CN1302788C - Externally applied medicine liquid for treating acne and its prepn - Google Patents
Externally applied medicine liquid for treating acne and its prepn Download PDFInfo
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- CN1302788C CN1302788C CNB2005100450377A CN200510045037A CN1302788C CN 1302788 C CN1302788 C CN 1302788C CN B2005100450377 A CNB2005100450377 A CN B2005100450377A CN 200510045037 A CN200510045037 A CN 200510045037A CN 1302788 C CN1302788 C CN 1302788C
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Abstract
The present invention relates to medicine liquid for treating acne and a preparation method thereof, wherein the medicine liquid is mainly prepared with skullcap root, ledebouriella root, garden burnet, schizonepeta herb, realgar, dahurian angelica, rhubarb, mongolian dandelion herb, etc. The Chinese medical materials are extracted to be prepared into the medicine liquid which is only externally applied and has an excellent curative effect on acne of teenage.
Description
One, technical field:
The present invention relates to a kind of prescription and preparation method for the treatment of the acne external medicinal liquid, belong to the Chinese medicine technical field.
Two, technical background:
Teenager adolesces will occur many acne (comedo) on the face.Squeezed and length, caused sometimes being worse off, inflammation, cross infection etc. have occurred.Rise one after another, this disappears, and that is long.Hustle and bustle, even stay cicatrix on the face.Severe patient is in forehead, facial linking to each other in flakes, and not only sense of personal worth baffles, and is depressed, hides contacts, and change has taken place personality, and old and feeble in advance.
Comedo forms and starts from the oils and fats hair follicle gland.It produces sebum, and sebum is discharged along hair, comes off but die when the cell of skin aging, and the more sebum of (especially a large amount of inhomogeneous coming off) and secretion becomes plug when sticking together, and adds the procreation of antibacterial and the effect of product thereof, begins swelling formation acne.At present, the product of treatment acne has " young tiger wind comedo liquid ", " LANJINZUHE ", " the pox root is clean ", " doctor's Bai acne skin Kang Lu ", " human world U.S. beauty treatment acne are clean ", " beautiful I " etc.
Also have some products as " the clean skin liquid in ocean " though non-be the product of single-minded treatment acne, also have part to treat the effect of acne.These products are playing very important function aspect the acne treatment, on market.
More than research and product have shown the necessity of treatment acne, social meaning and economic implications.And the multiformity product can coexist socially, shows that the research for the treatment of acne still is being in deeply, and product is in competition, and society is in the approval stage of selecting to product.The curative effect that Shang Weiyou generally acknowledges is good and fast, and unique product occurs.
In the process of more than ten years treatment teenager acne, we have summed up the external side of treatment acne.Extensively try out after making liquid preparation, the result shows that said preparation has efficient quick-acting characteristics, is worthy of popularization again.
Three, summary of the invention:
The present invention is directed to the deficiencies in the prior art, a kind of medicine for external use for the treatment of acne and preparation method thereof is provided.
The medicine for external use of treatment acne of the present invention comprises following component, is weight portion:
60～100 parts of 30～90 parts of Porias of Radix Scutellariae
30～90 parts of 20～50 portions of Radix Gentianaes of Radix Saposhnikoviae
60～100 parts of 30～100 parts of Herba Taraxacis of Radix Sanguisorbae or Rhizoma Saururi (Herba Saururi)s
3～6 parts of 50～100 parts of Radix Platycodoniss of Radix Sophorae Flavescentis
5～10 parts of 10～30 portions of Realgars of Herba Schizonepetae
30～90 parts of 60～100 parts of Radix Et Rhizoma Rhei of the Radix Angelicae Dahuricae.
The preferred ingredient of treatment acne medicine for external use is weight portion:
7 parts of Realgars
60 parts of Radix Scutellariaes
80 parts of the Radixs Angelicae Dahuricae
80 parts of Herba Taraxacis (or Rhizoma Saururi (Herba Saururi))
30 parts of Radix Saposhnikoviaes
65 parts of Radix Sangusorbaes
75 parts of Radix Sophorae Flavescentiss
20 parts of Herba Schizonepetae
80 parts of Porias
60 parts of Radix Gentianaes
60 parts of Radix Et Rhizoma Rhei
3～6 parts of Radix Platycodoniss.
Above-mentioned each component is:
Herb or the spica of Herba Schizonepetae (Schizoneqeta Tenuifolia Briq.).
The root of anti-(Saposhnikovia divaricata (Turc2.) Schischk.).
