CN1150914C - Injection for antivirus promoting immunity, and leaukogenic and its preparing process - Google Patents
Injection for antivirus promoting immunity, and leaukogenic and its preparing process Download PDFInfo
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- CN1150914C CN1150914C CNB001055682A CN00105568A CN1150914C CN 1150914 C CN1150914 C CN 1150914C CN B001055682 A CNB001055682 A CN B001055682A CN 00105568 A CN00105568 A CN 00105568A CN 1150914 C CN1150914 C CN 1150914C
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Abstract
The present invention relates to an injection capable of resisting virus and promoting immunity, and a preparation method thereof. The injection is mainly prepared from the following crude medicines: ginseng, ganoderma, atractylodes rhizome, isatis root, tremella, milkvetch root, etc. and is detailed prepared by the following working procedures: pulverization, immersion, decoction, filtering, extraction, fine filtration, preparation, etc. Compared with the prior art, the injection of the present invention has the advantages of good therapeutic effect, safety, reliability, non-toxicity, innocuousness, no residue, simple technology, low cost and strong practicability, and can be used for preventing and curing virosis, leukopenia and poor immune function; besides, the injection can be used in the adjuvant therapy for cancer and the technical field of medicine and health care, and is a good medicine for curing virosis and promoting immunity and leukogenic effect.
Description
The present invention relates to aqueous injection of a kind of antiviral, promoting immunity, promoting leucocytes and preparation method thereof.Relate to a kind of herbal mixture aqueous injection and preparation method thereof specifically with broad-spectrum high efficacy antivirus action, powerful immunological enhancement, promoting leucocytes effect.The medicine that utilizes the spirit of this invention to produce can be used for the low treatment of viral disease, leukopenia, immune function and the auxiliary treatment of low, leukopenic treatment of the immune function due to the carcinosis radiotherapy and chemotherapy and acquired immune deficiency syndrome (AIDS).
We know: immune function is low, virosis, leukopenia, cancer, acquired immune deficiency syndrome (AIDS) etc. are the formidable enemies who threatens human health.At present, the sickness rate of these diseases is more and more higher in the world, and the number of dying from these diseases increases year by year.Even to this day, still do not have the good curing medicine both at home and abroad, so that this class treatment of diseases becomes clinically the problem of headache the most.Though some scholars suggestion is with the biological product treatment, biological product cost height yields poorly, can't mass production, and recurrence easily after the drug withdrawal in addition, overall cure rate is not high, and easily propagates other disease, should not promote the use of.So studying above-mentioned treatment of diseases method has become the task of top priority.
Discover: after in the injection produced according to spirit of the present invention injects body, can synthesize antiviral substance in vivo, promoting leucocytes can significantly improve the cellular immunization and the humoral immunization function of body again.So it can be cured the disease, again can diseases prevention, and can building body, Fructus Alpiniae Oxyphyllae is prolonged life.Be the good medicine of treatment viral disease, antiviral, promoting immunity.
Research is also found: this invention still has anti-aging effects, the brain healthy effect, and opsonic action, vasodilative effect also has the destruction of cancer cells telomerase activation, the effect that the tumor body is dwindled.So, think control and the medical health care field that also can be used for cancer.
The present invention has finished prescription research through the effort of more than ten years, the side's of tearing open test, analysis of effective component, process study, efficacy experiment, pharmacological experiment, toxicity test, work such as clinical prerun.And finished preclinical whole data by the requirement of three kind new medicines research, for application I, II, III, IV clinical trial phase are got ready.
The object of the present invention is to provide aqueous injection of a kind of antiviral, promoting immunity, promoting leucocytes and preparation method thereof.
The object of the present invention is achieved like this: it mainly by Radix Ginseng, Ganoderma, Rhizoma Atractylodis, Radix Isatidis, Tremella, the Radix Astragali through pulverize, soak, decoct, filter, extract, operation such as allotment fine straining forms this invention---the aqueous injection of antiviral, promoting immunity, promoting leucocytes.
Raw material weight percentage ratio of the present invention is:
Radix Ginseng 10-30% Ganoderma 10-20%
Rhizoma Atractylodis 5-20% Radix Isatidis 10-40%
Tremella 5-15% Radix Astragali 15-40%
The preparation method of product of the present invention is:
1. the above-mentioned clean medical material that screens and weigh, processing and fabricating in the workshop that meets the GMP standard.
2. pulverize:
With above-mentioned clean medical material mixing, be processed into coarse powder.
3. soak:
With the drinking water that meets state health standards, be to mix at 1.5: 1 by the weight ratio of water and medicated powder, soaked 2 hours under the room temperature.
4. decoct:
After the immersion, decoct twice, boiled 30 minutes at every turn, the weight that adds water for the first time is 5-7 times of crude drug in whole weight, and the weight that adds water for the second time is 4-6 times of crude drug in whole weight, and collecting decoction is standby.
5. coarse filtration:
Get above-mentioned reserve liquid, filter, get filtrate for later use with the plate filter.
