CN103432247B - Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof - Google Patents
Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof Download PDFInfo
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- CN103432247B CN103432247B CN201310358196.7A CN201310358196A CN103432247B CN 103432247 B CN103432247 B CN 103432247B CN 201310358196 A CN201310358196 A CN 201310358196A CN 103432247 B CN103432247 B CN 103432247B
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- part composition
- chinese medicinal
- cerebral infarction
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Abstract
The invention discloses a traditional Chinese medicine effective part composition for treating ischemic stroke and a preparation method thereof. The traditional Chinese medicine effective part composition is composed of raw materials of herba cepbalanoplosis segeti, pillis ophidiae, momordica grosvenori, fleshfingered citron flower and cerasus humilis, and is prepared according to certain parts by weight. The traditional Chinese medicine effective part composition can be prepared into medicine for treating the ischemic stroke, has the effects of dispelling wind, nourishing blood, activating blood, dredging collaterals, nourishing yin and suppressing yang, can obviously treat the ischemic stroke, and has the advantages of no toxic and side effects and high safety.
Description
Technical field
The present invention relates to Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of cerebral infarction and preparation method thereof.
Background technology
Cerebral infarction refers to that the cerebral tissue ischemia, the anoxia that due to cerebral blood supply obstacle, cause necrose, the softening cerebrovascular disease that forms infarction.Its main clinical manifestation is hemiplegia and disturbance of consciousness, and common type has cerebral thrombosis and cerebral embolism.This disease all can occur throughout the year, changes relevant with seasonal climate.Primary disease is if treatment in time, and general patient's neurologic defect symptom can take a turn for the better rapidly in half a year in onset, complicated hypertension, heart disease, glycosuria patient, and functional rehabilitation is not good.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal effective-part composition for the preparation for the treatment of cerebral infarction, this Chinese medicinal effective-part composition can be treated cerebral infarction fast and effectively, has advantages of that therapeutic effect is remarkable, safe, has no side effect.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The cause of disease of cerebral infarction is in the majority with endogenous cause of ill occasioner, as disgruntled in feelings will, heart-fire cruelly very, priming endogenous wind and send out apoplexy; Or eating and drinking without temperance, dysfunction of the spleen in transportation, stagnation of phlegm converting into heat, priming liver-wind.
The Chinese medicinal effective-part composition for the treatment of cerebral infarction of the present invention is by making according to the raw material of mass fraction meter as follows: Herba Cirsii 28, Periostracum Serpentis 22, Fructus Momordicae 22, Flos Citri Sarcodactylis 10 and Prunus humilis 18.
The dosage form that the present invention treats the applicable processing of Chinese medicinal effective-part composition of cerebral infarction is oral liquid.
The preparation method of the Chinese medicinal effective-part composition for the treatment of cerebral infarction of the present invention comprises the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.14 cream, add ethanol, making it contain alcohol amount is 69%, and standing over night reclaims ethanol, concentrated;
(2) concentrated solution after concentrated is added to applicable adjuvant according to conventional formulation technique, processing oral liquid.
Compared with prior art, the present invention has following beneficial effect:
(1) compositions of the present invention has the effect of expelling wind and replenishing blood, promoting blood circulation to remove obstruction in the collateral, nourishing YIN for suppressing the hyperactive YANG, through test, and can fast treating cerebral infarction.
(2) present composition has no side effect.
(3) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.
The specific embodiment
Below in conjunction with embodiment, further explain the present invention, but embodiment does not limit in any form to the present invention.
embodiment 1
Get Herba Cirsii 28g, Periostracum Serpentis 22g, Fructus Momordicae 22g, Flos Citri Sarcodactylis 10g and Prunus humilis 18g, be crushed to coarse powder, add 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.14 cream, add ethanol, making it contain alcohol amount is 69%, and standing over night reclaims ethanol, obtain concentrated solution 1000ml, get simple syrup, add above-mentioned concentrated solution, and adjust pH to 4 with citric acid, adding distil water is to 5000ml, stir, after fine straining, be distributed in 15ml vial, be packaged to be oral liquid.
This product is yellowish-brown clear liquid, places in half a year and does not produce muddiness, and pH approximately 4, total solid 9% left and right.
embodiment 2
Clinical observation patient 300 examples, patient all has obvious cerebral infarction clinical symptoms and makes a definite diagnosis through clinicist.
The oral liquid that oral embodiment 1 makes, every day 2 times, each 15ml.Administration time is 30 days.
After 30 days, use patient's statistical result of embodiment 1 gained oral liquid in Table 1.
