CN103191292B - Sleep-promoting and brain-nourishing oral liquid and production method thereof, and production line for oral liquid - Google Patents
Sleep-promoting and brain-nourishing oral liquid and production method thereof, and production line for oral liquid Download PDFInfo
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- CN103191292B CN103191292B CN201310055633.8A CN201310055633A CN103191292B CN 103191292 B CN103191292 B CN 103191292B CN 201310055633 A CN201310055633 A CN 201310055633A CN 103191292 B CN103191292 B CN 103191292B
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Abstract
The invention provides a sleep-promoting and brain-nourishing oral liquid which is prepared from the following components by weight: 8 to 10 parts of prepared fleeceflower root, 8 to 12 parts of polygala root, 8 to 12 parts of arborvitae seed, 5 to 9 parts of barbary wolfberry fruit, 8 to 12 parts of dwarf lilyturf root, 4 to 6 parts of Chinese magnoliavine processed with vinegar, 4 to 8 parts of mulberry, 4 to 6 parts of jujube, 8 to 10 parts of red ginseng, 4 to 6 parts of honey-fried licorice root and 4 to 6 parts of rock sugar. The sleep-promoting and brain-nourishing oral liquid provided by the invention has the effects of benefiting qi, nourishing the kidney and tranquilizing the mind by nourishing the heart, is a natural purely Chinese herbal preparation with no toxic and side effects and can be used for treating symptoms like palpitaition and insomnia, dreaminess, forgetfulness, dizziness, headache and neurasthenia caused by deficiency of both the heart and the kidney. A supercritical carbon dioxide extraction technology and a water extraction method are used for extraction of the medicinal materials, so a high extraction rate is realized; the sleep-promoting and brain-nourishing oral liquid can overcome the problems of treatment of subordinate symptoms instead of principal symptoms, a lot of artificially synthesized components, chronic and irreversible damage to a human body and the like of a western medicine, so the oral liquid has good social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, the production method and its production more particularly, to a kind of sleeping supplementing the brain oral liquid
Line.
Background technology
With the quickening pace of modern life, insomnia is annoying increasing people.Contemporary people rhythm of life is fast, society is competing
Compete, intellectual work amount is big and complicated social networks that process all cause pressure to nervous system, makes the feel of nervous system
Awake system tension is raised, and cerebral cortex suppresses function to suffer damage, and body is chronically at sub-health state, result in insomnia, head
Bitterly, the various symptoms such as dreaminess, nervous.Belonged to using the sleeping Drug therapy insomnia of doctor trained in Western medicine and cured the symptoms, not the disease, its composition is mostly
Synthetic, long-term taking has chronic, irreversible infringement to liver, kidney.
Traditional theory of Chinese medical science thinks, the main fire of the heart, the main water of kidney, when heart-fire is too prosperous, deficiency of heart-yin, deficiency of kidney-YIN or meridians not
Logical grade can cause disarmony between the heart and kidney, so as to cause insomnia.Therefore, replace Western medicine from suitable Chinese crude drug, make insomniac's QI invigorating
Foster kidney, Guyuan reinforcing, YIN nourishing of enriching blood, tranquilizing by nourishing the heart, blood circulation promoting and blood stasis dispelling, nourishing YIN to lower pathogenic fire, gradually improve the endocrine of body, reach mark
This simultaneous effect controlled, is only the best approach of effectively treatment insomnia.
