CN103239571B - Chinese medicine effective part composition for treating alopecia areata and preparation method thereof - Google Patents

Chinese medicine effective part composition for treating alopecia areata and preparation method thereof Download PDF

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Publication number
CN103239571B
CN103239571B CN201310198015.9A CN201310198015A CN103239571B CN 103239571 B CN103239571 B CN 103239571B CN 201310198015 A CN201310198015 A CN 201310198015A CN 103239571 B CN103239571 B CN 103239571B
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China
Prior art keywords
part composition
alopecia areata
chinese medicinal
medicinal effective
chinese medicine
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Expired - Fee Related
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CN201310198015.9A
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Chinese (zh)
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CN103239571A (en
Inventor
张群
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GUANGZHOU YUNQIAO BIOLOGICAL TECHNOLOGY Co Ltd
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GUANGZHOU YUNQIAO BIOLOGICAL TECHNOLOGY Co Ltd
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Priority to CN201310198015.9A priority Critical patent/CN103239571B/en
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Abstract

The invention discloses a Chinese medicine effective part composition for treating alopecia areata. The Chinese medicine effective part composition is prepared from rainbow conk, radix tetrastigme, beautyberry leaf, perilla frutescens, fleshfingered citron flower and pueraria flower as raw materials according to certain parts by weight. The Chinese medicine effective part composition disclosed by the invention can be prepared into a medicament for treating alopecia areata, has the effects of nourishing liver and kidney, replenishing the vital essence and growing hair, tonifying qi and replenishing blood, and treating and removing blood stasis, can be used for significantly treating the alopecia areata, and has the advantages of being free of toxic and side effects and high in safety.

Description

A kind of Chinese medicinal effective-part composition that is used for the treatment of alopecia areata and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of alopecia areata and preparation method thereof.
Background technology
Alopecia areata is a kind ofly taking head, the common skin diseases disease of limitation speckle shape alopecia as feature to occur suddenly.Its pathogenic factor is made clear so far not yet completely, and it is generally acknowledged may be relevant with the factor such as autoimmune, heredity, and Nervous and Mental Factors is bring out and impel the reason increasing the weight of, thereby brings certain difficulty to clinical curing the disease.
The method majority of existing treatment alopecia areata is Chinese medicine external use lotion or acupuncture and moxibustion treatment.But because the reason of alopecia areata is had nothing in common with each other, therefore therapeutic effect differs greatly.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal effective-part composition for the preparation for the treatment of alopecia areata, this Chinese medicinal effective-part composition can be treated alopecia areata fast and effectively, has advantages of that therapeutic effect is remarkable, safe, has no side effect.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The Chinese medicinal effective-part composition for the treatment of alopecia areata of the present invention is by making according to the raw material of mass fraction meter as follows: Coriolous Dersicolor (Fr.) Quel 26, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 22, Folium Callicarpae Formosanae 19, Fructus Perillae Frutescentis 15, Flos Citri Sarcodactylis 10 and Flos puerariae lobatae 8.
The dosage form that the present invention treats the applicable processing of Chinese medicinal effective-part composition of alopecia areata is oral liquid.
The preparation method of the Chinese medicinal effective-part composition for the treatment of alopecia areata of the present invention comprises the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 3 hours at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.15 cream, add ethanol, making it contain alcohol amount is 62%, and hold over night reclaims ethanol, concentrated;
(2) concentrated solution after concentrated is added to applicable adjuvant according to conventional formulation technique, be processed into oral liquid.
Compared with prior art, the present invention has following beneficial effect:
(1) compositions of the present invention has effect of nourishing the liver and kidney, yin nourishing hair growth promoting, invigorating qi and benefiting blood, sensible blood stasis dispelling, through test, and can fast treating alopecia areata.The present invention is that to make oral liquid for oral administration, compared with traditional external-use lotion or acupuncture and moxibustion treatment, can cure faster alopecia areata.
(2) present composition has no side effect.
(3) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.
Detailed description of the invention
Further explain the present invention below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
embodiment 1
Get Coriolous Dersicolor (Fr.) Quel 26g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 22g, Folium Callicarpae Formosanae 19g, Fructus Perillae Frutescentis 15g, Flos Citri Sarcodactylis 10g and Flos puerariae lobatae 8g, be crushed to coarse powder, add 12 times of water gagings, decoct 3 times, decoct 3 hours at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.15 cream, add ethanol, making it contain alcohol amount is 62%, and hold over night reclaims ethanol, obtain concentrated solution 1000ml, get simple syrup, add above-mentioned concentrated solution, and with citric acid adjust pH to 4.2, adding distil water is to 5000ml, stir, after fine straining, be distributed in 15ml vial, be packaged to be oral liquid.
This product is yellow clear liquid, places in half a year and does not produce muddiness, pH approximately 4, total solid 5% left and right.
embodiment 2
Clinical observation patient 300 examples, patient all has obvious alopecia areata clinical symptoms and makes a definite diagnosis through clinicist.
The oral liquid that the oral embodiment 1 of patient makes, every day sooner or later respectively once, each 15ml.Take 20 days.
After 20 days, observe, until start again statistics the half a year of taking medicine, use patient's statistical result of embodiment 1 gained oral liquid in table 1.
Criterion of therapeutical effect: effectively comprise two grades.One-level is new for treatment interior alopecia later six months district bears, and new alopecia areata district no longer occurs; Secondary is for treating after half a year, and 50% alopecia areata district generates new, though there is new alopecia areata district to occur, before the treatment of scope ratio, dwindles.Invalid referring to after treatment, symptom and sign fail to improve, and even increase the weight of.
Table 1
Number of cases Effective Invalid Obvious effective rate (%)
300 289 11 96.3
Known by table 1, the oral liquid that embodiment 1 obtains has specially good effect in treatment alopecia areata.Chinese medicine of the present invention was made oral liquid after 20 days, can be within half a year highly significant healing or alleviate alopecia areata disease.Through follow-up following up a case by regular visits to, all not there is not the symptom of recurrence in the patient of above-mentioned drug administration.
embodiment 3
The oral liquid administration ICR mice that uses embodiment 1 to make, body weight 20 ~ 25g, male and female half and half, successive administration 90d.
Through prerun, the lotion toxicity that embodiment 1 makes is very low, does not measure LD50, measures therefore mice is carried out to maximum dosage-feeding on the one.Maximum dosage-feeding is 100ml/d, observes none example and be poisoned to death after 90 days, and all healthy survival, proves that the oral liquid that compositions of the present invention is made can not cause toxic and side effects to human body thus.

