CN1331512C - Mixture of eliminating sputum and relieving asthma and preparation method - Google Patents
Mixture of eliminating sputum and relieving asthma and preparation method Download PDFInfo
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- CN1331512C CN1331512C CNB200410036488XA CN200410036488A CN1331512C CN 1331512 C CN1331512 C CN 1331512C CN B200410036488X A CNB200410036488X A CN B200410036488XA CN 200410036488 A CN200410036488 A CN 200410036488A CN 1331512 C CN1331512 C CN 1331512C
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Abstract
The present invention discloses the prescription of a Chinese medicinal mixture for eliminating phlegm and relieving asthma and a preparation method thereof. The medicinal mixture is divided into a sugar-containing type and a sugar-free type, wherein the sugar-containing mixture comprises the following components: 300 to 600 parts of houttuynia, 100 to 200 parts of platycodon root, 100 to 200 parts of peppergrass seed, 150 to 300 parts of snakegourd fruit, 100 to 200 parts of peucedanum root, 100 to 200 parts of tatarian aster root, 100 to 200 parts of fritillaria, 100 to 300 parts mulberry bark, 100 to 200 parts of earthworm and 300 to 400 parts of crystal sugar (or honey), and the sugar-free mixture comprises the same components as that of the sugar-containing mixture except the crystal sugar (or honey). The preparation method of the mixture comprises the following steps: a. medicine selection; b. volatile oil extraction; c. decoction; d. concentration; e. alcohol deposition; f. liquid preparation. The mixture has strong functions for eliminating phlegm and relieving asthma, has an abirritative function for promoting diuresis, and is more suitable for patients with phlegm dyspnea and pulmonary edema or cardiac insufficiency.
Description
Affiliated technical field
The present invention relates to a kind of herb mixture and preparation method thereof, more specifically is eliminating phlegm and relieving asthma herb mixture and preparation method thereof.
Background technology
Cold season, acute and chronic bronochitic was a lot, and especially PD is to obstructive emphysema, pulmonary heart disease concurrent infection stage, and doctor trained in Western medicine gives conventional antibiotic and eliminating phlegm and relieving asthma western medicine, takes effect slowly.The patient reflects generally that for the expectorant western medicine curative effect is not obvious.Sometimes give atomizings such as Chymotrypsin, gentamycin and suck, many patients can't stand the special odor of medicine is anti-, even dyspnea increases the weight of when atomizing sucks, and simply refuses this therapy.Though the Chinese medicine expectorant effect is fine, open prescription and allow and oneself boil Chinese medicine, most people feel again to be difficult to grasp the duration and degree of heating and amount of water or the like, and fully feel trouble, are difficult to accept.
Original resolving phlegm and relieving asthma Chinese medicine preparation, its configuration and method for making are as follows: medicine components consists of: Herba Houttuyniae 300, Fructus Trichosanthis 150, Cortex Mori 150, Radix Platycodonis 100, Radix Peucedani 100, Radix Asteris 100, Pheretima 100, Semen Lepidii (Semen Descurainiae) (little stir-fry is smashed to pieces) 100, Bulbus Fritillariae Thunbergii (smashing to pieces) 100, crystal sugar 300.
Preparation method: will mix with nine herbal medicines of going forward earlier, and add water 5000 for the first time, extracting juice 2000 after the infusion, for the second time add water 3000, extracting juice 1000 after the infusion, then with the decoction liquor hybrid filtering of being got for twice, other boils the dissolving mixing with crystal sugar 300, and sterile filling promptly.
Function with cure mainly: eliminating phlegm and relieving asthma.Be used for acute and chronic bronchitis and other phlegm dyspnea pneumonopathy.Usage and consumption: oral.A 30～50ml, every day 3 times.
But this preparation exists 1. oral metered big, and carrying inconvenient 2. has deposited phenomenon, need shake up during clothes.Standing time short, day heat shortcoming such as easily go mouldy.
Summary of the invention
The objective of the invention is in order to overcome above inconvenience of decocting medicinal herbs, being difficult to of amount of water determined, being difficult to of the duration and degree of heating grasped, shortcomings such as oral metered is big, carry inconvenience, need shake up when deposited phenomenon, clothes are arranged, and standing time is short, day heat is easily gone mouldy, original oral liquid is concentrated, production technology is improved, a kind of new eliminating phlegm and relieving asthma mixture and preparation method thereof is provided, can solve above problem.
The objective of the invention is to realize in the following way.
