CN104258077A - Traditional Chinese medicine for treating fracture and preparation method thereof - Google Patents

Traditional Chinese medicine for treating fracture and preparation method thereof Download PDF

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Publication number
CN104258077A
CN104258077A CN201410531698.XA CN201410531698A CN104258077A CN 104258077 A CN104258077 A CN 104258077A CN 201410531698 A CN201410531698 A CN 201410531698A CN 104258077 A CN104258077 A CN 104258077A
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weight portion
weight
chinese medicine
fracture
filtrate
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姜永杰
薛晓媛
董晓玲
井夫斐
王霞
姜永梅
陈强
姜永华
崔新艳
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Abstract

The invention discloses traditional Chinese medicine for treating fracture and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: seed of longleaf xylosma, shinygreen creeper, jasminum subhumile, Eriosolena involucrata(Wall.)van Tieghem, Machilus velutina champ. ex Benth., stem and leaf of henry elaeagnus, haloragis chinensis, acranthera sinensis, leontice kiangnanensis, typhonium roxburgii, edgeworthia chrysantha, herb of twoleaf hoodshaped orchid, ampelopsis humulifolia bunge, colquhounia elegans, diplopterygium Chinense, calonyction aculeatum seed, ceratostigma willmattianum, barban, goshawk bone, glomeris and root of sheathed monkshood. The traditional Chinese medicine and the preparation method thereof have the benefits that the traditional Chinese medicine can effectively relieve or eliminate the pain caused by splint supporting, plaster immobilization and operation traction when a patient with bone injury suffers from fracture, has special efficacies of activating the fast osteoblast calcification of endosteum and periosteum for bone injury and fracture broken ends and further promoting the osteogenesis, is suitable for the treatment on various bone injuries and fractures and has the advantages of low raw material cost, good treatment effect, short treatment period, high cure rate and no toxic or side effect; the preparation method of the traditional Chinese medicine is simple in process and facilitates popularization and application.

Description

A kind of Chinese medicine for the treatment of fracture and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of Chinese medicine for the treatment of fracture and preparation method thereof.
Background technology
According to tcm theory: skeleton is the support of human body, has lacuna in it, hide bone marrow." Plain Questions arteries and veins wants precise and tiny opinion " claims " bone person, fu-viscera of marrow "." Plain Questions should resemble large opinion " explicitly points out: " kidney producing bone marrow, kidney essense is sufficient, then bone marrow biochemistry is active." namely human skeleton rely on the nutrition of bone marrow, bone marrow is kidney essense life.It is raw active that kidney essense enriches then medullization, and skeleton is firm, strong, once because of various pathological factor and oldly to suffer from a deficiency of the kidney, then can not fill the raw marrow of bone, skeleton loses supports, fragility is unable and form osteoporosis, is " Plain Questions vital QI of the body connecting with natural QI opinion " so-called: " kidney qi is wound, and processus styloideus radii is bad.Say in " ancient Chinese medical classics essential ideas ": " kidney storing essence, the raw marrow of essence, marrow bone growth promoting, therefore the conjunction of bone person kidney is also ", " essence foot is marrow foot then, and marrow is in bone, and then bone is strong for marrow foot ".Bone injury, femur head necrosis, osteoporosis, fracture all belong to Chinese medicine orthopaedics category.And osteoporosis be reduce with bone amount, the microstructure degeneration of bone for feature, cause the fragility of bone to increase and be easy to occur a kind of general bone energy disease of fracture.The traditional Chinese medical science is thought, suffering from a deficiency of the kidney is the basic reason that osteoporosis occurs.Even if the slight wound of sufferers of osteoporosis face also can cause fracture, the probability of fracture is higher, belongs to Chinese medicine atrophic debility of bones category.Therefore according to the tcm theory of ＂ kidney governing bones ＂, suffering from a deficiency of the kidney is that osteoporotic morbidity is crucial, therefore the suitable invigorating the kidney and strengthening the bones for the treatment of, if kidney essense is sufficient, then muscles and bones is effectively hard.Fracture is also clinical common multiple disease, and orthopedics and traumatology of Chinese medicine has the history of several thousand in China, in fractures, have accumulated rich experience."Nei Jing" is said: " impairment of QI resulting in pain, injury of configuration resulting in swelling ".Wang Bing note: " gas is invisible therefore grieved, and the tangible then wound of blood is swollen ".Fracture and injury QI and blood, hyperamization arteries and veins is from through absurd row, and stagnant blood is detained, and form blood stasis, so that QI-blood circulation is not normal, and the stasis of blood is long-pending does not fall apart, for swelling as pain." blood not reviver's stasis of blood does not go, and the stasis of blood does not go then can not connect " therefore control and work as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone.
The healing of bone injury, union of fracture is a complicated pathological processes, in periosteum, osteoblastic regeneration is the basis of union of fracture, its agglutination can be divided into hematoma to be formed, fibrous callus is formed, the process of the several alternately evolution successively of reconstruction of osseous callus formation and callus, union of fracture is divided into intermembranous ossification and endochondral ossification, and fracture in latter 24 hours, the periosteum at fracture end place starts hypertrophy plumpness, the internal layer hyperplasia of periosteum, produce osteoid tissue, form area of new bone, i.e. intermembranous ossification, its process is rapid, and is connected firmly.When os endochondrale is fracture, periosteum bone cortex and contiguous soft tissue are damaged, angiorrhexis is hemorrhage, hematoma is formed at fractures, because blood cell destroys, Fibrin exudation, granulation tissue is formed, hematoma starts machine, hematoma is surrounded by the proliferation of fibrous tissue being positioned at perihematoma, and stretches into wherein, is replaced by absorption by the effect of phagocyte and foreign-body giant cell.The absorption replacement of hematoma, often needs 2 ~ 3 weeks or the longer time just can complete.After absorption of hematoma substitutes, inmature fibrous tissue between fracture site, major part changes cartilage into, and intercalation is between the external callus of two fracture sites, and chondrocyte is through hyper-proliferative, degeneration, calcification and ossify, and this often needs 1 ~ 3 month.
