CN101926892B - Medicament for treating brain stroke - Google Patents
Medicament for treating brain stroke Download PDFInfo
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Abstract
The present invention relates to a medicament for treating brain stroke. The medicament is prepared from the following raw materials in part by weight: 8 to 18 parts of beautiful sweetgum fruit, 10 to 20 parts of kadsura coccinea, 6 to 12 parts of ground ivy, 10 to 18 parts of climbing fig, 15 to 20 parts of sarcandra, 5 to 20 parts of European verbena, 8 to 20 parts of piper wallichii, 10 to 25 parts of common scouring rush herb, 10 to 25 parts of salvia miltiorrhiza bunge, 10 to 20 parts of morinda, 8 to 12 parts of liquoric root, 6 to 12 parts of cassia twig, 10 to 20 parts of kudzuvine root and 8 to 20 parts of fructus viticis. The medicament has the functions of expelling wind, arousing spirit, promoting the restoration consciousness, expelling wind, freeing network vessels, expelling wind, dispersing swelling, restoring menstrual flow, invigorating blood circulation, softening blood vessels, reducing swelling, alleviating pain, strengthening muscles and bones, invigorating kidney, stopping nocturnal emission, and strengthening psoas channels and collaterals. For the cerebral hemorrhagic stroke, the cerebral ischemic stroke or cerebral hemorrhagic stroke after craniotomy and punching drainage, the medicament applied in time can produce the optimum therapeutic effect and an effective rate of 97.62 percent when the intravenous administration is ineffective, the condition is within twenty 20 days and stable, and the liquid medicaments can be swallowed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of apoplexy.
Background technology
The apoplexy doctor trained in Western medicine is divided into: hemorrhagic apoplexy, cerebral infarction two big classes; The traditional Chinese medical science divides the card standard that two kinds of apoplex involving the channels and collaterals and middle internal organs are arranged.No matter be hemorrhagic cerebral apoplexy, or ischemia apoplexy, all unconscious obstacles to press apoplex involving the channels and collaterals dialectical; Sicken for consciousness by the middle differentiation of disease according to pathological changes of the viscera and their.Both opinion causes of disease are identical, and its sick position is at brain, and the cause of disease is at wind, and wind is gone into the brain network, causes the brain channels and collaterals running to be obstructed, and real is apoplexy.Clinical manifestation is at coma, brain key obturation, mouthful eye
Tiltedly, hemianesthesia, hemiplegia, slurred speech, dysphagia, the frequent tic.Light patient: (1) the five fingers are partly clenched fist, and can bend moving in the time of firmly; (2) imbalance that strides, weak; (3) tongue body is hard partially, the speech slurred speech; (4) mind consciousness is unclear sometimes.Heavy patient: (1) the five fingers are arrested and are clenched, and lose to bend moving function, and the upper limb muscular strength is 0 grade; (2) thigh and calf is strong, loses limbs pain sensation function, loses and puts forth effort function, and lower-limb muscular strength is 0 grade; (3) the inside atrophy of tongue body can not representation language; (4) order is remained silent and is closed, syncope, and coma causes hemiplegia or panplegia state.
The apoplexy Therapeutic Method has intravenously administrable, acupuncture, oral Chinese and Western patent medicine at present.When the apoplexy state appears in the patient, after sending to hospital, adopt intravenously administrable usually, have 20% patient to cure approximately, about 60% patient can't cure, and causes sequela in various degree, 20% the conditions of patients of also having an appointment increases the weight of, even causes death, and its effective percentage is low.When apoplexy appears in the patient who has, the utilization acupuncture and moxibustion treatment, clinical discovery, indivedual apoplexy patients by acupuncture after the state of an illness can take a favorable turn, but cure rate is low, its effective percentage has only 10～20%; The patient who also has is by Chinese patent medicine or Chinese medicine and western medicine, and its medicine time is long, and sb.'s illness took a favorable turn slowly, and cure rate generally has only 10～15%, and its effective percentage is low equally.
Summary of the invention
Purpose of the present invention just provides a kind of in generation apoplexy 20 days, and the treatment apoplexy has the medicine of significant curative effect.
Fructus Liquidambaris: another name maple, Chinese sweet gum, maple are real, ball, sweetgum fruit, wolf order, wolves' eyes, nine gaps, maple ball on the maple fruit, maple, and its fruit another name Nie Zi, maple ball, wolf dormancy have dispelling wind and removing obstruction in the collateral, circulation of qi promoting detumescent, promoting blood circulation to remove blood stasis function.
Caulis Kadsurae Coccineae: another name kadsurae coccineae, lofty or bottomless red, ZUANGUFENG, food and drink do group, smelly rice dumpling, food and drink group, Cortex Ampelopsis Aconitifoliae Radicis rattan, wammel, thoroughly like a chain of pearls or a string of beads, the Rhizoma Seu Herba Bergeniae rattan, redly disappear outward, red mountain, the southern five tastes of Da Ye crossed, have dispel wind and remove dampness, the effect of promoting flow of QI and blood.
Radix seu Folium Gaultheriae Forrestii: another name HUOXUEDAN, Glechota longituba (Nakai) Kupr, Herba Glechomae, Herba Lysimachiae, the detumescence of dispeling the wind, promoting of the circulation of QI and removing the obstruction in the collaterals.
Caulis fici pumilae (Fructus Fici Pumilae): call bean jelly fruit, crow steamed bread, common floweringqince vine, wall stone tiger, hung son, bean jelly, Fructus Fici Pumilae, stem and leaf name " Caulis fici pumilae (Fructus Fici Pumilae) Caulis Trachelospermi " can active, the promoting of the circulation of QI and removing the obstruction in the collaterals of wind dispelling.