Eliminating phlegm and relieving asthma mixture of the present invention is wherein made raw materials of effective components and be basic composition is: Herba Houttuyniae 300～600, Radix Platycodonis 100～200, Semen Lepidii (Semen Descurainiae) 100～200, Fructus Trichosanthis 150～300, Radix Peucedani 100～200, Radix Asteris 100～200, Bulbus Fritillariae Uninbracteatae 100～200, Cortex Mori 100～300, Pheretima 100～200.
The objective of the invention is and to realize by following measure.
(1) the eliminating phlegm and relieving asthma mixture of sugar-containing type, wherein make raw materials of effective components and consist of:
Herba Houttuyniae 400, Radix Platycodonis 200, Semen Lepidii (Semen Descurainiae) 200, Fructus Trichosanthis 300, Radix Peucedani 150, Radix Asteris 150, Bulbus Fritillariae Cirrhosae 200, Cortex Mori 200, Pheretima 200, crystal sugar or Mel 300.
(2) Sugarless type eliminating phlegm and relieving asthma mixture, wherein make raw materials of effective components and consist of:
Herba Houttuyniae 400, Radix Platycodonis 200, Semen Lepidii (Semen Descurainiae) 200, Fructus Trichosanthis 300, Radix Peucedani 150, Radix Asteris 150, Bulbus Fritillariae Cirrhosae 200, Cortex Mori 200, Pheretima 200.
The preparation method of eliminating phlegm and relieving asthma mixture of the present invention may further comprise the steps:
A. above medical material is cleaned, Radix Platycodonis, Radix Peucedani, Radix Asteris, Cortex Mori section, the Pheretima cutting, the Fructus Trichosanthis shredding, the Bulbus Fritillariae Cirrhosae fragmentation, the little stir-fry of Semen Lepidii (Semen Descurainiae) back is broken.
B. extract volatile oil: Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted volatile oil, and standing demix divides the branch that anhydrates, and filters out impurities, and puts in the clean container standby.
C. decoct: medicinal residues and other Six-element medicines that Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted behind the volatile oil decoct twice, add 6 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1.5 hours, merge twice decoction liquor and leave standstill 12 hours.
D. concentrate: get the supernatant concentration that decocts after leaving standstill to relative density 1.17～1.19 in the time of 85 ℃.
E. precipitate with ethanol: get concentrated solution and add ethanol, make to contain the alcohol amount and reach 70%, cold preservation was left standstill 24 hours, got supernatant and reclaimed ethanol to the greatest extent, did not have the alcohol flavor, relative density 1.17～1.19 in the time of 55 ℃.
F. dosing: the clear paste behind the precipitate with ethanol is added purified water boiled 30 minutes, coarse filtration is to Agitation Tank, in molten sugar bowl, inject an amount of purified water in addition and boil, stir the adding crystal sugar, boiled 30 minutes, coarse filtration is to Agitation Tank, then with an amount of purified water with potassium sorbate dissolving and add in the Agitation Tank, add volatile oil, add an amount of purified water again and adjust total amount and make relative density be not less than 1.01, the cold filter after 24 hours of pH value 4.0～6.0, Cryoprecipitation, canned, sterilization, lamp inspection, packing are promptly.This mixture also can go to replace crystal sugar with Mel, and the clinical observation curative effect does not have significant difference.
Function with cure mainly: eliminating phlegm and relieving asthma.Be used for acute and chronic bronchitis and other phlegm dyspnea pneumonopathy.Oral, a 10～20ml, 3 times on the one.Diabetes, the hyperchlorhydria patient avoids clothes; Cold fluid-retention, insufficiency of the spleen loose stool patient avoids clothes.
The eliminating phlegm and relieving asthma mixture that is sugar-containing type that obtains by the method.
Remove sugaring technology in the preparation method of sugar-containing type eliminating phlegm and relieving asthma mixture, what obtain is Sugarless type eliminating phlegm and relieving asthma mixture.
Function with cure mainly: eliminating phlegm and relieving asthma.Be used for acute and chronic bronchitis and other phlegm dyspnea pneumonopathy.Oral, a 10～20ml, 3 times on the one.Cold fluid-retention, insufficiency of the spleen loose stool patient avoids clothes.
Often run into diabetes clinically, the patient of peptic ulcer and hyperchlorhydria suffers from respiratory tract disease simultaneously, and they can not take to contain sugared preparation, therefore designs Sugarless type eliminating phlegm and relieving asthma mixture, takes for all patients.Experiment showed, not add correctives, this mixture is also not too bitter, and the patient can accept.