Fracture is that the structural continuity in epiphyseal plate or joint is separated or interrupts.That fractures is categorized as closure and opening, imperfection and completeness is divided into by the breaking degree of fracture, stability and unstability can be divided into again by manual reduction, be divided into fissure fracture, subperiosteal fracture, cortical bone or periosteum portion fractures to fracture, tear fracture, transverse fracture, oblique fracture, spiral fracture, comminuted fracture, epiphysiolysis, compression fracture, depressed fracture etc. by the form of fracture line.At present, large hospital is all generally first by after fracture site normotopia with artificial to the treatment of fracture patient, with steel wire or with steel plate, Boards wall, and then at affected part outside plaster fixing, bed is rested, and this method relies on the spontaneous recovery regeneration capacity of the human body of patient own to engage fracture site; Or taking the blood circulation promoting medicines such as some similar YUNNAN BAIYAO again, object promotes that fracture heals or stop-pass antiinflammatory early; So-called " 100 days injured in the sinews or bones " need three months after fractures or the recovery of longer time in other words, namely dally over one's work, bring misery again to patient.
At present, the method for set a broken bone fracture mainly comprises Chinese traditional treatment and western medical treatment.Western medical treatment bone injury adopts hormone therapy or takes calcium preparation; Fracture mainly contains manual reduction and extenal fixation such as plintlet binder is fixed and continuous traction etc., generally takes open reduction internal fixtion etc. to critically ill patient, painful large because performing the operation, costly, and postoperative sequela of may leaving over, and make majority be reluctant to accept.Traditional Chinese medical science traditional therapy is pain relieving by force often, symptomatic treatment in acute condition, the rules such as relieving the primary symptom in a chronic case, and that tests is clinical, though there is certain curative effect, control symptom and produce effects slowly, healing only has the wait physiology normal healing phase, is about 7 ~ 10 weeks, and patient's course of disease and painful phase extend.Therefore, the multiplex hormone of current set a broken bone and a large amount of supplementary calcium preparation, the most employing patient of fracture beats the methods such as clamping plate, plaster fixing, operation traction, there is the course for the treatment of long, cure slow, patient pain's drawback such as unbearably, for such situation, clinically can effectively alleviate sufferer misery in the urgent need to one, also can the medicine of accelerating union of bone fracture.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine for the treatment of fracture and preparation method thereof, formula material medical material cost be low, good effect, short treating period, effectively alleviate patient suffering and have no side effect; Its preparation method, technique is simple, is beneficial to and applies.
For solving the problems of the technologies described above, provide a kind of Chinese medicine for the treatment of fracture, wherein, described Chinese medicine comprises following raw medicinal material: break by a fall strangle, bright close net Herba pteridii latiusculi, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Eriosolena involucrata (Wall.) van Tieghem, monkey high ferro, Caulis et Folium Elaeagni Henryi, Haloragis chinensis (Laur) Merr, sharp medicine flower, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Typhonium roxburgii schott, Edgeworthia chrysantha Lindl., Herba Neottianthes Cucullatae, heptangle Radix Ampelopsis, broken close flower, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, large moonflower seed, Radix Ceratostigmatis mini, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably: break by a fall and strangle 15 ~ 25 weight portions, close net Herba pteridii latiusculi 10 ~ 25 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 15 ~ 30 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 35 weight portion, monkey high ferro 15 ~ 25 weight portion, Caulis et Folium Elaeagni Henryi 10 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 10 ~ 25 weight portion, 20 ~ 35 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 40 weight portion, Typhonium roxburgii schott 5 ~ 15 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 25 weight portion, Herba Neottianthes Cucullatae 10 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 30 weight portion, brokenly closely spend 20 ~ 35 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 30 weight portion, large moonflower seed 20 ~ 30 weight portion, Radix Ceratostigmatis mini 8 ~ 18 weight portion, Herba ainsliaeae yunnanensis 10 ~ 25 weight portion, Os Accipiter 5 ~ 15 weight portion, Prospiroboli joannsi 20 ~ 40 weight portion and ink 75 ~ 15 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can also be preferably: break by a fall and strangle 15 ~ 20 weight portions, close net Herba pteridii latiusculi 15 ~ 20 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 20 ~ 25 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 30 weight portion, monkey high ferro 15 ~ 20 weight portion, Caulis et Folium Elaeagni Henryi 15 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 15 ~ 20 weight portion, 25 ~ 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 35 weight portion, Typhonium roxburgii schott 8 ~ 12 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 20 weight portion, Herba Neottianthes Cucullatae 15 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 25 weight portion, brokenly closely spend 25 ~ 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 25 weight portion, large moonflower seed 25 ~ 30 weight portion, Radix Ceratostigmatis mini 10 ~ 15 weight portion, Herba ainsliaeae yunnanensis 15 ~ 20 weight portion, Os Accipiter 5 ~ 10 weight portion, Prospiroboli joannsi 20 ~ 35 weight portion and ink 75 ~ 10 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: break by a fall and strangle 20 weight portions, close net Herba pteridii latiusculi 18 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 22 weight portion, Eriosolena involucrata (Wall.) van Tieghem 30 weight portion, monkey high ferro 18 weight portion, Caulis et Folium Elaeagni Henryi 15 weight portion, Haloragis chinensis (Laur) Merr 20 weight portion, 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 35 weight portion, Typhonium roxburgii schott 8 weight portion, Edgeworthia chrysantha Lindl. 20 weight portion, Herba Neottianthes Cucullatae 15 weight portion, heptangle Radix Ampelopsis 25 weight portion, brokenly closely spend 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 25 weight portion, large moonflower seed 25 weight portion, Radix Ceratostigmatis mini 10 weight portion, Herba ainsliaeae yunnanensis 20 weight portion, Os Accipiter 8 weight portion, Prospiroboli joannsi 30 weight portion and ink 78 weight portions.
Wherein, when the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 5 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 85% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 1 ~ 3 time relative to the alcohol heating reflux of the determining alcohol 90% ~ 95% of 3 ~ 5 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 75 DEG C 65 DEG C, relative density is the mastic of 1.22 ~ 1.25, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 3 ~ 5 times relative to the mixture quality obtained, and soaks 6-12 hour, and heating decoction 2 ~ 5 hours, filters; By filtering residue again with the water of 3 ~ 5 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 5 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.5 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, leave standstill 12 ~ 24 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.6g/mL ~ 1.8g/mL.
Wherein, when the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 5 times, each 2 ~ 3 hours, add the water of 5 ~ 8 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 85% ~ 90% ethanol to alcohol content be 50% ~ 55%, leave standstill 2 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 2 ~ 3 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2 weight portion ~ 5 weight portion stearic acid, 0.7 weight portion ~ 1.5 weight portion stearyl alcohol, 0.6 weight portion ~ 1.2 weight portion glyceryl monostearate, 3 weight portion ~ 6 weight portion liquid Paraffin, 6 weight portion ~ 10 weight portion dimethicones are mixed and heated to 80 DEG C ~ 85 DEG C, under constantly stirring, add 2 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.6 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.8 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1200 weight portion ~ 1600 weight portion distilled water are mixed and heated to 70 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 45 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C ~ 75 DEG C.
