CN1317330A - 一种治疗外感风热的复方中药制剂及其生产方法 - Google Patents
一种治疗外感风热的复方中药制剂及其生产方法 Download PDFInfo
- Publication number
- CN1317330A CN1317330A CN 00112840 CN00112840A CN1317330A CN 1317330 A CN1317330 A CN 1317330A CN 00112840 CN00112840 CN 00112840 CN 00112840 A CN00112840 A CN 00112840A CN 1317330 A CN1317330 A CN 1317330A
- Authority
- CN
- China
- Prior art keywords
- heat
- medicine
- wind
- production method
- chinese traditional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 23
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 12
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 206010019233 Headaches Diseases 0.000 abstract description 5
- 231100000869 headache Toxicity 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- 206010028748 Nasal obstruction Diseases 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 206010063659 Aversion Diseases 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 abstract description 2
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract 2
- 230000002588 toxic effect Effects 0.000 abstract 2
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 210000004243 sweat Anatomy 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 230000035922 thirst Effects 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 206010039101 Rhinorrhoea Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010013952 Dysphonia Diseases 0.000 description 3
- 208000010473 Hoarseness Diseases 0.000 description 3
- 206010020565 Hyperaemia Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoyl acetaldehyde Chemical compound CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 1
- 229960003321 baicalin Drugs 0.000 description 1
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明为一种具有清热解毒、清宣风热功效的、治疗外感风热的复方中药制剂，以及生产该药物的方法。制剂包括从以下组分的中药(重量百分比)中所得的提取物：金银花15－45%，黄芩15－30%，三七叶10－25%，鱼腥草15－35%。该药物对发热重、恶寒轻，有汗、头痛、鼻塞、流脓涕、咽喉红肿热痛、口干渴疗效好。其组方系特别为治疗外感风热所研制，无毒副作用；此外由于所用原料仅为天然植物，因此成本低。
Description
本发明涉及一种口服药物，具体说是一种具有清热解毒、清宣风热功效的、治疗外感风热的复方中药制剂，以及生产该药物的方法。
公开号为CN1179948A的中国专利文件公布了-种“抗病毒抗细菌中药复方制剂”，它主要含有以下成分(重量百分比)：氯原酸5-50％、黄芩甙10-75％、鱼腥草素0.5-15％、齐墩果酸2.5-40％。它具有清热解毒，广谱抗细菌、抗真菌，抗病毒、消炎镇痛、镇静等功效。该制剂的不足之处一是所用原料药均为提取物，成本较高；二是其组方未专门针对治疗外感风热而设计，因此对外感风热的疗效还有待提高。
本发明的目的是提供一种治疗外感风热的复方中药制剂及其生产方法，其组方专门针对外感风热症而设计，对该症的疗效好，并且生产成本低。
