CN1313108C - Medicine for treating cardiovascular and cerebrovascular disease - Google Patents
Medicine for treating cardiovascular and cerebrovascular disease Download PDFInfo
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- CN1313108C CN1313108C CNB2005100988407A CN200510098840A CN1313108C CN 1313108 C CN1313108 C CN 1313108C CN B2005100988407 A CNB2005100988407 A CN B2005100988407A CN 200510098840 A CN200510098840 A CN 200510098840A CN 1313108 C CN1313108 C CN 1313108C
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Abstract
The present invention discloses medicine for treating cardiovascular and cerebrovascular diseases, which is characterized in that the medicine is composed of 13 kinds of Chinese medicine raw materials such as red sage root, notoginseng, ginseng, chuanxiong rhizome, amber, leech, benzoin, schisandra, corydalis tuber, tuckahoe, grassleaved sweetflag rhizome, aconite root, and maythorn, and the medicine has the advantages of reasonable medication, scientific compatibility, and obvious treating effect and has the functions of channel communicating, vessel activating, pressure reducing, fat reducing, coronary vessel expanding, blood circulation improving, etc. The present invention can effectively treat hyperlipemia, blood symptom with high viscosity, cerebral thrombosis, coronary heart disease, arteriosclerosis, sequela of apoplexy, hypertension, etc., and is ideal medicine for treating cardiovascular and cerebrovascular system diseases and the sequela of apoplexy.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, particularly relating to a kind of is the medicine of the treatment cardiovascular and cerebrovascular disease made of raw material with the Chinese herbal medicine.
Background technology
Cardiovascular and cerebrovascular disease is common clinical, frequently-occurring disease, and human beings'health in serious threat.The Chinese medicine cardiovascular and cerebrovascular disease is with a long history, at aspects such as prevention, treatment, rehabilitations clear superiority is arranged, treating both the principal and secondary aspects of a disease, and prevention of recurrence, and do not have obvious adverse reaction.Domestic medical worker makes great efforts to excavate motherland's pools of traditional Chinese medicine, developed in succession as Chinese patent medicines such as FUFANG DANSHEN PIAN, SHANHAI PILL, XUESHUANXINMAINING, restorative bolus with tremendous power, ZHONGFENG HUICHUN WAN, XINNAOSHUTONG JIAONANG, made the treatment of cardiovascular and cerebrovascular disease and prevention that new development arranged.But these medicine majorities have problems such as prescription is single, cost is high, onset is slow, curative effect is not good enough.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, this medicine is to disease instant effect, curative effect height such as ischemic heart desease, incomplete brain blood supply, thrombus of heart blood vessels.
Solution of the present invention is, on the basis to the cause of disease of cardiovascular and cerebrovascular disease, pathology understanding, by inventor's clinical practice for many years, the pharmacology and the property of medicine according to Chinese herbal medicine, having selected Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, succinum, Hirudo, Benzoinum, Fructus Schisandrae Chinensis, Rhizoma Corydalis, Poria, Rhizoma Acori Graminei, Radix Aconiti Lateralis Preparata, Fructus Crataegi 13 flavor Chinese medicines for use is raw material, and formulated forms the medicine of treatment cardiovascular and cerebrovascular disease.