The content of the invention
It is an object of the invention to provide a kind of sleeping supplementing the brain oral liquid and its production line, to solve existing treatment insomnia
Curing the symptoms, not the disease existing for Western medicine, synthetic composition is more, there is the technical problems such as chronic, irreversible infringement to body.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is：A kind of sleeping supplementing the brain oral liquid, the mouth
Liquid is taken including following components and is made by weight ratio：Radix Polygoni Multiflori Preparata 8-10 parts, Radix Polygalae 8-12 part, Semen Platycladi 8-12 parts, Fructus Lycii
Sub- 5-9 parts, 8-12 parts Radix Ophiopogonis, Fructus Schisandrae Chinensis (processed with vinegar) 4-6 parts, Fructus Mori 4-8 parts, Fructus Jujubae 4-6 parts, Radix Ginseng Rubra 8-10 parts, Radix Glycyrrhizae Preparata 4-6
Part, crystal sugar 4-6 parts；
The production method of above-mentioned oral liquid is prepared, is comprised the following steps：A. by Fructus Schisandrae Chinensis (processed with vinegar), Fructus Mori, Fructus Jujubae, process it is sweet
Grass is added water to cook 3 times by being put in decoction vessel after weight proportion mixing, adds the decocting of 5 times of raw material gross weight to boil 3 every time
Individual hour is simultaneously filtered；Merge three filtrates, be condensed into relative density for 1.1-1.2（85℃）Concentrated solution A；
B., Radix Polygoni Multiflori Preparata, Radix Polygalae, Semen Platycladi, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra are crushed to respectively the pellet of 40 mesh fineness, are pressed
The weight proportion mixing；Pellet is put in the reactor of supercritical carbon dioxide extraction machine, using ethanol entrainer, with
The flow of 15-30L/min is passed through pressure in reactor for 10-30Mpa, the CO that temperature is 35-55 DEG C2, extracted, will
It is full of the CO of solute after extraction2Send into and separated at separator, make extract from CO2Middle precipitation, extract is sent into and is settled
In formula centrifuge, high speed centrifugation is carried out to it, after making the contamination precipitation in extract, extract is filtered, extracted
Liquid B；
C. concentrated solution A and extract B is mixed, adds ground crystal sugar 4-6 parts, after crystal sugar dissolving original liquid is added
The water dilute liquid medicine of weight 3-5 times, medicinal liquid feeding oral liquid is washed in baking embedding linkage machine for producing and makes oral liquid.
Preferably, being also added into following components in the sleeping supplementing the brain oral liquid：It is Semen Ziziphi Spinosae 4-6 parts, Rhizoma Chuanxiong 4-6 parts, sweet
Loose 2-3 parts；The production method of above-mentioned sleeping supplementing the brain oral liquid is prepared, is comprised the following steps：A. by Fructus Schisandrae Chinensis (processed with vinegar), Fructus Mori, big
Fructus Jujubae, Radix Glycyrrhizae Preparata are put in decoction vessel, are added water to cook 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；
Merge three filtrates, be condensed into relative density for 1.1-1.2（85℃）Concentrated solution A；
B., Radix Polygoni Multiflori Preparata, Radix Polygalae, Semen Platycladi, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra are crushed to respectively the pellet of 40 mesh fineness, are pressed
Weight proportion mixes；Pellet is put in the reactor of supercritical carbon dioxide extraction machine, using ethanol entrainer, with 15-
The flow of 30L/min is passed through pressure in reactor for 10-30Mpa, the CO that temperature is 35-55 DEG C2, extracted, will extract
It is full of the CO of solute afterwards2Send into and separated at separator, make extract from CO2Middle precipitation, by extract send into decanter type from
In scheming, high speed centrifugation is carried out to it, after making the contamination precipitation in extract, extract is filtered, obtain extract B；
C. Semen Ziziphi Spinosae 4-6 parts, Rhizoma Chuanxiong 4-6 parts, Radix Et Rhizoma Nardostachyos 2-3 parts are put in decoction vessel, are added water to cook 3 times, added every time
The decocting that 5 times of raw material gross weight boils 3 hours and filters；Merge three filtrates, be condensed into relative density for 1.1-1.2（85
℃）Concentrated solution C；
D. concentrated solution A, extract B and concentrated solution C are mixed, adds ground crystal sugar 4-6 parts, after crystal sugar dissolving
Plus the water dilute liquid medicine of original liquid weight 3-5 times, medicinal liquid feeding oral liquid is washed in baking embedding linkage machine for producing and makes oral liquid.
In the present invention, Radix Polygoni Multiflori Preparata has invigorating the liver and kidney, benefiting essence-blood, black beard and hair, the effect of bone and muscle strengthening.For blood deficiency and yellow complexion,
The diseases such as vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons.Radix Polygalae has tranquilize the mind and promote the intelligence, eliminating the phlegm, the function of detumescence, is used for
The diseases such as insomnia and dreamful sleep, forgetful palpitation with fear that disarmony between the heart and kidney causes, staring spells.Semen Platycladi flat property and sweet taste.Tool tranquilizing by nourishing the heart, intestine moistening are led to
Just effect.Control the diseases such as palpitation with fear, insomnia, night sweat, constipation.Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum.Its
Sweet in the mouth, it is mild-natured with the liver and the kidney tonifying the effect of, the traditional Chinese medical science commonly use it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, it is forgetful, dizzy,
The many tears of blurred vision, the disease such as quench one's thirst.
