CN106620314A - Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state - Google Patents
Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state Download PDFInfo
- Publication number
- CN106620314A CN106620314A CN201610993366.2A CN201610993366A CN106620314A CN 106620314 A CN106620314 A CN 106620314A CN 201610993366 A CN201610993366 A CN 201610993366A CN 106620314 A CN106620314 A CN 106620314A
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- liquid
- oral
- filtrate
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an oral sorrow-forgetting and sleep-promoting solution for improving a sub-health state. The oral traditional Chinese medicine solution is compatibly prepared from foldleaf daylily root, rose, spina date seeds, the fruit of Chinese wolfberry, wheat, Chinese-date, licorice roots and other raw materials according to appropriate dosage, the dosage of the traditional Chinese medicine materials is scientific and effective, and the oral solution can relieve sleep disorder, promotes appetite, makes users feel relieved, dispels melancholy, melts turbidity and reduces lipid. Raw material selection, medicinal material decoction, concentration, alcohol precipitation, filtration and ethyl alcohol recovery are performed to prepare an extracting solution, and then the extracting solution is prepared and filled to obtain the oral solution. The oral solution is based on the theory of traditional Chinese medicine, a traditional Chinese medicine formula having medical and food effects and treating and health-care effects is selected, the oral solution mainly has the functions of clearing away the heart-fire, calming the nerves, regulating yin and yang imbalance of a human body and improving the functions of the human body and can effectively improve the sub-health state of the human body. The components the traditional Chinese medicinal materials are processed into the oral solution according to a production process identified by food and medicine enterprises GMP, and the oral solution is convenient to eat and carry.
Description
Technical field
It is specifically a kind of to forget sorrow sleeping for improve sub-health state the invention belongs to Chinese prescription technical field
Oral liquid and preparation method thereof.
Background technology
Inferior health refers to non-sick unhealthy status, and this is the inferior health status of a class（Asia is inferior meaning）, it is that boundary is good for
State between health and disease, the symptom of the patient in sub-health state is mainly manifested in decrease of memory, and notice does not collect
In, slowness of thinking, slow in reacting, prolonged unhealthy emotion, not voluntarily, the sense of security is inadequate, and along with insomnia, appetite not
Shake, have palpitation, feeling the symptom such as tired out.Although each organ of human body does not have organic disease, function reduction.Cause inferior health
The reason for cause physical overdraw, the naturally-aged of people, modern psychosomatic, the low tide in human body biological periodic including fatigue
Phase etc..The traditional Chinese medical science thinks that many subhealth symptoms that function of five internal organs lowly shows belong to " consumptive disease card " vital essence deficiency, traditional Chinese medicine
With organic conception, according to the principle and method of diagnosis and treatment, start with from balanced conditioning function of five internal organs, regularly composition has
The organism of self and the of self-replication capacity.
The content of the invention
It is an object of the invention to provide it is a kind of improve sub-health state forget sorrow sleeping oral liquid and preparation method thereof, according to
Theory of traditional Chinese medical science and combination principle, using the Chinese medicine of medicine-food two-purpose, correct the yin and yang imbalance of human body, adjust function of human body, make one
Body is in good health status, reaches the effect of prevention and health care.
To meet above-mentioned purpose, the technical solution used in the present invention is：
A kind of to forget sorrow sleeping oral liquid for improve sub-health state, the effective component of the traditional Chinese medicine oral liquid is by following mass parts
Several bulk drugs are made：
20～35g of day lily, 5～15g of rose, 5～15g of spina date seed, 5～15g of the fruit of Chinese wolfberry, 20～60g of wheat, date 10～
40g, 5～15g of Radix Glycyrrhizae.
Preferably, the optimum proportioning of the traditional Chinese medicine oral liquid is：
Day lily 30g, rose 10g, spina date seed 10g, fruit of Chinese wolfberry 10g, wheat 50g, date 30g, Radix Glycyrrhizae 10g.
