CN1308017C - 一种治疗泻泄、痢疾和痧气的药物组合物 - Google Patents
一种治疗泻泄、痢疾和痧气的药物组合物 Download PDFInfo
- Publication number
- CN1308017C CN1308017C CNB2004100945125A CN200410094512A CN1308017C CN 1308017 C CN1308017 C CN 1308017C CN B2004100945125 A CNB2004100945125 A CN B2004100945125A CN 200410094512 A CN200410094512 A CN 200410094512A CN 1308017 C CN1308017 C CN 1308017C
- Authority
- CN
- China
- Prior art keywords
- dysentery
- present
- diarrhea
- group
- eruptive disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 201000010099 disease Diseases 0.000 title claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 26
- 208000001848 dysentery Diseases 0.000 title claims abstract description 15
- 239000000203 mixture Substances 0.000 title claims abstract description 6
- 239000003814 drug Substances 0.000 title abstract description 25
- 229940079593 drug Drugs 0.000 title description 6
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 17
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 12
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 16
- 241000628997 Flos Species 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 abstract description 5
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 abstract 1
- 235000019510 Long pepper Nutrition 0.000 abstract 1
- 240000003455 Piper longum Species 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 206010019345 Heat stroke Diseases 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 229960002362 neostigmine Drugs 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000000976 ink Substances 0.000 description 3
- ALWKGYPQUAPLQC-UHFFFAOYSA-N neostigmine Chemical compound CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 ALWKGYPQUAPLQC-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- -1 methyl neostigmine Chemical compound 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- RHAXKFFKGZJUOE-UHFFFAOYSA-N 7-acetyl-6-ethyl-3,5,8-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid Chemical compound O=C1C2=CC(O)=C(C(O)=O)C(C(O)=O)=C2C(=O)C2=C1C(O)=C(CC)C(C(C)=O)=C2O RHAXKFFKGZJUOE-UHFFFAOYSA-N 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002270 ergogenic effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
- 229960001625 furazolidone Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 例数 | 推进率(%) |
对照组低剂量组中剂量组高剂量组 | 10101010 | 55.78±1.0949.18±1.49*44.62±2.52*40.61±1.57* |
组别 | 例数 | 炭末推进率(%) |
空白组对照组低剂量组中剂量组高剂量组 | 1010101010 | 53.62±2.0667.46±2.4447.36±1.6*43.63±2.04*42.88±1.84* |
组别 | 例数 | 湿粪数 | 排湿粪动物数 |
对照组低剂量组中剂量组高剂量组 | 10101010 | 6.7±1.881.5±1.08*0.9±0.87*0.4±0.51* | 10864 |
组别 | 例数 | 扭体次数 |
空白组低剂量组中剂量组高剂量组阿斯匹林组 | 1010101010 | 31.1±9.3322.2±11.65*△17.1±10.37*△11.1±5.42*△8.3±6.27* |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100945125A CN1308017C (zh) | 2004-10-30 | 2004-10-30 | 一种治疗泻泄、痢疾和痧气的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100945125A CN1308017C (zh) | 2004-10-30 | 2004-10-30 | 一种治疗泻泄、痢疾和痧气的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1634466A CN1634466A (zh) | 2005-07-06 |
CN1308017C true CN1308017C (zh) | 2007-04-04 |
Family
ID=34847810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100945125A Active CN1308017C (zh) | 2004-10-30 | 2004-10-30 | 一种治疗泻泄、痢疾和痧气的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1308017C (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117379497B (zh) * | 2023-12-08 | 2024-02-27 | 浙江苏可安药业有限公司 | 中药组合物在制备抑制幽门螺杆菌的药物中的用途 |
-
2004
- 2004-10-30 CN CNB2004100945125A patent/CN1308017C/zh active Active
Non-Patent Citations (1)
Title |
---|
中华人民共和国卫生部药品标准中药成方制剂十五册 88,中华人民共和国药典委员会 1997 * |
Also Published As
Publication number | Publication date |
---|---|
CN1634466A (zh) | 2005-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Hangzhou Nanyang pharmaceutical company Assignor: Nanyang Pharmaceutical Co., Ltd., Zhejaing Contract fulfillment period: 2007.5.1 to 2017.4.30 Contract record no.: 2008330002704 Denomination of invention: Pharmaceutical composition for treating diarrhea, dysentery and eruptive disease Granted publication date: 20070404 License type: Exclusive license Record date: 20081217 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.5.1 TO 2017.4.30; CHANGE OF CONTRACT Name of requester: HANGZHOU NANYANG PHARMACEUTICAL CO., LTD. Effective date: 20081217 |
|
EM01 | Change of recordation of patent licensing contract |
Change date: 20100513 Contract record no.: 2008330002704 Assignee after: Hangzhou Nanyang Pharmaceutical Co., Ltd. Assignee before: Hangzhou Nanyang pharmaceutical company |
|
EM01 | Change of recordation of patent licensing contract |
Change date: 20130628 Contract record no.: 2008330002704 Assignee after: ZHEJIANG SUPOR SOUTHOCEAN PHARMACEUTICAL CO., LTD. Assignee before: Hangzhou Nanyang Pharmaceutical Co., Ltd. |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170719 Address after: 311200, Zhejiang, Hangzhou province Hangzhou large Jiangdong industrial agglomeration, No. 829 Fu Hang Road Patentee after: Hangzhou SUPOR Nanyang Pharmaceutical Co., Ltd. Address before: 317600 Yuhuan barley island economic development zone, Zhejiang Patentee before: Nanyang Pharmaceutical Co., Ltd., Zhejaing |
|
TR01 | Transfer of patent right | ||
CP03 | Change of name, title or address |
Address after: 310000 No. 829, changfuhang Road, Qianjin Street, Qiantang District, Hangzhou City, Zhejiang Province Patentee after: Zhejiang sukean Pharmaceutical Co.,Ltd. Address before: No.829, changfuhang Road, dajiangdong Industrial Cluster District, Hangzhou, Zhejiang 311200 Patentee before: HANGZHOU SUPOR SOUTH OCEAN PHARMACEUTICAL CO.,LTD. |
|
CP03 | Change of name, title or address |