Herba Houttuyniae, Fructus Trichosanthis, Bulbus Fritillariae Cirrhosae clearing heat, eliminating phlegm, relieving cough in the prescription; Radix Platycodonis, Radix Peucedani, Radix Asteris, crystal sugar expelling phlegm for arresting cough; Cortex Mori, Pheretima, Semen Lepidii (Semen Descurainiae) clearing heat and relieving dyspnea diuretic.Herba Houttuyniae, Radix Platycodonis can not only strengthen exempts from service, and with Fructus Trichosanthis, Pheretima, Bulbus Fritillariae Cirrhosae, Radix Asteris antibiosis and antiviral functions is arranged all.All medicines share, and stronger eliminating phlegm and relieving asthma effect is arranged.Heat-phlegm, dry phlegm, damp-phlegm through Chinese medical discrimination all can be used.Because of this mixture has gentle diuretic effect simultaneously, have pulmonary edema or cardiac insufficiency person concurrently for phlegm dyspnea, be more suitable for taking.
The specific embodiment:
Get earlier: Herba Houttuyniae 400g, Radix Platycodonis 200g, Semen Lepidii (Semen Descurainiae) 200g, Fructus Trichosanthis 300g, Radix Peucedani 150g, Radix Asteris 150g, Bulbus Fritillariae Cirrhosae 200g, Cortex Mori 200g, Pheretima 200g, crystal sugar or Mel 300g.
1. above nine flavor medical materials are cleaned, remove impurity and non-medicinal part, with about Radix Platycodonis, Radix Peucedani, Radix Asteris, Cortex Mori section 2mm, about Pheretima cutting 10～15mm, about Fructus Trichosanthis shredding 2～3mm, the Bulbus Fritillariae Cirrhosae fragmentation, the little stir-fry of Semen Lepidii (Semen Descurainiae) back is broken.
2. extraction volatile oil: Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted volatile oil, and standing demix divides branchs that anhydrate, and filters out impurities, and it is interior standby to put clean container.
3. decoct: medicinal residues and other Six-element medicine that Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted behind the volatile oil decoct twice, add 6 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1.5 hours, merge twice decoction liquor and leave standstill 12 hours.
4. concentrate: get the supernatant concentration that decocts after leaving standstill to relative density 1.17～1.19 in the time of 85 ℃.
5. precipitate with ethanol: get concentrated solution and add ethanol, make to contain the alcohol amount and reach 70%, cold preservation was left standstill 24 hours, got supernatant and reclaimed ethanol to the greatest extent, did not have the alcohol flavor, _ relative density 1.17～1.19 in the time of 55 ℃.
6. dosing: the clear paste behind the precipitate with ethanol is added purified water boiled 30 minutes, coarse filtration is injected an amount of purified water in addition and is boiled to Agitation Tank in molten sugar bowl, stir adding crystal sugar 300g, boiled 30 minutes, coarse filtration is to Agitation Tank, then with an amount of purified water with potassium sorbate 4g dissolving and add in the Agitation Tank, add volatile oil, it is 2000ml that an amount of purified water is adjusted total amount, adjust relative density simultaneously and be not less than 1.01, pH value 4.0～6.0, Cryoprecipitation is cold filter after 24 hours, canned, sterilization, lamp inspection, packing is promptly.But this mixture is deicing sugar and use Mel also, and the clinical observation curative effect does not have significant difference.
Clinical observation on the therapeutic effect:
1. chronic obstructive pulmonary disease (COPD) cooperates western medical treatment 30 examples with mixture, and contrasts with pure western medical treatment 28, can obviously improve patient's cardinal symptom and sign, improves clinic control rate utmost point produce effects fruit.
2. acute trachea-bronchitis cooperates western medical treatment 76 examples, cooperates western medical treatment pneumonia 8 examples, can improve cough quickly, expectoration, and symptom out of breath makes temperature recovery normal, shortens the course of disease, improves cure rate.
3. pulmonary carcinoma and obstructive pneumonia are treated 6 examples, can in time discharge airway secretions, alleviate dyspnea, improve the quality of living.
4. bronchial asthma cooperates western medicine 10 examples, can increase sputum and discharge, and alleviates dyspnea.
Claims (5)
1. the eliminating phlegm and relieving asthma herb mixture is wherein made raw materials of effective components and be basic composition is: Herba Houttuyniae 300～600, Radix Platycodonis 100～200, Semen Lepidii (Semen Descurainiae) 100～200, Fructus Trichosanthis 150～300, Radix Peucedani 100～200, Radix Asteris 100～200, Bulbus Fritillariae Uninbracteatae 100～200, Cortex Mori 100～300, Pheretima 100～200.
2. eliminating phlegm and relieving asthma herb mixture as claimed in claim 1 is wherein made raw materials of effective components and is consisted of: Herba Houttuyniae 400, Radix Platycodonis 200, Semen Lepidii (Semen Descurainiae) 200, Fructus Trichosanthis 300, Radix Peucedani 150, Radix Asteris 150, Bulbus Fritillariae Cirrhosae 200, Cortex Mori 200, Pheretima 200, crystal sugar or Mel 300.
