CN1347460A - 用于检测含标记的靶的单分子层和电极以及它们的应用方法 - Google Patents

用于检测含标记的靶的单分子层和电极以及它们的应用方法 Download PDF

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Publication number
CN1347460A
CN1347460A CN00806497A CN00806497A CN1347460A CN 1347460 A CN1347460 A CN 1347460A CN 00806497 A CN00806497 A CN 00806497A CN 00806497 A CN00806497 A CN 00806497A CN 1347460 A CN1347460 A CN 1347460A
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China
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group
phosphonate
monolayer
target
electrode
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CN00806497A
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English (en)
Chinese (zh)
Inventor
A·E·埃克哈德特
J·C·米库莱基
M·E·纳皮尔
R·S·托马斯
H·H·托尔普
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Publication of CN1347460A publication Critical patent/CN1347460A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Force Measurement Appropriate To Specific Purposes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN00806497A 1999-04-22 2000-02-04 用于检测含标记的靶的单分子层和电极以及它们的应用方法 Pending CN1347460A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/296,929 US6127127A (en) 1995-06-27 1999-04-22 Monolayer and electrode for detecting a label-bearing target and method of use thereof
US09/296929 1999-04-22

Publications (1)

Publication Number Publication Date
CN1347460A true CN1347460A (zh) 2002-05-01

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CN00806497A Pending CN1347460A (zh) 1999-04-22 2000-02-04 用于检测含标记的靶的单分子层和电极以及它们的应用方法

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Country Link
US (1) US6127127A (enExample)
EP (1) EP1185692B1 (enExample)
JP (1) JP2002542794A (enExample)
KR (1) KR20020008157A (enExample)
CN (1) CN1347460A (enExample)
AT (1) ATE312200T1 (enExample)
AU (1) AU781085B2 (enExample)
CA (1) CA2367594A1 (enExample)
DE (1) DE60024618D1 (enExample)
HK (1) HK1045178B (enExample)
NO (1) NO20014882L (enExample)
NZ (1) NZ514682A (enExample)
WO (1) WO2000065099A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107884370A (zh) * 2016-09-30 2018-04-06 斯帕克生物制药有限公司 鉴定药物分子的靶标蛋白质的方法

