CN1351653A - 抗细菌疫苗组合物 - Google Patents

抗细菌疫苗组合物 Download PDF

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Publication number
CN1351653A
CN1351653A CN00808020A CN00808020A CN1351653A CN 1351653 A CN1351653 A CN 1351653A CN 00808020 A CN00808020 A CN 00808020A CN 00808020 A CN00808020 A CN 00808020A CN 1351653 A CN1351653 A CN 1351653A
Authority
CN
China
Prior art keywords
leu
ala
val
lys
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00808020A
Other languages
English (en)
Chinese (zh)
Inventor
D·E·洛沃里
T·E·福勒
M·J·肯尼迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of CN1351653A publication Critical patent/CN1351653A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN00808020A 1999-04-09 2000-04-06 抗细菌疫苗组合物 Pending CN1351653A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12868999P 1999-04-09 1999-04-09
US60/128,689 1999-04-09
US15345399P 1999-09-10 1999-09-10
US60/153,453 1999-09-10

Publications (1)

Publication Number Publication Date
CN1351653A true CN1351653A (zh) 2002-05-29

Family

ID=26826843

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00808020A Pending CN1351653A (zh) 1999-04-09 2000-04-06 抗细菌疫苗组合物

Country Status (14)

Country Link
US (5) US20070237793A1 (OSRAM)
EP (5) EP2281834B1 (OSRAM)
JP (4) JP4892134B2 (OSRAM)
KR (4) KR20070011622A (OSRAM)
CN (1) CN1351653A (OSRAM)
AR (1) AR029622A1 (OSRAM)
AU (2) AU780887B2 (OSRAM)
BR (1) BR0009663A (OSRAM)
CA (1) CA2366520C (OSRAM)
ES (2) ES2535961T3 (OSRAM)
HK (1) HK1045856A1 (OSRAM)
MX (1) MXPA01010207A (OSRAM)
NZ (2) NZ514883A (OSRAM)
WO (1) WO2000061724A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115925536A (zh) * 2022-08-01 2023-04-07 北京农学院 靶向抑制DksA的小分子抑制剂和应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790950B2 (en) 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
EP2281834B1 (en) * 1999-04-09 2015-03-04 Zoetis P&U LLC Attenuated Pasteurellaceae bacterium having a mutation in a virulence gene
WO2003029470A1 (en) * 2001-09-26 2003-04-10 Kyowa Hakko Kogyo Co., Ltd. PROCESS FOR PRODUCING α1,4-GALACTOSYLTRANSFERASE AND GALACTOSE-CONTAINING COMPLEX SUGAR
US7449178B2 (en) 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria
DE60230717D1 (de) * 2002-04-05 2009-02-26 Merial Sas Attenuirte Gram-negative Bakterien
GB0228691D0 (en) * 2002-12-09 2003-01-15 Imp College Innovations Ltd Bacterial virulence genes
US20070065906A1 (en) * 2003-03-05 2007-03-22 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing heterologous protein in e. coli
US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
EP2073829B1 (en) * 2006-10-05 2012-06-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
JP2011522796A (ja) 2008-05-06 2011-08-04 ニューヨーク ブラッド センター， インコーポレイテッド 抗ウイルス細胞透過性ペプチド
DE102011016772B8 (de) * 2011-04-12 2024-08-14 Mercedes-Benz Group AG Verfahren und Vorrichtung zur Überwachung zumindest eines Fahrzeuginsassen und Verfahren zum Betrieb zumindest einer Assistenzvorrichtung
EP3062816B1 (en) 2013-11-01 2020-08-05 Boehringer Ingelheim Animal Health USA Inc. Attenuated pasteurella multocida vaccines & methods of making & use thereof
MX2019009409A (es) 2017-02-10 2019-09-27 Epitopix Llc Proteinas y composiciones de inmunizacion que contienen proteinas de pasteurella y metodos de uso.
TW202214294A (zh) 2020-09-30 2022-04-16 美商碩騰服務公司 具有ｈｙａＣ及ｎａｎＰ缺失之新穎多殺性巴斯德氏菌株及疫苗
TW202219269A (zh) 2020-09-30 2022-05-16 美國農業部 新型多殺性巴斯德氏菌株及具有ｈｙａＣ與ｎａｎＰ缺失之疫苗
CN113567415A (zh) * 2021-07-05 2021-10-29 广西大学 表面增强拉曼散射结合免疫层析技术检测布鲁氏杆菌方法
CN116593695B (zh) * 2022-12-29 2025-08-05 重庆澳龙生物制品有限公司 一种牛多杀性巴氏杆菌荚膜a型elisa抗体检测试剂盒及其制备方法和应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL52815A (en) * 1977-08-24 1983-03-31 Israel State Fowl cholera vaccine and process for producing an attenuated non-virulent strain of pasteurella multocida
US4735801A (en) * 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
DE3426532A1 (de) 1984-07-18 1986-01-30 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verwendung einer dna-sequenz zur expression sowie dna-struktur und expressionsvektor mit der dna-sequenz
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4877612A (en) 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
DK166762B1 (da) 1986-01-14 1993-07-12 Nederlanden Staat Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser
US4806352A (en) 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
IL86583A0 (en) * 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5376369A (en) * 1987-11-03 1994-12-27 Syntex (U.S.A.) Inc. Vaccine adjuvant
DK46693D0 (OSRAM) * 1993-04-23 1993-04-23 Novo Nordisk As
ES2131069T3 (es) * 1991-03-05 1999-07-16 Wellcome Found Expresion de proteinas recombinantes en bacterias atenuadas.
US5840312A (en) * 1991-05-02 1998-11-24 Institut Pasteur Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein
AU5591694A (en) * 1992-11-06 1994-06-08 Regents Of The University Of Minnesota Composition protective against (p. multocida) pasteurellosis infection
US5585277A (en) 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5587305A (en) 1993-12-06 1996-12-24 The United States Of America As Represented By The Department Of Agriculture Pasteurella haemolytica transformants
WO1995020652A1 (de) 1994-01-28 1995-08-03 Medigene Gmbh Verfahren zur bestimmung der aktivität eines regulatorischen faktors sowie verwendung dieses verfahrens
US5888783A (en) 1994-08-30 1999-03-30 Ajinomoto Co., Inc. Methods for producing L-valine and L-leucine
DK0796341T3 (da) 1994-12-09 1999-06-14 Imp College Innovations Ltd Identifikation af gener, som tillader tilpasning af en mikroorganisme til en særlig omgivelse
CA2170839A1 (en) * 1995-03-01 1996-09-02 Janet Macinnes Bacterial preparations, method for producing same, and their use as vaccines
US6355450B1 (en) 1995-04-21 2002-03-12 Human Genome Sciences, Inc. Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US5994066A (en) 1995-09-11 1999-11-30 Infectio Diagnostic, Inc. Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5925354A (en) 1995-11-30 1999-07-20 Michigan State University Riboflavin mutants as vaccines against Actinobacillus pleuropneumoniae
US5840556A (en) * 1996-05-08 1998-11-24 The United States Of America As Represented By The Department Of Agriculture Molecular genetic construction of vaccine strains of pasteurellaceae
HU226219B1 (en) * 1996-05-31 2008-06-30 Intervet Int Bv Live attenuated rtx-producing bacteria of the family pasteurellaceae
US6020474A (en) 1997-01-15 2000-02-01 Incyte Pharmaceuticals, Inc. ATP synthase subunits
US6673538B1 (en) 1997-07-25 2004-01-06 The Trustees Of Boston University Methods and compositions for designing vaccines
EP2281834B1 (en) * 1999-04-09 2015-03-04 Zoetis P&U LLC Attenuated Pasteurellaceae bacterium having a mutation in a virulence gene
US6790950B2 (en) 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
AU7131600A (en) 1999-06-21 2001-01-09 North Carolina State University Acid-inducible promoters for gene expression
CA2379119A1 (en) 1999-07-12 2001-01-18 Xoma Technology Ltd. Method to identify inhibitors f1/f0 atpase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115925536A (zh) * 2022-08-01 2023-04-07 北京农学院 靶向抑制DksA的小分子抑制剂和应用