Radix Ophiopogonis is used as medicine Radix Ophiopogonis for Liliaceae Ophiopogon plant with tuber.Nature,taste and action：Sweet, slight bitter, cool, Yin-nourishing and body fluid promoting,
Nourishing the lung to arrest cough, relieving restlessness that clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat.It is Fructus Schisandrae Chinensis taste temperature, sour, sweet, it is solid with convergence
It is puckery, supplementing QI for promoting the production of body fluid, effect of kidney calming.Fructus Schisandrae Chinensis (processed with vinegar) is with vinegar to mix Fructus Schisandrae Chinensis thoroughly, is placed in steamed rear solarization in hermetically sealed can
It is dry to form.Fructus Mori sweet in the mouth, acid, tremble with fear.GUIXIN, liver and kidney channel；With YIN nourishing of enriching blood, effect of fluid dryness.For vertigo and tinnitus,
Palpitation and insomnia.
Fructus Jujubae also known as Fructus Jujubae, sweet in the mouth, temperature.Energy invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.It is mainly used in deficiency of QI in middle-JIAO, weakness of the spleen and stomach, body
The diseases such as tired weak, anorexia and loose stool, blood deficiency and yellow complexion.Radix Ginseng Rubra is the ripe articles for use of ginseng, there is energy invigorating primordial QI, veins takes off admittedly, nourishing qi to stop work(
Effect.Radix Ginseng Rubra is used for weak body and prostration, cold weak pulse of limb, QI failing to control blood, heart failure, cardiogenic shock etc..Radix Glycyrrhizae is in a kind of tonification
Medical herbs.Feeble QI, taste is sweet and special.For invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；Nourishing the lung to arrest cough；Eliminating fire and detoxication；Coordinating the actions of various ingredients in a prescription.
The effects such as Rhizoma Chuanxiong has blood-activating and qi-promoting, wind-expelling pain-stopping, dissipating depression of QI dampness.Radix Et Rhizoma Nardostachyos have a regulating QI to relieve pain, relieving stagnation and activating the spleen it
Effect, is resistant to arrhythmia.Semen Ziziphi Spinosae has nourishing the liver, and mind calming the effect of calming the nerves, with calmness, convulsion, suppresses manic, hypnosis
Effect.Research shows that Semen Ziziphi Spinosae has approximate effect with phenobarbital class medicine, but without any side effects.
A kind of production line for preparing above-mentioned sleeping supplementing the brain oral liquid, including supercritical carbon dioxide extraction machine, it is described super to face
Boundary's carbon dioxide abstraction machine discharge nozzle is connected by feed pipe with sedimentation-type centrifuge feed pipe, the leakage fluid dram of sedimentation-type centrifuge
It is connected with the drenching tube for drying embedding linkage machine for producing is washed by feed pipe.
Preferably, the supercritical carbon dioxide extraction machine includes CO2Storage tank, high-pressure pump, extraction kettle, separator, institute
State CO2Storage tank right side is provided with high-pressure pump, and high-pressure pump right side is provided with heat exchanger, and heat exchanger right side is provided with extraction kettle,
Extraction kettle right side is provided with separator, the CO2Storage tank, sea water bath, compressor, extraction kettle, separator are connected with pipeline order
Connect, the separator and CO2CO is additionally provided between storage tank2Liquefier, separator bottom is provided with discharge nozzle.
Preferably, the sedimentation-type centrifuge includes casing, rotary drum, mair motor；Casing internal is provided with rotary drum, rotary drum
Left end is provided with auxiliary-motor, and hollow spindle is arranged with rotary drum, and feed pipe is provided with hollow spindle, and hollow spindle passes through belt
It is connected with mair motor, casing left end is provided with leakage fluid dram, casing right-hand member is provided with impurity discharging port.