Herba Verbenae: another name is stung grass along JIANGCAO, Bermuda grass, Herba lespedezae pilosae, Ma Bancao, Radix Agrimoniae, wind neck grass, Canis familiaris L., purple top Agrimony, wild catmint, horsewhip, Bermuda grass, horsewhip slightly, little Herba lespedezae pilosae, along smoothing out with the fingers grass, Aeschna melanictera grass, TUIXUECAO, iron-clad horses lotus, malaria horsewhip, Herba Chenopodii, Herba Passiflorae Cupiformis, Baima whip, Aeschna melanictera meal, Herba Lespedezae Cuneatae.Have the dissipating blood stasis of stimulating the menstrual flow, dispel the wind and satisfy water.
Caulis et Folium piperis: another name wine cake rattan, Cauliset Folium Piperis Hancei, climb that Luisia hancockii Rolfe, CAULIS PIPER WALLICHII, Caulis et Folium piperis, Hubei Fructus Piperis, fourth father, fourth public affairs are posted, Caulis Erycibes, Radix scopoliae sinensis, blue rattan, perfume (or spice) all over the sky, little Radix seu Caulis fici Martinii, have wind-damp dispelling, meridians that relax, strong waist knee joint.
The present invention selects said herbal medicine for use by rigorous prescription, can dispel the wind to stimulate the menstrual flow, search wind and go into network, can reach promoting of the circulation of QI and removing the obstruction in the collaterals, softening meridians again, so the monarch drug in the side of being.With wind medicine treatment apoplexy, confirmed by a large amount of modern pharmacological researches; The medicine that dispels the wind can improve the reactivity of cerebrovascular, cranial nerve and impel cerebral blood supply, and logical again cranial nerve is adjusted cerebral circulation; Carminative and qi-activating drug can both enliven brain microcirculation by expansion of cerebral vascular, and the increasing blood flow perfusion reaches the blood sector-style from the pharmacology curative effect of going out.
Herba Equiseti Hiemalis: call Herba Equiseti Hiemalis, BOJIECAO, centreless grass, refute city flower, file careless, written grass, Herba equiseti ramosissimi, Herba Equiseti Hiemalis, energy wind-dispelling heat-dissipating, hemostasis.
Ramulus Cinnamomi: call fragrant Ramulus Cinnamomi, Zhu's branch, Liu Gui, have the merit of the cold expelling of delivering, temperature three-way meridian, activating YANG and prormoting functioning of QI.
Radix Puerariae: another name Herba Gelsemii Elegantis, bitter Pueraria lobota, Pachyrhizua angulatus, Radix puerariae, Radix Puerariae, kudzu, Pueraria montana (Lour.) Merr., the energy dispersing wind-cold, expelling pathogenic factors from muscles is analgesic.
Fructus Viticis: another name water harvests that son, the white back of the body are raised, wild pepper reality, Fructus Vitics Simplicifoliae, FRUCTUS VITICIS, turnip, wild pepper, Auricularia polytricha (Mout) Sacc., pocket knife bean rattan, leeward, the white back of the body is careless in vain, has the merit of wind-dispelling heat-dissipating, the clear sharp head, refreshment.
The present invention selects for use Herba Equiseti Hiemalis, Ramulus Cinnamomi, Radix Puerariae and Fructus Viticis to be the ministerial drug in the side by rigorous prescription, pharmacological research proves, dispelling wind medicine and cold expelling medicine merge utilization, have multiple qualcomm meridian, the merit of activating YANG and prormoting functioning of QI, can dispel because of sick humorously, promote people bromhidrosis function promotes unblocked blood flowing indirectly, regulates cerebrovascular, logical again cranial nerve is in time repaired brain and is made it normal operation because of wind impaired nerve and vascular function.
Herba Cirsii: have another name called field thistle, wild Flos Carthami, spinule lid, thorn dish, cat Ji, blue or green field thistle, thousand needle grass, field thistle dish, field thistle, blue and green dish, luxuriant dish, rifle cutter dish, wild Flos Carthami, thorn angle dish, wooden thorn Chinese mugwort, thorn bar dish, thorn spinoblast, assassination grass, shepherd's purse shepherd's purse hair, little evil hen, Ci Luobu, Herba Cirsii nurse, oriental dodartia herb, cattle jab, sting tip grass, spinule lid, seventy-seven teeth, the energy cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.
Ramulus Uncariae Cum Uncis: another name hangs rattan, Ramulus Uncariae Cum Uncis hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, golden Ramulus Uncariae Cum Uncis, hook rattan, Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis, lifting lug, has heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect.
Radix Salviae Miltiorrhizae: another name salvia bowleyana Dunn, Radix Salviae Miltiorrhizae, seven-star fiber crops, Arisaema balansae Engl., Herba Wedeliae Wallichii root, Radix Campylotropis Hirtella (Herba Myrsines Africanae), energy blood circulation promoting and blood stasis dispelling, blood vessel dilating.
Herba Pileae Scriptae: call careless river coral, Herba Pileae Scriptae, ring dish, synthetism lotus, Herba Sarcandrae, kwan-yin tea, Ramulus Sambuci Williamsii, refute the joint tea, tender chieftain, careless Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), mountain stone orchid, press the bone orchid, Gallus jabouillei tea, chicken knee joint wind, Fructus Linderae Glaucae, GUFENG disappear, big Radix Clematidis, Herba Pileae Scriptae, the blue or green cycle of sixty years, MANSHANXIANG, next year red, Psychotria rubra (Lour.) Poir. is red, October is red, Psychotria rubra (Lour.) Poir. Pu, Radix Crotonis Crassifolii, synthetism tea, Chloranthus elatior, has the merit of promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the collateral.
