medicine of treatment as claimed in claim 4 is characterized in that
Radix Salviae Miltiorrhizae 150 gram Fructus Psoraleaes 300 gram Fructus Atriplicis Sibiricaees 300 grams
Get above-mentioned three flavor medical materials, add 1500 milliliters in water, decocted 2 hours, get decocting liquid, add water again and decocted 1 hour for 1500 milliliters, get decocting liquid, add water again and decocted 1 hour for 1500 milliliters, get decocting liquid, merge three times decocting liquid, be condensed into 2: 1, use the ethanol precipitation secondary, contain for the first time alcohol amount 75%, contain alcohol amount 85% for the second time, after each all cold preservation standing over night, filter, reclaim ethanol, add injection water to 1000 milliliter, fine straining is to clear and bright, and packing is sterilized.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99101473 CN1108809C (en) | 1999-02-26 | 1999-02-26 | Medicine for treating leukoderma and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99101473 CN1108809C (en) | 1999-02-26 | 1999-02-26 | Medicine for treating leukoderma and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1264590A CN1264590A (en) | 2000-08-30 |
| CN1108809C true CN1108809C (en) | 2003-05-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99101473 Expired - Fee Related CN1108809C (en) | 1999-02-26 | 1999-02-26 | Medicine for treating leukoderma and preparing process thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1108809C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461598A (en) * | 2013-09-24 | 2013-12-25 | 北京绿源求证科技发展有限责任公司 | Food health tea granule for improving leucoderma |
| CN103493933A (en) * | 2013-10-15 | 2014-01-08 | 北京绿源求证科技发展有限责任公司 | Healthcare food-made tea granules for improving leucoderma |
| CN104474195A (en) * | 2014-12-24 | 2015-04-01 | 上海市徐汇区中心医院 | Traditional Chinese medicine compound preparation for treating leucoderma and preparation method of traditional Chinese medicine compound preparation |
| CN107569532A (en) * | 2017-09-13 | 2018-01-12 | 中国科学院新疆理化技术研究所 | A kind of dimension medicine compound of leucoderma and preparation method thereof |
-
1999
- 1999-02-26 CN CN 99101473 patent/CN1108809C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1264590A (en) | 2000-08-30 |
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