Preferably, the baking embedding linkage machine for producing of washing includes bottle washer, high temp tunnel sterilizing oven, filling liquid pressure
Lid machine, bottle washer includes water heater, ultrasonic transducer, bath rotating disk, and bottle washer left side is provided with into bottleneck, under entering bottleneck
Side is provided with ultrasonic transducer, and wash bottle motor spindle is provided with water heater, and bottle washer middle part is provided with bath rotating disk, bottle washer
Right side is provided with high temp tunnel sterilizing oven, and high temp tunnel sterilizing oven top is provided with medium effeciency filter, under medium effeciency filter
Side is provided with blower fan, and blower fan outside is provided with high efficiency particulate air filter, and baking oven middle part arranges having heaters, and baking oven lower right-hand side is provided with
Exhaust duct；High temp tunnel sterilizing oven right side is provided with filling liquid capping machine, and filling capping machine left end is provided with Rotary Machine, turns
Bottle machine top is provided with inflation drencher, and inflation drencher is provided with drenching tube, and inflation drencher right side is provided with capsuling machine.
The present invention has functions that QI invigorating nourishing kidney, YIN nourishing of enriching blood, tranquilizing by nourishing the heart.This product is natural pure Chinese medicinal preparation, nothing
Toxic and side effects, can be used for the diseases such as palpitation and insomnia, dreaminess, forgetful, dizzy headache, neurasthenia caused by the void of heart kidney two.Medical material extracts
Take and used supercritical carbon dioxide extraction method, extraction ratio is high, relatively low extraction temperature avoid in medical material it is thermo-responsive into
The destruction being divided into point.The oral liquid energy of the sleeping supplementing the brain improves Western medicine and cures the symptoms, not the disease, and synthetic composition is more, has chronic to body
, irreversible infringement the problems such as, thus with good social benefit.
Description of the drawings
Fig. 1 is the schematic diagram of supercritical carbon dioxide extraction machine；
Fig. 2 is the structural representation of sedimentation-type centrifuge；
Fig. 3 is to wash the structural representation for drying embedding linkage machine for producing.
Specific embodiment
With reference to the accompanying drawings and detailed description, technical scheme is described in further detail.
Fig. 1 is the schematic diagram of supercritical carbon dioxide extraction machine, and Fig. 2 is the schematic diagram of sedimentation-type centrifuge, and Fig. 3 is to wash baking
The schematic diagram of embedding linkage machine for producing.As seen from the figure, the production line of the sleeping supplementing the brain oral liquid, including supercritical carbon dioxide extracts
Take machine 1, wash baking embedding linkage machine for producing 3；The right side of the supercritical carbon dioxide extraction machine 1 is provided with sedimentation-type centrifuge 2, sinks
The right side of drop formula centrifuge 2 is provided with washes baking embedding linkage machine for producing 3.
The supercritical carbon dioxide extraction machine 1 includes CO2Storage tank 11, compressor 13, extraction kettle 15, separator 16 etc.,
The CO2The right side of storage tank 11 is provided with high-pressure pump 12, and the right side of high-pressure pump 12 is provided with heat exchanger 13, and the right side of heat exchanger 13 sets
Extraction kettle 14 is equipped with, the right side of extraction kettle 14 is provided with separator 15, the CO2Storage tank 11, high-pressure pump 12, heat exchanger 13, extraction
Take kettle 14, separator 15 to be linked in sequence with pipeline, the bottom of the separator 15 is provided with discharge nozzle 16, separator 15 and CO2
CO is additionally provided between storage tank 112Liquefier 17.Product through extracting is discharged from discharge nozzle 16, CO2Then send CO back to2Storage tank 11
Recycle.Discharge nozzle 16 is connected with the feed pipe 25 of sedimentation-type centrifuge 2.
The sedimentation-type centrifuge 2 includes casing 21, rotary drum 22, mair motor etc.；Casing 21 is internally provided with rotary drum 22, turns
The left end of drum 22 is provided with auxiliary-motor 23, rotary drum 22 and is arranged with hollow spindle 24, and feed pipe 25 is provided with hollow spindle 24, empty
The belt pulley 26 being arranged on heart main shaft 24 is connected by belt with the mair motor 27 of the bottom of casing 21, and the left end of casing 21 is provided with row
Liquid mouth 28, the right-hand member of casing 21 is provided with impurity discharging port 29.Entered by leakage fluid dram 28 after settlement separate extract deslagging filtering
Discharge, the impurity such as medicinal residues, soil is discharged by impurity discharging port 29.The leakage fluid dram 28 of sedimentation-type centrifuge 2 passes through feed pipe 281 and washes baking
The drenching tube 333 of embedding linkage machine for producing 3 connects.