Radix Ilicis Pubescentis: another name fur tree, crow tail fourth, carbuncle tree, Artemisia anomala, spire Ilicis Purpureae, Prunus mume Xi Ye Qing, bitter Cipangopaludina chinensis, mouse gnaw, mountain Ilicis Purpureae, hair drape over one's shoulders tree, Folium Camelliae sinensis Ilicis Purpureae, extreme misery medicine, larynx poison, the broken pellet of rice, high mountain Ilicis Purpureae, cat autumn son grass, the female son of hair, U.S. young any of several broadleaf plants, mao Lay, six green grass or young crops, short ladder, the ladder of anti-paste the, fire iron wood, mountain Fel Ursi, poison, tart flavour wood, the energy blood circulation and channel invigorating, the detumescent pain relieving.
The present invention selects for use Herba Cirsii, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Herba Pileae Scriptae and Radix Ilicis Pubescentis to be the left medicine in the side by rigorous prescription, the compound recipe function be invigorate blood circulation, removing heat from blood, blood stasis dispelling blood, clearing away heat from blood effect, can impel big cerebral blood stasis to loose, ischemia can lead to, arteriosclerosis, unblocked blood flowing, the brain network of collaborative brain is with neural normal multiple logical.Clinical discovery, the long-term blood vessel operation of cerebral hemorrhage, ischemia is not smooth, all can spontaneous endogenous wind, because of blood vessel and nerve are the synthetic operation circulation.Clinical verification is being dispeled the wind, and also should doublely control blood vessel, blood when controlling syndrome caused by wind pathogen, promotes the unimpeded circulation of blood vessel.In order to reach better therapeutic, medicine of the present invention also makes up with crust halberd, Rhizoma Cibotii, Semen Euryales, Radix Glycyrrhizae.
Crust halberd: the long wind of another name chicken, chicken dormancy rattan, Intestinum Gallus domesticus wind, Herba Morindae Parvifoliae, triangle vine, Radix Morindae Officinalis, energy kidney-replenishing, bone and muscle strengthening, strong waist knee joint, wind-damp dispelling.
Rhizoma Cibotii: another name Rhizoma Cibotii, energy invigorating the liver and kidney, bone and muscle strengthening.
Semen Euryales: another name Caput Gallus domesticus, Gorgon fruit, Caput Gallus domesticus bud, Caput Gallus domesticus lotus, can benefit rush down controlling nocturnal emission with astringent drugs, spleen invigorating.
Because of the apoplexy patient is the resistance of brain arteries and veins brain network numbness, or blood oozing from the body openings or subcuta neous tissue brain arteries and veins causes hemiplegia or panplegia to cause that whole body meridian relaxes outward to contract, cause extremity function muscular strength imbalance, though because of with dispeling the wind, wind dispelling, invigorating blood circulation, expand the compound recipe medication of vessel softening, promoted blood vessel, blood, meridians and normally moved.Clinical discovery, though the trick meridians have function to take a turn for the better, upper limb arm muscular strength, lower limb thigh and calf muscular strength also can be felt numbness of hands and feet, weak when motion.So with crust halberd, Rhizoma Cibotii, bone and muscle strengthening is mended meridians by force among the present invention; Transfer the kidney invigorating essence, controlling nocturnal emission with astringent drugs with Semen Euryales; Come coordinating the actions of various ingredients in a prescription with Radix Glycyrrhizae, improve compound recipe combination clinical pharmacology function performance coordinating effect, so the history medicine in the side of being.Clinical verification, the monarch and his subjects of the present invention help history, compound recipe medication combination, apoplexy is caused the imbalance of sequela, upper limb muscular strength, lower-limb muscular strength is 0 grade, can't take care of oneself, the strong volume of trick is bent, hemiplegia, panplegia, if patient's utilization in time in 20 days can both obtain curative effect fast, the curative effect that returns to one's perfect health.
The present invention is made by following raw medicaments in portion by weight: 8～12 parts in 8～18 parts of Fructus Liquidambaris, 10～20 parts of Caulis Kadsurae Coccineae, 6～12 parts of Radix seu Folium Gaultheriae Forrestiis, 10～18 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 15～20 parts of Herba Pileae Scriptaes, 5～20 parts of Herba Verbenae, 8～20 parts of Caulis et Folium piperiss, 10～25 parts of Herba Equiseties Hiemalis, 10～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of halberds of crust and Radix Glycyrrhizae.
The further technical scheme of the present invention: 8～20 parts of 8～18 parts of Fructus Liquidambaris, 10～20 parts of Caulis Kadsurae Coccineae, 6～12 parts of Radix seu Folium Gaultheriae Forrestiis, 10～18 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 15～20 parts of Herba Pileae Scriptaes, 5～20 parts of Herba Verbenae, 8～20 parts of Caulis et Folium piperiss, 10～25 parts of Herba Equiseties Hiemalis, 10～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of halberds of crust, 8～12 parts in Radix Glycyrrhizae, 6～12 parts of Ramulus Cinnamomi, 10～20 parts of Radix Puerariaes and Fructus Viticises.
