CN1319975C - 喜树碱类似物及其制备方法 - Google Patents

喜树碱类似物及其制备方法 Download PDF

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Publication number
CN1319975C
CN1319975C CNB008086966A CN00808696A CN1319975C CN 1319975 C CN1319975 C CN 1319975C CN B008086966 A CNB008086966 A CN B008086966A CN 00808696 A CN00808696 A CN 00808696A CN 1319975 C CN1319975 C CN 1319975C
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China
Prior art keywords
alkyl
camptothecin
group
amino
compound
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Expired - Fee Related
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CNB008086966A
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English (en)
Chinese (zh)
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CN1367694A (zh
Inventor
D·P·柯伦
D·博
T·G·伯克
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University of Kentucky Research Foundation
University of Pittsburgh
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University of Kentucky Research Foundation
University of Pittsburgh
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Publication of CN1367694A publication Critical patent/CN1367694A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
CNB008086966A 1999-04-09 2000-04-07 喜树碱类似物及其制备方法 Expired - Fee Related CN1319975C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/290,019 US6207832B1 (en) 1999-04-09 1999-04-09 Camptothecin analogs and methods of preparation thereof
US09/290,019 1999-04-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101049994A Division CN101058579A (zh) 1999-04-09 2000-04-07 喜树碱类似物及其制备方法

Publications (2)

Publication Number Publication Date
CN1367694A CN1367694A (zh) 2002-09-04
CN1319975C true CN1319975C (zh) 2007-06-06

Family

ID=23114196

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB008086966A Expired - Fee Related CN1319975C (zh) 1999-04-09 2000-04-07 喜树碱类似物及其制备方法
CNA2007101049994A Pending CN101058579A (zh) 1999-04-09 2000-04-07 喜树碱类似物及其制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2007101049994A Pending CN101058579A (zh) 1999-04-09 2000-04-07 喜树碱类似物及其制备方法

Country Status (13)

Country Link
US (7) US6207832B1 (cg-RX-API-DMAC10.html)
EP (1) EP1173180B1 (cg-RX-API-DMAC10.html)
JP (1) JP4866505B2 (cg-RX-API-DMAC10.html)
KR (1) KR100717900B1 (cg-RX-API-DMAC10.html)
CN (2) CN1319975C (cg-RX-API-DMAC10.html)
AT (1) ATE399171T1 (cg-RX-API-DMAC10.html)
AU (1) AU781302B2 (cg-RX-API-DMAC10.html)
CA (1) CA2369270C (cg-RX-API-DMAC10.html)
DE (1) DE60039291D1 (cg-RX-API-DMAC10.html)
ES (1) ES2308977T3 (cg-RX-API-DMAC10.html)
HK (1) HK1046374B (cg-RX-API-DMAC10.html)
NZ (1) NZ514635A (cg-RX-API-DMAC10.html)
WO (1) WO2000061146A1 (cg-RX-API-DMAC10.html)

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FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6629995B1 (en) * 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) * 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
WO2003068778A1 (en) * 2002-02-18 2003-08-21 Dr. Reddy's Laboratories Limited A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
WO2003099825A1 (en) * 2002-05-22 2003-12-04 University Of Pittsburgh Synthesis of polycyclic quinolines
AU2003243397A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Homo-camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
CA2502870C (en) * 2002-10-31 2011-07-26 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins
US7064202B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US7064206B1 (en) 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
CN101023119B (zh) * 2004-09-22 2010-05-05 日本化药株式会社 新型嵌段共聚物，胶束制剂以及含胶束制剂为活性组分的抗癌剂
JP5030799B2 (ja) * 2005-03-02 2012-09-19 ニュー センチュリー ファーマシューティカルズ インコーポレイテッド アルブミン結合性薬物の安全性および効力を増大させる方法および組成物
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
CA2652656A1 (en) 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
EP2080779B1 (en) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
KR101589582B1 (ko) * 2008-03-18 2016-01-28 니폰 가야꾸 가부시끼가이샤 생리활성물질의 고분자량 결합체
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
JP5711378B2 (ja) 2011-09-11 2015-04-30 日本化薬株式会社 ブロック共重合体の製造方法
CN118414339A (zh) * 2021-12-16 2024-07-30 迈威(上海)生物科技股份有限公司 一种喜树碱类化合物及其偶联物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468859A (en) * 1993-06-10 1995-11-21 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
WO1997000876A1 (fr) * 1995-06-21 1997-01-09 Societe De Conseils De Recherches Et D'applications Scientifiques (Scras) Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1998007727A1 (en) * 1996-08-19 1998-02-26 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US5744605A (en) * 1993-06-30 1998-04-28 University Of Pittsburgh Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
WO1998028305A1 (fr) * 1996-12-20 1998-07-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptothecine, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
WO1999011646A1 (fr) * 1997-08-29 1999-03-11 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Analogues optiquement purs de la camptothecine, intermediaire de synthese optiquement pur et son procede de preparation