Beneficial effect of the present invention: play clamping plate when patient with bone fracture fracture can effectively be alleviated or eliminate to Chinese medicine of the present invention, pain that plaster fixing, operation cause, the bone fracture broken ends of fractured bone is activated to the rapid calcification of osteoblast of perimyelis, periosteum, and then promote that New born formation has special efficacy.Have blood circulation promoting and blood stasis dispelling, reunion of fractured tendons and bones, nourishing the liver and kidney, reducing swelling and alleviating pain, promote the focus effect of repairing fast, the present invention is applicable to the treatment of various bone fracture, and raw medicinal material cost is low, good effect, short treating period, cure rate are high and have no side effect.Extensive patients is made to remove the hardship of the hurt like hell of bone fracture, without the need to using strong analgesic again.The present invention can promote that callus is formed rapidly, and the physiological healing phase obviously shifts to an earlier date, thus reaches the object of set a broken bone fracture.Its preparation method, technique is simple, is beneficial to and applies.
Detailed description of the invention
In order to effectively eliminate or alleviate the misery of fracture patient, accelerate the quickly-healing of fracture, the present invention is according to theory of Chinese medical science, provide a kind of Chinese medicine for the treatment of fracture, wherein, described Chinese medicine comprises following raw medicinal material: break by a fall strangle, bright close net Herba pteridii latiusculi, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Eriosolena involucrata (Wall.) van Tieghem, monkey high ferro, Caulis et Folium Elaeagni Henryi, Haloragis chinensis (Laur) Merr, sharp medicine flower, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Typhonium roxburgii schott, Edgeworthia chrysantha Lindl., Herba Neottianthes Cucullatae, heptangle Radix Ampelopsis, broken close flower, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, large moonflower seed, Radix Ceratostigmatis mini, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven.
Wherein, the pharmacology of various raw medicinal material is as follows:
Break by a fall and strangle: bitter in the mouth; Puckery; Cold in nature.Clearing away heat-damp and promoting diuresis; Blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain; Lactogenic.Main jaundice; Edema; Traumatic injury; Fracture; Amenorrhea; Carbuncle sore tumefacting virus; Galactostasis; Skin ulcer tinea; Scrofula.Guangzhou air force " conventional Chinese herbal medicine handbook ": cool the blood dissipate blood stasis, reducing swelling and alleviating pain.Control bruise or fracture, dislocation.(taking passages " China's book on Chinese herbal medicine ")
The close net Herba pteridii latiusculi of light: puckery, temperature.Slightly poisonous.Invigorate blood circulation, pain relieving, synthetism, detumescence.Cure mainly traumatic injury, fracture.(taking passages " national Chinese herbal medicine compilation ")
Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai: bitter, pungent is flat.Expelling wind and removing dampness, promoting the circulation of blood pain relieving.Cure mainly rheumatic arthritis, lumbago, cold, fever, systemic pain, traumatic injury, fracture, traumatic hemorrhage.(taking passages " national Chinese herbal medicine compilation ")
Eriosolena involucrata (Wall.) van Tieghem: pungent, temperature.Poisonous.Analgesia, dissipating blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling.Cure mainly stomachache, bone breaks, the injury of tendon and muscle, traumatic injury, rheumatic ostalgia, various pain.(taking passages " national Chinese herbal medicine compilation ")
Monkey high ferro: bitter, cool.Preventing phlegm from forming and stopping coughing, reducing swelling and alleviating pain, astringing to arrest bleeding.For bronchitis; Burn and scald is controlled in external, traumatic hemorrhage, carbuncle, fracture.(taking passages " national Chinese herbal medicine compilation ")
Caulis et Folium Elaeagni Henryi: sweet; Warm in nature.Return bladder; Lung; Liver Channel.Dissipating blood stasis for subsidence of swelling; Bone-setting pain stopping; Antiasthmatic-antitussive.Main treating swelling and pain by traumatic injury; Fracture; Rheumatic ostalgia; Asthma." Luchuan book on Chinese herbal medicine ": fracture-setting powder amasss, reducing swelling and alleviating pain.Control injury and bone fracture, damage is swollen and ache, rheumatic ostalgia.(taking passages " China's book on Chinese herbal medicine ")
Haloragis chinensis (Laur) Merr: promoting blood circulation and detumescence; Relieving cough and asthma.Main injury and bone fracture; Asthma; Cough." GUIHAIA register ": for refuting bone.(taking passages " China's book on Chinese herbal medicine ")
Point medicine flower: sweet in the mouth; Property is put down.QI invigorating tonify deficiency; Promoting blood circulation and detumescence; Removing toxic substances.Main body deadhead is swooned; Traumatic injury; Fracture; Aphtha of the mouth and tongue; Venom.(taking passages " China's book on Chinese herbal medicine ")
Gymnospermium kiangnanense (P. L. Chiu) Loconte: bitter in the mouth; Property is put down.Removing toxic substances and promoting subsidence of swelling; Promoting blood circulation and stopping pain; Hemostasis.Main traumatic injury; Acute lumbar muscle sprain; Stiff neck; Fracture pain; Chest pain; Headache and dizzy; Stomachache; Digestive tract hemorrhage; Spit blood; Traumatic hemorrhage.(taking passages " China's book on Chinese herbal medicine ")
Typhonium roxburgii schott: acrid in the mouth; Warm in nature; Poisonous.Return liver; Stomach warp.Promoting blood circulation and stopping pain; Removing toxic substances; Hemostasis.Main air pain of dampness syndrome; Gastric abscess; Stomachache is had loose bowels traumatic injury; Fracture; Furuncle toxic swelling; Venom; Traumatic hemorrhage." Xinhua book on Chinese herbal medicine outline " tuber: acrid in the mouth, fiber crops, warm in nature, poisonous.There is the function of analgesia, removing toxic substances and promoting subsidence of swelling.For venom, sore toxic swelling, traumatic hemorrhage, traumatic injury, fracture, enteritis, stomachache, gastric ulcer.(taking passages " China's book on Chinese herbal medicine ")
Edgeworthia chrysantha Lindl.: sweet, temperature.Root: relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain.For rheumatic arthralgia, lumbago; Traumatic injury is controlled in external, fracture.(taking passages " national Chinese herbal medicine compilation ")