Claims (4)

1. treat a Chinese medicinal effective-part composition for alopecia areata, it is characterized in that by making according to the raw material of mass fraction meter as follows: Coriolous Dersicolor (Fr.) Quel 26, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 22, Folium Callicarpae Formosanae 19, Fructus Perillae Frutescentis 15, Flos Citri Sarcodactylis 10 and Flos puerariae lobatae 8.
2. the Chinese medicinal effective-part composition for the treatment of alopecia areata according to claim 1, is characterized in that described Chinese medicinal effective-part composition makes oral liquid.
3. the preparation method for the treatment of the Chinese medicinal effective-part composition of alopecia areata described in claim 1 or 2, is characterized in that comprising the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 3 hours at every turn; Filter merging filtrate after decocting liquid, be evaporated to relative concentration and be 1.15 cream, add ethanol, making it contain alcohol amount is 62%, and hold over night reclaims ethanol, concentrated;
(2) concentrated solution after concentrated is added to applicable adjuvant according to conventional formulation technique, be processed into oral liquid.
4. the application of Chinese medicinal effective-part composition described in claim 1 or 2, is characterized in that the medicine of described Chinese medicinal effective-part composition for the preparation for the treatment of alopecia areata.
CN201310198015.9A 2013-05-26 2013-05-26 Chinese medicine effective part composition for treating alopecia areata and preparation method thereof Expired - Fee Related CN103239571B (en)

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CN201310198015.9A CN103239571B (en) 2013-05-26 2013-05-26 Chinese medicine effective part composition for treating alopecia areata and preparation method thereof

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CN201310198015.9A CN103239571B (en) 2013-05-26 2013-05-26 Chinese medicine effective part composition for treating alopecia areata and preparation method thereof

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JP3885204B2 (en) * 2002-04-16 2007-02-21 株式会社Cac External agent for promoting cell activity
US20080044370A1 (en) * 2004-05-21 2008-02-21 Tadashi Goino Composition For Scalp And Hair Of Scalp
CN100356974C (en) * 2005-08-17 2007-12-26 王林祥 Healthcare wine and its preparation method

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