CN1323677C

CN1323677C - Medicine for osteoporosis

Info

Publication number: CN1323677C
Application number: CNB2004100250164A
Authority: CN
Inventors: 陈根生
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-06-03
Filing date: 2004-06-03
Publication date: 2007-07-04
Anticipated expiration: 2024-06-03
Also published as: CN1583069A

Abstract

The present invention relates to an osteoporosis treating medicine which comprises the following raw materials (parts by weight): 8 to 12 parts of Rhizoma Drynariae, 4 to 7 parts of eucommia bark, 4 to 7 parts of Chinese taxillus twig, 2 to 4 parts of cibot rhizome, 3 to 6 parts of chuanxiong rhizome, 3 to 5 parts of angelica, 4 to 6 parts of safflower, 3 to 5 parts of largehead atractylodes rhizome and 6 to 10 parts of cyathula root. The medicine is prepared by carefully selecting medicines according to the Chinese medical theory that kidney governs the bones and engenders marrow, and the treatment method of mainly tonifying the liver and the kidney, strengthening the spleen, harmonizing the stomach, quickening the blood, dispelling stasis, etc. Experimental research in the aspects of clinic and the inside and the outside of animal bodies indicates that the osteoporosis treating medicine of the present invention can basically adjust and convert bone metabolism into normal balance.

Description

The medicine of treatment osteoporosis

Technical field

The present invention relates to medicine, especially a kind of medicine for the treatment of osteoporosis.

Background technology

Bone is a kind of Biocomposite material, constitutes the support of bone by organic gel fibril network structure, and inorganic matter calcium, phosphorus are filled in wherein.Osteoporosis is to be reduced to principal character with general bone amount, osseous tissue microstructure degenerative change, and with sclerotin fragility increases, mechanical strength descends and risk of fractures raises an osteoid metabolic disease.Osteoporosis is divided two classes: a class mainly refers to the female patient in the menopause 15-20, and porous spot accounts for about 70% of this disease sum based on the spongy bone of spinal vertebral and extremities joint portion at this moment; Two classes mainly are meant the masculinity and femininity gerontal patient on 70 years old, and this moment, cortical bone also loosened, and sclerotin becomes fragile, attenuation, and the pulp cavity caliber increases, and accounts for 30% of sum.Women's postmenopausal osteoporosis is meant ovarian function failure, decrease in estrogen, secondary hyperthyroidism, calcitonin hyposecretion, thereby cause bone resorption greater than bone formation, the microstructure degenerative change that occurs with low bone amount and osseous tissue is its feature.Women's postmenopausal osteoporosis patient, about about 6000-7500 ten thousand people of China, about whole world 2.2-2.5 hundred million people, still not having ideal medicine at present treats, main Therapeutic Method has: 1, controversies in hormone replacement in the elderly, need more than the life-time service 7-10, determined curative effect, but severe complications such as the carcinogenic rate of 5-10% and metrorrhagia are arranged; 2, the use of calcium preparation and fluoride preparation can improve the density of bone, but because of not improving the metabolism of bone, increase the fragility of bone on the contrary; 3, the use of phosphate preparation, it can suppress osteoclast activity, but can not promote skeletonization; 4, the use of XIANLING GUBAO, the Chinese medicine preparation of producing by Guizhou celestial miraculous cure industry company limited, state's internal therapy should the most representative Chinese patent medicine of disease at present, the true medicine of curative effect.

Summary of the invention

The medicine of the treatment osteoporosis that purpose of the present invention just provides a kind of determined curative effect, has no side effect, pure Chinese herbal medicine is made.

The medicine of treatment osteoporosis of the present invention is made up of the following weight parts raw material: Rhizoma Drynariae 8-12, Cortex Eucommiae 4-7, Herba Taxilli 4-7, Rhizoma Cibotii 2-4, Rhizoma Chuanxiong 3-6, Radix Angelicae Sinensis 3-5, Flos Carthami 4-6, Rhizoma Atractylodis Macrocephalae 3-5, Radix Cyathulae 6-10.

The medicine of treatment osteoporosis of the present invention can be prepared into the common drug dosage form by formulation method routinely.

The preparation method of the medicine of treatment osteoporosis of the present invention is: choose raw material by above-mentioned composition, screening, clean, concoct, dry, pulverize, sieve, encapsulated.

The property of medicine of each component raw material in the medicine of treatment osteoporosis of the present invention:

Rhizoma Drynariae: can control the lumbago due to renal deficiency flaccidity of the lower limbs, Hiccough and deaf, chronic diarrhea.Promoting blood circulation and hemostasis is continuous hinders: being applicable to that falling winks frustrates injury of tendon and muscle fracture.

The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Vascular hypertension.

Herba Taxilli: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Be used for that rheumatic arthralgia, soreness of the waist and knees, muscles and bones are unable, frequent fetal movement, early abortion, vascular hypertension.

Rhizoma Cibotii: invigorating the liver and kidney, remove rheumatism, strong waist foot, sharp joint.Cure mainly lumbago, rheumatism, frequent micturition, seminal emission, leukorrhagia, hemorrhage.

Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores Flos Carthami: the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.

The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis is antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

Radix Cyathulae: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Be used for soreness of waist and knee joint, muscles and bones is unable, amenorrhea abdominal mass, dizziness due to hyperactivity of liver-YANG.

The medicine of treatment osteoporosis of the present invention is the theory according to the traditional Chinese medical science " the kidney generating marrow and dominating bone ", based on liver and kidney tonifying, takes into account method of treatment such as spleen invigorating peace stomach, blood circulation promoting and blood stasis dispelling, and selected medicine is formulated.It is monarch drug with the Rhizoma Drynariae, and the Cortex Eucommiae, Herba Taxilli, Rhizoma Cibotii are ministerial drug, and Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami are adjuvant drug, and the Rhizoma Atractylodis Macrocephalae, Radix Cyathulae are messenger drug.Compatibility is based on Chinese medicine " organic conception " and " treatment of disease must aim at its pathogenesis " two big rules.