Herba Neottianthes Cucullatae: sweet is flat.Heart tonifying is excited, promoting blood circulation to remove blood stasis.For traumatic stupor, traumatic injury, fracture.(taking passages " national Chinese herbal medicine compilation ")
Heptangle Radix Ampelopsis: pungent, heat.Promoting blood circulation to remove blood stasis, eliminating inflammation and expelling toxin, granulation promoting long bone, expelling wind and removing dampness.Cure mainly traumatic injury, fracture furuncle swells and ache, rheumatic arthritis.(taking passages " national Chinese herbal medicine compilation ")
Broken close flower: bitter in the mouth; Cool in nature.Removing toxic substances dysentery relieving; Synthetism is stopped blooding.Main toxic-heat and blood stasis; Traumatic injury is turned round and is improperly familiar with; Fracture; Traumatic hemorrhage.(taking passages " China's book on Chinese herbal medicine ")
China's Diplopterygium glaucum (Thunb ex Houtt) Nakai: micro-hardship; Micro-puckery; Cool.Hemostasis; Synthetism.Main epistaxis; Fracture.(taking passages " China's book on Chinese herbal medicine ")
Large moonflower seed: bitter; Pungent; Flat.Promoting blood circulation to remove blood stasis; Reducing swelling and alleviating pain.Main treating swelling and pain by traumatic injury; Fracture.(taking passages " China's book on Chinese herbal medicine ")
Radix Ceratostigmatis mini: pungent; Bitter; Warm in nature; Poisonous.Spleen; The heart.Wind-damp dispelling; The meridian dredging; Pain relieving.Main rheumatic numbness; Gastral cavity abdomen hypochondriac pain; Traumatic injury; Fracture; Vasculitis; Parotitis." Yunnan Chinese herbal medicine ": dredge the meridian passage, wind-damp dispelling.Dispelling the wind and dampness pathogens is numb, vasculitis.(taking passages " China's book on Chinese herbal medicine ")
Herba ainsliaeae yunnanensis: pungent, bitter is flat.Wind-damp dispelling, relaxing muscles and tendons bone, symplectic bone.Cure mainly traumatic injury, fracture, rheumatism bones and muscles pain.(taking passages " national Chinese herbal medicine compilation ")
Os Accipiter: acrid in the mouth; Salty; Warm in nature. liver; Kidney channel. wind-damp dispelling; Reuniting the fractured tendons and bones.Main bones and muscles pain; Damage fracture.(taking passages " China's book on Chinese herbal medicine ")
Prospiroboli joannsi: salty, temperature.Relaxing muscles and tendons to promote blood circulation, bone-setting pain stopping.For traumatic injury, fracture, dislocation.(taking passages " national Chinese herbal medicine compilation ")
Ink seven: pungent, bitter, temperature.Slightly poisonous.Promoting the circulation of QI to relieve pain, promoting blood flow to regulate menstruation.Cure mainly stomachache, menoxenia, traumatic injury, fracture such as to swell and ache the disease.(taking passages " national Chinese herbal medicine compilation ")
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material preferably can break by a fall and strangle 15 ~ 25 weight portions, close net Herba pteridii latiusculi 10 ~ 25 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 15 ~ 30 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 35 weight portion, monkey high ferro 15 ~ 25 weight portion, Caulis et Folium Elaeagni Henryi 10 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 10 ~ 25 weight portion, 20 ~ 35 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 40 weight portion, Typhonium roxburgii schott 5 ~ 15 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 25 weight portion, Herba Neottianthes Cucullatae 10 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 30 weight portion, brokenly closely spend 20 ~ 35 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 30 weight portion, large moonflower seed 20 ~ 30 weight portion, Radix Ceratostigmatis mini 8 ~ 18 weight portion, Herba ainsliaeae yunnanensis 10 ~ 25 weight portion, Os Accipiter 5 ~ 15 weight portion, Prospiroboli joannsi 20 ~ 40 weight portion and ink 75 ~ 15 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can also be preferably: break by a fall and strangle 15 ~ 20 weight portions, close net Herba pteridii latiusculi 15 ~ 20 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 20 ~ 25 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 30 weight portion, monkey high ferro 15 ~ 20 weight portion, Caulis et Folium Elaeagni Henryi 15 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 15 ~ 20 weight portion, 25 ~ 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 35 weight portion, Typhonium roxburgii schott 8 ~ 12 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 20 weight portion, Herba Neottianthes Cucullatae 15 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 25 weight portion, brokenly closely spend 25 ~ 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 25 weight portion, large moonflower seed 25 ~ 30 weight portion, Radix Ceratostigmatis mini 10 ~ 15 weight portion, Herba ainsliaeae yunnanensis 15 ~ 20 weight portion, Os Accipiter 5 ~ 10 weight portion, Prospiroboli joannsi 20 ~ 35 weight portion and ink 75 ~ 10 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: break by a fall and strangle 20 weight portions, close net Herba pteridii latiusculi 18 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 22 weight portion, Eriosolena involucrata (Wall.) van Tieghem 30 weight portion, monkey high ferro 18 weight portion, Caulis et Folium Elaeagni Henryi 15 weight portion, Haloragis chinensis (Laur) Merr 20 weight portion, 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 35 weight portion, Typhonium roxburgii schott 8 weight portion, Edgeworthia chrysantha Lindl. 20 weight portion, Herba Neottianthes Cucullatae 15 weight portion, heptangle Radix Ampelopsis 25 weight portion, brokenly closely spend 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 25 weight portion, large moonflower seed 25 weight portion, Radix Ceratostigmatis mini 10 weight portion, Herba ainsliaeae yunnanensis 20 weight portion, Os Accipiter 8 weight portion, Prospiroboli joannsi 30 weight portion and ink 78 weight portions.
Wherein, when the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 5 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 85% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 1 ~ 3 time relative to the alcohol heating reflux of the determining alcohol 90% ~ 95% of 3 ~ 5 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 75 DEG C 65 DEG C, relative density is the mastic of 1.22 ~ 1.25, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 3 ~ 5 times relative to the mixture quality obtained, and soaks 6-12 hour, and heating decoction 2 ~ 5 hours, filters; By filtering residue again with the water of 3 ~ 5 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 5 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.5 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, leave standstill 12 ~ 24 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.6g/mL ~ 1.8g/mL.