本发明复方中药制剂包括从以下组分的中药(重量百分比)中所得的提取物：金银花15-45％，黄芩15-30％，三七叶10-25％，鱼腥草15-35％。
本发明复方中药制剂进一步优化的组成是包括从以下组分的中药(重量百分比)中所得的提取物：金银花24-40％，黄芩17-25％，三七叶12-22％，鱼腥草17-32％。所说的提取物最好是醇提取物。
本发明复方中药制剂的生产方法如下：将金银花、黄芩、三七叶、鱼腥草加水浸泡后煎煮二至四次，最好煎煮三次，合并煎液，滤过，滤液减压浓缩后加乙醇至含醇量达60-70％，静置后滤除沉淀，滤液回收乙醇并浓缩成稠膏，低温干燥，研成粉末。
本发明所述配方中的金银花气清香，味淡，微苦，清热解毒，凉散风热，用于热血毒痢，风热感冒，温病发热。黄芩清热泻火解毒，止血，用于湿温，肺热咳嗽，高热燥渴。三七叶清热、消肿、定痛镇痛，能够增强免疫力，有补益的作用。鱼腥草清热解毒，消痈排脓，利尿通淋，四味中药经科学组方，具有清热解毒、清宣风热之功。主要对发热重、恶寒轻，有汗、头痛、鼻塞、流脓涕、咽喉红肿热痛、口干渴疗效较好。临床治疗小儿外感风热症总有效率96.67％，治愈率达60.7％，治疗效果非常突出，有一定的市场前景。临床实验结果如下：
患者情况：150名3-15岁患者，其中轻型44例，症状为发热T37-38℃，伴有流涕、喷嚏、头痛，可有轻度咳嗽、声嘶、咽痛、咽充血、扁桃体肿大等；中型71例，症状为发热T38-39℃，伴有流涕、喷嚏、鼻塞、头痛，可有中度咳嗽、声嘶、咽痛、咽充血、扁桃体肿大，咽后壁淋巴滤泡增生；重型35例，症状为发热T38-39℃，伴全身不适，精神差，食欲不振，畏寒、头痛、咳嗽及鼻部症状较重，可有声嘶、咽痛、咽充血、扁桃体肿大，咽峡部及扁桃体上可有斑状渗出物，咽腔、软、悬雍垂的黏膜上可见灰白色疱疹或溃疡。
治疗方案：口服本发明的胶囊剂，每10kg体重服一粒，每天3次，每个疗程5天。
疗效标准：
痊愈-服药24-48小时内，体温恢复正常，不再回升，症候消失，异常指标恢复正常；
显效-服药24-48小时内，体温恢复正常，不再回升，主要征候大部分消失，异常指标接近正常；
有效-服药48-72小时内，体温恢复正常，不再回升，主要征候大部分消失，异常指标有所改善；
无效-体温、症状无改善。
治疗结果：
疗程比较表
总例数 1天 2天 3天
150 70(47％) 47(31％) 33(22％)
分型疗效观察表分型 例数 痊愈 显效 有效 无效 总有效率轻型 44 44(100％) 0 0 0 100％中型 71 31(43.66％) 23(32.3％) 15(21.13％) 2(2.82％) 97.18重型 35 16(45.71％) 12(34.28％) 4(11.43％) 3(8.57％) 91.43
本发明的有益效果是其组方系特别为治疗外感风热所研制，因此对外感风热的疗效好，无毒副作用；此外由于所用原料仅为天然植物，因此成本低。
实施例1：
取金银花1200g，黄芩880g，三七叶700g，鱼腥草990g加水浸泡后煎煮三次，合并煎液，滤过，滤液减压浓缩后加乙醇至含醇量达65％，静置后滤除沉淀，滤液回收乙醇并浓缩成稠膏，低温干燥，研成粉末，加入适量辅料，压片制成片剂。
实施例2：
取金银花1230g，黄芩900g，三七叶720g，鱼腥草980g加水浸泡后煎煮三次，合并煎液，滤过，滤液减压浓缩后加乙醇至含醇量达63％，静置后滤除沉淀，滤液回收乙醇并浓缩成稠膏，低温干燥，研成粉末，加入适量辅料，制成颗粒，分装胶囊。
实施例3：
取金银花698g，黄芩1150g，三七叶693g，鱼腥草1309g加水浸泡后煎煮三次，合并煎液，滤过，滤液减压浓缩后加乙醇至含醇量达68％，静置后滤除沉淀，滤液回收乙醇并浓缩成稠膏，低温干燥，研成粉末，加入适量辅料，制成颗粒，分装胶囊。
以上实施例仅为了对本发明作进一步的说明，而本发明的范围不受所举实施例的局限。
Claims (5)
1、一种治疗外感风热的复方中药制剂，其特征是包括从以下组分的中药(重量百分比)中所得的提取物：金银花14-45％，黄芩15-30％，三七叶10-25％，鱼腥草15-35％。
2、如权利要求1所说的复方中药制剂，其特征是包括从以下组分的中药(重量百分比)中所得的提取物：金银花24-40％，黄芩17-25％，三七叶12-22％，鱼腥草17-32％。
3、如权利要求2所说的复方中药制剂，其特征是所说的提取物为醇提提取物。
4、如权利要求1至3所说的复方中药制剂的生产方法，其特征是将金银花、黄芩、三七叶、鱼腥草加水浸泡后煎煮二至四次，合并煎液，滤过，滤液减压浓缩后加乙醇至含醇量达60-70％，静置后滤除沉淀，滤液回收乙醇并浓缩成稠膏，低温干燥，研成粉末。
5、如权利要求4所说的复方中药制剂的生产方法，其特征是将金银花、黄芩、三七叶、鱼腥草加水浸泡后煎煮三次。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112840 CN1124142C (zh) | 2000-04-08 | 2000-04-08 | 一种治疗外感风热的复方中药制剂及其生产方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112840 CN1124142C (zh) | 2000-04-08 | 2000-04-08 | 一种治疗外感风热的复方中药制剂及其生产方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1317330A true CN1317330A (zh) | 2001-10-17 |