The baking embedding linkage machine for producing 3 of washing includes bottle washer 31, high temp tunnel sterilizing oven 32, filling liquid capping machine
33, bottle washer 31 includes water heater 311, ultrasonic transducer 312, bath rotating disk 313 etc., the left side of bottle washer 31 be provided with into
Bottleneck 314, enters the lower section of bottleneck 314 and is provided with ultrasonic transducer 312, and the bottom of bottle washer 31 is provided with water heater 311, wash bottle
The middle part of machine 31 is provided with bath rotating disk 313.Bottle washer 31 can carry out ultrasound wave cleaning to medicine bottle, remove the dirt being attached on bottle
Dye thing, then carries out drip washing by bath rotating disk 313.The right side of bottle washer 31 is provided with high temp tunnel sterilizing oven 32, high temp tunnel
The top of sterilizing oven 32 is provided with medium effeciency filter 321, and the both sides of medium effeciency filter 321 are provided with blower fan 322, the outside of blower fan 322
High efficiency particulate air filter 323 is provided with, the middle part of baking oven 32 arranges having heaters 324, and the lower right-hand side of baking oven 32 is provided with exhaust duct 325.
Filling liquid capping machine 33 of the medicine bottle on the right side of feeding after drying in high temp tunnel sterilizing oven 32, the left end of filling capping machine 33 sets
Rotary Machine 331 is equipped with, the top of Rotary Machine 331 is provided with inflation drencher 332, on inflation drencher drenching tube 333 is provided with, fills
The right side of gas drencher 332 is provided with capsuling machine 333.The gear 3 can be completed sequentially from wash bottle, drying, fill, sealing etc.
Row operation.
The preparation of sleeping supplementing the brain oral liquid：
Embodiment 1：4 parts of Fructus Schisandrae Chinensis (processed with vinegar), 4 parts of Fructus Mori, 4 parts of Fructus Jujubae, 4 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 8 parts of Radix Polygoni Multiflori Preparata, 8 parts of Radix Polygalae, 8 parts of Semen Platycladi, 5 parts of Fructus Lycii, 8 parts of Radix Ophiopogonis,
8 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）The pellet of 40 mesh fineness is crushed to respectively, is mixed by weight ratio；Pellet is put
In entering the reactor of supercritical carbon dioxide extracter, using ethanol entrainer, with the flow of 15-30L/min in reactor
Pressure is passed through for 10Mpa, the CO that temperature is 55 DEG C2, extracted, the CO of solute will be full of after extraction2Send at separator
Separated, made extract from CO2Middle precipitation, extract is sent in sedimentation-type centrifuge, and to it high speed centrifugation is carried out, and makes extraction
After taking the contamination precipitation in thing, extract is filtered, obtain extract B；After concentrated solution A is mixed with extract B, add
4 parts of ground crystal sugar, adds water after crystal sugar dissolving（Original liquid weight 3-5 times, similarly hereinafter）Exchange is 1000ml, then by medicinal liquid
Feeding oral liquid is washed in baking embedding linkage machine for producing and makes oral liquid.
Embodiment 2：5 parts of Fructus Schisandrae Chinensis (processed with vinegar), 6 parts of Fructus Mori, 5 parts of Fructus Jujubae, 5 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 9 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Polygalae, 10 parts of Semen Platycladi, 7 parts of Fructus Lycii, Radix Ophiopogonis 10
Part, 9 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）It is crushed to respectively after 40 mesh fineness and mixes；Pellet is put into into supercritical dioxy
In changing the reactor of carbon extracter, using ethanol entrainer, being passed through pressure in reactor with the flow of 22.5L/min is
20Mpa, temperature are 45 DEG C of CO2, extracted, the CO of solute will be full of after extraction2Send into and separated at separator, make
Extract is from CO2Middle precipitation；Extract is sent in sedimentation-type centrifuge, high speed centrifugation is carried out to it, make miscellaneous in extract
After matter precipitation, extract is filtered, obtain extract B；After concentrated solution A is mixed with extract B, ground ice is added
5 parts of sugar, the exchange that adds water after crystal sugar dissolving is 1000ml, then washes medicinal liquid feeding oral liquid and makes in baking embedding linkage machine for producing
Into oral liquid.