Wherein, when the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 5 times, each 2 ~ 3 hours, add the water of 5 ~ 8 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 85% ~ 90% ethanol to alcohol content be 50% ~ 55%, leave standstill 2 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 2 ~ 3 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2 weight portion ~ 5 weight portion stearic acid, 0.7 weight portion ~ 1.5 weight portion stearyl alcohol, 0.6 weight portion ~ 1.2 weight portion glyceryl monostearate, 3 weight portion ~ 6 weight portion liquid Paraffin, 6 weight portion ~ 10 weight portion dimethicones are mixed and heated to 80 DEG C ~ 85 DEG C, under constantly stirring, add 2 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.6 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.8 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1200 weight portion ~ 1600 weight portion distilled water are mixed and heated to 70 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 45 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C ~ 75 DEG C.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 syrup 1 of the present invention
Get to break by a fall and strangle 200g, bright close net Herba pteridii latiusculi 180g, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 220g, Eriosolena involucrata (Wall.) van Tieghem 300g, monkey high ferro 180g, Caulis et Folium Elaeagni Henryi 150g, Haloragis chinensis (Laur) Merr 200g, sharp medicine flower 300g, Gymnospermium kiangnanense (P. L. Chiu) Loconte 350g, Typhonium roxburgii schott 80g, Edgeworthia chrysantha Lindl. 200g, Herba Neottianthes Cucullatae 150g, heptangle Radix Ampelopsis 250g, broken close colored 300g, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai 250g, large moonflower seed 250g, Radix Ceratostigmatis mini 100g, Herba ainsliaeae yunnanensis 200g, Os Accipiter 80g, Prospiroboli joannsi 300g and black seven 80g.
Its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 90% of 5 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% of 3 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 85% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 90% of 5 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 65 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 5 times relative to the mixture quality obtained, soaks 12 hours, and heating decoction 3 hours, filters; By filtering residue again with the water of 5 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing first step, second step and the 3rd step obtained, adds the water dissolution relative to mixture quality 1 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours under 6 DEG C of conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.3 times obtained, and stirs and dissolves, adjust ph to 7.0, adds water appropriate, stirs, leave standstill 24 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.8g/mL.
Embodiment 2 syrup 2 of the present invention
Get to break by a fall and strangle 160g, bright close net Herba pteridii latiusculi 170g, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 200g, Eriosolena involucrata (Wall.) van Tieghem 250g, monkey high ferro 150g, Caulis et Folium Elaeagni Henryi 180g, Haloragis chinensis (Laur) Merr 150g, sharp medicine flower 260g, Gymnospermium kiangnanense (P. L. Chiu) Loconte 300g, Typhonium roxburgii schott 100g, Edgeworthia chrysantha Lindl. 180g, Herba Neottianthes Cucullatae 160g, heptangle Radix Ampelopsis 200g, broken close colored 280g, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai 200g, large moonflower seed 260g, Radix Ceratostigmatis mini 120g, Herba ainsliaeae yunnanensis 170g, Os Accipiter 90g, Prospiroboli joannsi 280g and black seven 100g.
Its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% of 4 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 5 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.3g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 3 times relative to the alcohol heating reflux of the determining alcohol 95% of 3 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 75 DEG C 65 DEG C, relative density is the mastic of 1.24, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 3 times relative to the mixture quality obtained, soaks 6 hours, and heating decoction 5 hours, filters; By filtering residue again with the water of 4 times relative to the mixture quality obtained, heating decoction 1 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing first step, second step and the 3rd step obtained, adds the water dissolution relative to mixture quality 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 72 hours under 7 DEG C of conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, adds water appropriate, stirs, leave standstill 12 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.7g/mL.
Embodiment 3 unguentum 1 of the present invention
Get to break by a fall and strangle 180g, bright close net Herba pteridii latiusculi 200g, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 230g, Eriosolena involucrata (Wall.) van Tieghem 280g, monkey high ferro 200g, Caulis et Folium Elaeagni Henryi 160g, Haloragis chinensis (Laur) Merr 180g, sharp medicine flower 280g, Gymnospermium kiangnanense (P. L. Chiu) Loconte 260g, Typhonium roxburgii schott 90g, Edgeworthia chrysantha Lindl. 160g, Herba Neottianthes Cucullatae 170g, heptangle Radix Ampelopsis 210g, broken close colored 260g, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai 220g, large moonflower seed 270g, Radix Ceratostigmatis mini 110g, Herba ainsliaeae yunnanensis 180g, Os Accipiter 60g, Prospiroboli joannsi 250g and black seven 60g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion above-mentioned raw materials medical material, decocts with water 2 times, each 3 hours, add the water of 6 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ethanol to alcohol content be 50%, leave standstill 3 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
Second step, relative to the 100 weight portion mixed-powders that the first step obtains, 2 weight portion stearic acid, 1.1 weight portion stearyl alcohol, 1.0 weight portion glyceryl monostearates, 5 weight portion liquid Paraffin, 8 weight portion dimethicones are mixed and heated to 85 DEG C, under constantly stirring, add 3 part by weight of vitamin E dissolve, obtain oil phase;
1.2 weight portion sodium lauryl sulphates, 1.1 weight portion triethanolamine, 1 weight portion ethyl hydroxybenzoate, 1500 weight portion distilled water, relative to the 100 weight portion mixed-powders that the first step obtains, are mixed and heated to 80 DEG C by the 3rd step, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 50 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 70 DEG C.
Embodiment 4 unguentum 2 of the present invention
Get to break by a fall and strangle 250g, bright close net Herba pteridii latiusculi 220g, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 300g, Eriosolena involucrata (Wall.) van Tieghem 320g, monkey high ferro 210g, Caulis et Folium Elaeagni Henryi 180g, Haloragis chinensis (Laur) Merr 220g, sharp medicine flower 330g, Gymnospermium kiangnanense (P. L. Chiu) Loconte 280g, Typhonium roxburgii schott 120g, Edgeworthia chrysantha Lindl. 230g, Herba Neottianthes Cucullatae 180g, heptangle Radix Ampelopsis 280g, broken close colored 320g, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai 230g, large moonflower seed 280g, Radix Ceratostigmatis mini 140g, Herba ainsliaeae yunnanensis 220g, Os Accipiter 100g, Prospiroboli joannsi 350g and black seven 110g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion above-mentioned raw materials medical material, decocts with water 5 times, each 2 hours, add the water of 7 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 85% ethanol to alcohol content be 55%, leave standstill 4 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 3 hours;
Second step, relative to the 100 weight portion mixed-powders that the first step obtains, 3 weight portion stearic acid, 1.0 weight portion stearyl alcohol, 1.1 weight portion glyceryl monostearates, 3 weight portion liquid Paraffin, 6 weight portion dimethicones are mixed and heated to 80 DEG C, under constantly stirring, add 2 part by weight of vitamin E dissolve, obtain oil phase;
1.1 weight portion sodium lauryl sulphates, 1.3 weight portion triethanolamine, 2 weight portion ethyl hydroxybenzoates, 1600 weight portion distilled water, relative to the 100 weight portion mixed-powders that the first step obtains, are mixed and heated to 75 DEG C by the 3rd step, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 75 DEG C.
