CN1322134C - 表达系统 - Google Patents

表达系统 Download PDF

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Publication number
CN1322134C
CN1322134C CNB018124097A CN01812409A CN1322134C CN 1322134 C CN1322134 C CN 1322134C CN B018124097 A CNB018124097 A CN B018124097A CN 01812409 A CN01812409 A CN 01812409A CN 1322134 C CN1322134 C CN 1322134C
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CN
China
Prior art keywords
ser
asn
thr
leu
lys
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018124097A
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English (en)
Chinese (zh)
Other versions
CN1440459A (zh
Inventor
E·D·威廉森
J·米勒
N·J·瓦尔克
L·W·J·拜利
P·T·霍尔登
H·C·弗利克－史密斯
H·L·布利芬特
R·W·蒂特巴尔
A·W·托平
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UK Secretary of State for Defence
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UK Secretary of State for Defence
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Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Publication of CN1440459A publication Critical patent/CN1440459A/zh
Application granted granted Critical
Publication of CN1322134C publication Critical patent/CN1322134C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB018124097A 2000-07-08 2001-07-06 表达系统 Expired - Fee Related CN1322134C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0016702.3A GB0016702D0 (en) 2000-07-08 2000-07-08 Expression system
GB0016702.3 2000-07-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2006101290967A Division CN101012458A (zh) 2000-07-08 2001-07-06 表达系统

Publications (2)

Publication Number Publication Date
CN1440459A CN1440459A (zh) 2003-09-03
CN1322134C true CN1322134C (zh) 2007-06-20

Family

ID=9895205

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2006101290967A Pending CN101012458A (zh) 2000-07-08 2001-07-06 表达系统
CNB018124097A Expired - Fee Related CN1322134C (zh) 2000-07-08 2001-07-06 表达系统

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2006101290967A Pending CN101012458A (zh) 2000-07-08 2001-07-06 表达系统

Country Status (10)