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6346387B1 (en) 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US7815963B2 (en) * 1996-10-17 2010-10-19 The Trustees Of Princeton University Enhanced bonding layers on titanium materials
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7348183B2 (en) * 2000-10-16 2008-03-25 Board Of Trustees Of The University Of Arkansas Self-contained microelectrochemical bioassay platforms and methods
CN1481441A (zh) * 2000-10-20 2004-03-10 斯坦福大学受托管理委员会 根据瞬时电信号表征样品中分子间相互作用和运动的方法和设备
US6632536B2 (en) * 2000-12-28 2003-10-14 International Business Machines Corporation Self-assembled monolayer etch barrier for indium-tin-oxide useful in manufacturing thin film transistor-liquid crystal displays
DE10126798A1 (de) * 2001-06-01 2002-12-19 Nanotype Gmbh Verfahren zur Bestimmung einer Probe
US20020182606A1 (en) * 2001-06-04 2002-12-05 Xanthon, Inc. Detection of single nucleotide polymorphisms
US20040248282A1 (en) * 2001-06-11 2004-12-09 Pisharody Sobha M. Electronic detection of biological molecules using thin layers
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
JP2004534226A (ja) * 2001-06-29 2004-11-11 メソ スケイル テクノロジーズ，エルエルシー 発光試験測定用のアッセイプレート、リーダシステム及び方法
WO2003062783A2 (en) * 2001-07-20 2003-07-31 North Carolina State University Light addressable electrochemical detection of duplex structures
JP4262426B2 (ja) * 2001-09-03 2009-05-13 富士フイルム株式会社 核酸断片固定電極及びその利用
US20050014151A1 (en) * 2001-09-12 2005-01-20 Marcus Textor Device with chemical surface patterns
AU2004201425B2 (en) * 2001-09-24 2007-06-28 University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
US7202028B2 (en) * 2001-09-24 2007-04-10 The University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
EP1583842A4 (en) * 2001-09-24 2007-07-04 Univ North Carolina PROCESS FOR ELECTROCHEMICAL DETECTION OF MULTIPLE TARGET LINKS
US20040014078A1 (en) * 2002-02-06 2004-01-22 James Xia Compositions and methods for rolling circle amplification
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
GB0211449D0 (en) * 2002-05-17 2002-06-26 Oxford Biosensors Ltd Analyte measurement
ATE544867T1 (de) * 2002-12-11 2012-02-15 Centre Nat Rech Scient Methode zur elektronischen detektion wenigstens einer spezifischen interaktion zwischen einem proben- und einem zielmolekül
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
KR100547015B1 (ko) * 2003-05-23 2006-01-26 주식회사 올메디쿠스 일정한 크기 이상의 분석물질을 정량 분석하기 위한바이오센서 및 그 제조방법
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
WO2005042783A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Temperature-jump enhanced electrochemical detection of nucleic acid hybridization
US7981362B2 (en) * 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
US8048377B1 (en) 2004-03-08 2011-11-01 Hewlett-Packard Development Company, L.P. Immobilizing chemical or biological sensing molecules on semi-conducting nanowires
US7462452B2 (en) * 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US20060094024A1 (en) * 2004-11-01 2006-05-04 Pirrung Michael C Electrochemical arrays
US20090203547A1 (en) * 2005-02-18 2009-08-13 Albert Banes Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions
US20070235346A1 (en) * 2006-04-11 2007-10-11 Popovich Natasha D System and methods for providing corrected analyte concentration measurements
US7909983B2 (en) * 2006-05-04 2011-03-22 Nipro Diagnostics, Inc. System and methods for automatically recognizing a control solution
CN101506380A (zh) * 2006-08-11 2009-08-12 香港科技大学 用电导或电化学活跃标签实时定量分析与监察核酸扩增的方法与系统
US20080131709A1 (en) * 2006-09-28 2008-06-05 Aculon Inc. Composite structure with organophosphonate adherent layer and method of preparing
US9688718B2 (en) 2008-01-11 2017-06-27 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising hydrogenases and related products, methods and systems
WO2009100201A2 (en) * 2008-02-07 2009-08-13 Lawrence Livermore National Security, Llc Functionalized platform for arrays configured for optical detection of targets and related arrays, methods and systems
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US20110195862A1 (en) 2010-02-08 2011-08-11 Pett-Ridge Jennifer Devices, methods and systems for target detection
EP2661485A4 (en) 2011-01-06 2018-11-21 Meso Scale Technologies, LLC Assay cartridges and methods of using the same
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
WO2016049061A1 (en) 2014-09-22 2016-03-31 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems
US12226529B2 (en) 2015-08-25 2025-02-18 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