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US5428166A (en) * 1992-06-18 1995-06-27 North Carolina State University Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
US6150343A (en) * 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6211371B1 (en) * 1993-06-30 2001-04-03 University Of Pittsburgh Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
US6136978A (en) 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US5935967A (en) 1995-06-05 1999-08-10 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of highly lipophilic camptothecin derivatives
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
WO1999006310A2 (en) * 1997-08-04 1999-02-11 Abb Power T & D Company Inc. Method and apparatus for manufacturing a variable insulated helically wound electrical coil
US6057303A (en) 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6250342B1 (en) * 1999-09-02 2001-06-26 David Lonardelli Cv joint boot clamp tightening tool

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468859A (en) * 1993-06-10 1995-11-21 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5700939A (en) * 1993-06-10 1997-12-23 Smithkline Beecham Corporation Intermediates useful in camptothecin synthesis
US5744605A (en) * 1993-06-30 1998-04-28 University Of Pittsburgh Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
WO1997000876A1 (fr) * 1995-06-21 1997-01-09 Societe De Conseils De Recherches Et D'applications Scientifiques (Scras) Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1998007727A1 (en) * 1996-08-19 1998-02-26 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
WO1998028305A1 (fr) * 1996-12-20 1998-07-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptothecine, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
WO1999011646A1 (fr) * 1997-08-29 1999-03-11 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Analogues optiquement purs de la camptothecine, intermediaire de synthese optiquement pur et son procede de preparation

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Publication number Publication date
KR100717900B1 (ko) 2007-05-14
JP4866505B2 (ja) 2012-02-01
US7982041B2 (en) 2011-07-19
EP1173180A4 (en) 2004-12-01
US20030088101A1 (en) 2003-05-08
US20090198061A1 (en) 2009-08-06
US20050014775A1 (en) 2005-01-20
US20010003779A1 (en) 2001-06-14
US6809103B2 (en) 2004-10-26
HK1046374A1 (en) 2003-01-10
WO2000061146A1 (en) 2000-10-19
ES2308977T3 (es) 2008-12-16
CN1367694A (zh) 2002-09-04
US6410731B2 (en) 2002-06-25
WO2000061146A9 (en) 2002-01-03
US20080027224A1 (en) 2008-01-31
US6207832B1 (en) 2001-03-27
JP2002541201A (ja) 2002-12-03
AU4217700A (en) 2000-11-14
ATE399171T1 (de) 2008-07-15
CA2369270A1 (en) 2000-10-19
AU781302B2 (en) 2005-05-12
NZ514635A (en) 2004-02-27
EP1173180A1 (en) 2002-01-23
HK1046374B (zh) 2007-08-24
CA2369270C (en) 2011-08-16
DE60039291D1 (de) 2008-08-07
US7538220B2 (en) 2009-05-26
US20120136153A1 (en) 2012-05-31
EP1173180B1 (en) 2008-06-25
US7220860B2 (en) 2007-05-22
KR20010113784A (ko) 2001-12-28
CN101058579A (zh) 2007-10-24

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