CN1726968A - Compound injection of black ants of prepared Chinese medicine for treating leucoderma - Google Patents

Abstract

A Chinese medicine ''Black ant injection'' for treating leukoderma is prepared from 15 Chinese-medicinal materials including black ant, ganoderma, musk, etc through pretreating, low-temp pulverizing, extracting, separation, purifying, adding liquid, filter, pouring in container and sterilizing.

Description

The leukodermic Chinese patent medicine compound injection of black ants of a kind of treatment

The present invention's leukodermic Chinese medicine injection of a kind of treatment and pharmaceutical field, be raw material specifically with Chinese medicine, earlier the Chinese medicine medical material processing of prescription is concocted,----the vitiligo compound injection that technical matters such as 50% ethanol----water integrated extraction technique effective component extracting, separation and purification, dosing, filtration, embedding, sterilization are prepared from, effect is remarkable to adopt 95% ethanol.The invention still further relates to the preparation method of compound injection.

Vitiligo is a kind of common posteriority pigmented dermatosis, and pathological manifestations is that the melanocyte of skin, mucosa is destroyed, and the skin lesion district obviously reduces or disappears.Symptom is that limitation or general property depigmentation speckle appear in skin.This disease is taken off to become homeless by the melanin of skin and hair follicle and is caused.Though vitiligo does not influence patient's body health and physiological activity substantially, but directly influence patient's outward appearance appearance by the skin lesion that primary disease causes, bring great stress and psychological burden to them, many negative factors have all been brought in aspects such as most of patient's life, study, work, social activity, thereby influenced patient's life quality.Vitiligo all has generation in all parts of the world, can falling ill per capita of the different colours of skin, age, sex is a kind of common chronic depigmentation dermatoses.But different regions, not agnate crowd's prevalence be difference to some extent.According to statistics, leukodermic sickness rate is about 1%--2%, and promptly in whole world population, nearly 4000-5000 ten thousand people suffer from vitiligo.In general, the dark people of the colour of skin falls ill higher; On the contrary, the shallow people's sickness rate of the colour of skin is lower.The patients with vitiligo of the U.S. is approximately 200--400 ten thousand, accounts for the 1%--2% of country's total population; Japanese sickness rate is 2%; The sickness rate on an island of Denmark is 0.38%; The vitiligo sickness rate of South India is then up to 4%.China is populous, the region difference, and crowd's sickness rate report differs.Fructus Pruni woods elite public relations is hand in hand appealed by international community, captures vitiligo early.

Modern medicine study shows: reasons such as inherited genetic factors, spiritual neural factor, immune factor, microcirculation disturbance, trace element and vitamin deficiency, tyrosinase activity reduction, endocrine regulation cause tyrosine phenylalanine systemic-function forfeiture in the pigment cell of skin, can not be oxidized to tyrosine the dihydroxy benzenes propylhomoserin and can not form melanocyte, dermatosis for a kind of posteriority limitation metabolism of pigment imbalance, the traditional Chinese medical science is thought the origin cause of formation deficiency of the liver and kindey of primary disease, ailment said due to cold or exposure is invaded skin, occlusion of the pores of skin, the pent-up of ailment said due to cold or exposure stagnant heat, due to the QI and blood retardance, the not flourish skin of blood.Uygur's medical science thinks that leukodermic etiology and pathogenesis is a He Lite expectorant " the people, plain body cold-damp is heavier, deficiency of yang of liver and kidney; be subjected to ailment said due to cold or exposure outward; the wind and cold wetting phase is fought, and invades skin, causes the human body qi depression to blood stasis; occlusion of the pores of skin; blood is not allowed skin, and the pigment affinity is reduced, the different parts of skin is to the sensitivity difference of " humidity "; more sensitive position decolouring earlier bleaches, and forms white macula.

Medicine of the present invention belongs to the traditional medicine category.Motherland's medical science is that international community generally acknowledges to the therapeutic effect of chronic disease, and " acute disease sees a doctor trained in western medicine, and slow disease is registered the department of Chinese medicine " become idea sanctified by usage of hospitalier.Because Chinese medicine contains plurality of active ingredients, can solve the insoluble problem of doctor trained in Western medicine at a plurality of curative drug action target spots, and active strong, the curative effect height, toxic and side effects is little.Be beneficial to the persistence medication after treatment of chronic disease