WO2018204495A1 (en) 2017-05-02 2018-11-08 Synthetic Genomics, Inc. Nanolipoprotein particles and related compositions methods and systems for loading rna
WO2018204421A2 (en) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Momp telonanoparticles, and related compositions, methods and systems
WO2019075261A1 (en) * 2017-10-11 2019-04-18 Microvention, Inc. PHOSPHONATES AND THEIR USES
CN116242814B (zh) * 2023-04-14 2025-10-03 中国农业大学 一种联吡啶类化合物的荧光检测方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3278334D1 (en) * 1981-10-23 1988-05-19 Genetics Int Inc Sensor for components of a liquid mixture
EP0149339B1 (en) * 1983-12-16 1989-08-23 MediSense, Inc. Assay for nucleic acids
US4704353A (en) * 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4883579A (en) * 1984-04-27 1989-11-28 Molecular Devices Corporation Photoresponsive redox detection and discrimination
GB8417301D0 (en) * 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US5112974A (en) * 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
US5157032A (en) * 1985-01-18 1992-10-20 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents and probes to DNA
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
GB8606719D0 (en) * 1986-03-19 1986-04-23 Lister Preventive Med Genetic probes
US5066372A (en) * 1986-05-02 1991-11-19 Ciba Corning Diagnostics Corp. Unitary multiple electrode sensor
US4908307A (en) * 1986-12-19 1990-03-13 Karin D. Rodland Hybridization method and probe for detecting nucleic acid sequences
US4963815A (en) * 1987-07-10 1990-10-16 Molecular Devices Corporation Photoresponsive electrode for determination of redox potential
US5108889A (en) * 1988-10-12 1992-04-28 Thorne, Smith, Astill Technologies, Inc. Assay for determining analyte using mercury release followed by detection via interaction with aluminum
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5194372A (en) * 1989-07-10 1993-03-16 Hitachi, Ltd. Method and apparatus for detecting disorders in genomic substances
JPH0376600A (ja) * 1989-08-21 1991-04-02 Hitachi Ltd 遺伝子変異検出法
CA2033692A1 (en) * 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
AU7575291A (en) * 1990-04-06 1991-10-30 Syngene, Inc. Process and composition for performing dna assays
US5667976A (en) * 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
DE69125441T2 (de) * 1990-09-28 1997-11-06 Toshiba Kawasaki Kk Verfahren zum Gennachweis
US5776672A (en) * 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
JP3076600B2 (ja) 1990-11-20 2000-08-14 株式会社日本マイクロニクス 表示パネル用プローバ
US5272056A (en) * 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
FR2673289B1 (fr) * 1991-02-21 1994-06-17 Asulab Sa Capteur de mesure de la quantite d'un composant en solution.
US5171853A (en) * 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5565322A (en) * 1991-11-07 1996-10-15 Nanogen, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system
GB9206671D0 (en) * 1992-03-27 1992-05-13 Cranfield Biotech Ltd Electrochemical detection of dna hybridisation
US5552274A (en) * 1992-09-07 1996-09-03 Terumo Kabushiki Kaisha Method for detecting target sequences by oscillation frequency
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
FR2703359B1 (fr) * 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
EP0705271B1 (en) * 1993-06-25 2002-11-13 Affymetrix, Inc. (a Delaware Corporation) Hybridization and sequencing of nucleic acids
US5494562A (en) * 1994-06-27 1996-02-27 Ciba Corning Diagnostics Corp. Electrochemical sensors
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
IT1275482B (it) * 1995-07-05 1997-08-07 Cooperativa Centro Ricerche Po Biosensori elettrochimici basati su trasduttori compositi
CA2255952A1 (en) * 1996-05-22 1997-11-27 Australian Membrane And Biotechnology Research Institute Nucleic acid sensor
AU739375B2 (en) * 1996-11-05 2001-10-11 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
ATE322010T1 (de) * 1996-11-29 2006-04-15 Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer- membranen und ihre anwendungsverfahren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107884370A (zh) * 2016-09-30 2018-04-06 斯帕克生物制药有限公司 鉴定药物分子的靶标蛋白质的方法

Also Published As

Publication number Publication date
AU3483000A (en) 2000-11-10
US6127127A (en) 2000-10-03
DE60024618D1 (de) 2006-01-12
EP1185692B1 (en) 2005-12-07
HK1045178B (en) 2006-08-11
NO20014882L (no) 2001-12-27
HK1045178A1 (en) 2002-11-15
CA2367594A1 (en) 2000-11-02
KR20020008157A (ko) 2002-01-29
NO20014882D0 (no) 2001-10-08
AU781085B2 (en) 2005-05-05
EP1185692A1 (en) 2002-03-13
JP2002542794A (ja) 2002-12-17
WO2000065099A1 (en) 2000-11-02
NZ514682A (en) 2003-07-25
ATE312200T1 (de) 2005-12-15

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