CN1316254A - Injection for antivirus promoting immunity, and leaukogenic and its preparing process - Google Patents
Injection for antivirus promoting immunity, and leaukogenic and its preparing process Download PDFInfo
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- CN1316254A CN1316254A CN 00105568 CN00105568A CN1316254A CN 1316254 A CN1316254 A CN 1316254A CN 00105568 CN00105568 CN 00105568 CN 00105568 A CN00105568 A CN 00105568A CN 1316254 A CN1316254 A CN 1316254A
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Abstract
An injection for preventing and treating viral diseases, leukocytopenia, hypoimmunity and cancers is prepared from 6 Chinese-medicinal materials including, ginseng, ganoderma, atractylodes rhizome, isatis root, etc through crushing, immersion, decocting, filtering, extracting, fine filtering and mixing. Its advantages include high curative effect and safety, no toxin and low cost.
Description
The present invention relates to a kind of antiviral, promoting immunity, rise plain boiled water injection and preparation method thereof.Relate to a kind of herbal mixture aqueous injection and preparation method thereof specifically with broad-spectrum high efficacy antivirus action, powerful immunological enhancement, promoting leucocytes effect.The medicine that utilizes the spirit of this invention to produce can be used for the low treatment of viral disease, leukopenia, immune function and the immune function due to the carcinosis radiotherapy and chemotherapy is low, the auxiliary treatment of leukopenia treatment and acquired immune deficiency syndrome (AIDS).
We know: immune function is low, virosis, leukopenia, cancer, acquired immune deficiency syndrome (AIDS) etc. are the formidable enemies who threatens human health.At present, the sickness rate of these diseases is more and more higher in the world, and the number of dying from these diseases increases year by year.Even to this day, still do not have the good curing medicine both at home and abroad, so that this class treatment of diseases becomes clinically the problem of headache the most.Though some scholars suggestion is with the biological product treatment, biological product cost height yields poorly, can't mass production, and recurrence easily after the drug withdrawal in addition, overall cure rate is not high, and easily propagates other disease, should not promote the use of.So, study above-mentioned treatment of diseases method and become the task of top priority.
Discover: after in the injection produced according to spirit of the present invention injects body, can synthesize antiviral substance in vivo, promoting leucocytes can significantly improve the cellular immunization and the humoral immunization function of body again.So it can be cured the disease, again can diseases prevention, and can building body, Fructus Alpiniae Oxyphyllae is prolonged life.Be the good medicine of treatment viral disease, antiviral, promoting immunity.
Research is also found: this invention still has anti-aging effects, the brain healthy effect, and opsonic action, vasodilative effect also has the destruction of cancer cells telomerase activation, the effect that the tumor body is dwindled.So, think control and the medical health care field that also can be used for cancer.
The present invention has finished prescription research through the effort of more than ten years, the side's of tearing open test, analysis of effective component, process study, efficacy experiment, pharmacological experiment, toxicity test, work such as clinical prerun.And finished preclinical whole data by the requirement of three kind new medicines research, for application I, II, III clinical trial phase are got ready.
The object of the present invention is to provide a kind of antiviral, promoting immunity, rise plain boiled water injection and preparation method thereof.
The object of the present invention is achieved like this: it mainly by Radix Ginseng, Ganoderma, Rhizoma Atractylodis, Radix Isatidis, Tremella, the Radix Astragali through pulverize, soak, decoct, filter, extract, operation such as allotment fine straining forms this invention---antiviral, promoting immunity, rise the plain boiled water injection.
Weight percentages of components of the present invention is:
Radix Ginseng 10---30% Ganoderma 10---20%
Rhizoma Atractylodis 5---20% Radix Isatidis 10---40%
Tremella 5---15% Radix Astragali 15%---40%
Antiviral of the present invention, promoting immunity, the preparation method that rises the plain boiled water injection are:
1. be purchased the screening and the above-mentioned clean medical material of weighing, processing and fabricating in the workshop that meets the GMP standard.
2. pulverize:
With above-mentioned clean medical material mixing, be processed into coarse powder.
3. soak:
With the drinking water that meets state health standards, be to mix at 1.5: 1 by the weight ratio of water and medicated powder, at room temperature soaked 2 hours.
4. decoct:
After the immersion, decoct twice, boiled 30 minutes at every turn.The weight that adds for the first time water is 5-7 times of crude drug in whole weight, and the weight that adds water for the second time is 4-6 times of crude drug in whole weight, and collecting decoction is standby.
5. coarse filtration:
Get above-mentioned reserve liquid, filter, get filtrate for later use with the plate filter.
6. concentrate:
Get above-mentioned reserve liquid, be concentrated into 1/3 of crude drug in whole weight with the concentrating under reduced pressure jar, indoor natural cooling, standby.