The present invention is further technical scheme also: 8～18 parts of Fructus Liquidambaris, 10～20 parts of Caulis Kadsurae Coccineae, 6～12 parts of Radix seu Folium Gaultheriae Forrestiis, 10～18 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 15～20 parts of Herba Pileae Scriptaes, 5～20 parts of Herba Verbenae, 8～20 parts of Caulis et Folium piperiss, 10～25 parts of Herba Equiseties Hiemalis, 10～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of crust halberds, 8～12 parts in Radix Glycyrrhizae, 6～12 parts of Ramulus Cinnamomi, 10～20 parts of Radix Puerariaes, 8～20 parts of Fructus Viticises, 8～12 parts of Herba Cirsiis, 8～16 parts of Ramulus Uncariae Cum Uncis, 10～30 parts of Radix Ilicis Pubescentiss, 6～18 parts of 15～30 parts of Rhizoma Cibotii and Semen Euryaless.
The present invention has wind dispelling refreshment, logical brain key, wind dispelling collateral dredging, the detumescence of dispeling the wind again, restores menstrual flow and invigorates blood circulation, the merit of vessel softening, reducing swelling and alleviating pain, strong muscles and bones, tonifying the kidney to consolidate the essence, strong psoas muscle meridians.No matter be the cerebral hemorrhage apoplexy, or cerebral infarction or operation open the cerebral hemorrhage apoplexy after cranium, the punching drain, do not have when taking effect at intravenously administrable, ill in 20 days, as long as stable disease can gulp down stream juice medicinal liquid, in time use medicine of the present invention, curative effect the best, effective percentage reaches 97.62%.
1. the present invention treats the clinical efficacy of apoplexy
1. data
1.1 diagnostic criteria: collect the complete disease data of patient, the clinical diagnosis foundation, the tcm diagnosis standard, according to State Administration of Traditional Chinese Medicine, encephalopathy emergency treatment scientific research cooperative groups is drafted formulation " apoplexy diagnosis and efficacy assessment standard " (trying), the 4th national cerebrovascular academic conference cerebrovascular classification diagnosis standard of Western medicine diagnose standard reference nineteen ninety-five Chinese Medical Association checked confirmation hemorrhagic cerebral apoplexy, ischemia apoplexy through CT or MRI.
1.2 physical data
Be selected from August, 1998-2010 year March the be in hospital apoplexy patient of 1-30 day of Guangdong Province's Meizhou City the People's Hospital, the People's Hospital, Pingyuan County, Pingyuan County institute of traditional Chinese medicine, Zhongshan City Renmin Hospital, the People's Hospital, Zengcheng City, the People's Hospital, Dapu County, the People's Hospital, Xingning City, the People's Hospital, Fengshun County, the People's Hospital, Jiaoling County, Nan Ao county people's hospital, all meet diagnostic criteria, be total to cerebral infarction patient's 88 examples (male's 55 examples, women's 33 examples) that collection has been left hospital; In the ischemia apoplexy patient oldest 84 years old, minimum 42 years old; In the cerebral infarction patient, 4 examples of being in hospital 1～4,55 examples of being in hospital 5～15,29 examples of being in hospital 16～30.In hemorrhagic cerebral apoplexy patient 80 examples (male's 48 examples, women's 32 examples), 87 years old of hemorrhagic cerebral apoplexy patient age maximum, minimum 38 years old; The cerebral hemorrhage paralytic who was in hospital 1～4 has 2 examples, 47 examples that have of being in hospital 5～15,31 examples that have of being in hospital 16～30.
When leaving hospital by hospital discharge certificate CT report review conclusion be respectively: left side top cerebral hemorrhage, right cerebral hemorrhage, left side cerebrum base section district hemorrhage, right side basal ganglia region cerebral hemorrhage, brain hat are hemorrhage, the left side anterior cerebral artery breaks hemorrhage.Ischemia apoplexy is by leaving hospital CT image prompting: left side cerebrum base section district right side brain stem district cerebral infarction, multiple cerebral infarctions in various degree such as right cerebral thrombosis blocks, Basal ganglia Nie Ye multiple cerebral infarction in right side is cold, right side Basal ganglia cerebral infarction, frontal lobe corona radiata district, left side Basal ganglia cerebral infarction, left side prerolandic artery Rolando blood vessel infraction, left side occipital lobe temporal lobe and brain hat multiple cerebral infarction.
1.3 clinical symptoms
In hemorrhagic cerebral apoplexy 80 examples, implement operation of opening cranium totally 22 examples (male's 15 examples, women's 7 examples), the stream juice of wherein can not eating, slotting stomach gavages 10 examples, can gulp down 12 examples that have of stream juice medicinal liquid, and its clinical symptoms is: consciousness mind is unclear sometimes, can say improper remark, mouthful mouth heresy is askew, upper limb muscular strength 0 minute, slurred speech, the lower-limb muscular strength imbalance, both hands inwardly curl, and five fingers can not be clenched fist, can't take care of oneself, the invalid degree integration of function of nervous system is below 5 minutes.Left and right sides brain punching drain is hemorrhage 44 examples (male's 25 examples, women's 19 examples), clinical symptoms is: imputability, the left upper extremity ankylosis, muscular strength 0 minute, left lower extremity muscular strength 4 minutes, can not move in the right upper extremity joint, it is moving that right arm can be bent, and the five fingers are partly clenched fist, and the right crus of diaphragm thigh and calf that strides loses and puts forth effort, can eat gruel, invalid degree integration 9～13 minutes.What left and right sides cerebral hemorrhage apoplexy was not had an operation intravenously administrable has 14 examples (male's 8 examples, women's 6 examples), clinical symptoms: the language performance bradykinesia, and left foot is weak, the force unbalance that striding, left hand can partly be clenched fist, and the right hand can be bent fist.The five fingers can not be bent, and the mouth mouth can be evil askew during speech, can both eat gruel, invalid degree integration 6～9 minutes.