The medicament composing prescription that the present invention treats the black refreshing injection of leukodermic Chinese patent medicine is followed main 6 pathogeny of vitiligo and is carried out prescription.[1] is the medicine that to regulate immunologic function; [2] be can activity of tyrosinase medicine; [3] be the medicine that can promote that melanocyte forms; [4] be to strengthen light activated medicine; [5] be the medicine that is rich in trace element; [6] be blood circulation promoting and blood stasis dispelling, the medicine of microcirculation improvement.Wherein Ganoderma, the Radix Astragali have liver-nourishing kidney-boosting, the strong body of nourishing, strengthening the body resistance.Regulate body's immunity, improve non-specific immunity, strengthen macrophage phagocytic function.Mend event fat, kidney warming and yang invigorating, this product contains mends so fat is plain and isomery mends so the fat element belongs to furocoumarin class material, can improve skin to ultraviolet sensitivity, promote melanocyte to form, its ethanol extraction activates and raises tyrosinase activity and melanin growing amount dependency." Stigma Croci " blood circulation promoting and blood stasis dispelling, the removing pathogenic heat from blood and toxic substance from the body of stimulating the menstrual flow.Experimentation confirms that Stigma Croci has the effect that promotes that melanin forms.Contain multiple Radix Dauci Sativae chemical compound and vitamin B1, B2 etc. again, help leukodermic rehabilitation.Mend event fat, Folium Fici, can strengthen skin ultraviolet sensitivity." Caulis Vernoniae andersonii " has the effect of dispersing cold for relieving pain, blood stasis dispersing and deswelling, parasite killing speckle dispelling, is rich in the human body various trace elements, as copper, zinc, ferrum, manganese etc." Formica fusca " has the function of kidney tonifying nourishing the liver, blood circulation promoting and blood stasis dispelling, wind dispelling cold expelling.This product that shows modern pharmacological research is rich in vitamin B1, B2, B12, D, E and trace element Cu, Zn, Sn, Mn etc. are with several amino acids and have immunological enhancement.Can improve macrophage phagocytic function, promote nonspecific immunity, promote immunoglobulin to form, promote lymphocyte transformation.Also by regulating the balance of helper T cell and suppressor T cell, play the immunosuppressant effect simultaneously.Moschus, Flos Carthami, Semen Persicae, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling expansion peripheral blood vessel, microcirculation improvement.Semen Persicae extract can increase tyrosinase activity again, quickens the conversion of enzymatic reaction, increases melanic synthetic.Pheretima heat clearing away, suppressing the hyperactive liver, collateral dredging.Contain trace element such as copper, zinc, magnesium, ferrum, strontium, molybdenum.All medicines share, and remove the tool liver and kidney tonifying, and expelling wind and activating blood circulation outside the tranquilizing by nourishing the heart, can promote that still leukocyte increases in the peripheral blood, and enhancing human body immunity function and skin mucosa absorb the ultraviolet ability, and trace element supplement promotes the heavy person's effect of pigment.Deceive refreshing injection through toxicity test, the avirulence side effect.

Another purpose that the present invention treats leukodermic Chinese patent medicine provides a kind of preparation method of this medicine.It is characterized in that earlier the Chinese medicine medical material processing of prescription being concocted adopt 95% ethanol----50% ethanol----water integrated extraction technique effective component extracting, separation and purification, dosing, filtration, embedding, sterilization, quality testing.Gained 2ml or 5ml injection.

The present invention treats the black refreshing injection of leukodermic Chinese patent medicine, based on more than, observe in conjunction with the use of clinical, nearly thousand routine patients with vitiligo for many years, total effective rate is more than 96.6%, if unite with oral medicine, effect is better.So the black refreshing injection new drug of vitiligo Chinese medicine of the present invention is effective prescription of a kind of worth exploitation, popularization, raising vitiligo cure rate really, and is significant, has a extensive future.

Claims (4)

1, the leukodermic Chinese patent medicine compound injection of black ants of a kind of treatment is characterized in that it is the medicament of being made by following proportioning raw materials:

Formica fusca 10---25 Caulis Vernoniae andersonii 10---30 Ganoderma 10---25

Radix Astragali 10---30 Moschus 5---10 Stigma Croci 10---20

Flos Carthami 10---30 Pheretima 10---20 Rhizoma Chuanxiong 10---30

Cortex Moutan 10---30 Radix Arnebiae (Radix Lithospermi) 10---30 Fructus Tribuli 10---30

Mend so fat 10---30 Folium Fici 10---30 Radix Glycyrrhizae 10---20

2, treatment vitiligo Chinese patent medicine according to claim 1 is characterized in that the weight proportion of each raw material is:

Formica fusca 20 Caulis Vernoniae andersoniis 30 Ganodermas 20 Radixs Astragali 30

Moschus 8 Stigma Crocis 20 Flos Carthamis 20 Rhizoma Chuanxiongs 20

Pheretima 15 Cortex Moutans 30 Radix Arnebiae (Radix Lithospermi)s 30 Fructus Tribulis 30

So Folium Fici 30 mends fat 30 Radix Glycyrrhizaes 20

3, treatment vitiligo Chinese patent medicine according to claim 1 and 2 is characterized in that said medicament is an injection.

4, according to the preparation method of claim 1 or 2 or 3 described treatment vitiligo Chinese patent medicine injection, it is characterized in that earlier the Chinese medicine medical material processing of prescription being concocted--50% ethanol---water integrated extraction technique effective component extracting that adopts 95% ethanol, separation and purification, dosing, filtration, embedding, sterilization, quality testing.Gained 2ml or 5ml injection.