Embodiment 3：6 parts of Fructus Schisandrae Chinensis (processed with vinegar), 8 parts of Fructus Mori, 6 parts of Fructus Jujubae, 6 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 10 parts of Radix Polygoni Multiflori Preparata, 12 parts of Radix Polygalae, 12 parts of Semen Platycladi, 9 parts of Fructus Lycii, Radix Ophiopogonis 12
Part, 10 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）It is crushed to respectively after 40 mesh fineness and mixes；Pellet is put into into supercritical two
In the reactor of carbonoxide extracter, using ethanol entrainer, being passed through pressure in reactor with the flow of 30L/min is
30Mpa, temperature are 35 DEG C of CO2, extracted, the CO of solute will be full of after extraction2Send into and separated at separator, make
Extract is from CO2Middle precipitation；Extract is sent in sedimentation-type centrifuge, high speed centrifugation is carried out to it, make miscellaneous in extract
After matter precipitation, extract is filtered, obtain extract B；After concentrated solution A is mixed with extract B, ground ice is added
6 parts of sugar, the exchange that adds water after crystal sugar dissolving is 1000ml, then washes medicinal liquid feeding oral liquid and makes in baking embedding linkage machine for producing
Into oral liquid.
Embodiment 4：4 parts of Fructus Schisandrae Chinensis (processed with vinegar), 4 parts of Fructus Mori, 4 parts of Fructus Jujubae, 4 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 8 parts of Radix Polygoni Multiflori Preparata, 8 parts of Radix Polygalae, 8 parts of Semen Platycladi, 5 parts of Fructus Lycii, 8 parts of Radix Ophiopogonis,
8 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）It is crushed to respectively after 40 mesh fineness and mixes；Pellet is put into into supercritical titanium dioxide
In the reactor of carbon extracter, using ethanol entrainer, with the flow of 15L/min to reactor in be passed through pressure as 10Mpa, temperature
Spend the CO for 55 DEG C2, extracted, the CO of solute will be full of after extraction2Send into separator at separated, make extract from
CO2Middle precipitation；Extract is sent in sedimentation-type centrifuge, high speed centrifugation is carried out to it, after making the contamination precipitation in extract,
Extract is filtered, extract B is obtained；4 parts of Semen Ziziphi Spinosae, 4 parts of Rhizoma Chuanxiong, 2 parts of Radix Et Rhizoma Nardostachyos are put in decoction vessel, are added water to cook
3 times, the decocting of 5 times of raw material gross weight is added to boil 3 hours and filter every time；Merge three filtrates, being condensed into relative density is
1.1—1.2（85℃）Concentrated solution C；After by concentrated solution A, extract B, concentrated solution C mixing, 4 parts ground of crystal sugar is added,
The exchange that adds water is 1000ml, then washes in baking embedding linkage machine for producing medicinal liquid feeding oral liquid and makes oral liquid.
Embodiment 5：5 parts of Fructus Schisandrae Chinensis (processed with vinegar), 6 parts of Fructus Mori, 5 parts of Fructus Jujubae, 5 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 9 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Polygalae, 10 parts of Semen Platycladi, 7 parts of Fructus Lycii, Radix Ophiopogonis 10
Part, 9 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）It is crushed to respectively after 40 mesh fineness and mixes；Pellet is put into into supercritical dioxy
In changing the reactor of carbon extracter, using ethanol entrainer, being passed through pressure in reactor with the flow of 22.5L/min is
20Mpa, temperature are 45 DEG C of CO2, extracted, the CO of solute will be full of after extraction2Send into and separated at separator, make
Extract is from CO2Middle precipitation；Extract is sent in sedimentation-type centrifuge, high speed centrifugation is carried out to it, make miscellaneous in extract
After matter precipitation, extract is filtered, obtain extract B；5 parts of Semen Ziziphi Spinosae, 5 parts of Rhizoma Chuanxiong, 2.5 parts of Radix Et Rhizoma Nardostachyos are put into into decoction vessel
In, add water to cook 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into
Relative density is 1.1-1.2（85℃）Concentrated solution C；After by concentrated solution A, extract B, concentrated solution C mixing, add ground
5 parts of crystal sugar, add water exchange for 1000ml after crystal sugar dissolving, then medicinal liquid feeding oral liquid is washed into baking embedding linkage machine for producing
In make oral liquid.
