The Chinese medicine decoction of Cure for insomnia
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine decoction of Cure for insomnia.
Background technology
As everyone knows, insomnia all can occur throughout the year, take spring as maximum.This is because of climate variability in spring, usually makes normal person's anxious state of mind very fast, easily disturbs the intrinsic physiological function of people; In addition air pressure is low, easily causes the hormone disturbance of human brain secretion.As poor in self adaptive capacity, cause inside and outside disequilibrium, just easily bring out insomnia.The traditional Chinese medical science is thought, the liver belonging to wood, happiness bar reach, with spring rise send out yang-energy corresponding.If do not notice that feelings will takes good care of oneself, feelings will is unsuccessful, irritability depression, and liver is lost bar and reaches, stagnated QI transforming into fire, being insomnia appears in disturbing the mind upwards.Show as difficulty falling asleep, intermittently discontinuous, and wake up prematurely, after waking up, can not continue again to sleep, do not have enough sleep, malaise, asthenia sensation, how because health condition is not good, pain perception discomfort, circadian rhythm is upset, sleep environment impact etc., also have be afraid of sleep and insomnia.Insomnia is called " unable to close the eyes ", " insomnia ", " must not crouch " in "Nei Jing", and thinks that insomnia reason mainly contains two kinds, and the one, the impact of other diseases, as cough, vomiting, abdominal distention etc., makes the people must not peacefully sleeping; The 2nd, negative and positive of qi and blood is become estranged, make people not able person sleep.Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even forms the dependence to the medicine of sleeping peacefully, and long-term taking is slept peacefully, medicine can cause iatrogenic disease.
Summary of the invention
Object of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, and a kind of Chinese medicine decoction of Cure for insomnia is provided, and cost is low, there is no obvious toxic-side effects, and treated effect is higher.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine decoction of Cure for insomnia, it is characterized in that crude drug composition counts with weight portion: Radix Codonopsis 13~18, Rhizoma Atractylodis Macrocephalae (parched) 13~18, Rhizoma Atractylodis (parched) 17~23, Poria 17~23, Herba Eupatorii 12~16, Fructus Piperis Longi 3~7, Semen Ginkgo core 3~7, jujube nucleus 18~25, Semen Platycladi 13~17, Caulis Polygoni Multiflori 28~34, Flos Albiziae 10~14, Radix Curcumae 14~16, Rhizoma Polygoni Cuspidati 14~16, Semen Armeniacae Amarum 8~11, Fructus Amomi Rotundus 10~13, Semen Coicis 28~34, Rhizoma Pinelliae Preparatum 8~12, Cortex Magnoliae Officinalis 8~12, Semen Nelumbinis 13~17, Radix Polygalae 16~20, Radix Ophiopogonis 7~10, after above-mentioned 21 taste crude drug are mixed, be soaked in water, the filtrate of removing slag after decocting to obtain.
In prescription of the present invention, Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting, and for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc., and " Bencao Congxin " recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than middle feeble QI, mend in order to adjust, very smooth and proper."; Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; Rhizoma Atractylodis (parched) nature and flavor are pungent, bitter, and temperature is returned spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and cold, and improving eyesight, for distension and fullness in the abdomen, has loose bowels, edema, rheumatic arthralgia, anemofrigid cold, nyctalopia; Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel, has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, and effect of mind tranquilizing and the heart calming, can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade; Herba Eupatorii nature and flavor are pungent, flat, return spleen, stomach, lung meridian, expelling summer-heat and damp, ward off dirty and in, cure mainly experience heat-damp in summer, cold and heat headache, accumulate in moistening, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, mouthful in sweet greasy, disappear truly; Fructus Piperis Longi warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving, for coldness and pain in the epigastrium, vomit, have loose bowels, migraine, nasal sinusitis, external treatment toothache, coronary heart diseases and angina pectoris, control trusted subordinate's cold type of pain, vomiting acid regurgitation, increased borborygmus and diarrhea, cold-dysentery, scrotal hernia, headache, nasal sinusitis, toothache; Semen Ginkgo core is sweet, bitter, puckery, flat, poisonous, returns lung meridian, cures mainly astringing lung QI for relieving asthma, and leukorrhagia stopping is turbid, and urine reducing is breathed with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition; Jujube nucleus nourishing the liver, mind calming, calms the nerves, and arresting sweating is controlled restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility; Semen Platycladi nature and flavor are sweet, flat, GUIXIN, kidney, large intestine channel, and tranquilizing by nourishing the heart, loosening bowel to relieve constipation, for restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation; Caulis Polygoni Multiflori nourishes heart, and calms the nerves, and dredging collateral, dispels the wind, and cures mainly insomnia, impairment caused by overstrain, and hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies, sweet micro-hardship, flat; Flos Albiziae nature and flavor are sweet, flat, Shu Yu, regulate the flow of vital energy, calm the nerves, active, nourish blood, YIN nourishing kidney, improving eyesight clears away heart-fire; Radix Curcumae nature and flavor are pungent, bitter, cold, return liver, the heart, lung meridian, regulating qi to disperse stagnation, and heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, for amenorrhea dysmenorrhea chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine; The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold, and returns liver, gallbladder, lung meridian, heat-clearing and toxic substances removing, and promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea , WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus; In Semen Armeniacae Amarum, contain amygdaloside, amygdaloside can be hydrolyzed by enteric microorganism enzyme or the contained emulsin of Semen Armeniacae Amarum itself in vivo, produces micro-hydrocyanic acid and benzaldehyde, and respiratory center is had to inhibitory action, reaches antitussive, antiasthmatic effect; Fructus Amomi Rotundus has good fragrant stomach invigorating, wind dispelling effect effect, can promote gastric secretion, and excited intestinal tube is wriggled, and drives away enteral pneumatosis, and suppresses enteral abnormal fermentation; Semen Coicis is cool in nature, sweet in the mouth, light, and spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, Semen Coicis can be used for treating edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen; Rhizoma Pinelliae Preparatum is pungent, warm, returns spleen, stomach, lung meridian, drying dampness to eliminate phlegm, and for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache; Cortex Magnoliae Officinalis nature and flavor hardships, pungent, warm in nature, return through spleen channel, stomach warp, large intestine channel, circulation of qi promoting removing food stagnancy, dampness is except full, and lowering the adverse QI to relieve asthma, cures mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant is stopped up QI rising in reverse order, and fullness in the chest is breathed with cough; Semen Nelumbinis sweet in the mouth, puckery, property is flat, returns spleen, kidney, heart channel, has the function of supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, tranquilizing by nourishing the heart; Radix Polygalae hardship, pungent, tepor, GUIXIN, kidney, lung meridian, the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, detumescence, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, for dryness of the lung dry cough, chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria, YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough, for few thirsty, the dry cough spitting of blood in Tianjin of lung-stomach yin deficiency, the cards such as the palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat.
The present invention is used for the treatment of insomnia, and cost is low, there is no obvious toxic-side effects, and treated effect is higher.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Adopt Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Atractylodis (parched), Poria, Herba Eupatorii, Fructus Piperis Longi, Semen Ginkgo core, jujube nucleus, Semen Platycladi, Caulis Polygoni Multiflori, Flos Albiziae, Radix Curcumae, Rhizoma Polygoni Cuspidati, Semen Armeniacae Amarum, Fructus Amomi Rotundus, Semen Coicis, Rhizoma Pinelliae Preparatum, Cortex Magnoliae Officinalis, Semen Nelumbinis, Radix Polygalae, Radix Ophiopogonis, for crude drug is prepared from, its component (take weight portion) is Radix Codonopsis 15, Rhizoma Atractylodis Macrocephalae (parched) 15, Rhizoma Atractylodis (parched) 20, Poria 18, Herba Eupatorii 14, Fructus Piperis Longi 5, Semen Ginkgo core 6, jujube nucleus 22, Semen Platycladi 15, Caulis Polygoni Multiflori 31, Flos Albiziae 13, Radix Curcumae 15, Rhizoma Polygoni Cuspidati 15, Semen Armeniacae Amarum 10, Fructus Amomi Rotundus 12, Semen Coicis 30, Rhizoma Pinelliae Preparatum 11, Cortex Magnoliae Officinalis 10, Semen Nelumbinis 15, Radix Polygalae 17, Radix Ophiopogonis 9, get 2.52 kilograms of above-mentioned 21 kinds of crude drug gross weights, after selected cleaning, use at ambient temperature 15000ml water soaking 3-4 hour, then decoct 60 minutes, through the routine filtration of removing slag, high pressure, after sterilization process, gained filtrate 4800ml, sterile bag subpackage, sealing, every bag of 100ml.Early, late twice (medicine) being taken before meal, each oral one bag 8 days is a course for the treatment of, each course for the treatment of is every three days, takes continuously three courses for the treatment of of decoction of the present invention.
The embodiment that the each raw material of the present invention also can the listed ratio of according to the form below (weight portion) mixes realizes.Its processing technique is identical with embodiment 1.
Below in conjunction with my institute, the clinical preliminary test that In Shandong Weihai women and children hospital carries out is done further, is described in detail the present invention:
1, case selection: this organizes 60 examples, male 21 examples, female's 39 examples, age 15-53 year, 29 years old mean age, course of disease 2-7, average 4.6 years.
2, Therapeutic Method: early, late twice (medicine) being taken before meal, each oral a bag 10 days is a course for the treatment of, and every three days, take continuously three courses for the treatment of of the present invention each course for the treatment of.