Radix Salviae Miltiorrhizae is a kind of traditional blood-activating and stasis-removing, often is used to treat diseases such as coronary heart disease, angina pectoris, cerebral infarction clinically.Research in recent years finds that also Radix Salviae Miltiorrhizae acetate magnesium is that the polyphenol hydrochlorate of main component is the most important effective ingredient of Treated with Radix Salviae Miltiorrhizae cardiovascular disease.Salvianolate can make degree of myocardial ischemia significantly descend, and the myocardial ischemia scope is dwindled, and the primary cellular defect when alleviating myocardial ischemia has significant function of resisting myocardial ischemia.Salvianolate can reduce the heart oxygen consumption simultaneously, and can resist the inductive platelet aggregation of ADP and suppress thrombosis." A Supplement to the Compendium of Materia Medica " of Qing Dynasty's ZHAO Xue-Min thought: Radix Notoginseng " Radix Notoginseng enriches blood the first for class Radix Ginseng quite, ginseng qi-tonifying the first, flavor with and merit also waits, the old friend also claims a day Radix Notoginseng, Radix Notoginseng is the most precious person in the medicine ".Radix Notoginseng contains ginsenoside, glucose ginsenoside, arasaponin, Herba Gynostemmatis Saponin etc., and these Saponin pharmaceuticals industries are called Radix Notoginseng total arasaponins, and Radix Notoginseng total arasaponins is the effective ingredient of treatment cardiovascular disease.Verified by animal experiment and clinical practice, Radix Notoginseng has the body of reduction oxygen consumption, improves body to anoxybiotic tolerance, anticoagulant, and expansion of cerebral vascular makes cerebral blood flow increase antithrombotic and blood coagulation resisting function.In view of the pharmacological action of above-mentioned two flavor Chinese medicines, selecting Radix Salviae Miltiorrhizae and Radix Notoginseng for use is monarch drug.
Radix Ginseng has strongly invigorating primordial QI, invigorating the spleen to benefit the lung, and promoting the production of body fluid to quench thirst, the effects such as increasing intelligence of calming the nerves, theory of Chinese medical science is thought: " qi as the commander of blood, the capable then blood of gas is capable, the stagnation of QI is the blood addiction then ", the blood addiction then helps the formation of thrombosis.Rhizoma Chuanxiong can reduce the oxygen-derived free radicals level, and the balance between regulation and control thromboxane and prostacyclin suppresses hematoblastic and sticks, effect such as gathering.Hirudo contains anticoagulant material hirudin, also contains heparin, antithrombotic element etc. in addition, can treat cerebral thrombosis, diseases such as myocardial infarction.According to the pharmacological action of above-mentioned three flavor Chinese medicines, selecting Radix Ginseng, Rhizoma Chuanxiong and Hirudo for use is ministerial drug, strengthens monarch drug effect and synergism.
Benzoinum contains benzoic acid, has promoting flow of QI and blood and the phlegm-dispelling functions of having one's ideas straightened out.Succinum contains resin, volatile oil and succinoabietinolic acid, has promoting blood circulation to remove blood stasis and the diuresis of calming the nerves.Fructus Schisandrae Chinensis can be regulated cardiovascular system and improve blood circulation, and excited and enhancing central nervous system has cardiotonic.Rhizoma Corydalis contains multiple alkaloid, has analgesia, effect is told in the Xie Jinghe town.According to the pharmacological action of above-mentioned four flavor Chinese medicines, select for use Benzoinum, succinum, Fructus Schisandrae Chinensis and Rhizoma Corydalis to be adjuvant drug in the side.
Poria has diuresis, calmness and blood sugar lowering effect.Rhizoma Acori Graminei contains volatile oil, has the resuscitation inducing and mind tranquilizing effect.Radix Aconiti Lateralis Preparata contains multiple alkaloid, has cardiotonic, messenger drug warmly invigorating heart-YANG tying-in effect in this side.Fructus Crataegi has blood vessel dilating, coronary blood flow increasing and blood pressure lowering cardiotonic, and this Fang Zhongwei makes in many medicine stomaches greasy stagnating, and cardiac disorder mostly is the old people, spleen and stomach function a little less than, so assistant makes the digestion collaborative promoting blood flow and remove blood stasis drug that is good for the stomach.According to the pharmacological action of above-mentioned four flavor Chinese medicines, selecting Poria, Rhizoma Acori Graminei, Radix Aconiti Lateralis Preparata and Fructus Crataegi for use is the messenger drug that warming YANG is good for the stomach and has one's ideas straightened out.
The present invention treats the medicine of cardiovascular and cerebrovascular disease and can prepare by the weight portion proportioning of Radix Salviae Miltiorrhizae 120-180, Radix Notoginseng 80-120, Radix Ginseng 40-60, Rhizoma Chuanxiong 80-120, succinum 40-60, Hirudo 40-60, Benzoinum 24-36, Fructus Schisandrae Chinensis 40-60, Rhizoma Corydalis 40-60, Poria 40-60, Rhizoma Acori Graminei 24-36, Radix Aconiti Lateralis Preparata 32-48, Fructus Crataegi 56-84.
Treat the prioritization scheme of the medicine of cardiovascular and cerebrovascular disease as the present invention, preferably press the weight portion proportioning preparation of Radix Salviae Miltiorrhizae 135-165, Radix Notoginseng 90-110, Radix Ginseng 45-55, Rhizoma Chuanxiong 90-110, succinum 45-55, Hirudo 45-55, Benzoinum 27-33, Fructus Schisandrae Chinensis 45-55, Rhizoma Corydalis 45-55, Poria 45-55, Rhizoma Acori Graminei 27-33, Radix Aconiti Lateralis Preparata 36-44, Fructus Crataegi 63-77.
Treat the preferred plan of the medicine of cardiovascular and cerebrovascular disease as the present invention, press the weight portion proportioning preparation of Radix Salviae Miltiorrhizae 150, Radix Notoginseng 100, Radix Ginseng 50, Rhizoma Chuanxiong 100, succinum 50, Hirudo 50, Benzoinum 30, Fructus Schisandrae Chinensis 50, Rhizoma Corydalis 50, Poria 50, Rhizoma Acori Graminei 30, Radix Aconiti Lateralis Preparata 40, Fructus Crataegi 70.
The process for preparing medicine that the present invention treats cardiovascular and cerebrovascular disease is:
1, Hirudo cutting, drying adds yellow wine and mixes thoroughly, and is vexed slightly, fries to little yellow with slow fire;
2, Rhizoma Corydalis is mixed thoroughly with vinegar, soaks into, and to the vinegar exhaustion, fries to little dried with slow fire;
3, waste behind Radix Salviae Miltiorrhizae, the Fructus Crataegi difference water infusion secondary, reuse slow fire simmer down to flowing soaking paste;
4, Benzoinum and succinum are ground into fine powder;
5, Hirudo, Rhizoma Corydalis and Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Poria, Rhizoma Acori Graminei and the Radix Aconiti Lateralis Preparata pulverize separately that cooks become the coarse granule shape;
6, in described ratio Radix Salviae Miltiorrhizae, Fructus Crataegi fluid extract are pulverized medicine with other and lump together and mix thoroughly, dry, be ground into 200 order fine powders again, obtain the powder of this medicine.
The medicine that the present invention treats cardiovascular and cerebrovascular disease has following advantage: the present invention selects for use 13 flavor Chinese medicine formulated to form, and medication is reasonable, the compatibility science, and curative effect is obvious.Have dredge the meridian passage, blood pressure lowering, blood fat reducing, expansion coronary vasodilator, improve blood circulation, strengthen immune function of human body, reconcile endocrine, promote equilibrium between yin and yang, can reach the therapeutic effect of giving consideration to both the incidental and fundamental.The present invention adopts prepared from traditional Chinese medicines to form, and selects YAOJING, and good effect is paid attention to whole structure and taken into account with partial result, and instant effect, cure rate height, manufacturing process is simple, cost is low, have no side effect, take advantages such as safe.Through clinical proof, by every day three times, morning, noon and afternoon respectively once, each 4-6 overcomes usefulness, and one month is a course of treatment, takes 1-3 the course of treatment usually, can treat hyperlipidemia, high blood viscosity, cerebral thrombosis, coronary heart disease, arteriosclerosis, apoplexy sequela and hypertension etc. effectively, there is not any untoward reaction, and evident in efficacy, be the ideal medicament of treatment diseases of cardiovascular and cerebrovascular systems and apoplexy sequela.
The specific embodiment
Embodiment 1:(1) 500 gram Hirudos are cleaned cutting, drying adds 50 gram yellow wine and mixes thoroughly, and vexed slightly, slow fire is fried to little yellow.(2) Rhizoma Corydalis that 500 grams are cleaned, drying is mixed thoroughly with vinegar, soaks into, and to the vinegar exhaustion, puts in the pot and fries to little dried with slow fire.(3) with waste, slow fire simmer down to flowing soaking paste once more behind 1500 gram Radix Salviae Miltiorrhizaes and the Fructus Crataegi 700 Keshan short, bristly hair or beards difference water infusion secondary.(4) 300 gram Benzoinumes and 500 gram succinums are ground into fine powder.(5) the above-mentioned 500 gram Hirudos that cook, 500 gram Rhizoma Corydalis and 500 gram Radix Ginsengs, 1000 gram Radix Notoginseng, 1000 gram Rhizoma Chuanxiongs, 500 gram Fructus Schisandrae Chinensis, 500 gram Poria, 300 gram Rhizoma Acori Graminei, 400 gram Radix Aconiti Lateralis Preparatas are ground into the coarse granule shape.(6) above-mentioned Radix Salviae Miltiorrhizae, Fructus Crataegi fluid extract are pulverized medicine with other and mix and mix thoroughly, dry, be ground into fine powder again, obtain the powder of this medicine.Incapsulate, every powder charge powder 1.2 grams, bottle, sterilize the finished medicines of treatment cardiovascular and cerebrovascular disease.Administrated method is an oral capsule, every day 2-3 time, each 3-5 grain.
Embodiment 2: the manufacture method of pressing embodiment 1 is made the powder of medicine of the present invention, and the consumption of each crude drug is as follows: Radix Salviae Miltiorrhizae 1700 grams, Radix Notoginseng 1100 grams, Radix Ginseng 450 grams, Rhizoma Chuanxiong 900 grams, succinum 450 grams, Hirudo 500 grams, Benzoinum 250 grams, Fructus Schisandrae Chinensis 420 grams, Rhizoma Corydalis 420 grams, Poria 500 grams, Rhizoma Acori Graminei 250 grams, Radix Aconiti Lateralis Preparata 350 grams, Fructus Crataegi 800 grams.Medicated powder is incapsulated, every adorn 1.2 the gram, bottle, sterilize the treatment cardiovascular and cerebrovascular disease finished medicines.Administrated method is an oral capsule, every 2-3 time, and each 3-5 grain.
Embodiment 3: the manufacture method of pressing embodiment 1 is made the powder of medicine of the present invention, and the consumption of each crude drug is as follows: Radix Salviae Miltiorrhizae 1400 grams, Radix Notoginseng 1100 grams, Radix Ginseng 420 grams, Rhizoma Chuanxiong 1100 grams, succinum 510 grams, Hirudo 550 grams, Benzoinum 280 grams, Fructus Schisandrae Chinensis 450 grams, Rhizoma Corydalis 550 grams, Poria 450 grams, Rhizoma Acori Graminei 320 grams, Radix Aconiti Lateralis Preparata 420 grams, Fructus Crataegi 720 grams.Medicated powder is incapsulated, every adorn 1.2 the gram, bottle, sterilize the treatment cardiovascular and cerebrovascular disease finished medicines.Administrated method is an oral capsule, every 2-3 time, and each 3-5 grain.
Embodiment 4: Dao Erji, the man, 55 years old, the cadre, systolic pressure about 170 is taken the capsule of embodiment 1, early, middle and late three times of every day, each 5, take one month after, blood pressure stabilization is about 140.
Embodiment 5: Ge Rile, woman, 60 years old, the herdsman, systolic pressure 170-180 has ischemic angina pectoris, takes the capsule of embodiment 2, early, middle and late three times of every day, each 5, take 3 months after, angina pectoris symptom disappears, blood pressure is reduced to about 140, triglyceride (TG) by 2.56 reduce to 1.68 mMs/liter.
Embodiment 6: Li Hongsheng, the man, 62 years old, citizen, cerebral infarction sequela can not be walked, and takes embodiment 3 capsules, every day early, middle late three times, each 5, treat after one month, can walk by crutch; T-CHOL (TC) by 8.5 mMs/lifting to 6.0 mM/liter, triglyceride (TG) by 2.5 reduce to 2.0 mMs/liter.
Claims (3)
1, a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that: it is made up of Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, succinum, Hirudo, Benzoinum, Fructus Schisandrae Chinensis, Rhizoma Corydalis, Poria, Rhizoma Acori Graminei, Radix Aconiti Lateralis Preparata, Fructus Crataegi 13 flavor raw material of Chinese medicine, and its weight portion proportioning is Radix Salviae Miltiorrhizae 120-180, Radix Notoginseng 80-120, Radix Ginseng 40-60, Rhizoma Chuanxiong 80-120, succinum 40-60, Hirudo 40-60, Benzoinum 24-36, Fructus Schisandrae Chinensis 40-60, Rhizoma Corydalis 40-60, Poria 40-60, Rhizoma Acori Graminei 24-36, Radix Aconiti Lateralis Preparata 32-48, Fructus Crataegi 56-84.
2, the medicine of treatment cardiovascular and cerebrovascular disease according to claim 1, wherein the weight portion proportioning of each raw material of Chinese medicine is Radix Salviae Miltiorrhizae 135-165, Radix Notoginseng 90-110, Radix Ginseng 45-55, Rhizoma Chuanxiong 90-110, succinum 45-55, Hirudo 45-55, Benzoinum 27-33, Fructus Schisandrae Chinensis 45-55, Rhizoma Corydalis 45-55, Poria 45-55, Rhizoma Acori Graminei 27-33, Radix Aconiti Lateralis Preparata 36-44, Fructus Crataegi 63-77.
3, the medicine of treatment cardiovascular and cerebrovascular disease according to claim 1, wherein the weight portion proportioning of each raw material of Chinese medicine is Radix Salviae Miltiorrhizae 150, Radix Notoginseng 100, Radix Ginseng 50, Rhizoma Chuanxiong 100, succinum 50, Hirudo 50, Benzoinum 30, Fructus Schisandrae Chinensis 50, Rhizoma Corydalis 50, Poria 50, Rhizoma Acori Graminei 30, Radix Aconiti Lateralis Preparata 40, Fructus Crataegi 70.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100988407A CN1313108C (en) | 2005-09-02 | 2005-09-02 | Medicine for treating cardiovascular and cerebrovascular disease |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100988407A CN1313108C (en) | 2005-09-02 | 2005-09-02 | Medicine for treating cardiovascular and cerebrovascular disease |
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| CN1733019A CN1733019A (en) | 2006-02-15 |
| CN1313108C true CN1313108C (en) | 2007-05-02 |
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| CN101502541B (en) * | 2008-02-04 | 2011-12-28 | 成都地奥九泓制药厂 | Styrax plant and use of extract thereof |
| CN104257959B (en) * | 2014-09-23 | 2018-06-22 | 苏州市天灵中药饮片有限公司 | A kind of Chinese medical extract of blood pressure lowering and preparation method thereof |
| CN106857991A (en) * | 2017-03-15 | 2017-06-20 | 广西凌云县盘古生态产业发展有限公司 | A kind of fat decreasing tea and preparation method thereof |
Citations (2)
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|---|---|---|---|---|
| CN1228328A (en) * | 1998-03-05 | 1999-09-15 | 陈寿熙 | Jingshutong soluble granules |
| CN1293049A (en) * | 2000-09-19 | 2001-05-02 | 马继龙 | 'Shexingkeyu' capsule for treating cardiovascular and cerebrovascular diseases and its preparing process |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228328A (en) * | 1998-03-05 | 1999-09-15 | 陈寿熙 | Jingshutong soluble granules |
| CN1293049A (en) * | 2000-09-19 | 2001-05-02 | 马继龙 | 'Shexingkeyu' capsule for treating cardiovascular and cerebrovascular diseases and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| 谈谈冠心病心绞痛的证治规律近况 宛新铮，贵阳中医学院学报，第2期 1981 * |
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