Embodiment 6：6 parts of Fructus Schisandrae Chinensis (processed with vinegar), 8 parts of Fructus Mori, 6 parts of Fructus Jujubae, 6 parts of Radix Glycyrrhizae Preparata are put in decoction vessel, plus decocting
Boil 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into relative density
For 1.1-1.2（85℃）Concentrated solution A；By 10 parts of Radix Polygoni Multiflori Preparata, 12 parts of Radix Polygalae, 12 parts of Semen Platycladi, 9 parts of Fructus Lycii, Radix Ophiopogonis 12
Part, 10 parts of Radix Ginseng Rubra（Based on production 1000ml oral liquids）It is crushed to respectively after 40 mesh fineness and mixes；Pellet is put into into supercritical two
In the reactor of carbonoxide extracter, using ethanol entrainer, being passed through pressure in reactor with the flow of 30L/min is
30Mpa, temperature are 35 DEG C of CO2, extracted, the CO of solute will be full of after extraction2Send into and separated at separator, make
Extract is from CO2Middle precipitation；Extract is sent in sedimentation-type centrifuge, high speed centrifugation is carried out to it, make miscellaneous in extract
After matter precipitation, extract is filtered, obtain extract B；6 parts of Semen Ziziphi Spinosae, 6 parts of Rhizoma Chuanxiong, 3 parts of Radix Et Rhizoma Nardostachyos are put into into decoction vessel
In, add water to cook 3 times, add the decocting of 5 times of raw material gross weight to boil 3 hours and filter every time；Merge three filtrates, be condensed into
Relative density is 1.1-1.2（85℃）Concentrated solution C；After by concentrated solution A, extract B, concentrated solution C mixing, add ground
5 parts of crystal sugar, add water exchange for 1000ml after crystal sugar dissolving, then medicinal liquid feeding oral liquid is washed into baking embedding linkage machine for producing
In make oral liquid.
Beneficial effects of the present invention are further verified below by way of curative effect of medication contrast test.
The insomniac 200 of hospital of Hubei Province registration is selected, object of study meets：1. Chinese Spirit obstacle is met
Classification and the diagnostic criteria of diagnostic criteria third edition insomnia；2. the course of disease more than 6 months；3. Athens insomnia scale（AIS）（8
Individual symptom project：Time for falling asleep, night revival, than expectation early awakening, total sleep time, emotion on daytime, total sleep quality, body on daytime
Body function, daytime are drowsy；By 4 grades of scorings, 0 grade normal, and 1 grade slight, and 2 grades significantly, and 3 grades serious）Total score is all higher than 6 points；4. use
Hamilton depressive scale and Manifest Anxiety Scale scoring exclude depression, anxiety neurosis；5. without serious hepatic and renal function injure；6. without substantially
Drug allergy and person is not resistant to it.
Insomniac is divided into into experimental group and matched group, sex, age, course of disease of two groups of patients etc. to be matched.Treatment
Group 100 (embodiment 1-3,4-6 is each 50) gives daily sleeping supplementing the brain oral liquid 30ml（A day three times, each 10ml）, it is right
The placebo of same dose is taken according to group, after continuously tracking three months, clinical efficacy is considered table total score and is estimated according to A Sen,
It is clinical cure less than 4 points, 4-6 point is effective, is invalid more than 6 points.
Result above shows that the effective percentage of embodiment 1-6 is 96-98% in experimental group, and matched group is 32%, and two groups have aobvious
Write sex differernce.Especially the clinical cure rate of oral liquid has reached 78% obtained by embodiment 4-6 in experimental group, and effect especially shows
Write, it can be seen that, the sleeping supplementing the brain oral liquid is effectively to treatment of insomnia patients shape.
The following is the concrete case of several uses sleeping supplementing the brain oral liquid：
1. king so-and-so, 36 years old, Hubei people from Zhushan County fell ill for 2008, shows as serious insomnia, and no headache is dizzy, sleeps whole night
Not, daytime is very tired out, it is impossible to which normal work, patient is very painful.Take the sleeping supplementing the brain oral liquid 1 obtained by embodiment 3
Take an evident turn for the better after individual month, symptom disappears substantially after 2 months.
2. Lee, 28 years old, Hubei people from Tianmen because of long-term living and diet and worked and rested irregular, causes to have a sleepless night all night, body shape
Condition worse and worse, changes the sleeping supplementing the brain oral liquid 1 month that takes obtained by embodiment 3 and rests on time, has been almost recovered.