The medicine of treatment osteoporosis of the present invention through clinical practice for many years, shows determined curative effect, from 1996-1999, with self-control Drug therapy women postmenopausal osteoporosis, and establish the matched group contrast, 121 examples are organized in treatment, matched group 118 examples, two groups of cases were 1 course of treatment with 1 month all, and available 1-6 course of treatment, Chinese medicine is decocted in water for oral dose 1 dose of every day, 2 fry in shallow oil 2 each extracting juice 150ml of clothes, gradation clothes.Efficacy assessment standard: (1) produce effects: clinical symptoms all disappears, and recovers the normal activity function, and union of fracture or compression vertebral body partly recover.(2) effective: clinical symptoms is most of to disappear, union of fracture or delayed union, and vertebral body compression nothing increases the weight of, and osteoporosis is improved, and recovers daily routines.(3) invalid: main clinic symptoms, sign, movable function and osteoporosis do not have improvement or increase the weight of.Therapeutic outcome: treatment group produce effects 78 examples, effective 26 examples, invalid 17 examples, total effective rate 86%; Matched group produce effects 41 examples, effective 34 examples, invalid 43 examples, total effective rate 63.3%.Two groups of total effective rates relatively have notable difference (P＜0.01), and relatively there were significant differences (P＜0.01) for two groups of obvious effective rates.Above case is followed up a case by regular visits to 1-5, and treatment is organized none example refracture is taken place.Wrist fracture, 5 routine compression fracture of lumbar vertebra, 4 routine radius far-end fractures take place in matched group then 2 examples.

The medicine of treatment osteoporosis of the present invention is through China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute's animal prerun.Adopt and give 7 weeks of female mice gastric infusion, dosage is in 4g crude drug/kg body weight--16g crude drug/kg body weight, test shows, can make the active significantly reduction of castration mouse phosphatase acid serum, serum inorganic phosphorus content significantly raises, simultaneously can reduce femur length, increase the femur transverse diameter, Chinese medicine preparation " XIANLING GUBAO " the effect similar trend that it is produced the celestial miraculous cure industry of influence and the Guizhou company limited of castration mouse blood biochemical and skeleton.

Show that from experimentatioies clinical and inside and outside two aspects of animal body the medicine of treatment osteoporosis of the present invention can fundamentally be adjusted bone metabolism, make it to transform to normal state balance direction.

The specific embodiment

Embodiment 1:

A kind of medicine for the treatment of osteoporosis is made up of the following weight parts raw material:

Rhizoma Drynariae 10, the Cortex Eucommiae 5, Herba Taxilli 4, Rhizoma Cibotii 4, Rhizoma Chuanxiong 5, Radix Angelicae Sinensis 4, Flos Carthami 4, the Rhizoma Atractylodis Macrocephalae 3, Radix Cyathulae 8.

Its preparation method is: choose raw material by above-mentioned composition, screening, clean, concoct, dry, pulverize, sieve, encapsulated.

Embodiment 2:

Rhizoma Drynariae 8, the Cortex Eucommiae 6, Herba Taxilli 6, Rhizoma Cibotii 2, Rhizoma Chuanxiong 4, Radix Angelicae Sinensis 5, Flos Carthami 6, the Rhizoma Atractylodis Macrocephalae 5, Radix Cyathulae 10.

Its preparation method is identical with embodiment 1.

Embodiment 3:

Rhizoma Drynariae 12, the Cortex Eucommiae 4, Herba Taxilli 7, Rhizoma Cibotii 3, Rhizoma Chuanxiong 3, Radix Angelicae Sinensis 4, Flos Carthami 5, the Rhizoma Atractylodis Macrocephalae 4, Radix Cyathulae 6.

Its preparation method is identical with embodiment 1.

Claims

1, a kind of medicine for the treatment of osteoporosis is characterized in that it is made up of the following weight parts raw material: Rhizoma Drynariae 8-12, Cortex Eucommiae 4-7, Herba Taxilli 4-7, Rhizoma Cibotii 2-4, Rhizoma Chuanxiong 3-6, Radix Angelicae Sinensis 3-5, Flos Carthami 4-6, Rhizoma Atractylodis Macrocephalae 3-5, Radix Cyathulae 6-10.

2, the medicine of treatment osteoporosis according to claim 1 is characterized in that it is made up of the following weight parts raw material: Rhizoma Drynariae 10, the Cortex Eucommiae 5, Herba Taxilli 4, Rhizoma Cibotii 4, Rhizoma Chuanxiong 5, Radix Angelicae Sinensis 4, Flos Carthami 4, the Rhizoma Atractylodis Macrocephalae 3, Radix Cyathulae 8.

3, the medicine of treatment osteoporosis according to claim 1 is characterized in that it is made up of the following weight parts raw material: Rhizoma Drynariae 8, the Cortex Eucommiae 6, Herba Taxilli 6, Rhizoma Cibotii 2, Rhizoma Chuanxiong 4, Radix Angelicae Sinensis 5, Flos Carthami 6, the Rhizoma Atractylodis Macrocephalae 5, Radix Cyathulae 10.

4, the medicine of treatment osteoporosis according to claim 1 is characterized in that it is made up of the following weight parts raw material: Rhizoma Drynariae 12, the Cortex Eucommiae 4, Herba Taxilli 7, Rhizoma Cibotii 3, Rhizoma Chuanxiong 3, Radix Angelicae Sinensis 4, Flos Carthami 5, the Rhizoma Atractylodis Macrocephalae 4, Radix Cyathulae 6.