Pharmacological toxicity is tested:
1. acute toxicity test: unguentum 2 prepared by syrup 2 prepared by the syrup 1 prepared with the embodiment of the present invention 1, embodiment 2, the unguentum 1 of embodiment 3 preparation and embodiment 4, give 4 groups of white mice feeding dispensings respectively with 120 of clinical consumption per day times, 220 times, 150 times and 260 times respectively or smear, observing 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
2. long term toxicity test: the syrup 2 prepared of syrup 1 prepared by the embodiment of the present invention 1, embodiment 2 to two groups of mices by 8.97,18.32 crude drugs/kg, unguentum 2 prepared by the unguentum 1 embodiment of the present invention 3 prepared and embodiment 4 to two groups of mices by 26.93 and 38.89g crude drug/kg, respectively to 4 groups of mice continuous uses (feeding or smear) 10 weeks, every day 2 times, and drug withdrawal is after 4 weeks, adds up.Result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to 4 groups of test mices all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 10 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Pharmacodynamic experiment:
For showing effect of medicine tool blood circulation promoting and blood stasis dispelling of the present invention, reunion of fractured tendons and bones, nourishing the liver and kidney, reducing swelling and alleviating pain, to treatment fracture, prevention and therapy osteoporosis has significant curative effect, and this stimulating food medicine is through a series of zoopery, and result shows that its curative effect is good.
1, test specimen
Test group: the syrup 1 of the embodiment of the present invention 1, distilled water diluting becomes solution.Positive controls: tablet for curing fracture, Hebei hundred is apt to pharmaceutcal corporation, Ltd and is produced, the accurate word Z20063720 of traditional Chinese medicines, removing sugar-coat, porphyrize, and distilled water diluting becomes solution; Blank group: for not containing the normal saline of any activity, toxicity control medicine.
2, testing program:
(1) test of pesticide effectiveness establish the present invention's (high, medium and low dosage) group, contrast medicine group, blank group.(2) experimentally main " study of tcm new drug guideline (pharmacy, pharmacology, toxicology) " relevant chapters and sections according to the issue of Ministry of Public Health medicine positive office and pertinent literature carry out this institute.Some experiment systems are according to internationally recognized method or copy according to this laboratory situation and the method improved after multiple condition is groped.This data all represents with means standard deviation (± s).Data one factor analysis of variance, compares between LSD method group.
3, dosage regimen
4, on the impact of osteoporosis rat:
4-1, experimental technique:
The foundation of experiment grouping and model rat with osteoporosis is got normal Wistar rats 60 and is divided into 5 groups at random; Get wherein 15 as model group, press tretinoin 80mg/kg gavage 14 days merely, after the 14th day, stop administration; Get wherein 15 as tablet for curing fracture matched group; Remaining 30 rats are as the high, medium and low dosage group of the present invention.As tablet for curing fracture matched group and the high, medium and low dosage group of the present invention, while gavaging tretinoin by the dosage of 80mg/kg, gavage corresponding medicine, and after gavaging 14 days, withdraw tretinoin, continue administration 14 days, respectively organize rat next day and pull out after eyeball gets blood and put to death.Separation of serum, surveys blood calcium (Ca), phosphorus (P), serum alkaline phosphatase (ALP), and gets the indexs such as the further analysis of left and right femur do key weight, BMD, bone density, Bones morphology.
4-2, result of the test:
Table 1 is on the impact (± s) of experiment Osteoporosis Rats serum calcium, phosphorus, content of alkaline phosphatase
Note: compare with matched group, * P<0.05, * * P<0.01; Compare with normal saline group, △ P<0.05.
5, on the impact of fracture:
5-1, experimental technique: rat is divided at random 5 groups and often organizes 20, be respectively blank group, small dose group of the present invention, middle dosage group, heavy dose of group and positive drug control group.Except blank group, all the other each treated animals, respectively under ether light anaesthesia, lower 2/3 place in left leg, free-handly causes closure artificial fracture.Postoperatively all do not fix, from operation same day, except Normal group, model control group, all the other each treated animals gastric infusions respectively, capacity was 1.5ml/100g body weight, and Normal group, model control group give equivalent 0.9% normal saline, continuous 15 days.In the 15th day each group get 15 rats respectively with urethane 1g/kg anesthesia, abdominal aortic blood, measures hemorheology, blood plasma alkaline phosphatase activities; Get fracture specimen, measure calcium, phosphorus and collagen content in callus.More each group difference situation, carries out t inspection respectively.
5-2, result of the test:
Table 2 is on the impact (± s) of the change of experiment fracture rat serum rheology, blood plasma alkali phosphatase
Note: compare with model group, * * P<0.01; With contrast medicine group and compare ◇ P<0.05.
Table 3 is on calcium, phosphorus, glue collagen content impact (± s) in experiment fracture rat callus
Note: compare with blank group, * P<0.05, * * P<0.01; With contrast medicine group and compare ◇ P<0.05.
Above-mentioned experiment proves: in Chinese medicine of the present invention, effect of each drug component produces synergism, the content of serum calcium, phosphorus, alkali phosphatase can be increased, add bone density, Bones morphology is made to become better, increase local blood circulation, enhance metabolism, promote fracture site bone matrix calcium deposition, there is the effect improving bone amount; Growth promoting effects hormone (GH) secretion simultaneously; By the regulating and controlling effect to skeletal growth factor, the generation improving the content of bone morphogenetic protein (BMP), promote osteoblast secretion TGF-t3, promote IGF 1.To fractures successful.