Country Link
US (3) US7537771B2 (enExample)
EP (2) EP1808489B1 (enExample)
JP (2) JP2004502460A (enExample)
CN (2) CN101012458A (enExample)
AU (1) AU2007201553B8 (enExample)
CA (2) CA2658217A1 (enExample)
GB (1) GB0016702D0 (enExample)
RU (2) RU2385348C2 (enExample)
WO (1) WO2002004646A1 (enExample)
ZA (1) ZA200210206B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016702D0 (en) 2000-07-08 2000-08-23 Secr Defence Brit Expression system
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
WO2004024067A2 (en) * 2002-09-10 2004-03-25 Vical Incorporated Codon-optimized polynucleotide-based vaccines against bacillus anthracis infection
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
AU2003303307B2 (en) * 2002-11-15 2006-12-07 Gen-Probe Incorporated Assay and compositions for detection of bacillus anthracis nucleic acid
WO2005026203A2 (en) 2003-09-18 2005-03-24 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna promoters and anthrax vaccines
FR2860005A1 (fr) * 2003-09-23 2005-03-25 Univ Aix Marseille Ii Methode de detection d'agents bacteriens ou viraux de bioterrorisme
WO2005030991A1 (fr) * 2003-09-23 2005-04-07 Universite De La Mediterranee (Aix-Marseille Ii) Methode de detection d’agents bacteriens ou viraux de bioterrorisme
GB0401036D0 (en) * 2004-01-17 2004-02-18 Royal Holloway University Of L Improvements in or relating to vaccination
US8101735B2 (en) 2004-06-16 2012-01-24 Health Protection Agency Preparation of protective antigen
US7355027B2 (en) 2004-06-16 2008-04-08 Dynport Vaccine Company Llc Bacillus anthracis protective antigen
US8603824B2 (en) 2004-07-26 2013-12-10 Pfenex, Inc. Process for improved protein expression by strain engineering
CN100336908C (zh) * 2004-09-10 2007-09-12 中国人民解放军军事医学科学院微生物流行病研究所 一种制备重组炭疽保护性抗原的方法及其专用表达质粒
WO2006068647A1 (en) * 2004-12-20 2006-06-29 United States Army Medical Research And Materiel Command Internal positive control for probe-based nucleic acid molecule assays and methods of making and using thereof
GB0504940D0 (en) * 2005-03-10 2005-04-20 Secr Defence Vaccine formulation
WO2008048289A2 (en) 2005-11-14 2008-04-24 University Of Maryland Biotechnology Institute Off. Of Research Admin./Tech. Dev. Salmonella based oral vaccines for anthrax
GB0525213D0 (en) * 2005-12-12 2006-01-18 Secr Defence Vaccine
US20070202117A1 (en) * 2005-12-22 2007-08-30 Herman Groen Compositions and Methods Of Modulating the Immune Response
GB0607462D0 (en) 2006-04-13 2006-05-24 Avecia Ltd Assay
JP2008231063A (ja) * 2007-03-22 2008-10-02 Takano Foods Kk 納豆菌ワクチン
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CA2964910C (en) 2007-04-27 2018-01-09 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
WO2010038076A1 (en) * 2008-10-02 2010-04-08 Pharmathene Uk Limited Anthrax vaccine formulation and uses thereof
WO2010080188A2 (en) * 2008-10-14 2010-07-15 The Regents Of The University Of Michigan Epitope targeted anthrax vaccine
US20100183675A1 (en) * 2009-01-22 2010-07-22 Allan Watkinson Stable vaccine compositions and methods of use
US8187611B2 (en) * 2009-10-29 2012-05-29 Albert Einstein College Of Medicine Of Yeshiva University Anti-peptide antibodies that cross react with protective antigen of Bacillus anthracis and uses thereof
US20110110968A1 (en) * 2009-11-12 2011-05-12 Stanley Goldman Human optimized Bacillus anthracis protective antigen
CN101798565B (zh) * 2010-02-26 2013-08-07 中国人民解放军军事医学科学院生物工程研究所 能在芽孢表面展示pa20蛋白的炭疽芽孢杆菌及其应用
RU2633504C1 (ru) * 2016-12-27 2017-10-12 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук (ФИЦ Биотехнологии РАН) Штамм E.coli - продуцент полноразмерного протективного антигена Bacillus anthracis в форме вирусоподобных частиц
RU2633508C1 (ru) * 2016-12-27 2017-10-12 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук (ФИЦ Биотехнологии РАН) Штамм E. coli - продуцент изолированного домена 1 протективного антигена Bacillus anthracis в форме вирусоподобных частиц
WO2020116686A1 (ko) * 2018-12-06 2020-06-11 고려대학교 산학협력단 인간 항-antxr 키메라 항원 수용체 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677274A (en) * 1993-02-12 1997-10-14 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Anthrax toxin fusion proteins and related methods
WO2000002522A2 (en) * 1998-07-10 2000-01-20 U.S. Medical Research Institute Of Infectious Diseases Anthrax vaccine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2115433C1 (ru) * 1992-08-28 1998-07-20 Научно-исследовательский институт микробиологии МО РФ Вакцина сибиреязвенная комбинированная
RU2110575C1 (ru) * 1995-07-19 1998-05-10 Государственное Федеральное предприятие Государственный научный центр прикладной микробиологии Рекомбинантная плазмидная днк pro pf 5, определяющая синтез капсульного антигена fi возбудителя чумы и протективного антигена возбудителя сибирской язвы, и способ конструирования рекомбинантной плазмидной днк pro pf5
GB0016702D0 (en) 2000-07-08 2000-08-23 Secr Defence Brit Expression system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677274A (en) * 1993-02-12 1997-10-14 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Anthrax toxin fusion proteins and related methods
WO2000002522A2 (en) * 1998-07-10 2000-01-20 U.S. Medical Research Institute Of Infectious Diseases Anthrax vaccine

Also Published As

Publication number Publication date
RU2270865C2 (ru) 2006-02-27
AU6930501A (en) 2002-01-21
ZA200210206B (en) 2004-03-17
US8313928B2 (en) 2012-11-20
US9346860B2 (en) 2016-05-24
AU2007201553A1 (en) 2007-05-03
CA2413045A1 (en) 2002-01-17
EP1808489B1 (en) 2016-03-23
WO2002004646A1 (en) 2002-01-17
AU2007201553B8 (en) 2010-06-03
US20100266639A1 (en) 2010-10-21
JP2004502460A (ja) 2004-01-29
EP1808489A1 (en) 2007-07-18
US20030170263A1 (en) 2003-09-11
AU2007201553B2 (en) 2010-04-22
JP2012010706A (ja) 2012-01-19
CA2658217A1 (en) 2002-01-17
GB0016702D0 (en) 2000-08-23
CA2413045C (en) 2016-06-21
US20130164823A1 (en) 2013-06-27
CN101012458A (zh) 2007-08-08
RU2004134341A (ru) 2006-05-10
RU2385348C2 (ru) 2010-03-27
US7537771B2 (en) 2009-05-26
CN1440459A (zh) 2003-09-03
EP1301606A1 (en) 2003-04-16

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C06 Publication
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C10 Entry into substantive examination
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C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070620

Termination date: 20130706