3, diagnosis is differentiated:
(1) difficulty falling asleep.Refer to that dropping asleep latency extends (being longer than 30 minutes).
(2) sleep disorder.The finger awakening time is increased (more than 30 minutes every night); Reduce the actual length of one's sleep (less than 6 hours every night); The awakening time accounts for the length of one's sleep more than 10%.
(3) sleep table is shallow.The 3-4 phase that refers to NREM sleep is visited the minimizing of sleeping, and 10% of not enough sleep total time, the minimizing of REM sleep ratio, also shows Depth of sleep deficiency.
(4) early awakening.The sleep time more normal time advance 30 minutes of having waken up of having waken up.
(5) do not have enough sleep.Refer generally to adult sleep total time less than 6 hours, or Sleep efficiency (being the ratio of sleeping full night total time and writing time)≤80%.In teenager, < 90% and middle-aged and elderly people < 65% are the standard of not having enough sleep.Generally speaking, whether do not have enough sleep, also should be in conjunction with sleep habit at ordinary times of patient and daytime subjective symptoms and determine.
(6) Sleep architecture imbalance: mainly refer to NREM/REM sleep cycle < 3 times, and (or) the NREM/REM ratio length of one's sleep is not normal.
4, criterion of therapeutical effect: curative effect determinate standard--State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".Clinical recovery: sleep is normal, the length of one's sleep, more than 6 hours simultaneous phenomenon disappeared.Effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improves.Invalid: before sleeping as taking medicine, or extend less than the length of one's sleep 2 hours, symptom is without improvement.
5, therapeutic outcome: the present invention treats 60 examples, takes medicine three courses for the treatment of, clinical recovery 17 examples, effective 39 examples, invalid 4 examples, cure rate 28%, effective percentage 65%, inefficiency 7%, total effective rate 93%.
Typical case's case therapeutic outcome
1, sex: man, 32 years old age, 2 years causes often online are directed at insomnia more than 2 years to the late into the night, every night by eating a slice clonazepam and mirtazapine half sheet just can be slept two or three hours and be dream entirely, the present health that do not know why becomes very weakness now, performance is afraid of cold, inappetence, hyperhidrosis, loses weight, also start to occur headache, the symptoms such as stomachache.
2, sex: female, at 48 years old age, the state of an illness is described: dizzy insomnia.Early 2 of the accidental chambers of heart beating 87 times, Color Sonography is normal, cervical vertebra c3,6 intervertebrals are outstanding dura mater leading edge pressurized to dead astern, and neck marrow is without extremely, and bilateral vertebral artery pipe symmetry, is positive permanent current spacing wave and once treated situation and effect; Traction massage 1 month, has an injection 5 days to no effect.
3, sex: female, 37 years old age, the state of an illness is described: nearly 3 years of once intermittent insomnia, all can continue one to three months at every turn, eat of the Chinese patent medicine of Cure for insomnia, as GUIPI WAN, Tianwang Buxin Dan, ANSHEN BUXIN WAN, joining melatonin all can take a turn for the better, saw that Henan Yi Jia hospital said that Cure for insomnia has good method June last year on the net, can first try out, this medicine on probation of result eaten less than half an hour just dark sleepy, feel with regard to sleepy all day, eat after drug withdrawal in ten days with regard to serious insomnia, the time of falling asleep in an ensuing week is altogether less than ten hours, and depressed, mood dysphoria, easily enrage, even cry and scream, taking traditional Chinese medicine afterwards, conditioning a period of time, this there is a change for the better, but it is always bad to sleep, all fear every evening can't fall asleep, more so more can't fall asleep, daytime, spirit was very poor, emotion is also bad, if just keep in mind long-term such it would be better in the dust, a nearest old docter of TCM presses disarmony between the heart and kidney treatment, with be Chinese goldthread colla corii asini decoction, having taken falls asleep evening a period of time had not resembled former difficulty so, still feel to sleep badly, easily wake up with a start, how to do again thing laboriously daytime, after wakeing up, feel to ache with it, as think that muscle is tightly drawn always, do not loosen, the sensation that never sleepy is felt.
4, sex: female, the age: 42, because of irriate, feel bad and frighten the bad early awakening of sleep 15 years, starting most heart has uncomfortable in chestly, breathes hard, and early rich symptom, perspires, do not take notice of very much in the past, these several years serious, is mainly that cardia has constriction, weight sense, uncomfortable in chest, pain, the most serious is to lie awake all night, and tight with regard to heart one just will be sleeping time, scalp one fiber crops just wake up with a start, psychology fear and, done electrocardio, electroencephalogram, color ultrasound, also has ambulatory electrocardiogram all out of question.
Above four people are through the treatment of my institute, and early, late twice (medicine) being taken before meal decoction of the present invention, each oral one bag 10 days is a course for the treatment of, and each course for the treatment of is every three days, all fully recover after taking continuously three courses for the treatment of of the present invention.