CN103432247A - Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof - Google Patents
Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof Download PDFInfo
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- CN103432247A CN103432247A CN2013103581967A CN201310358196A CN103432247A CN 103432247 A CN103432247 A CN 103432247A CN 2013103581967 A CN2013103581967 A CN 2013103581967A CN 201310358196 A CN201310358196 A CN 201310358196A CN 103432247 A CN103432247 A CN 103432247A
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- part composition
- chinese medicinal
- cerebral infarction
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- chinese medicine
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- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 208000032382 Ischaemic stroke Diseases 0.000 title abstract 4
- 235000008104 Prunus humilis Nutrition 0.000 claims abstract description 4
- 241000057271 Prunus humilis Species 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 18
- 206010008118 cerebral infarction Diseases 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000628997 Flos Species 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 240000004307 Citrus medica Species 0.000 abstract 1
- 235000005706 Prunus prostrata Nutrition 0.000 abstract 1
- 244000185386 Thladiantha grosvenorii Species 0.000 abstract 1
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a traditional Chinese medicine effective part composition for treating ischemic stroke and a preparation method thereof. The traditional Chinese medicine effective part composition is composed of raw materials of herba cepbalanoplosis segeti, pillis ophidiae, momordica grosvenori, fleshfingered citron flower and cerasus humilis, and is prepared according to certain parts by weight. The traditional Chinese medicine effective part composition can be prepared into medicine for treating the ischemic stroke, has the effects of dispelling wind, nourishing blood, activating blood, dredging collaterals, nourishing yin and suppressing yang, can obviously treat the ischemic stroke, and has the advantages of no toxic and side effects and high safety.
Description
Technical field
The present invention relates to the Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of cerebral infarction and preparation method thereof.
Background technology
Cerebral infarction refers to that the cerebral tissue ischemia, the anoxia that cause due to the cerebral blood supply obstacle necrose, the softening cerebrovascular disease that forms infarction.Its main clinical manifestation is hemiplegia and disturbance of consciousness, and common type has cerebral thrombosis and cerebral embolism.This disease all can occur throughout the year, with seasonal climate, changes relevant.Primary disease is if in time treatment, and general patient's neurologic defect symptom can take a turn for the better rapidly in half a year in onset, complicated hypertension, heart disease, glycosuria patient, and functional rehabilitation is not good.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal effective-part composition for the preparation of the treatment cerebral infarction, this Chinese medicinal effective-part composition can be treated cerebral infarction fast and effectively, has advantages of that therapeutic effect is remarkable, safe, has no side effect.
Another purpose of the present invention is to provide the preparation method of above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The cause of disease of cerebral infarction is in the majority with the endogenous cause of ill occasioner, as disgruntled as feelings will, heart-fire cruelly very, priming endogenous wind and send out apoplexy; Or eating and drinking without temperance, dysfunction of the spleen in transportation, stagnation of phlegm converting into heat, priming liver-wind.
The Chinese medicinal effective-part composition for the treatment of cerebral infarction of the present invention is by making according to the raw material of mass fraction meter as follows: Herba Cirsii 28, Periostracum Serpentis 22, Fructus Momordicae 22, Flos Citri Sarcodactylis 10 and Prunus humilis 18.
The dosage form that the present invention treats the applicable processing of Chinese medicinal effective-part composition of cerebral infarction is oral liquid.
The preparation method of the Chinese medicinal effective-part composition for the treatment of cerebral infarction of the present invention comprises the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Merging filtrate after the filtration decocting liquid, be evaporated to the cream that relative concentration is 1.14, adds ethanol, and making it contain the alcohol amount is 69%, and standing over night, reclaim ethanol, concentrated;
(2) concentrated solution after concentrating is added to applicable adjuvant according to conventional formulation technique, the processing oral liquid.
Compared with prior art, the present invention has following beneficial effect:
(1) compositions of the present invention has the effect of expelling wind and replenishing blood, promoting blood circulation to remove obstruction in the collateral, nourishing YIN for suppressing the hyperactive YANG, through test, and can the fast treating cerebral infarction.
(2) present composition has no side effect.
(3) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
embodiment 1
Get Herba Cirsii 28g, Periostracum Serpentis 22g, Fructus Momordicae 22g, Flos Citri Sarcodactylis 10g and Prunus humilis 18g, be crushed to coarse powder, add 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Merging filtrate after the filtration decocting liquid, be evaporated to the cream that relative concentration is 1.14, adds ethanol, making it contain the alcohol amount is 69%, and standing over night, reclaim ethanol, obtain concentrated solution 1000ml, get simple syrup, add above-mentioned concentrated solution, and adjust pH to 4 with citric acid, adding distil water is to 5000ml, stir, be distributed into after fine straining in the 15ml vial, be packaged to be oral liquid.
This product is the yellowish-brown clear liquid, places in half a year and does not produce muddiness, and pH approximately 4, total solid 9% left and right.
embodiment 2
Clinical observation patient 300 examples, patient all has obvious cerebral infarction clinical symptoms and makes a definite diagnosis through the clinicist.
The oral liquid that oral embodiment 1 makes, every day 2 times, each 15ml.Administration time is 30 days.