A kind of preparation method for forgetting sorrow sleeping oral liquid for improving sub-health state, it is comprised the following steps：
Step one, get the raw materials ready：Weigh according to the above-mentioned mass fraction for forgetting sorrow sleeping oral liquid effective component for improving sub-health state
Bulk drug, the purified water for adding 8～12 times of amounts of bulk drug gross mass is soaked 1～1.5 hour；
Step 2, cleaning oral liquid bottle, bottle cap：Oral liquid bottle is washed with ultrasonic wave oral liquid bottle washing machine, and checks its cleaning
It is standby after degree；It is that 75% edible alcohol is soaked after 50～80min by Oral liquid bottle lid concentration, takes out, dries, it is standby；
Step 3, medicinal material extract：
A, decocting herbs：The soaked bulk drug of Jing steps one is decocted 1 hour, is filtered and is obtained first time filtrate；After filtration
The raw material dregs of a decoction in add 8～12 times amount purified waters decoct 1 hour, filter obtain second filtrate, after decocting twice
Filtrate merge, the dregs of a decoction discard, and filtrate is standby；
B, concentration：The filtrate that step a is prepared is -0.07～-0.08Mpa in vacuum, and temperature is 70～80 DEG C of environment
Under carry out reduced pressure concentration, the mass ratio for concentrating the filtrate to liquid and bulk drug is 1:It is standby after 2-2.5；
C, alcohol precipitation, filtration：After the concentration liquid temp prepared by step b drops to room temperature, ethanol matter is added at a slow speed in concentrate
Amount degree is 95% edible alcohol, while quick agitated liquid, ethanol mass percentage content reaches into concentrate
After 55～65%, precipitation solution stands 24～30 hours；Take the upper liquid of precipitation solution and filter, obtain filtrate standby；
D, recovery ethanol：By the filtrate prepared by step c in the environment of temperature is for 70～80 DEG C, decompression recycling ethanol is carried out,
And it is 1.05～1.1 to be concentrated into relative density of medicine liquid, as herbal extract；
Step 4, prepare oral liquid：By the herbal extract prepared by step 3, according to herbal extract and the mass ratio of liquid
For 1:2 ratio adds purified water dilution, stirs and evenly mixs prepared rough liquid；Rough liquid is filtered, semi-finished product are obtained；Again will
Bottle placer is filled in the cleaned oral liquid bottle of Jing step 2 on semi-finished product, using ampoule leak detection sterilizing cabinet sterilization, sterilizing temperature
Spend for 105～120 DEG C, sterilization time is 50～60min；Prepared product be improve sub-health state to forget sorrow sleeping oral
Liquid.
The bulk drug forgotten selected by sorrow sleeping oral liquid for improving sub-health state of the present invention is medicine food
Homologous Chinese medicine, is the medicinal material of Gansu main product.Wherein：
Day lily：For the bud of liliaceous plant day lily Hemerocallis citrine Baroni.It is sweet, it is cool in nature.Have
Clearing heat and promoting diuresis, wide chest solution is strongly fragrant, the effect of removing pattogenic heat from the blood and toxic material from the body.Scanty drak urine is cured mainly, jaundice is uncomfortable in chest vexed, sleeps less, hemorrhoidal hemorrhage, sore
Carbuncle.
Rose；For the dry flower of rosaceous plant rose Rose rugosa Thunb..Property sweet, slight bitter, temperature.Return
Liver, the spleen channel.With promoting qi circulation and removing obstruction in the collateral, and blood, pain relieving.For stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, deficiency of food evil of vomitting, irregular menstruation, the pain of injury caused by falling and tumbling.
Spina date seed：For rhamnaceae plant wild jujube Ziziphus jujuba Mill.var.spinosa（Bunge） Hu ex
The dry mature seed of H.F.Chou.Sweet, acid, it is mild-natured.Return liver, courage, the heart channel of Hang-Shaoyin.With nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating,
The effect of promoting the production of body fluid.For restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
The fruit of Chinese wolfberry:For the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..It is sweet, put down.
Return liver and kidney channel.With nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, interior heat
Quench one's thirst, blood deficiency chlorosis, blurred vision.
Wheat:For the dry fruit of grass barley Triticum aestivumL..It is sweet, it is cool in nature.Thoughts of returning home warp.
The effect of with except abnormal heat, hidroschesis.Cure mainly fever due to yin deficiency；Night sweat；Spontaneous perspiration.
Date：For the dry mature fruit of Rhamnaceae plant jujube Ziziphus jujuba Mill..It is sweet, it is warm in nature.Return
Spleen, stomach, the heart channel of Hang-Shaoyin.With the effect of tonifying middle-Jiao and Qi, nourishing blood and tranquilization.For spleen eating less, weak loose stool, hysteria of womam.