Also Published As

Publication number Publication date
EP1860117A2 (en) 2007-11-28
US9289486B2 (en) 2016-03-22
AU2005203189A1 (en) 2005-08-18
US20090202594A1 (en) 2009-08-13
CA2366520A1 (en) 2000-10-19
AR029622A1 (es) 2003-07-10
JP2010284165A (ja) 2010-12-24
NZ514883A (en) 2004-03-26
US7763262B2 (en) 2010-07-27
CA2366520C (en) 2013-10-01
EP2281835A2 (en) 2011-02-09
JP5973634B2 (ja) 2016-08-23
EP2281834B1 (en) 2015-03-04
US8974798B2 (en) 2015-03-10
EP2281834A2 (en) 2011-02-09
ES2439645T3 (es) 2014-01-24
ES2535961T3 (es) 2015-05-19
KR20010112937A (ko) 2001-12-22
EP1171577A2 (en) 2002-01-16
WO2000061724A3 (en) 2001-02-01
EP2281834A3 (en) 2011-11-23
JP5377433B2 (ja) 2013-12-25
KR20060116041A (ko) 2006-11-13
JP2016019528A (ja) 2016-02-04
AU780887B2 (en) 2005-04-21
BR0009663A (pt) 2002-04-09
JP2013121347A (ja) 2013-06-20
US20120148625A1 (en) 2012-06-14
WO2000061724A2 (en) 2000-10-19
JP4892134B2 (ja) 2012-03-07
EP2281833B1 (en) 2014-07-02
HK1045856A1 (zh) 2002-12-13
EP2281835A3 (en) 2011-11-23
EP1860117A3 (en) 2008-09-03
AU4077600A (en) 2000-11-14
US20150182615A1 (en) 2015-07-02
US20070237793A1 (en) 2007-10-11
NZ530012A (en) 2005-10-28
AU2005203189B2 (en) 2007-12-20
EP2281833A2 (en) 2011-02-09
US20100322975A1 (en) 2010-12-23
EP2281835B1 (en) 2013-11-06
MXPA01010207A (es) 2003-07-21
KR20060134225A (ko) 2006-12-27
EP2281833A3 (en) 2011-11-30
JP2002541790A (ja) 2002-12-10
KR20070011622A (ko) 2007-01-24

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