| CN1124142C CN1124142C (zh) | 2003-10-15 |
Family
ID=4582668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00112840 Expired - Fee Related CN1124142C (zh) | 2000-04-08 | 2000-04-08 | 一种治疗外感风热的复方中药制剂及其生产方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1124142C (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314187A (zh) * | 2018-03-29 | 2019-10-11 | 北京盈科瑞创新药物研究有限公司 | 一种吸入用银芩溶液制剂及其制备方法 |
-
2000
- 2000-04-08 CN CN 00112840 patent/CN1124142C/zh not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314187A (zh) * | 2018-03-29 | 2019-10-11 | 北京盈科瑞创新药物研究有限公司 | 一种吸入用银芩溶液制剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1124142C (zh) | 2003-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102430048B (zh) | 一种治疗咳嗽的中药组合物及其制备方法 | |
| CN112569332A (zh) | 小柴胡提取物在治疗病毒性肺炎中的应用 | |
| CN100409882C (zh) | 一种清热解毒退烧药物 | |
| CN102284022A (zh) | 一种止咳药物及其制备方法 | |
| CN1335163A (zh) | 一种治疗感冒及咳嗽的中成药 | |
| CN103182019A (zh) | 治疗复发性口腔溃疡的中药组合物 | |
| CN1682828A (zh) | 银黄清肺胶囊及其制备方法 | |
| CN103385993A (zh) | 一种治疗胃溃疡的中药制剂及制备方法 | |
| CN103349693B (zh) | 一种治疗过敏性鼻炎的外用中药组合物 | |
| CN103223059A (zh) | 一种治疗复发性口腔溃疡的中药组合物 | |
| CN1124142C (zh) | 一种治疗外感风热的复方中药制剂及其生产方法 | |
| CN106075229A (zh) | 一种治疗风热感冒的中药组合物制剂 | |
| CN103845616A (zh) | 一种消炎杀菌的药物组合物 | |
| CN1358525A (zh) | 撤热消炎中药口服液 | |
| CN113786436B (zh) | 一种中药组合物及其制剂和在治亚急性甲状腺炎中的应用 | |
| CN1686391A (zh) | 一种治疗热毒内盛所致病症的药物 | |
| CN114404549B (zh) | 一种治疗慢性萎缩性胃炎的中药组合物及其制备方法 | |
| CN1172661A (zh) | 速效跌打刀伤草药酒 | |
| CN1103224C (zh) | 一种治疗寒咳的中成药及其制备方法 | |
| CN1103599C (zh) | 一种治疗哮喘病的药物组合物及其制备方法 | |
| CN101259165A (zh) | 柴黄制剂及其生产方法 | |
| CN1234395C (zh) | 一种预防和治疗感冒病毒及sars病毒引起的呼吸道感染的药茶及其生产方法 | |
| CN1824139A (zh) | 清热镇痛中药 | |
| CN113456755A (zh) | 一种用于治疗皮肤瘙痒的药膏及其制备方法 | |
| CN102247470A (zh) | 一种防治小儿上呼吸道感染的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: Kunming Pharmaceutical Industry Group Corp., Ltd. Applicant before: Kunming Pharmaceutical Co., Ltd. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: KUNMING MEDICINE STOCK CO., LTD. TO: KUNMING MEDICINE GROUP STOCK CO., LTD. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20031015 Termination date: 20140408 |