After 30 days, use patient's statistical result of embodiment 1 gained oral liquid in Table 1.
Criterion of therapeutical effect: produce effects refers to through the clinical diagnosis related symptoms and disappears, and observes more than 1 year not recidivist.Invalid is that symptom and sign slightly are improved but still repeatedly show effect or have no improvement person.
Table 1
| Number of cases | Produce effects | Invalid | Obvious effective rate (%) |
| 300 | 279 | 21 | 93 |
Known by table 1, the oral liquid that embodiment 1 obtains has specially good effect at the treatment cerebral infarction.After Chinese medicine of the present invention is made oral liquid, can be in 30 days highly significant healing or alleviate the cerebral infarction disease.
embodiment 3
The oral liquid administration ICR mice of using embodiment 1 to make, body weight 20 ~ 25g, male and female half and half, successive administration 90d.
Through prerun, the lotion toxicity that embodiment 1 makes is very low, does not measure LD50, therefore mice is carried out to maximum dosage-feeding on the one, measures.Maximum dosage-feeding is 150ml/d, observes none example after 90 days and is poisoned to death, and all healthy survival, prove that the oral liquid that compositions of the present invention is made can not cause toxic and side effects to human body thus.
Claims (4)
1. a Chinese medicinal effective-part composition for the treatment of cerebral infarction, is characterized in that by making according to the raw material of mass fraction meter as follows: Herba Cirsii 28, Periostracum Serpentis 22, Fructus Momordicae 22, Flos Citri Sarcodactylis 10 and Prunus humilis 18.
2. the Chinese medicinal effective-part composition for the treatment of cerebral infarction according to claim 1, is characterized in that described Chinese medicine composition makes oral liquid.
3. the preparation method of the Chinese medicinal effective-part composition of the described treatment cerebral infarction of claim 1 or 2, is characterized in that comprising the steps:
(1) each Chinese medicinal components is pulverized, added 12 times of water gagings, decoct 3 times, decoct 1 hour at every turn; Merging filtrate after the filtration decocting liquid, be evaporated to the cream that relative concentration is 1.14, adds ethanol, and making it contain the alcohol amount is 69%, and standing over night, reclaim ethanol, concentrated;
(2) concentrated solution after concentrating is added to applicable adjuvant according to conventional formulation technique, the processing oral liquid.
4. the application of claim 1 or 2 described Chinese medicinal effective-part composition, is characterized in that the medicine of described Chinese medicinal effective-part composition for the preparation of the treatment cerebral infarction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310358196.7A CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310358196.7A CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103432247A true CN103432247A (en) | 2013-12-11 |
| CN103432247B CN103432247B (en) | 2014-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310358196.7A Expired - Fee Related CN103432247B (en) | 2013-08-17 | 2013-08-17 | Traditional Chinese medicine effective part composition for treating ischemic stroke and preparation method thereof |
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| Country | Link |
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| CN (1) | CN103432247B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200005907A (en) | 2018-07-09 | 2020-01-17 | 숙명여자대학교산학협력단 | Composition for neuroprotection containing extract or fraction of Prunus cerasoides as an effective component |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926892A (en) * | 2010-08-01 | 2010-12-29 | 黄超权 | Medicament for treating brain stroke |
| CN102670769A (en) * | 2011-03-18 | 2012-09-19 | 李启辉 | Tea lowering blood pressure and enabling all natural plants to serve as formula and preparation method thereof |
| CN103041196A (en) * | 2012-12-17 | 2013-04-17 | 青岛力宇仓储机械设备有限公司 | Medicine for treating cerebral diseases |
-
2013
- 2013-08-17 CN CN201310358196.7A patent/CN103432247B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926892A (en) * | 2010-08-01 | 2010-12-29 | 黄超权 | Medicament for treating brain stroke |
| CN102670769A (en) * | 2011-03-18 | 2012-09-19 | 李启辉 | Tea lowering blood pressure and enabling all natural plants to serve as formula and preparation method thereof |
| CN103041196A (en) * | 2012-12-17 | 2013-04-17 | 青岛力宇仓储机械设备有限公司 | Medicine for treating cerebral diseases |
Non-Patent Citations (1)
| Title |
|---|
| 李鸿泓等: "中药治疗缺血性中风研究进展", 《山西中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200005907A (en) | 2018-07-09 | 2020-01-17 | 숙명여자대학교산학협력단 | Composition for neuroprotection containing extract or fraction of Prunus cerasoides as an effective component |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103432247B (en) | 2014-11-05 |
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Owner name: ZHANG QUN Free format text: FORMER OWNER: GUANGZHOU YUNQIAO BIOTECHNOLOGY CO., LTD. Effective date: 20140929 |
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Effective date of registration: 20140929 Address after: The Eastern Development Zone of Guangzhou City, Guangdong province 510000 two Building Room 302 Xinyuan Street Chunhui Applicant after: Zhang Qun Address before: 510000, Guangzhou, Guangdong, Luogang District Province, No. 6, No. 601, Lai Lai Road Applicant before: Guangzhou Yunqiao Biological Technology Co., Ltd. |
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Granted publication date: 20141105 Termination date: 20150817 |
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