Radix Glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
The dry root and rhizome of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..It is sweet, it is mild-natured.The thoughts of returning home, lung,
Spleen, stomach.It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, the effect of coordinating the drug actions of a prescription.For weakness of the spleen and the stomach,
Lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Under the guidance of traditional Chinese medical theory, the integration of drinking and medicinal herbs for forgetting sorrow sleeping oral liquid using Gansu main product of the present invention
The raw material such as day lily, rose be the immunologic function that body can be improved with help effect, the negative and positive for correcting human body are lost
Weighing apparatus.According to the functional characteristics of medicinal material, the present invention is prepared from using modern extraction process, can adjust function of human body, for tired
Hot-tempered, insomnia, energy decline, hypofunction etc. are uncomfortable, reach prevention and health-care effect.
It is of the present invention to forget sorrow sleeping oral liquid in preparation process, for supplementary material for improve sub-health state
Selection, production equipment and production technology all should meet the requirement of the industry GMP certification such as pharmacy, food, production process Chinese medicine
Sorting, extraction, preparation production, packaging etc. operation be both needed to meet the requirement of food and medicine production technology quality.
Chinese medicine preparation prepared by the present invention is oral liquid, has both met the requirement of prescription, is easy to take again, good absorbing, is had
Beneficial to the performance of health-care effect.
Beneficial effects of the present invention:
（1）The present invention selects the raw materials such as day lily, the rose of integration of drinking and medicinal herbs of Gansu main product to match somebody with somebody based on traditional Chinese medical theory
5 one-tenth Chinese medicinal formulaes, indication is allayed excitement to clear away heart-fire, and corrects the yin and yang imbalance of human body, can improve the function of human body, can be effectively
Improve the state of human-body sub-health；
（2）Chinese medicine is carried out compatibility by the present invention according to appropriate dosage, Chinese medicine dosage science, effectively, can be alleviated to sleep and is hindered
Hinder, whet the appetite, solution of feeling relieved is strongly fragrant, changes turbid lipid-loweringing；
（3）The Chinese medicine of each component is processed into mouth by the present invention according to the requirement of food, the production technology of enterprises GMP certifications
Liquid is taken, it is edible, easy to carry.
Specific embodiment
With reference to specific embodiment, the present invention is further detailed explanation.
Embodiment 1
A kind of to forget sorrow sleeping oral liquid for improve sub-health state, the raw material ratio of the traditional Chinese medicine oral liquid is：
Day lily 30g, rose 10g, spina date seed 10g, fruit of Chinese wolfberry 10g, wheat 50g, date 30g, Radix Glycyrrhizae 10g.
For improving the preparation method for forgetting sorrow sleeping oral liquid of sub-health state, it is comprised the following steps：
Step one, get the raw materials ready：Weigh according to the above-mentioned mass fraction for forgetting sorrow sleeping oral liquid effective component for improving sub-health state
Bulk drug, the purified water for adding 10 times of amounts of bulk drug gross mass is soaked 1 hour；
Step 2, cleaning oral liquid bottle, bottle cap：Oral liquid bottle is washed with ultrasonic wave oral liquid bottle washing machine, and checks its cleaning
It is standby after degree；It is after 75% edible alcohol immersion 60min, to take out by Oral liquid bottle lid concentration, dries, it is standby；
Step 3, medicinal material extract：
A, decocting herbs：The soaked bulk drug of Jing steps one is decocted 1 hour, is filtered and is obtained first time filtrate；After filtration
The raw material dregs of a decoction in add 10 times amount purified waters decoct 1 hour, filter obtain second filtrate, by twice decoct after filter
Liquid merges, and the dregs of a decoction are discarded, and filtrate is standby；
B, concentration：The filtrate that step a is prepared vacuum be -0.07～-0.08Mpa, temperature be 70 DEG C in the environment of enter
Row reduced pressure concentration, it is 1 to concentrate the filtrate to liquid with the mass ratio of bulk drug:It is standby after 2；
C, alcohol precipitation, filtration：After the concentration liquid temp prepared by step b drops to room temperature, ethanol matter is added at a slow speed in concentrate
Amount degree is 95% edible alcohol, while quick agitated liquid, ethanol mass percentage content reaches into concentrate
After 60%, precipitation solution stands 24 hours；Take the upper liquid of precipitation solution and filter, obtain filtrate standby；
D, recovery ethanol：By the filtrate prepared by step c in the environment of temperature is for 70 DEG C, decompression recycling ethanol is carried out, and it is dense
It is 1.05～1.07 to be reduced to relative density of medicine liquid, used as herbal extract；
Step 4, prepare oral liquid：By the herbal extract prepared by step 3, according to herbal extract and the mass ratio of liquid
For 1:2 ratio adds purified water dilution, stirs and evenly mixs prepared rough liquid；Rough liquid is filtered, semi-finished product are obtained；Again will
Bottle placer is filled in the cleaned oral liquid bottle of Jing step 2 on semi-finished product, using ampoule leak detection sterilizing cabinet sterilization, sterilizing temperature
Spend for 110 DEG C, sterilization time is 60min；Prepared product be improve sub-health state forget sorrow sleeping oral liquid.
