CN1326857C - 新的1,4－二氮杂双环烷烃衍生物、其制备和应用 - Google Patents

新的1,4－二氮杂双环烷烃衍生物、其制备和应用 Download PDF

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Publication number
CN1326857C
CN1326857C CNB038232626A CN03823262A CN1326857C CN 1326857 C CN1326857 C CN 1326857C CN B038232626 A CNB038232626 A CN B038232626A CN 03823262 A CN03823262 A CN 03823262A CN 1326857 C CN1326857 C CN 1326857C
Authority
CN
China
Prior art keywords
diazabicyclo
nonane
compound
oxadiazol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038232626A
Other languages
English (en)
Chinese (zh)
Other versions
CN1684965A (zh
Inventor
D·彼得斯
G·M·奥尔森
E·O·尼尔森
T·D·约根森
P·K·阿林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
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Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en
Publication of CN1684965A publication Critical patent/CN1684965A/zh
Application granted granted Critical
Publication of CN1326857C publication Critical patent/CN1326857C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB038232626A 2002-09-30 2003-09-29 新的1,4－二氮杂双环烷烃衍生物、其制备和应用 Expired - Fee Related CN1326857C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
DKPA200201738 2002-11-11
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
CN1684965A CN1684965A (zh) 2005-10-19
CN1326857C true CN1326857C (zh) 2007-07-18

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038232626A Expired - Fee Related CN1326857C (zh) 2002-09-30 2003-09-29 新的1,4－二氮杂双环烷烃衍生物、其制备和应用

Country Status (11)

Country Link
JP (1) JP4711391B2 (https=)
KR (1) KR20050062575A (https=)
CN (1) CN1326857C (https=)
BR (1) BR0314183A (https=)
IL (1) IL166821A (https=)
IS (1) IS7829A (https=)
MX (1) MXPA05003344A (https=)
NO (1) NO20052124L (https=)
PT (1) PT1551835E (https=)
RU (1) RU2323218C2 (https=)
SI (1) SI1551835T1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2368614C2 (ru) * 2004-02-04 2009-09-27 НьюроСёрч А/С Диазабициклические арильные производные в качестве модуляторов холинергических рецепторов
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
US8158619B2 (en) * 2006-05-30 2012-04-17 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
KR20090110353A (ko) * 2007-02-15 2009-10-21 아젠터 디스커버리 리미티드 Ｍ３ 무스카린 수용체로서의 헤테로시클릭 유도체
AU2012338581B2 (en) 2011-11-18 2016-12-08 Nxera Pharma Uk Limited Muscarinic M1 receptor agonists
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
EA201800367A1 (ru) * 2015-12-10 2019-02-28 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения болезни хантингтона
CN108752286B (zh) * 2016-09-18 2021-05-11 广西师范大学 1，2，8-氧代二氮杂环壬烷衍生物及其合成方法和应用
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307140A1 (en) * 1987-09-10 1989-03-15 Merck Sharp & Dohme Ltd. Oxadiazolyl-azabicycloheptanes for the treatment of senile dementia
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO2000034279A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001055150A1 (fr) * 2000-01-28 2001-08-02 Sanofi-Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001092260A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001092259A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.22]nonane-phenylisoxazole, leur preparation et leur application en therapeutique
EP1219622A2 (en) * 2000-12-29 2002-07-03 Pfizer Products Inc. Pharmaceutical compositions for CNS and other disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ282567B6 (cs) * 1993-12-29 1997-08-13 Pfizer Inc. Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi
US6809107B1 (en) * 1999-07-09 2004-10-26 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions and methods
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307140A1 (en) * 1987-09-10 1989-03-15 Merck Sharp & Dohme Ltd. Oxadiazolyl-azabicycloheptanes for the treatment of senile dementia
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO2000034279A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001055150A1 (fr) * 2000-01-28 2001-08-02 Sanofi-Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001092260A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2001092259A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.22]nonane-phenylisoxazole, leur preparation et leur application en therapeutique
EP1219622A2 (en) * 2000-12-29 2002-07-03 Pfizer Products Inc. Pharmaceutical compositions for CNS and other disorders

Also Published As

Publication number Publication date
IL166821A0 (en) 2006-01-15
JP2006503062A (ja) 2006-01-26
SI1551835T1 (sl) 2007-06-30
IS7829A (is) 2005-04-28
NO20052124L (no) 2005-06-29
IL166821A (en) 2009-06-15
HK1081954A1 (en) 2006-05-26
KR20050062575A (ko) 2005-06-23
BR0314183A (pt) 2005-08-09
RU2005105048A (ru) 2005-11-20
NO20052124D0 (no) 2005-04-29
PT1551835E (pt) 2007-03-30
RU2323218C2 (ru) 2008-04-27
MXPA05003344A (es) 2005-11-23
CN1684965A (zh) 2005-10-19
JP4711391B2 (ja) 2011-06-29

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