Clinical experiment:
1. clinical data: amount to case 120 example, wherein man 68 example, female 52 example; The oldest 75 years old, minimum 16 years old, average 35 years old; The course of disease is the longest 6 days, the shortest 1 day, average 12 hours; Crush injury 43 is routine, motor-vehicle accident injury 39 is routine, get injured by a fall 28 examples, other reason causes injury 10 examples; Belong to closed fracture 45 example, open fracture 75 example; Cross-section shape 28 example, oblique 51 examples, spiral type 26 example, pulverizes shape 15 example.
2. Therapeutic Method and dose: after adopting operation and traditional method reduction, adopts different fixing meanss to fix according to fracture concrete condition.Taking the syrup 1 of the embodiment of the present invention 1, each 10ml, every day 2 times, 7 days is a course for the treatment of; Or smear with the unguentum 1 of the embodiment of the present invention 3, within every 3 days, changing dressings 1 time, 15 days is a course for the treatment of.Taking the photograph X-ray film at treatments period, understand growth of spur situation, judging the clinical healing time in conjunction with having a medical check-up with or without callus.
3. efficacy evaluation:
1. criterion of therapeutical effect, " Chinese medical disease Standardization of diagnosis and curative effect " according to national Department of Health in 1994 issue is formulated.Excellent: than the normal healing time person that shifts to an earlier date 2 weeks or more; Good: to shift to an earlier date 1 week than normal healing time; Can: the normal both 10 weeks clinical union of bone time; , even there is fracture delayed union or disunion in difference: extend than normal healing time.
2. therapeutic effect: in 120 examples, excellent: 80 examples, account for 66.7%; Good: 28 examples, account for 23.3%; Can: 10 examples, account for 12%; Difference: 2, accounts for 0.02%.Acceptance rate 90%.
Concrete case 1: Zhao, female, 30 years old, because the lower ring road mouth import department from subway station is fallen off the stairs by shoes skidding, right lower limb traumatic injury, at once shank severe pain, action of can not standing, suffers from lower limb tenderness sharp-pointed, can touch to obtain bone rubbing feeling, X-ray examination is shown in left tibia and fibula lower fracture, and far-end is shifted to the right.Diagnosis: right tibiofibula lower fracture.Therapeutic Method: 1, manual reduction, correct deformity; The unguentum of 2, the external application embodiment of the present invention 3 is changed dressings once for 1,3 days.3, clip plate holder is tied up fixing.The patient after 2 times that changes dressings can walk, also without obvious pain with descending; Medication 4 times, when 12 days, x-ray mating plate shows fracture end good apposition, and fracture line is fuzzy, removes clamping plate, terminates treatment.
Concrete case 2: Chen, man, 42 years old, because traffic accident wound causes the dry fracture of left humerus.Therapeutic Method: 1, reduction: under assistant maintains traction, in doctor props up fracture with two hands thumbs proximal lateral pushes to, all the other four finger rings are embraced outside distal medial pulls to, make inside two fracture sites concordant, and micro-outside angulation, then two thumbs inwardly push away again, correct angulation, two fracture sites are calmed down return former.Then forearm is placed in neutral position, before suffering limb is suspended to breast with super shoulder Boards wall, scarf bandage; 2, the syrup 1 of the embodiment of the present invention 1 for oral administration, each 10ml, every day 2 times 7 days is a course for the treatment of; Allow patient start after 6 days to temper elbow joint flexion-extension motion voluntarily simultaneously.After three weeks, remove extenal fixation, check X sheet shows: fracture site has seriality bone cangue to be passed through, and fracture reduction is good to line, and patient's right upper extremity function is recovered (shoulder, elbow, wrist joint function recover completely) completely.

Claims (8)

1. treat the Chinese medicine of fracture for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: break by a fall strangle, bright close net Herba pteridii latiusculi, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Eriosolena involucrata (Wall.) van Tieghem, monkey high ferro, Caulis et Folium Elaeagni Henryi, Haloragis chinensis (Laur) Merr, sharp medicine flower, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Typhonium roxburgii schott, Edgeworthia chrysantha Lindl., Herba Neottianthes Cucullatae, heptangle Radix Ampelopsis, broken close flower, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, large moonflower seed, Radix Ceratostigmatis mini, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven.
2. treat the Chinese medicine of fracture according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of various raw medicinal material is: break by a fall and strangle 15 ~ 25 weight portions, close net Herba pteridii latiusculi 10 ~ 25 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 15 ~ 30 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 35 weight portion, monkey high ferro 15 ~ 25 weight portion, Caulis et Folium Elaeagni Henryi 10 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 10 ~ 25 weight portion, 20 ~ 35 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 40 weight portion, Typhonium roxburgii schott 5 ~ 15 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 25 weight portion, Herba Neottianthes Cucullatae 10 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 30 weight portion, brokenly closely spend 20 ~ 35 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 30 weight portion, large moonflower seed 20 ~ 30 weight portion, Radix Ceratostigmatis mini 8 ~ 18 weight portion, Herba ainsliaeae yunnanensis 10 ~ 25 weight portion, Os Accipiter 5 ~ 15 weight portion, Prospiroboli joannsi 20 ~ 40 weight portion and ink 75 ~ 15 weight portions.
3. according to claim 1 or 2, treat the Chinese medicine of fracture, it is characterized in that, in described Chinese medicine, the ratio of weight and number of various raw medicinal material is: break by a fall and strangle 15 ~ 20 weight portions, close net Herba pteridii latiusculi 15 ~ 20 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 20 ~ 25 weight portion, Eriosolena involucrata (Wall.) van Tieghem 20 ~ 30 weight portion, monkey high ferro 15 ~ 20 weight portion, Caulis et Folium Elaeagni Henryi 15 ~ 20 weight portion, Haloragis chinensis (Laur) Merr 15 ~ 20 weight portion, 25 ~ 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 25 ~ 35 weight portion, Typhonium roxburgii schott 8 ~ 12 weight portion, Edgeworthia chrysantha Lindl. 15 ~ 20 weight portion, Herba Neottianthes Cucullatae 15 ~ 18 weight portion, heptangle Radix Ampelopsis 15 ~ 25 weight portion, brokenly closely spend 25 ~ 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 15 ~ 25 weight portion, large moonflower seed 25 ~ 30 weight portion, Radix Ceratostigmatis mini 10 ~ 15 weight portion, Herba ainsliaeae yunnanensis 15 ~ 20 weight portion, Os Accipiter 5 ~ 10 weight portion, Prospiroboli joannsi 20 ~ 35 weight portion and ink 75 ~ 10 weight portions.