Embodiment 2
A kind of to forget sorrow sleeping oral liquid for improve sub-health state, the effective component of the traditional Chinese medicine oral liquid is by following mass parts
Several bulk drugs are made：
Day lily 20g, rose 5g, spina date seed 5g, fruit of Chinese wolfberry 5g, wheat 20g, date 10g, Radix Glycyrrhizae 5g.
For improving the preparation method for forgetting sorrow sleeping oral liquid of sub-health state, it is comprised the following steps：
Step one, get the raw materials ready：Weigh according to the above-mentioned mass fraction for forgetting sorrow sleeping oral liquid effective component for improving sub-health state
Bulk drug, the purified water for adding 8 times of amounts of bulk drug gross mass is soaked 1 hour；
Step 2, cleaning oral liquid bottle, bottle cap：Oral liquid bottle is washed with ultrasonic wave oral liquid bottle washing machine, and checks its cleaning
It is standby after degree；It is after 75% edible alcohol immersion 50min, to take out by Oral liquid bottle lid concentration, dries, it is standby；
Step 3, medicinal material extract：
A, decocting herbs：The soaked bulk drug of Jing steps one is decocted 1 hour, is filtered and is obtained first time filtrate；After filtration
The raw material dregs of a decoction in add 8 times amount purified waters decoct 1 hour, filter obtain second filtrate, by twice decoct after filter
Liquid merges, and the dregs of a decoction are discarded, and filtrate is standby；
B, concentration：The filtrate that step a is prepared vacuum be -0.07～-0.08Mpa, temperature be 70 DEG C in the environment of enter
Row reduced pressure concentration, it is 1 to concentrate the filtrate to liquid with the mass ratio of bulk drug:It is standby after 2.5；
C, alcohol precipitation, filtration：After the concentration liquid temp prepared by step b drops to room temperature, ethanol matter is added at a slow speed in concentrate
Amount degree is 95% edible alcohol, while quick agitated liquid, ethanol mass percentage content reaches into concentrate
After 55%, precipitation solution stands 28 hours；Take the upper liquid of precipitation solution and filter, obtain filtrate standby；
D, recovery ethanol：By the filtrate prepared by step c in the environment of temperature is for 70 DEG C, decompression recycling ethanol is carried out, and it is dense
It is 1.05 to be reduced to relative density of medicine liquid, used as herbal extract；
Step 4, prepare oral liquid：By the herbal extract prepared by step 3, according to herbal extract and the mass ratio of liquid
For 1:2 ratio adds purified water dilution, stirs and evenly mixs prepared rough liquid；Rough liquid is filtered, semi-finished product are obtained；Again will
Bottle placer is filled in the cleaned oral liquid bottle of Jing step 2 on semi-finished product, using ampoule leak detection sterilizing cabinet sterilization, sterilizing temperature
Spend for 105 DEG C, sterilization time is 50min；Prepared product be improve sub-health state forget sorrow sleeping oral liquid.
Embodiment 3
A kind of to forget sorrow sleeping oral liquid for improve sub-health state, the effective component of the traditional Chinese medicine oral liquid is by following mass parts
Several bulk drugs are made：
Day lily 35g, rose 15g, spina date seed 15g, fruit of Chinese wolfberry 15g, wheat 60g, date 40g, Radix Glycyrrhizae 15g.