Criterion of therapeutical effect: effective referring to through clinical diagnosis related symptoms disappears, observes 1 year recidivist not above.Invalid is that symptom and sign are slightly improved but still repeatedly show effect or have no improvement person.
Table 1
| Number of cases | Effective | Invalid | Obvious effective rate (%) |
| 300 | 279 | 21 | 93 |
Known by table 1, the oral liquid that embodiment 1 obtains has specially good effect at treatment cerebral infarction.Chinese medicine of the present invention is made after oral liquid, can be in 30 days highly significant healing or alleviate cerebral infarction disease.
embodiment 3
The oral liquid administration ICR mice of using embodiment 1 to make, body weight 20 ~ 25g, male and female half and half, successive administration 90d.
Through prerun, the lotion toxicity that embodiment 1 makes is very low, does not measure LD50, therefore mice is carried out to maximum dosage-feeding on the one, measures.Maximum dosage-feeding is 150ml/d, observes none example and be poisoned to death after 90 days, and all healthy survival, proves that the oral liquid that compositions of the present invention is made can not cause toxic and side effects to human body thus.
Claims (2)
1. treat a Chinese medicinal effective-part composition for cerebral infarction, it is characterized in that by making according to the raw material of mass fraction meter as follows: Herba Cirsii 28, Periostracum Serpentis 22, Fructus Momordicae 22, Flos Citri Sarcodactylis 10 and Prunus humilis 18.
2. the Chinese medicinal effective-part composition for the treatment of cerebral infarction according to claim 1, is characterized in that described Chinese medicinal effective-part composition is oral liquid.
3. described in claim 1 or 2, treat the preparation method of the Chinese medicinal effective-part composition of cerebral infarction, it is characterized in that comprising the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.14 cream, add ethanol, making it contain alcohol amount is 69%, and standing over night reclaims ethanol, concentrated;
(2) concentrated solution after concentrated is added to applicable adjuvant according to conventional formulation technique, be processed into oral liquid.
4. the application of Chinese medicinal effective-part composition described in claim 1 or 2, is characterized in that described Chinese medicinal effective-part composition is for the preparation of the medicine for the treatment of cerebral infarction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310358196.7A CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310358196.7A CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103432247A CN103432247A (en) | 2013-12-11 |
| CN103432247B true CN103432247B (en) | 2014-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310358196.7A Expired - Fee Related CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102103423B1 (en) | 2018-07-09 | 2020-04-23 | 숙명여자대학교산학협력단 | Composition for neuroprotection containing extract or fraction of Prunus cerasoides as an effective component |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926892A (en) * | 2010-08-01 | 2010-12-29 | 黄超权 | Medicament for treating brain stroke |
| CN102670769A (en) * | 2011-03-18 | 2012-09-19 | 李启辉 | Tea lowering blood pressure and enabling all natural plants to serve as formula and preparation method thereof |
| CN103041196A (en) * | 2012-12-17 | 2013-04-17 | 青岛力宇仓储机械设备有限公司 | Medicine for treating cerebral diseases |
-
2013
- 2013-08-17 CN CN201310358196.7A patent/CN103432247B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926892A (en) * | 2010-08-01 | 2010-12-29 | 黄超权 | Medicament for treating brain stroke |
| CN102670769A (en) * | 2011-03-18 | 2012-09-19 | 李启辉 | Tea lowering blood pressure and enabling all natural plants to serve as formula and preparation method thereof |
| CN103041196A (en) * | 2012-12-17 | 2013-04-17 | 青岛力宇仓储机械设备有限公司 | Medicine for treating cerebral diseases |
Non-Patent Citations (2)
| Title |
|---|
| 中药治疗缺血性中风研究进展;李鸿泓等;《山西中医》;20020228;第18卷(第01期);第52-54页 * |
| 李鸿泓等.中药治疗缺血性中风研究进展.《山西中医》.2002,第18卷(第01期), * |
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Owner name: ZHANG QUN Free format text: FORMER OWNER: GUANGZHOU YUNQIAO BIOTECHNOLOGY CO., LTD. Effective date: 20140929 |
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Effective date of registration: 20140929 Address after: The Eastern Development Zone of Guangzhou City, Guangdong province 510000 two Building Room 302 Xinyuan Street Chunhui Applicant after: Zhang Qun Address before: 510000, Guangzhou, Guangdong, Luogang District Province, No. 6, No. 601, Lai Lai Road Applicant before: Guangzhou Yunqiao Biological Technology Co., Ltd. |
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