3. Lee, male, 46 years old, Hubei Prunus persica f. compressa people.It is insomniac to show as lying awake all night for many years, dizziness and tinnitus, it is difficult to enter
Sleep.Seek medical advice and medicine for a long time and fail to be effectively improved.The sleeping supplementing the brain oral liquid obtained by embodiment 5 is taken after 1 month, on
State symptom to take an evident turn for the better, after taking 3 months, symptom is substantially eliminated, recover order orthobiosiss.
4. Zhang, female, 33 years old, Qijiang County, Chongqing City people.Patient causes palpitation and insomnia, dizzy head occur greatly because of operating pressure
Bitterly, the disease such as soreness of the waist and knees, once long-term taking was stable waits Western medicine, and produces toleration and dependency, and health go fromes bad to worse.Afterwards
Patient changes two weeks after the sleeping supplementing the brain oral liquid taken obtained by embodiment 6 high-quality deep sleep, controls substantially within 1 month
More.In having returned to normal study and work.
5. marquis so-and-so, man, 51 years old, Hubei Prunus persica f. compressa people.Occur within nearly 1 year easily waking up more than dream, the disease such as five vexed hot-tempered, spiritlessness and weakness,
Patient is agonizing.The sleeping supplementing the brain oral liquid obtained by embodiment 6 is taken after 1 month, recovers normal.
Claims (1)
1. a kind of sleeping supplementing the brain oral liquid, is characterized in that the oral liquid by following components and makes by weight ratio：Radix Polygoni Multiflori Preparata
8-10 parts, Radix Polygalae 8-12 part, Semen Platycladi 8-12 parts, Fructus Lycii 5-9 parts, 8-12 parts Radix Ophiopogonis, Fructus Schisandrae Chinensis (processed with vinegar) 4-6 parts, Fructus Mori 4-8
Part, Fructus Jujubae 4-6 parts, Radix Ginseng Rubra 8-10 parts, Radix Glycyrrhizae Preparata 4-6 parts, crystal sugar 4-6 parts, Semen Ziziphi Spinosae 4-6 parts, Rhizoma Chuanxiong 4-6 parts, Radix Et Rhizoma Nardostachyos 2-3
Part；The production method of above-mentioned sleeping supplementing the brain oral liquid is prepared, is comprised the following steps：
A. Fructus Schisandrae Chinensis (processed with vinegar), Fructus Mori, Fructus Jujubae, Radix Glycyrrhizae Preparata are put in decoction vessel, are added water to cook 3 times, raw material gross weight is added every time
The decocting of 5 times of amount boils 3 hours and filters；Merge three filtrates, be condensed into the concentrated solution A that relative density is 1.1-1.2；
B., Radix Polygoni Multiflori Preparata, Radix Polygalae, Semen Platycladi, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra are crushed to respectively the pellet of 40 mesh fineness, by weight
Proportioning mixes；Pellet is put in the reactor of supercritical carbon dioxide extraction machine, using ethanol entrainer, with 15-30L/min
Flow pressure is passed through in reactor for 10-30Mpa, temperature is 35-55 DEG C of CO2, extracted, will be full of after extraction
The CO of solute2Send into and separated at separator, make extract from CO2Middle precipitation, sends extract into sedimentation-type centrifuge
In, high speed centrifugation is carried out to it, after making the contamination precipitation in extract, extract is filtered, obtain extract B；
C. Semen Ziziphi Spinosae 4-6 parts, Rhizoma Chuanxiong 4-6 parts, Radix Et Rhizoma Nardostachyos 2-3 parts are put in decoction vessel, are added water to cook 3 times, raw material is added every time
The decocting that 5 times of gross weight boils 3 hours and filters；Merge three filtrates, be condensed into the concentrated solution that relative density is 1.1-1.2
C；
D. concentrated solution A, extract B and concentrated solution C are mixed, adds ground crystal sugar 4-6 parts, after crystal sugar dissolving active compound is added
The water dilute liquid medicine of liquid weight 3-5 times, medicinal liquid feeding oral liquid is washed in baking embedding linkage machine for producing and makes oral liquid.
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| CN201310055633.8A CN103191292B (en) | 2013-02-22 | 2013-02-22 | Sleep-promoting and brain-nourishing oral liquid and production method thereof, and production line for oral liquid |
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