In ischemia apoplexy patient 88 examples, wherein right brain large tracts of land is blocked 1 example (women 1 example), and clinical symptoms is: a mouthful frame closes, coma, the strong volume of the big forearm of both hands is bent, and the both hands the five fingers can not be bent, inwardly arrests and clenches, both feet thigh and calf meridians relax and contract, strong volume is bent, and muscular strength is 0 grade up and down, can not gulp down stream juice certainly, slotting stomach gavages, invalid degree integration 0 minute.Right brain large tracts of land old infarct 28 examples (male 15 examples, women's 13 examples), clinical symptoms is: dysphagia can gulp down stream juice, mouthful mouth
Tiltedly, language is unclear sometimes, and the left upper extremity joint is normal, and the left hand the five fingers can partly be clenched fist, and loses to bend moving function, left foot functional disorder, invalid degree integration 5 minutes.Right cerebral infarction 21 examples (male's 12 examples, women's 9 examples), clinical symptoms is: can eat gruel, left hand arm upper limb muscular strength is normal, and left hand arm lower-limb muscular strength is weak, and the five fingers are partly clenched fist, and can not bend, and the left lower extremity joint is weak, and striding needs the people to help mouth mouth during speech
Heresy, the slight sensation of tongue body is hard partially, invalid degree integration 10～13 minutes.Left side brain large tracts of land old infarct 26 examples (male's 18 examples, women's 8 examples), clinical symptoms is: the right side hemiplegia, and right upper extremity muscular strength 0 minute, the five fingers are arrested and are clenched, lose and bend moving function, right lower extremity muscular strength functional disorder is inwardly arrested and is bent muscular strength 0 minute, language is undesired sometimes, the intercommunication bradykinesia can be eaten stream juice, invalid degree integration 5 minutes.Left side cerebral infarction 12 examples (male's 10 examples, women's 2 examples), clinical symptoms is: the right hand the five fingers are partly clenched fist, and can bend in the time of firmly, can bend to raise the head and rise, and language is normal, meeting sialorrhea during speech, mouthful mouth is slight
Tiltedly, the right crus of diaphragm force unbalance that striding can be benumbed when striding, and striding needs the people to help, and the right side head can be benumbed, and can eat gruel, invalid degree integration 10～13 minutes.
2. Therapeutic Method:
Oral: restrain of the present invention medicated powder Baoshang with 300 every day, and each oral 150 milliliters, obey every day three times, 15 minutes after meal clothes, 30 is a course of treatment, obeys 2 courses of treatment altogether.
Gavage: in the patient of the stream juice of can not taking food, the earlier slotting stomach tube, suck nutritional solution 100-200ml with syringe, directly in the perfusion stomach tube, gavaged stream juice nutritional solution every 5 hours, directly inject 150 milliliters of medicinal liquids in the stomach tube with syringe after 15 minutes, gavage every day three times, irritate 450 milliliters of medicinal liquids altogether.
According to apoplexy patient with slight symptoms's situation, can take first and second kind prescription of the present invention; The patient of apoplexy serious symptom can take the third prescription of the present invention.
2.2 criterion of therapeutical effect
Adopt score to send out method, be conceived to the recovery extent of mind, language and motion, judge the rehabilitation rate.
Cure: hemiplegic limb recovery, apoplexy transference cure, imputability, language performance do not have difficulty, and life can be taken care of oneself full marks 28 minutes.
Produce effects: language performance is still not exclusively fluent, Myodynamia recovery III-IV level, and the slight weak sensation that striden naturally, life can be taken care of oneself or half self-care, imputability, integration was at 10～14 minutes.
Effectively: vital sign is normal, and hemiplegic limb takes a turn for the better, Myodynamia recovery II-III level, and language performance is unclear, can't take care of oneself integration 6～9 minutes.
Invalid: integration is the 0-5 branch.
3. therapeutic outcome:
The present invention treats apoplexy totally 168 examples (ischemia apoplexy 88 examples, hemorrhagic cerebral apoplexy 80 examples), cures 143 examples, accounts for 85.12%; Produce effects 13 examples account for 7.74%; Effective 8 examples account for 4.76%; Invalid 4 examples account for 2.38%.
3.1 no matter hemorrhagic cerebral apoplexy, ischemia apoplexy, as long as the patient can gulp down stream juice medicinal liquid, the heart, liver, spleen, lung, kidney do not have serious pathological changes, even the apoplexy sequela of cranium, punching drain hematocele is opened in operation, oral medicine of the present invention has the hope of quick rehabilitation.
3.2 no matter patient's cerebral hemorrhage what, when not opening brainpan, the patient merges and the apoplexy state occurs, as long as conditions of patients is stable, can gulp down stream juice medicinal liquid, takes medicinal liquid curative effect the best of the present invention.The patient takes 3-8 day, and clinical discovery mind, consciousness, language recovery are fast, and the 10-30 day hemiplegia symptom of taking medicine takes a turn for the better fast, and the body meridians relax to contract partially changes soft, and trick is flexible, and finger is clenched fist to stretch and bent effectively, and the strong meridians of thigh and calf recover, and it is strong to stride.