For improving the preparation method for forgetting sorrow sleeping oral liquid of sub-health state, it is comprised the following steps：
Step one, get the raw materials ready：Weigh according to the above-mentioned mass fraction for forgetting sorrow sleeping oral liquid effective component for improving sub-health state
Bulk drug, the purified water for adding 12 times of amounts of bulk drug gross mass is soaked 1.5 hours；
Step 2, cleaning oral liquid bottle, bottle cap：Oral liquid bottle is washed with ultrasonic wave oral liquid bottle washing machine, and checks its cleaning
It is standby after degree；It is after 75% edible alcohol immersion 80min, to take out by Oral liquid bottle lid concentration, dries, it is standby；
Step 3, medicinal material extract：
A, decocting herbs：The soaked bulk drug of Jing steps one is decocted 1 hour, is filtered and is obtained first time filtrate；After filtration
The raw material dregs of a decoction in add 12 times amount purified waters decoct 1 hour, filter obtain second filtrate, by twice decoct after filter
Liquid merges, and the dregs of a decoction are discarded, and filtrate is standby；
B, concentration：The filtrate that step a is prepared vacuum be -0.07～-0.08Mpa, temperature be 80 DEG C in the environment of enter
Row reduced pressure concentration, it is 1 to concentrate the filtrate to liquid with the mass ratio of bulk drug:It is standby after 2.5；
C, alcohol precipitation, filtration：After the concentration liquid temp prepared by step b drops to room temperature, ethanol matter is added at a slow speed in concentrate
Amount degree is 95% edible alcohol, while quick agitated liquid, ethanol mass percentage content reaches into concentrate
After 65%, precipitation solution stands 30 hours；Take the upper liquid of precipitation solution and filter, obtain filtrate standby；
D, recovery ethanol：By the filtrate prepared by step c in the environment of temperature is for 80 DEG C, decompression recycling ethanol is carried out, and it is dense
It is 1.1 to be reduced to relative density of medicine liquid, used as herbal extract；
Step 4, prepare oral liquid：By the herbal extract prepared by step 3, according to herbal extract and the mass ratio of liquid
For 1:2 ratio adds purified water dilution, stirs and evenly mixs prepared rough liquid；Rough liquid is filtered, semi-finished product are obtained；Again will
Bottle placer is filled in the cleaned oral liquid bottle of Jing step 2 on semi-finished product, using ampoule leak detection sterilizing cabinet sterilization, sterilizing temperature
Spend for 120 DEG C, sterilization time is 60min；Prepared product be improve sub-health state forget sorrow sleeping oral liquid.
The traditional Chinese medicine oral liquid for improving sub-health state prepared by said method is used for the acquired effect of clinical treatment experiment
It is really：
Case 1：
Patient symptom：Patient one, female, 45 years old age, company clerk.Mood is irritated, emotional instability, poor appetite, and sleep is not
It is good, fatigue and weak, not interested to working, tongue nature is light, and tongue is greasy in vain, thready rapid pulse, string.
Take dosage, the time of medicine：Take it is of the present invention improve sub-health state forget sorrow sleeping oral liquid, every time
10ml, 3 times a day, totally 4 weeks.
Effect after taking：Appetite improves, and sleep has obvious improvement, and has deep sleep.Spirit takes a turn for the better.
Case 2：
Patient symptom：Patient two, female, 56 years old age, certain department head.Look wane and sallow, it is One's spirits are drooping, perspire, have a sleepless night February
Have a surplus, complexion is white all of a sudden, and tongue is greasy in vain, and arteries and veins is thin, weak.
Take dosage, the time of medicine：Clothes invention it is described improve sub-health state forget sorrow sleeping oral liquid, every time
10ml, 3 times a day, totally 3 weeks.
Effect after taking：It is emotionally stable, appetite increases, sleep has clear improvement, perspiration symptom mitigation.
Case 3：
Patient symptom：Patient three, female, 38 years old age, secondary school teachers.Irritable, anorexia is slept bad, and tongue is white, matter
Greasy, arteries and veins is thin.
Take dosage, the time of medicine：Clothes invention it is described improve sub-health state forget sorrow sleeping oral liquid, every time
10ml, 3 times a day, totally 4 weeks.
Effect after taking：Mood takes a turn for the better, and has rosy cheeks, and appetite increases, sleep improvement.
Case 4：Patient four
Patient symptom：Man, at 42 years old age, civil servant, look tired out, not high to work, life interest, indigestion, during sleep
Wake up when sleeping, sleep quality is not good, yellow and greasy fur, arteries and veins is thin, string.