3. eliminating phlegm and relieving asthma herb mixture as claimed in claim 1 is wherein made raw materials of effective components and is consisted of: Herba Houttuyniae 400, Radix Platycodonis 200, Semen Lepidii (Semen Descurainiae) 200, Fructus Trichosanthis 300, Radix Peucedani 150, Radix Asteris 150, Bulbus Fritillariae Cirrhosae 200, Cortex Mori 200, Pheretima 200.
4. the preparation method of eliminating phlegm and relieving asthma herb mixture as claimed in claim 2 is characterized in that comprising the steps:
A. above medical material is cleaned, Radix Platycodonis, Radix Peucedani, Radix Asteris, Cortex Mori section, the Pheretima cutting, the Fructus Trichosanthis shredding, the Bulbus Fritillariae Cirrhosae fragmentation, the little stir-fry of Semen Lepidii (Semen Descurainiae) back is broken;
B. extract volatile oil: Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted volatile oil, and standing demix divides the branch that anhydrates, and filters out impurities, and puts in the clean container standby;
C. decoct: medicinal residues and other Six-element medicines that Herba Houttuyniae, Fructus Trichosanthis, Radix Peucedani are extracted behind the volatile oil decoct twice, add 6 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1.5 hours, merge twice decoction liquor and leave standstill 12 hours;
D. concentrate: get the supernatant concentration that decocts after leaving standstill to relative density 1.17～1.19 in the time of 85 ℃;
E. precipitate with ethanol: get concentrated solution and add ethanol, make to contain the alcohol amount and reach 70%, cold preservation was left standstill 24 hours, got supernatant and reclaimed ethanol to the greatest extent, did not have the alcohol flavor, relative density 1.17～1.19 in the time of 55 ℃;
F. dosing: the clear paste behind the precipitate with ethanol is added purified water boiled 30 minutes, coarse filtration is to Agitation Tank, in molten sugar bowl, inject an amount of purified water in addition and boil, stir the adding crystal sugar, boiled 30 minutes, coarse filtration is to Agitation Tank, then with an amount of purified water with potassium sorbate dissolving and add in the Agitation Tank, add volatile oil, add an amount of purified water again and adjust total amount and make relative density be not less than 1.01, the cold filter after 24 hours of pH value 4.0～6.0, Cryoprecipitation, canned, sterilization, lamp inspection, packing are promptly.
5. the preparation method of eliminating phlegm and relieving asthma herb mixture as claimed in claim 4 is characterized in that this preparation method removes the preparation method that sugaring technology is the Sugarless type drug mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200410036488XA CN1331512C (en) | 2004-12-14 | 2004-12-14 | Mixture of eliminating sputum and relieving asthma and preparation method |
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| CNB200410036488XA CN1331512C (en) | 2004-12-14 | 2004-12-14 | Mixture of eliminating sputum and relieving asthma and preparation method |
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| CN1660174A CN1660174A (en) | 2005-08-31 |
| CN1331512C true CN1331512C (en) | 2007-08-15 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223103A (en) * | 2013-05-20 | 2013-07-31 | 杜明成 | Medical composition for treating chronic obstructive pulmonary disease |
| CN104984134A (en) * | 2015-07-22 | 2015-10-21 | 刘青云 | Drug for treating chronic obstructive pulmonary disease |
| CN105796830A (en) * | 2016-04-19 | 2016-07-27 | 王刚 | Traditional Chinese medicine for treating sinobronchiales syndrome |
| CN109939089A (en) * | 2017-12-21 | 2019-06-28 | 盈科瑞（横琴）药物研究院有限公司 | A kind of peaceful pharmaceutical solutions of sucking lung and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159347A (en) * | 1996-11-14 | 1997-09-17 | 戚嘉和 | Traditional Chinese medicine Jinjiangkebao for treating cough |
| CN1180546A (en) * | 1996-10-21 | 1998-05-06 | 王堇屹 | Medicament for treating asthma disease and its preparation method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180546A (en) * | 1996-10-21 | 1998-05-06 | 王堇屹 | Medicament for treating asthma disease and its preparation method |
| CN1159347A (en) * | 1996-11-14 | 1997-09-17 | 戚嘉和 | Traditional Chinese medicine Jinjiangkebao for treating cough |
Non-Patent Citations (1)
| Title |
|---|
| 化痰平喘合剂治疗慢性阻塞性肺疾病30例 东野长新，东野广刚，河北中医，第26卷第9期 2004 * |
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Granted publication date: 20070815 Termination date: 20100114 |