3.3 the patient was taken place in ischemia apoplexy 2-15 day, take medicine of the present invention cure rate on the 30th and reach 85.3%, the patient is taken place in the hemorrhagic, ischemia apoplexy 15～20 days, took medicine of the present invention 30, effective percentage 97.2%, the cerebral hemorrhage of serious the five internal organs complication pathological changes, the patient of cerebral ischemia apoplexy are arranged, and medication is invalid only to account for 2.4%.
Model case one
Wu X is beautiful, woman, 46 years old.On October 7th, 2009, fell on the ground the morning suddenly, promptly send the treatment of the People's Hospital, Longchuan County, Guangdong Province.CT prompting: left side top cerebral hemorrhage 29cc.With intravenous drip administration 18 days, though the state of an illness take a favorable turn, the right hand lost muscular strength, and right crus of diaphragm loses to be puted forth effort, and was in hospital to change Meizhou City the People's Hospital, CT prompting: 1, cerebral hemorrhage on the 18th on October 25th, 2009; 2, hypertension is 3 grades, drips medicine with vein every day and cures, be in hospital and do not see that sb.'s illness took a favorable turn on 15th, on November 10th, 2009 hemiplegia leave hospital.Hospital discharge certificate prompting: 1, cerebral hemorrhage; 2, hypertension is 3 grades.On November 12nd, 2009, patient's condition of illness of leaving hospital was: right crus of diaphragm can not be raised, kinetic energy translation slightly, but lose muscular strength, put forth effort, and right hand shoulder joint can pain, and muscular strength is poor, and the right hand the five fingers can not bend and stretch, and inwardly partly clench fist, and mind is not good enough, and hemiplegia be can't take care of oneself at bed.
This patient is through clinical analysis of diagnosis, meet encephalopathy emergency department of State Administration of Traditional Chinese Medicine " apoplexy diagnosis and efficacy assessment standard " (try), Western medicine diagnose meets nineteen ninety-five the 4th cerebrovascular academic conference revision of Chinese Medical Association " all kinds of cerebrovascular disease diagnosis main points ", the patient loses disease after belonging to hemorrhagic apoplexy.All Western medicine therapies of stopping using on November 12nd, 2009 are promptly used Chinese herbal medicine of the present invention, at 9 o'clock in per morning, at 12 o'clock at noon, in at 7 o'clock in evening, took medicine in 15 minutes after meal, with the third prescription of medicine of treatment apoplexy, every consumption potion, 600 milliliters of pot medicines, each oral 200 milliliters of doses, 30 days course of treatment.After taking medicine 3, patient's right crus of diaphragm muscular strength takes a turn for the better, hand steered wall can slowly be walked; After taking medicine 10, right crus of diaphragm is puted forth effort to recover, and the patient can stride alone and go slowly, and the right hand the five fingers are flexible, but do not have grip; Continuous clothes decoction on the 30th, phone is followed up a case by regular visits to, and it is fast that right crus of diaphragm is puted forth effort to recover, and the patient can steadily walk and stride, and takes care of oneself, but still feels weak when striding, is afraid of to fall, and right hand function muscular strength takes a turn for the better, and the five fingers can be clenched fist.For preventing the encephalopathy recurrence, the patient adheres to and continuous clothes decoction on the 30th, pays a return visit on January 13rd, 2010, find that patient's right crus of diaphragm muscular strength puts forth effort normally, squat down and bend over steadily effectively that the five fingers are stretched is in the wrong, stretch act, it is strong to clench fist, and being in can firewood, cook, and rehabilitation is to the normal health level.
Model case two
Lee X is right, the man, and 53 years old, December in 2005 WA morning on the 15th, the sensation left hand is unable, and left foot is weak, promptly send the treatment of the People's Hospital, Pingyuan County, CT prompting: bilateral basal joint, bilateral thalamus, right temporo radioactivity multiple cerebral infarction.Adopt the doctor trained in Western medicine vein to drip medicine one, the patient leaves hospital discharge diagnosis in December in 2005 the hemiplegia morning on the 16th: 1, cerebral infarction; 2, hypertension is three grades.The morning on the 16th, patient's symptom of leaving hospital was: left hand limb power function is lacked of proper care entirely, the five fingers are arrested and are clenched, and left foot skin is colder, and left foot can be stretched, can not bend, kinetic energy translation slightly, the lower limb toe joint can not be bent, loses and puts forth effort, mind is tired, can eat gruel, wear the clothes, can't take care of oneself, blood pressure 100～180mmHg is paralyzed in bed.
This patient meets emergency department of State Administration of Traditional Chinese Medicine " apoplexy diagnosis and efficacy assessment standard " through clinical analysis of diagnosis
(trying), Western medicine diagnose meet nineteen ninety-five the 4th national cerebrovascular association's view revision of Chinese Medical Association " all kinds of cerebrovascular disease diagnosis main points ", belong to ischemia apoplexy.On December 17th, 2005, patient's all western medicine therapies of stopping using, promptly treat second kind of prescription of medicine of apoplexy, at 8 o'clock in per morning, at 12 o'clock at noon with the present invention, at 7 o'clock in evening, took medicine in 15 minutes after meal, every consumption potion, pot dose is 600 milliliters, each oral 200 milliliters of doses serve on 30 days courses of treatment.After taking medicine 6, left foot is puted forth effort to take a turn for the better the defecation of leaving the bed; Paid a return visit after taking medicine 10, the hand steered waddy of patient can slowly be walked, and the left hand the five fingers can be bent moving naturally, but do not have grip; Followed up a case by regular visits to after taking medicine 20, the patient is without slowly enure walking of waddy, but it is weak to stride, and the left hand the five fingers are bent the moving grip that has, and left hand arm muscular strength takes a turn for the better and can bend, and can reach crown height, but can not directly lift, blood pressure drops 90～150mmHg; Take medicine revisited on the 30th, and the patient can squat down, bend over, and the left foot muscular strength, puted forth effort, and strode steadily, and the upper limb joint activity is stretched and lifted normally, stretches elevator muscle power and recovers, but stretch the paralysis sensation is arranged when lifting, and blood pressure recovers to drop to 75～130mmHg.In order to consolidate curative effect, the continuous clothes of patient decoction on the 30th, the soup 60 days of taking medicine altogether, the clinical return visit once more found: patient's left foot muscular strength is bent moving normal, squat down, bend over, stride, put forth effort steadily strong, the left arm joint motion is natural, does not have soft pain, does not have the paralysis sensation, and five fingers are clenched fist in the wrong moving strong, blood pressure stabilization is at 75～125mmHg, mind consciousness is normal, and life is taken care of oneself fully, is back on the job.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, but it is not represented as unique embodiment of the present invention.