Take dosage, the time of medicine：Clothes invention it is described improve sub-health state forget sorrow sleeping oral liquid, every time
10ml, 3 times a day, totally 2 weeks.
Effect after taking：Mood improves, and is emotionally stable, and appetite improves, and sleep takes an evident turn for the better.
Claims (3)
- It is 1. a kind of to forget sorrow sleeping oral liquid for improve sub-health state, it is characterised in that：The drug effect of the traditional Chinese medicine oral liquid into Divide and be made up of the bulk drug of following mass fraction：20～35g of day lily, 5～15g of rose, 5～15g of spina date seed, 5～15g of the fruit of Chinese wolfberry, 20～60g of wheat, date 10～ 40g, 5～15g of Radix Glycyrrhizae.
- It is 2. according to claim 1 to forget sorrow sleeping oral liquid for improve sub-health state, it is characterised in that：The Chinese medicine The optimum proportioning of oral liquid is：Day lily 30g, rose 10g, spina date seed 10g, fruit of Chinese wolfberry 10g, wheat 50g, date 30g, Radix Glycyrrhizae 10g.
- 3. a kind of preparation method for forgetting sorrow sleeping oral liquid for improving sub-health state, it is characterised in that：It includes following Step：Step one, get the raw materials ready：Bulk drug is weighed according to the mass fraction described in claim 1 or claim 2, raw material is added The purified water of 8～12 times of amounts of medicine gross mass is soaked 1～1.5 hour；Step 2, cleaning oral liquid bottle, bottle cap：Oral liquid bottle is washed with ultrasonic wave oral liquid bottle washing machine, and checks its cleaning It is standby after degree；It is that 75% edible alcohol is soaked after 50～80min by Oral liquid bottle lid concentration, takes out, dries, it is standby；Step 3, medicinal material extract：A, decocting herbs：The soaked bulk drug of Jing steps one is decocted 1 hour, is filtered and is obtained first time filtrate；After filtration The raw material dregs of a decoction in add 8～12 times amount purified waters decoct 1 hour, filter obtain second filtrate, after decocting twice Filtrate merge, the dregs of a decoction discard, and filtrate is standby；B, concentration：The filtrate that step a is prepared is -0.07～-0.08Mpa in vacuum, and temperature is 70～80 DEG C of environment Under carry out reduced pressure concentration, the mass ratio for concentrating the filtrate to liquid and bulk drug is 1:It is standby after 2～2.5；C, alcohol precipitation, filtration：After the concentration liquid temp prepared by step b drops to room temperature, ethanol matter is added at a slow speed in concentrate Amount degree is 95% edible alcohol, while quick agitated liquid, ethanol mass percentage content reaches into concentrate After 55～65%, precipitation solution stands 24～30 hours；Take the upper liquid of precipitation solution and filter, obtain filtrate standby；D, recovery ethanol：By the filtrate prepared by step c in the environment of temperature is for 70～80 DEG C, decompression recycling ethanol is carried out, And it is 1.05～1.1 to be concentrated into relative density of medicine liquid, as herbal extract；Step 4, prepare oral liquid：By the herbal extract prepared by step 3, according to herbal extract and the mass ratio of liquid For 1:2 ratio adds purified water dilution, stirs and evenly mixs prepared rough liquid；Rough liquid is filtered, semi-finished product are obtained；Again will Bottle placer is filled in the cleaned oral liquid bottle of Jing step 2 on semi-finished product, using ampoule leak detection sterilizing cabinet sterilization, sterilizing temperature Spend for 105～120 DEG C, sterilization time is 50～60min；Prepared product be improve sub-health state to forget sorrow sleeping oral Liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610993366.2A CN106620314A (en) | 2016-11-11 | 2016-11-11 | Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610993366.2A CN106620314A (en) | 2016-11-11 | 2016-11-11 | Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620314A true CN106620314A (en) | 2017-05-10 |
Family
ID=58805625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610993366.2A Pending CN106620314A (en) | 2016-11-11 | 2016-11-11 | Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106620314A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111869771A (en) * | 2020-08-11 | 2020-11-03 | 甘肃养汇鲜生态农业有限公司 | Nerve-soothing, sleep-aiding and depression-resisting substitutional tea |