6. concentrate:
Get above-mentioned filtrate, be concentrated into 1/3 of crude drug in whole weight with the concentrating under reduced pressure jar, indoor natural cooling, standby.
7. extract:
With above-mentioned concentrated solution precipitate with ethanol three times, left standstill 24 hours at every turn, filter, reclaim ethanol.
For the first time, getting above-mentioned concentrated solution adds ethanol more than 95% and makes it contain the alcohol amount to be 55%, to leave standstill 24 hours, use the bottle,suction sucking filtration.Get filtrate and reclaim ethanol and concentrated with the concentrating under reduced pressure jar, emit concentrated solution from the concentrating under reduced pressure jar, the cooling back is standby.
For the second time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, and the cooling back is standby.
For the third time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, standby.
8. adsorption bleaching filters:
Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then use the bottle,suction sucking filtration.Get filtrate, standby.
9. allocate the fine straining quality inspection:
Get above-mentioned reserve liquid and add the injection water and contain crude drug in whole 1g to every milliliter, transfer pH value between the 6.0-7.0, be filled into clarification, enter next procedure after quality inspection is qualified with No. 4 filter sticks with the 10%NaOH aqueous solution.
10. embedding, sterilization:
With filling and sealing machine liquid medicine filling that above-mentioned quality inspection is qualified in through cutting neck, garden mouth, clean, in the peace bottle after the oven dry and sealing by fusing, putting 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet.
(11) quality inspection:
Peace bottle after the sterilization is through color water leak detection, and inspect by random samples qualified after, send into next procedure.
(12) printing package:
Use the ink writer lettering, after packing, promptly get this invention---the aqueous injection of antiviral, promoting immunity, promoting leucocytes, oral also effective owing to this invention, think dosage forms such as also can be made into oral liquid or sheet, diffusing, ball, granule.
Technological process in the above-mentioned preparation method and extracting method do not limit the present invention.Also can adopt other suitable technology and extracting method according to the character of active ingredient, but, all should be considered as within the scope of the present invention according to all improvement and variation that spirit of the present invention is carried out.
What deserves to be mentioned is: the raw materials used pharmacopeia that is of this medicine is recorded, and medicine crude drug among having no side effect can be daily edible or be health product, raw material is easily purchased, and cost is low, the price height, technology is very not complicated, and exploitation degree height has reached the level of commercially producing, technology maturation, easy to implement, invest for a short time, instant effect is fit to large, medium and small pharmaceutical factory and produces.
The present invention compared with prior art, its curative effect height, safe and reliable, nontoxic, harmless, noresidue, technology is simple, and is with low cost, practical.Can be used for viral disease, leukopenia, the control that immune function is low, the auxiliary treatment of cancer and medical health care field.Be the treatment viral disease, the good medicine of promoting immunity and promoting leucocytes.
Below in conjunction with embodiment the present invention is described, embodiment scheme described here does not limit the present invention, and one of skill in the art can improve and change according to spirit of the present invention, and all these improvements and changes all should be considered as within the scope of the invention.
Embodiment:
1. screen and weigh clean medical material Radix Ginseng 20 grams, Ganoderma 10 grams, Rhizoma Atractylodis 10 grams, Radix Isatidis 30 grams, Tremella 10 grams, the Radix Astragali 20 grams amount to 100 grams processing and fabricating in the dry airy laboratory of sanitation and hygiene.
2. pulverize:
With above-mentioned clean medical material mixing, be processed into coarse powder.
3. soak:
Mix with the clean medical material of above-mentioned 100 grams with 150 gram tap waters, at room temperature soaked 2 hours.
4. decoct:
After the immersion, decoct twice, boiled 30 minutes at every turn, add water 600 grams for the first time, after being fried boiling 30 minutes, get decocting liquid, add water 500 grams for the second time, after being fried boiling 30 minutes, get decocting liquid, two decocting liquids merge, and are standby.
5. coarse filtration:
Get above-mentioned reserve liquid, filter, get filtrate for later use with buchner funnel.
6. concentrate:
Get above-mentioned filtrate, be concentrated into 1/3 of crude drug in whole weight, promptly 33 restrain with rotary decompression evaporator, indoor natural cooling, standby.
7. extract:
With above-mentioned concentrated solution precipitate with ethanol three times, left standstill 24 hours at every turn, filter, reclaim ethanol.
For the first time, getting above-mentioned concentrated solution adds ethanol more than 95% and makes it contain the alcohol amount to be 55%, to leave standstill 24 hours, filter with buchner funnel, get filtrate and reclaim ethanol and concentrated with rotary decompression evaporator, emit concentrated solution from rotary decompression evaporator, the cooling back is standby.
For the second time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, filters with buchner funnel, gets filtrate and also concentrates with rotary decompression evaporator recovery ethanol, emits concentrated solution, and the cooling back is standby.
For the third time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, filters with buchner funnel, gets filtrate and also concentrates with rotary decompression evaporator recovery ethanol, emits to concentrate and crosses, standby.