7. extract:
Above-mentioned reserve liquid precipitate with ethanol three times (contain the alcohol amount at every turn and be respectively 55%, 75%, 83%) was left standstill 24 hours at every turn, filter, reclaim ethanol.
For the first time, getting above-mentioned reserve liquid adds ethanol more than 95% and makes it contain the alcohol amount to be 55%, to leave standstill 24 hours, use the bottle,suction sucking filtration.Get filtrate and reclaim ethanol and concentrated with the concentrating under reduced pressure jar, emit concentrated solution from the concentrating under reduced pressure jar, the cooling back is standby.
For the second time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, and the cooling back is standby.
For the third time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, standby.
8. adsorption bleaching filters:
Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then use the bottle,suction sucking filtration.Get filtrate, standby.
9. allocate the fine straining quality inspection:
Get above-mentioned reserve liquid and add the injection water and contain crude drug in whole 1g to every milliliter, transfer pH value between the 6.0-7.0, be filtered to clarification with No. 4 filter sticks with the 10%NaOH aqueous solution.Enter next procedure after quality inspection is qualified.
10. embedding, sterilization:
With filling and sealing machine liquid medicine filling that above-mentioned quality inspection is qualified in through cutting neck, garden mouth, clean, in the peace bottle after the oven dry and sealing by fusing, putting 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet.
⑾ quality inspection:
Peace bottle after the sterilization is through color water leak detection, and inspect by random samples qualified after, send into next procedure:
⑿ printing package:
Use the ink writer lettering, after packing, promptly get this invention---antiviral, promoting immunity, rise the plain boiled water injection.
What deserves to be mentioned is: the raw materials used pharmacopeia that is of this medicine is recorded, and medicine crude drug among the nontoxic pair of effect can be daily edible or be health product, raw material is easily purchased, and cost is low, the price height, technology is very not complicated, and exploitation degree height has reached and has commercially produced injustice, technology maturation, easy to implement, invest for a short time, instant effect is fit to large, medium and small pharmaceutical factory and produces.
The present invention compared with prior art, its curative effect height, safe and reliable, nontoxic, harmless, noresidue, technology is simple, and is with low cost, practical.Can be used for viral disease, leukopenia, the control that immune function is low, the auxiliary treatment of cancer and medical health care field.Be the treatment viral disease, promoting immunity and the white good medicine of liter.
Below in conjunction with embodiment the present invention is described, the scheme of embodiment described here, do not limit the present invention, one of skill in the art can make improvements and change according to spirit of the present invention, and these all improvement and variation all should be considered as within the scope of the invention.Scope and spirit of the present invention are limited by claims.
Embodiment:
1. be purchased screening and weigh clean medical material Radix Ginseng 20 grams, Ganoderma 10 grams, Rhizoma Atractylodis 10 grams, Radix Isatidis 30 grams, Tremella 10 grams, the Radix Astragali 20 grams, amount to 100 grams processing and fabricating in the dry airy laboratory of sanitation and hygiene.
2. pulverize:
With above-mentioned medical material mixing, be processed into coarse powder.
3. soak:
Mix with the clean medical material of above-mentioned 100 grams with the 150g tap water, at room temperature soaked 2 hours.
4. decoct:
After the immersion, decoct twice, be fried boiling 30 minutes at every turn, add water 600g for the first time, after being fried boiling 30 minutes, get decocting liquid.For the second time add water 500g, after being fried boiling 30 minutes, get decocting liquid.Two decocting liquids merge, and are standby.
5. coarse filtration:
Get above-mentioned reserve liquid, filter, get filtrate with buchner funnel, standby.
6. concentrate:
Get above-mentioned filtrate, be concentrated into 1/3 of crude drug in whole weight, promptly 33 restrain with rotary decompression evaporator, indoor natural cooling, standby.
7. extract:
Above-mentioned concentrated solution precipitate with ethanol three times (contain the alcohol amount at every turn and be respectively 55%, 75%, 83%) was left standstill 24 hours at every turn, filter, reclaim ethanol.
For the first time, above-mentioned concentrated solution being added ethanol more than 95% makes it contain the alcohol amount to be 55%, to leave standstill 24 hours, filter with buchner funnel.Get filtrate and reclaim ethanol and concentrated with rotary decompression evaporator, emit concentrated solution, the cooling back is standby.
For the second time, with above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, filters with buchner funnel, gets filtrate and also concentrates with rotary decompression evaporator recovery ethanol, emits concentrated solution, and the cooling back is standby.
For the third time, with above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, filters with buchner funnel, gets filtrate and also concentrates with rotary decompression evaporator recovery ethanol, emits concentrated solution, standby.
8. adsorb, decolour, filter:
Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then filter with buchner funnel.Get filtrate, standby.