| CN112493382A (en) * | 2020-10-30 | 2021-03-16 | 成都致耀医药科技有限公司 | Antioxidant and anti-aging plant beverage and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069723A (en) * | 2007-05-25 | 2007-11-14 | 上海育生堂科技有限公司 | Oral liquor of anti-fatigue and intensifying immunity and preparing method |
| CN104666474A (en) * | 2015-01-27 | 2015-06-03 | 华南理工大学 | Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract |
| CN105796981A (en) * | 2016-05-06 | 2016-07-27 | 李成义 | Traditional Chinese medicine oral liquid for improving sub-health state and preparation method of traditional Chinese medicine oral liquid |
-
2016
- 2016-11-11 CN CN201610993366.2A patent/CN106620314A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069723A (en) * | 2007-05-25 | 2007-11-14 | 上海育生堂科技有限公司 | Oral liquor of anti-fatigue and intensifying immunity and preparing method |
| CN104666474A (en) * | 2015-01-27 | 2015-06-03 | 华南理工大学 | Spina date seed extract and brain-strengthening and sleeping-promoting oral liquid containing spina date seed extract |
| CN105796981A (en) * | 2016-05-06 | 2016-07-27 | 李成义 | Traditional Chinese medicine oral liquid for improving sub-health state and preparation method of traditional Chinese medicine oral liquid |
Non-Patent Citations (1)
| Title |
|---|
| 高秋涛等: "枸杞粉改善老年人体质状态的随机双盲临床试验研究", 《中国临床药理学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111869771A (en) * | 2020-08-11 | 2020-11-03 | 甘肃养汇鲜生态农业有限公司 | Nerve-soothing, sleep-aiding and depression-resisting substitutional tea |
| CN112493382A (en) * | 2020-10-30 | 2021-03-16 | 成都致耀医药科技有限公司 | Antioxidant and anti-aging plant beverage and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102283999B (en) | Traditional Chinese medicine preparation for treating insomnia | |
| CN103725573B (en) | A kind of imperial osmanthus wine and preparation method thereof | |
| CN104222861A (en) | Nerve soothing health-care porridge for treating insomnia | |
| CN107156590A (en) | Vegetable solid beverage and preparation method thereof | |
| CN103340405B (en) | A kind of health food for relieving physical fatigue and preparation method thereof | |
| CN106924388B (en) | A kind of pharmaceutical composition for treating insomnia and preparation method thereof, preparation and application | |
| CN103484333A (en) | Formula and production method of brain-strengthening and tranquillizing ginseng wine | |
| CN108355088A (en) | A kind of spina date seed medicinal liquor and preparation method thereof improving sleep quality | |
| CN105595339A (en) | Medicinal food formulation for qi-deficiency constitution | |
| CN106620314A (en) | Oral sorrow-forgetting and sleep-promoting solution for improving sub-health state | |
| CN105796981A (en) | Traditional Chinese medicine oral liquid for improving sub-health state and preparation method of traditional Chinese medicine oral liquid | |
| CN104474251B (en) | Composition and its preparation and the application of function are consolidated with brain tonic | |
| CN104225295B (en) | Composition for improving sleep, and preparation method and application thereof | |
| CN103230457B (en) | A kind of Chinese medicine composition treating viral myocarditis and preparation method thereof and purposes | |
| CN101342326B (en) | Preparation method for traditional Chinese medicine for treating fire excess from Yin deficiency type nodal tachyeardia | |
| CN104017701B (en) | The logical health-care white spirit of a kind of the five internal organs weighing apparatus | |
| CN103191292B (en) | Sleep-promoting and brain-nourishing oral liquid and production method thereof, and production line for oral liquid | |
| CN102716454A (en) | Medicine for treating infantile diarrhea and preparation method of medicine | |
| CN106138785A (en) | One treats neurasthenic Chinese medicine composition and preparation method thereof | |
| CN106361976A (en) | Compound preparation for calming nerves, promoting sleep and keeping beauty and preparation method of compound preparation | |
| CN104938717A (en) | Dendrobium officinale health tea for relieving sub-health symptoms | |
| CN109999167A (en) | A kind of Chinese medicine composition having both conditioning mood and health of losing weight | |
| CN104026663A (en) | Rhizoma nardostachyos soup with functions of enlivening spleen and strengthening stomach and production method thereof | |
| CN109370855A (en) | It is a kind of with improving taste, mitigate abdomen secret anguish and improve health liquor and preparation method thereof of sleep function | |
| CN104687142A (en) | Formula and production method of ginseng soup stock for strengthening brain and tranquillizing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |