CN1335843A - 疱疹病毒的硫脲抑制剂 - Google Patents

疱疹病毒的硫脲抑制剂 Download PDF

Info

Publication number
CN1335843A
CN1335843A CN99815807A CN99815807A CN1335843A CN 1335843 A CN1335843 A CN 1335843A CN 99815807 A CN99815807 A CN 99815807A CN 99815807 A CN99815807 A CN 99815807A CN 1335843 A CN1335843 A CN 1335843A
Authority
CN
China
Prior art keywords
phenyl
chloro
amino
carbon atom
thioureido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99815807A
Other languages
English (en)
Chinese (zh)
Inventor
J·D·布卢姆
M·J·迪格安迪
R·G·杜什
S·A·兰格
B·M·奥哈拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1335843A publication Critical patent/CN1335843A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
CN99815807A 1998-12-09 1999-12-06 疱疹病毒的硫脲抑制剂 Pending CN1335843A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09
US09/208,540 1998-12-09

Publications (1)

Publication Number Publication Date
CN1335843A true CN1335843A (zh) 2002-02-13

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99815807A Pending CN1335843A (zh) 1998-12-09 1999-12-06 疱疹病毒的硫脲抑制剂

Country Status (18)

Country Link
EP (1) EP1140913A1 (ko)
JP (1) JP2002531558A (ko)
KR (1) KR20010086082A (ko)
CN (1) CN1335843A (ko)
AU (1) AU756043B2 (ko)
BG (1) BG105580A (ko)
BR (1) BR9916042A (ko)
CA (1) CA2351390A1 (ko)
CZ (1) CZ20011958A3 (ko)
EA (1) EA200100637A1 (ko)
HU (1) HUP0104758A3 (ko)
ID (1) ID29064A (ko)
IL (1) IL143203A0 (ko)
NO (1) NO20012836L (ko)
PL (1) PL348177A1 (ko)
SK (1) SK7692001A3 (ko)
TR (1) TR200101598T2 (ko)
ZA (1) ZA200104373B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60023853T2 (de) * 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
JP3938651B2 (ja) * 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−３、５−（トリフルオロメチル）ベンジルアミンの製造方法
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
US20100016298A1 (en) * 2005-08-29 2010-01-21 Housey Gerad M Theramutein modulators
CN108642926B (zh) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 一种涤纶染色清洗用的硫脲衍生物及其制备方法
EP4063349A4 (en) * 2019-11-19 2023-12-20 Takeda Pharmaceutical Company Limited METHOD FOR PRODUCING A PYRROLIDINE COMPOUND

Also Published As

Publication number Publication date
HUP0104758A3 (en) 2002-05-28
HUP0104758A2 (hu) 2002-04-29
ID29064A (id) 2001-07-26
BR9916042A (pt) 2001-12-04
EP1140913A1 (en) 2001-10-10
PL348177A1 (en) 2002-05-06
CZ20011958A3 (cs) 2001-10-17
TR200101598T2 (tr) 2001-10-22
NO20012836D0 (no) 2001-06-08
CA2351390A1 (en) 2000-06-15
NO20012836L (no) 2001-08-08
JP2002531558A (ja) 2002-09-24
SK7692001A3 (en) 2002-09-10
KR20010086082A (ko) 2001-09-07
AU756043B2 (en) 2003-01-02
BG105580A (bg) 2002-01-31
AU3112200A (en) 2000-06-26
IL143203A0 (en) 2002-04-21
ZA200104373B (en) 2002-09-18
EA200100637A1 (ru) 2001-12-24

Similar Documents

Publication Publication Date Title
CN1171872C (zh) 调节PPARγ活性的化合物
CN1211382C (zh) 喹唑啉二甲苯磺酸盐化合物
CN1169795C (zh) 环胺取代的含氮杂环化合物及其组合物
CN1219768C (zh) 作为mek酶的抑制剂的喹啉衍生物
CN1267431C (zh) 取代的喹唑啉衍生物及其在制备作为抑制剂的药物中的用途
CN1234358C (zh) 苯并噻唑衍生物
CN1252054C (zh) 抑制生长因子的作用的喹啉衍生物
CN1114402C (zh) 异噻唑酮类化合物、含它们的制剂及其用途
CN1926103A (zh) 磺酰基吡咯作为hdac抑制剂
CN1333750A (zh) 含乙酰胺和取代的乙酰胺的疱疹病毒硫脲抑制剂
CN1906155A (zh) 异羟肟酸酯衍生物及其医药用途
CN1214041A (zh) 磺化的氨基酸衍生物及含有它的金属蛋白酶抑制剂
CN1351590A (zh) 化合物
CN1413210A (zh) 用于治疗炎症、自身免疫性疾病和呼吸系统疾病的vla－4依赖性细胞结合的非肽基抑制剂
CN1678586A (zh) 取代的喹啉ccr5受体拮抗剂
CN1747936A (zh) 作为治疗试剂的取代吡咯衍生物
CN1942445A (zh) 作为jack3激酶调节剂的新的喹啉－甲酰胺类化合物
CN1849318A (zh) 用2,4－嘧啶二胺化合物预防和治疗自体免疫疾病的方法
CN1331688A (zh) 氨基吡啶衍生物
CN1279669A (zh) 芳族砜异羟肟酸金属蛋白酶抑制剂
CN1349519A (zh) 葡糖激酶活化剂
CN101068797A (zh) 含有噻唑环的羧酸衍生物及其药物用途
CN1070173C (zh) 用作药物的苯甲酰基胍衍生物
CN1348446A (zh) 含苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂
CN1237961A (zh) 用作蛋白酶抑制剂的氨基胍和烷氧基胍类化合物

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication