CN1314909A - 具有抗HIV活性的d4T的磷酸芳基酯衍生物 - Google Patents

具有抗HIV活性的d4T的磷酸芳基酯衍生物 Download PDF

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Publication number
CN1314909A
CN1314909A CN99810072A CN99810072A CN1314909A CN 1314909 A CN1314909 A CN 1314909A CN 99810072 A CN99810072 A CN 99810072A CN 99810072 A CN99810072 A CN 99810072A CN 1314909 A CN1314909 A CN 1314909A
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CN
China
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compound
composition
hiv
group
aryl
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Pending
Application number
CN99810072A
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English (en)
Chinese (zh)
Inventor
F·M·乌昆
R·维格
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Parker Hughes Institute
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Parker Hughes Institute
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Publication date
Application filed by Parker Hughes Institute filed Critical Parker Hughes Institute
Publication of CN1314909A publication Critical patent/CN1314909A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN99810072A 1998-06-29 1999-06-29 具有抗HIV活性的d4T的磷酸芳基酯衍生物 Pending CN1314909A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/107,716 US6030957A (en) 1998-06-29 1998-06-29 Aryl phosphate derivatives of d4T having anti-HIV activity
US09/107716 1998-06-30

Publications (1)

Publication Number Publication Date
CN1314909A true CN1314909A (zh) 2001-09-26

Family

ID=22318071

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99810072A Pending CN1314909A (zh) 1998-06-29 1999-06-29 具有抗HIV活性的d4T的磷酸芳基酯衍生物

Country Status (14)

Country Link
US (7) US6030957A (https=)
EP (1) EP1090018B1 (https=)
JP (1) JP2002519355A (https=)
KR (1) KR20010071673A (https=)
CN (1) CN1314909A (https=)
AT (1) ATE277940T1 (https=)
AU (1) AU4846999A (https=)
BR (1) BR9911685A (https=)
CA (1) CA2336285A1 (https=)
DE (1) DE69920696T2 (https=)
HU (1) HUP0102527A3 (https=)
IL (1) IL140388A0 (https=)
NO (1) NO20006685L (https=)
WO (1) WO2000000501A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403014A (zh) * 2011-01-03 2013-11-20 南京迈勒克生物技术研究中心 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7144874B2 (en) * 2002-10-25 2006-12-05 Parker Hughes Institute Aryl phosphate derivatives of d4T having activity against resistant HIV strains
US6030957A (en) * 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity
US20070015733A1 (en) * 1998-06-29 2007-01-18 Parker Hughes Institute Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
AU3897800A (en) * 1999-03-19 2000-10-09 Parker Hughes Institute One pot synthesis of 5'-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
US6825177B2 (en) * 2000-10-30 2004-11-30 Parker Hughes Institute Aryl phosphate derivatives of d4T with potent anti-viral activity
DK1334108T3 (da) * 2000-11-13 2005-07-11 Parker Hughes Inst Arylfosfatderivater af d4T
US7405202B2 (en) * 2002-05-28 2008-07-29 Regents Of The University Of Minnesota CRISP polypeptides as contraceptives and inhibitors of sperm capacitation
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
US20040076931A1 (en) * 2002-10-18 2004-04-22 Cashflow Technologies, Inc. Educational interactive games
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
GB0401088D0 (en) 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
CA2571079A1 (en) * 2004-06-24 2006-02-02 Merck & Co., Inc. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
WO2006026656A1 (en) * 2004-08-31 2006-03-09 Parker Hughes Institute Cytotoxic nucleoside analog compound 003 for treating cancer
WO2006063149A1 (en) 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
JP2008535648A (ja) * 2005-03-09 2008-09-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ナノ複合膜ならびにそれを作製および使用する方法
US7892618B2 (en) * 2005-03-21 2011-02-22 Sony Corporation Deterring theft of optical media
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
JP2012521359A (ja) * 2009-03-20 2012-09-13 アリオス バイオファーマ インク． 置換されたヌクレオシドアナログおよびヌクレオチドアナログ
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
HK1206362A1 (zh) 2012-03-21 2016-01-08 Alios Biopharma, Inc. 硫代氨基磷酸酯核苷酸前藥的固體形式
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
US9447132B2 (en) 2013-04-12 2016-09-20 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707362A (en) 1985-02-15 1987-11-17 Biotek, Inc. Sustained release composition
US4841039A (en) 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4983393A (en) 1987-07-21 1991-01-08 Maximed Corporation Intra-vaginal device and method for sustained drug release
JPH06189998A (ja) 1992-11-06 1994-07-12 C & Co:Yugen コンド―ム
EP0626970A1 (en) 1992-12-18 1994-12-07 The University Of Alberta Dihydropyrimidine nucleosides with antiviral properties
ZA947572B (en) 1993-09-29 1995-09-28 Hampton Roads Medical College Contraceptive compositions
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5659023A (en) * 1995-02-01 1997-08-19 Gilead Sciences, Inc. Nucleotide analogues
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
BR9709228A (pt) 1996-05-09 1999-08-10 Michel G Bergeron Método e formulações para prevenir e/ou tratar qualquer infecção (especificamente as dst incluindo hiv) inflamátoria neoplastica ou qualquer outro tipo de doenças das mucosas e/ou pele
US6030957A (en) 1998-06-29 2000-02-29 Wayne Hughes Institute Aryl phosphate derivatives of d4T having anti-HIV activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403014A (zh) * 2011-01-03 2013-11-20 南京迈勒克生物技术研究中心 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途
CN103403014B (zh) * 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途

Also Published As

Publication number Publication date
HUP0102527A2 (hu) 2001-12-28
KR20010071673A (ko) 2001-07-31
DE69920696T2 (de) 2006-03-02
JP2002519355A (ja) 2002-07-02
BR9911685A (pt) 2001-12-18
AU4846999A (en) 2000-01-17
US6537975B1 (en) 2003-03-25
DE69920696D1 (de) 2004-11-04
US6503890B1 (en) 2003-01-07
EP1090018B1 (en) 2004-09-29
EP1090018A1 (en) 2001-04-11
NO20006685D0 (no) 2000-12-28
IL140388A0 (en) 2002-02-10
US6528495B1 (en) 2003-03-04
WO2000000501A1 (en) 2000-01-06
US7071176B2 (en) 2006-07-04
ATE277940T1 (de) 2004-10-15
HUP0102527A3 (en) 2002-04-29
NO20006685L (no) 2001-02-28
US6670336B1 (en) 2003-12-30
US6350736B1 (en) 2002-02-26
US20040171577A1 (en) 2004-09-02
US6030957A (en) 2000-02-29
CA2336285A1 (en) 2000-01-06

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