4. according to claim 1 or 2 or 3, treat the Chinese medicine of fracture, it is characterized in that, in described Chinese medicine, the ratio of weight and number of various raw medicinal material is: break by a fall and strangle 20 weight portions, close net Herba pteridii latiusculi 18 weight portion of light, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai 22 weight portion, Eriosolena involucrata (Wall.) van Tieghem 30 weight portion, monkey high ferro 18 weight portion, Caulis et Folium Elaeagni Henryi 15 weight portion, Haloragis chinensis (Laur) Merr 20 weight portion, 30 weight portions spent by point medicine, Gymnospermium kiangnanense (P. L. Chiu) Loconte 35 weight portion, Typhonium roxburgii schott 8 weight portion, Edgeworthia chrysantha Lindl. 20 weight portion, Herba Neottianthes Cucullatae 15 weight portion, heptangle Radix Ampelopsis 25 weight portion, brokenly closely spend 30 weight portions, China's Diplopterygium glaucum (Thunb ex Houtt) Nakai 25 weight portion, large moonflower seed 25 weight portion, Radix Ceratostigmatis mini 10 weight portion, Herba ainsliaeae yunnanensis 20 weight portion, Os Accipiter 8 weight portion, Prospiroboli joannsi 30 weight portion and ink 78 weight portions.
5. according to claim 1-4, treat the Chinese medicine of fracture, it is characterized in that, when the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 5 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 85% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 1 ~ 3 time relative to the alcohol heating reflux of the determining alcohol 90% ~ 95% of 3 ~ 5 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 75 DEG C 65 DEG C, relative density is the mastic of 1.22 ~ 1.25, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 3 ~ 5 times relative to the mixture quality obtained, and soaks 6-12 hour, and heating decoction 2 ~ 5 hours, filters; By filtering residue again with the water of 3 ~ 5 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 5 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.5 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, leave standstill 12 ~ 24 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.6g/mL ~ 1.8g/mL.
6. according to claim 1-4, treat the Chinese medicine of fracture, it is characterized in that, when the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 5 times, each 2 ~ 3 hours, add the water of 5 ~ 8 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 85% ~ 90% ethanol to alcohol content be 50% ~ 55%, leave standstill 2 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 2 ~ 3 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2 weight portion ~ 5 weight portion stearic acid, 0.7 weight portion ~ 1.5 weight portion stearyl alcohol, 0.6 weight portion ~ 1.2 weight portion glyceryl monostearate, 3 weight portion ~ 6 weight portion liquid Paraffin, 6 weight portion ~ 10 weight portion dimethicones are mixed and heated to 80 DEG C ~ 85 DEG C, under constantly stirring, add 2 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.6 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.8 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1200 weight portion ~ 1600 weight portion distilled water are mixed and heated to 70 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 45 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C ~ 75 DEG C.
7. according to any one of Claims 1 to 4, treat a preparation method for the Chinese medicine of fracture, it is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:
Step one, to break by a fall strangle, Jasminum subhumile W. W. Smith var. Glabrieymosum (W. W. Smith) Miao ex p． Y. Bai, Caulis et Folium Elaeagni Henryi, Gymnospermium kiangnanense (P. L. Chiu) Loconte, Chinese Diplopterygium glaucum (Thunb ex Houtt) Nakai, Herba ainsliaeae yunnanensis, Os Accipiter, Prospiroboli joannsi and ink seven mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 5 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1 ~ 1.3g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 85% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Step 2, close for light net Herba pteridii latiusculi, Eriosolena involucrata (Wall.) van Tieghem, Haloragis chinensis (Laur) Merr, Typhonium roxburgii schott, heptangle Radix Ampelopsis, broken close flower and Radix Ceratostigmatis mini are mixed in described ratio, add and extract 1 ~ 3 time relative to the alcohol heating reflux of the determining alcohol 90% ~ 95% of 3 ~ 5 times of the mixture quality obtained, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 75 DEG C 65 DEG C, relative density is the mastic of 1.22 ~ 1.25, and the mastic spray dryer after concentrated is dried to powder;
Step 3, mixes surplus stock medical material in described ratio, adds the water of 3 ~ 5 times relative to the mixture quality obtained, and soaks 6-12 hour, and heating decoction 2 ~ 5 hours, filters; By filtering residue again with the water of 3 ~ 5 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
Step 4, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 5 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.5 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, leave standstill 12 ~ 24 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.6g/mL ~ 1.8g/mL.
8. according to any one of Claims 1 to 4, treat a preparation method for the Chinese medicine of fracture, it is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 5 times, each 2 ~ 3 hours, add the water of 5 ~ 8 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 85% ~ 90% ethanol to alcohol content be 50% ~ 55%, leave standstill 2 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 300 mesh sieves, adopt ultra violet lamp sterilizing in 2 ~ 3 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2 weight portion ~ 5 weight portion stearic acid, 0.7 weight portion ~ 1.5 weight portion stearyl alcohol, 0.6 weight portion ~ 1.2 weight portion glyceryl monostearate, 3 weight portion ~ 6 weight portion liquid Paraffin, 6 weight portion ~ 10 weight portion dimethicones are mixed and heated to 80 DEG C ~ 85 DEG C, under constantly stirring, add 2 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.6 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.8 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1200 weight portion ~ 1600 weight portion distilled water are mixed and heated to 70 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 45 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C ~ 75 DEG C.
CN201410531698.XA 2014-10-10 2014-10-10 Traditional Chinese medicine for treating fracture and preparation method thereof Pending CN104258077A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105902709A (en) * 2016-05-04 2016-08-31 刘金枝 Traditional Chinese medicine external application agent for treating bone fracture and nursing method
CN106177219A (en) * 2016-07-26 2016-12-07 胡明兰 A kind of Chinese medicine preparation treating fractures and bone injuries

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* Cited by examiner, † Cited by third party
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孙美珍等主编: "《骨伤科病实用方》", 30 September 1993, 南京：江苏科学技术出版社 *
王学礼、郑怀林主编: "《世界传统医学养生保健学》", 30 June 1998, 北京：科学出版社 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105902709A (en) * 2016-05-04 2016-08-31 刘金枝 Traditional Chinese medicine external application agent for treating bone fracture and nursing method
CN106177219A (en) * 2016-07-26 2016-12-07 胡明兰 A kind of Chinese medicine preparation treating fractures and bone injuries

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Application publication date: 20150107