9. allocate the fine straining quality inspection:
Get above-mentioned reserve liquid and add the injection water to 100ml, transfer pH value to 6.5 with the 10%NaOH aqueous solution, losing with No. 4 is filtered to clarification, enters next procedure after quality inspection is qualified.
10. embedding, sterilization:
With filling and sealing machine with above-mentioned quality inspection the liquid medicine filling after qualified in through cutting neck, garden mouth, clean, in the dried 2ml peace bottle and sealing by fusing, putting 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet.Also can manual embedding, the water bath with thermostatic control sterilization.
⑾ quality inspection:
Leak detection back by Pharmacopoeia of People's Republic of China injection item down regulation checks, send into next procedure after qualified.
⑿ printing package:
Promptly get this invention with ink writer lettering or manual lettering, after packing---antiviral, promoting immunity, rise the plain boiled water injection.
Claims (2)
- An antiviral, promoting immunity, rise the plain boiled water injection, it is mainly made through technologies such as pulverizing, immersion, decoction, filtration, extraction, fine straining, allotments by Radix Ginseng, Ganoderma, Rhizoma Atractylodis, Radix Isatidis, Tremella, the Radix Astragali etc.It is characterized in that dosage form is an injection owing to oral certain curative effect also arranged, think also can be made into oral liquid or sheet, loose, ball, granule etc. are used for oral administration.
- 2. antiviral according to claim 1, promoting immunity, rise the plain boiled water injection, its feature is that also its preparation method is:1. be purchased the screening and the above-mentioned clean medical material of weighing, processing and fabricating in the workshop that meets the GMP standard.2. pulverize:With above-mentioned clean medical material mixing, be processed into coarse powder.3. soak:With the drinking water that meets state health standards, be to mix at 1.5: 1 by the weight ratio of water and medicated powder, at room temperature soaked 2 hours.4. decoct:After the immersion, decoct twice, boiled 30 minutes at every turn.The weight that adds for the first time water is 5-7 times of crude drug in whole weight, and the weight that adds water for the second time is 4-6 times of crude drug in whole weight, and collecting decoction is standby.5. coarse filtration:Get above-mentioned reserve liquid, filter, get filtrate for later use with the plate filter.6. concentrate:Get above-mentioned filtrate, be concentrated into 1/3 of crude drug in whole weight with the concentrating under reduced pressure jar, indoor natural cooling, standby.7. extract:Above-mentioned concentrated solution precipitate with ethanol three times (contain the alcohol amount at every turn and be respectively 55%, 75%, 83%) was left standstill 24 hours at every turn, filter, reclaim ethanol.For the first time, getting above-mentioned concentrated solution adds ethanol more than 95% and makes it contain the alcohol amount to be 55%, to leave standstill 24 hours, use the bottle,suction sucking filtration.Get filtrate and reclaim ethanol and concentrated with the concentrating under reduced pressure jar, emit concentrated solution from the concentrating under reduced pressure jar, the cooling back is standby.For the second time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, and the cooling back is standby.For the third time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, standby.8. adsorption bleaching filters:Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then use the bottle,suction sucking filtration.Get filtrate, standby.9. allocate the fine straining quality inspection:Get above-mentioned reserve liquid and add the injection water and contain crude drug in whole 1g to every milliliter, transfer pH value between the 6.0-7.0, be filtered to clarification with No. 4 filter sticks with the 10%NaOH aqueous solution.Enter next procedure after quality inspection is qualified.10. embedding, sterilization:With filling and sealing machine liquid medicine filling that above-mentioned quality inspection is qualified in through cutting neck, garden mouth, clean, in the peace bottle after the oven dry and sealing by fusing, putting 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet.⑾ quality inspection:Peace bottle after the sterilization is through color water leak detection, and inspect by random samples qualified after, send into next procedure.⑿ printing package:Use the ink writer lettering, after packing, promptly get this invention---antiviral, promoting immunity, rise the plain boiled water injection.Technological process in the above-mentioned preparation method and extracting method do not limit the present invention.Also can adopt other suitable technology and extracting method according to the character of active ingredient, but, all should be considered as within the scope of the present invention according to all improvement and variation that spirit of the present invention is carried out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001055682A CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001055682A CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1316254A true CN1316254A (en) | 2001-10-10 |
| CN1150914C CN1150914C (en) | 2004-05-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001055682A Expired - Fee Related CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1150914C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907125B (en) * | 2005-08-01 | 2012-01-11 | 章传华 | Red beet health food for radiotherapy and chemotherapy and its preparation method |
-
2000
- 2000-04-03 CN CNB001055682A patent/CN1150914C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907125B (en) * | 2005-08-01 | 2012-01-11 | 章传华 | Red beet health food for radiotherapy and chemotherapy and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN1150914C (en) | 2004-05-26 |
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Granted publication date: 20040526 |