Embodiment one
Fructus Liquidambaris 8 gram, Caulis Kadsurae Coccineae 10 grams, Radix seu Folium Gaultheriae Forrestii 6 grams, Caulis fici pumilae (Fructus Fici Pumilae) 10 grams, Herba Pileae Scriptae 15 grams, Herba Verbenae 5 grams, Caulis et Folium piperis 8 grams, Herba Equiseti Hiemalis's 10 grams, Radix Salviae Miltiorrhizae 10 grams, crust halberd 10 grams and Radix Glycyrrhizae 8 gram mix homogeneously, pulverize, dry, sterilize, pack, make powder.
Embodiment two
Fructus Liquidambaris 18 grams, Caulis Kadsurae Coccineae 20 grams, Radix seu Folium Gaultheriae Forrestii 12 grams, Caulis fici pumilae (Fructus Fici Pumilae) 18 grams, Herba Pileae Scriptae 20 grams, Herba Verbenae 20 grams, Caulis et Folium piperis 20 grams, Herba Equiseti Hiemalis's 25 grams, Radix Salviae Miltiorrhizae 25 grams, crust halberd 20 grams and Radix Glycyrrhizae 12 grams are made tablet according to a conventional method.
Embodiment three
Fructus Liquidambaris 13 grams, Caulis Kadsurae Coccineae 15 grams, Radix seu Folium Gaultheriae Forrestii 9 grams, Caulis fici pumilae (Fructus Fici Pumilae) 14 grams, Herba Pileae Scriptae 18 grams, Herba Verbenae 12 grams, Caulis et Folium piperis 14 grams, Herba Equiseti Hiemalis's 17 grams, Radix Salviae Miltiorrhizae 18 grams, crust halberd 15 grams and Radix Glycyrrhizae 10 grams are made pill according to a conventional method.
Embodiment four
Fructus Liquidambaris 8 grams, Caulis Kadsurae Coccineae 10 grams, Radix seu Folium Gaultheriae Forrestii 6 grams, Caulis fici pumilae (Fructus Fici Pumilae) 10 grams, Herba Pileae Scriptae 15 grams, Herba Verbenae 5 grams, Caulis et Folium piperis 8 grams, Herba Equiseti Hiemalis's 10 grams, Radix Salviae Miltiorrhizae 10 grams, crust halberd 10 grams, Radix Glycyrrhizae 8 grams, Ramulus Cinnamomi 6 grams, Radix Puerariae 10 grams and Fructus Viticis 8 grams are made capsule according to a conventional method.
Embodiment five
Fructus Liquidambaris 18 grams, Caulis Kadsurae Coccineae 20 grams, Radix seu Folium Gaultheriae Forrestii 12 grams, Caulis fici pumilae (Fructus Fici Pumilae) 18 grams, Herba Pileae Scriptae 20 grams, Herba Verbenae 20 grams, Caulis et Folium piperis 20 grams, Herba Equiseti Hiemalis's 25 grams, Radix Salviae Miltiorrhizae 25 grams, crust halberd 20 grams, Radix Glycyrrhizae 12 grams, Ramulus Cinnamomi 12 grams, Radix Puerariae 20 grams and Fructus Viticis 20 grams are made oral liquid according to a conventional method.
Embodiment six
Fructus Liquidambaris 12 grams, Caulis Kadsurae Coccineae 19 grams, Radix seu Folium Gaultheriae Forrestii 8 grams, Caulis fici pumilae (Fructus Fici Pumilae) 13 grams, Herba Pileae Scriptae 17 grams, Herba Verbenae 13 grams, Caulis et Folium piperis 15 grams, Herba Equiseti Hiemalis's 18 grams, Radix Salviae Miltiorrhizae 17 grams, crust halberd 16 grams, Radix Glycyrrhizae 9 grams, Ramulus Cinnamomi 10 grams, Radix Puerariae 14 grams and Fructus Viticis 14 grams are made pill according to a conventional method.
Embodiment seven
Fructus Liquidambaris 8 gram, Caulis Kadsurae Coccineae 10 grams, Radix seu Folium Gaultheriae Forrestii 6 grams, Caulis fici pumilae (Fructus Fici Pumilae) 10 grams, Herba Pileae Scriptae 15 grams, Herba Verbenae 5 grams, Caulis et Folium piperis 8 grams, Herba Equiseti Hiemalis's 10 grams, Radix Salviae Miltiorrhizae 10 grams, crust halberd 10 grams, Radix Glycyrrhizae 8 grams, Ramulus Cinnamomi 6 grams, Radix Puerariae 10 grams, Fructus Viticis 8 grams, Herba Cirsii 8 grams, Ramulus Uncariae Cum Uncis 8 grams, Radix Ilicis Pubescentis 10 grams, Rhizoma Cibotii 15 grams and Semen Euryales 6 gram mix homogeneously, pulverize, dry, sterilize, pack, make powder.