8. adsorption bleaching filters:
Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then filter with buchner funnel, get filtrate, standby.
9. allocate the fine straining quality inspection:
Get above-mentioned reserve liquid and add injection water to 100 milliliter, transfer pH value to 6.5, be filled into clarification, enter next procedure after quality inspection is qualified with No. 4 filter bulbs with the 10%NaOH aqueous solution.
10. embedding, sterilization:
With filling and sealing machine liquid medicine filling that above-mentioned quality inspection is qualified in through cutting neck, garden mouth, clean, in the peace bottle after the oven dry and sealing by fusing, putting 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet, also embedding by hand, Heng tepidarium sterilization.
(11) quality inspection:
Peace bottle after the sterilization is after color water leak detection, by Pharmacopoeia of People's Republic of China injection item down regulation check, send into next procedure after qualified.
(12) printing package:
Use the ink writer lettering, after packing, promptly get this invention---the aqueous injection of antiviral, promoting immunity, promoting leucocytes.
Claims (2)
1, the aqueous injection of a kind of antiviral, promoting immunity, promoting leucocytes is characterized in that it being to be made by following raw materials by weight percent: Radix Ginseng 10-30%, Ganoderma 10-20%, Rhizoma Atractylodis 5-20%, Radix Isatidis 10-40%, Tremella 5-15%, Radix Astragali 15-40%.
2, the method for preparing the described product of claim 1 is characterized in that carrying out according to the following steps:
1. the above-mentioned clean medical material that screens and weigh, processing and fabricating in the workshop that meets the GMP standard,
2. pulverize:
With above-mentioned clean medical material mixing, be processed into coarse powder,
3. soak:
With the drinking water that meets state health standards, be to mix at 1.5: 1 by the weight ratio of water and medicated powder, soaked 2 hours under the room temperature,
4. decoct:
After the immersion, decoct twice, boiled 30 minutes at every turn, the weight that adds water for the first time is 5-7 times of crude drug in whole weight, and the weight that adds water for the second time is 4-6 times of crude drug in whole weight, and collecting decoction is standby,
5. coarse filtration:
Get above-mentioned reserve liquid, filter, get filtrate for later use with the plate filter,
6. concentrate:
Get above-mentioned filtrate, be concentrated into 1/3 of crude drug in whole weight with the concentrating under reduced pressure jar, indoor natural cooling, standby,
7. extract:
With above-mentioned concentrated solution precipitate with ethanol three times, left standstill 24 hours at every turn, filter, reclaim ethanol,
For the first time, get above-mentioned concentrated solution and add ethanol more than 95% and make it contain the alcohol amount to be 55%, to leave standstill 24 hours, use the bottle,suction sucking filtration, get filtrate and reclaim ethanol with the concentrating under reduced pressure jar and concentrate, from the concentrating under reduced pressure jar, emit concentrated solution, standby after the cooling,
For the second time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 75%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits concentrated solution, and the cooling back is standby,
For the third time, get above-mentioned reserve liquid, add the ethanol more than 95%, making it contain the alcohol amount is 83%, leaves standstill 24 hours, uses the bottle,suction sucking filtration, gets filtrate and also concentrates with concentrating under reduced pressure jar recovery ethanol, emits to concentrate and crosses, standby,
8. adsorption bleaching filters:
Get above-mentioned reserve liquid and add 0.3% active carbon, be heated to 80 ℃ under stirring, 30 minutes, then use the bottle,suction sucking filtration, get filtrate, standby,
9. allocate the fine straining quality inspection:
Get above-mentioned reserve liquid and add the injection water and contain crude drug in whole 1g to every milliliter, transfer pH value between the 6.0-7.0, be filled into clarification, enter next procedure after quality inspection is qualified with No. 4 filter sticks with the 10%NaOH aqueous solution,
10. embedding, sterilization:
With filling and sealing machine liquid medicine filling that above-mentioned quality inspection is qualified in through cutting neck, round mouth, clean, in the peace bottle after the oven dry and sealing by fusing, put 100 ℃ of 30 minutes flowing steams sterilizations in the sterilization cabinet,
(11) quality inspection:
Peace bottle after the sterilization is through color water leak detection, and inspect by random samples qualified after, send into next procedure,
(12) printing package:
Use the ink writer lettering, through the packing after promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001055682A CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001055682A CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1316254A CN1316254A (en) | 2001-10-10 |
| CN1150914C true CN1150914C (en) | 2004-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001055682A Expired - Fee Related CN1150914C (en) | 2000-04-03 | 2000-04-03 | Injection for antivirus promoting immunity, and leaukogenic and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1150914C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907125B (en) * | 2005-08-01 | 2012-01-11 | 章传华 | Red beet health food for radiotherapy and chemotherapy and its preparation method |
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2000
- 2000-04-03 CN CNB001055682A patent/CN1150914C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1316254A (en) | 2001-10-10 |
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Granted publication date: 20040526 |