Embodiment eight
Fructus Liquidambaris 18 grams, Caulis Kadsurae Coccineae 20 grams, Radix seu Folium Gaultheriae Forrestii 12 grams, Caulis fici pumilae (Fructus Fici Pumilae) 18 grams, Herba Pileae Scriptae 20 grams, Herba Verbenae 20 grams, Caulis et Folium piperis 20 grams, Herba Equiseti Hiemalis's 25 grams, Radix Salviae Miltiorrhizae 25 grams, crust halberd 20 grams, Radix Glycyrrhizae 12 grams, Ramulus Cinnamomi 12 grams, Radix Puerariae 20 grams, Fructus Viticis 20 grams, Herba Cirsii 12 gram, Ramulus Uncariae Cum Uncis 16 grams, Radix Ilicis Pubescentis 30 grams, Rhizoma Cibotii 30 grams and Semen Euryales 18 gram mix homogeneously, pulverize, dry, sterilize, pack, make powder.
Embodiment nine
Fructus Liquidambaris 11 grams, Caulis Kadsurae Coccineae 13 grams, Radix seu Folium Gaultheriae Forrestii 8 grams, Caulis fici pumilae (Fructus Fici Pumilae) 13 grams, Herba Pileae Scriptae 16 grams, Herba Verbenae 11 grams, Caulis et Folium piperis 13 grams, Herba Equiseti Hiemalis's 16 grams, Radix Salviae Miltiorrhizae 16 grams, crust halberd 14 grams, Radix Glycyrrhizae 9 grams, Ramulus Cinnamomi 8 grams, Radix Puerariae 14 grams, Fructus Viticis 10 grams, Herba Cirsii 11 grams, Ramulus Uncariae Cum Uncis 13 grams, Radix Ilicis Pubescentis 21 grams, Rhizoma Cibotii 25 grams and Semen Euryales 13 grams are made pill according to a conventional method.
Claims (2)
1. medicine for the treatment of apoplexy is characterized in that it being to be made by following raw medicaments in portion by weight: 8～20 parts of 8～18 parts of Fructus Liquidambaris, 10～20 parts of Caulis Kadsurae Coccineae, 6～12 parts of Radix seu Folium Gaultheriae Forrestiis, 10～18 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 15～20 parts of Herba Pileae Scriptaes, 5～20 parts of Herba Verbenae, 8～20 parts of Caulis et Folium piperiss, 10～25 parts of Herba Equiseties Hiemalis, 10～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of halberds of crust, 8～12 parts in Radix Glycyrrhizae, 6～12 parts of Ramulus Cinnamomi, 10～20 parts of Radix Puerariaes and Fructus Viticises.
2. medicine for the treatment of apoplexy is characterized in that it being to be made by following raw medicaments in portion by weight: 6～18 parts of 8～18 parts of Fructus Liquidambaris, 10～20 parts of Caulis Kadsurae Coccineae, 6～12 parts of Radix seu Folium Gaultheriae Forrestiis, 10～18 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 15～20 parts of Herba Pileae Scriptaes, 5～20 parts of Herba Verbenae, 8～20 parts of Caulis et Folium piperiss, 10～25 parts of Herba Equiseties Hiemalis, 10～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of halberds of crust, 8～12 parts in Radix Glycyrrhizae, 6～12 parts of Ramulus Cinnamomi, 10～20 parts of Radix Puerariaes, 8～20 parts of Fructus Viticises, 8～12 parts of Herba Cirsiis, 8～16 parts of Ramulus Uncariae Cum Uncis, 10～30 parts of Radix Ilicis Pubescentiss, 15～30 parts of Rhizoma Cibotii and Semen Euryaless.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103623268B (en) * | 2013-12-04 | 2015-07-15 | 张国显 | Reconstruction pill for neurological rehabilitation and preparation method thereof |
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| CN103432247B (en) * | 2013-08-17 | 2014-11-05 | 张群 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
| CN103463345A (en) * | 2013-08-27 | 2013-12-25 | 王国荣 | Chinese herbal preparation for treating cerebral thrombosis |
| CN104116935A (en) * | 2014-08-01 | 2014-10-29 | 张媛媛 | Traditional Chinese medicament for treating cerebral thrombosis |
| CN105395640A (en) * | 2015-12-29 | 2016-03-16 | 青岛昌安达药业有限公司 | Traditional Chinese medicine preparation for preventing and treating stroke |
| CN105395641A (en) * | 2015-12-29 | 2016-03-16 | 青岛昌安达药业有限公司 | Traditional Chinese medicine composition for preventing and treating stroke |
| CN105456415A (en) * | 2015-12-29 | 2016-04-06 | 青岛昌安达药业有限公司 | Traditional Chinese medicine for preventing and treating apoplexia |
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| CN1290532A (en) * | 2000-09-26 | 2001-04-11 | 袁曙光 | Method for preparing Chinese medicine for curing apoplexy and hemiparalysis |
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| CN1290532A (en) * | 2000-09-26 | 2001-04-11 | 袁曙光 | Method for preparing Chinese medicine for curing apoplexy and hemiparalysis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103623268B (en) * | 2013-12-04 | 2015-07-15 | 张国显 | Reconstruction pill for neurological rehabilitation and preparation method thereof |
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