The root of the Radix Angelicae Dahuricae (Angelica dahurica Benth te Hook. or Angelica anomala Lallem. or Angelica taiwaniana Boiss.).
The root of Radix Scutellariae (Scutellria Baicalensis Georgi.).
The root of Radix Gentianae (Gentiana scabra Bunge. or Gentina triflora Pall. or Gentianamanshurica Kitag.).
The root of Radix Sophorae Flavescentis (Sophora flavescens Ait.).
The root of Herba Taraxaci (Taraxacum mongolicum Hand-mazz.).
The root stock of Radix Et Rhizoma Rhei (Rheum palmatum L. or R.tanguticum Masim.Ex Regel. or R.officinalBaill.).
The sclerotium of Poria (Poria cocos (Schw.) wolf).
The root or the herb of Rhizoma Saururi (Herba Saururi) (Saururus chinensis (Lour.) Baill.).
Radix Sanguisorbae: the root of (Sanguisorba officinalis L.).
Radix Platycodonis: the root of Platyoodan grandiglorum (Jacq.) DC.
Function with cure mainly:
The inflammatory rosacea caused by lung-wind that clearing away lung-heat, the lung-wind syndrome of dispelling, resolving phlegm and softening hard masses are located to take place with face, thoracic dorsal etc.
By monarch, minister, help, make the principles of formulating prescriptions to analyze prescription compatibility of medicines:
The Radix Scutellariae bitter in the mouth is cold in nature, return lung, gallbladder, stomach, large intestine footpath, the effect of heat clearing away, dry, wet, detoxifcation is arranged, and is longer than eliminating heat from the lung especially; The Radix Et Rhizoma Rhei bitter in the mouth is cold in nature, is good at cleansing the gastrointestinal excess-heat, removes dryness accumulated in the stomach and intestine, and the tumor of dispelling of stagnating, invigorate blood circulation is a monarch drug with Radix Scutellariae altogether.Radix Angelicae Dahuricae acrid in the mouth is warm in nature, attaches to the lung and stomach meridians, dispels the wind, evacuation of pus, detumescence, sensible effect; BAIFU a kind of reed mentioned in ancient books promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer and Realgar, Herba Taraxaci, Radix Sophorae Flavescentis are ministerial drug altogether.The sweet tepor of Radix Saposhnikoviae acrid in the mouth is returned bladder, liver, spleen channel, and having dispels the wind wins the using warming therapy effect; Radix Sanguisorbae removing heat from blood, convergence and Herba Schizonepetae are adjuvant drug altogether.Radix Platycodonis medicine carrying tying-in is messenger drug.Take a broad view of full side's clearing away lung-heat, resolving phlegm and softening hard masses, the removing heat from blood that dispels the wind, the tumor of dispelling detoxifcation make the skin catharsis unimpeded, push away the effect that Chen Zhixin amounts to the acne of dispelling.
The preparation method of the external medicinal liquid of above-mentioned treatment acne is as follows:
(1) takes by weighing the Chinese medicine of formula ratio, except that Realgar, other Chinese medicines lump together, decocting 3 times, perhaps add water to just flooded till, 40 ℃ were soaked 2～3 hours, leached soak, and the residue medicinal residues add water to just and flood, soaking 1 hour post-heating boils, keep boiling 0.5 hour, leach liquid, filtering residue adds water again to be done once equally;
(2) three times filtrate merges, and adding edible ethanol to alcohol concentration in the filtrate that merges is 30～85%, and natural room temperature leaves standstill and avales or at 5～12 ℃ of following Cryoprecipitation, filter to get filtrate;
(3) ethanol evaporation in the filtrate is concentrated into heavy 4 times of medicinal liquid raw material, to the medical activated carbon adsorption bleaching that wherein adds 1% weight, stirred 1 hour, filter to get filtrate, the filtrate achromatism and clarity, and then be concentrated into 2 times of medicinal liquid weight, and adding 0.2% active carbon again and stir decolouring 1 hour, medicinal liquid is clear and bright;
(4) take by weighing the formula ratio Realgar, porphyrize joins and boils off 1～10mg/kg in the alcoholic acid medicinal liquid, at 5～12 ℃ of following Cryoprecipitation, gets clear and bright supernatant, all the other filtrations, and filtrate and supernatant merge, fill;
(5) product is through 100 ℃ of boiling sterilizations.
Product liquid medicine is clear and bright with atomic yellow.This liquid medicine can only external, can not take orally.Product should be placed on child touch film less than the place.
Four, the specific embodiment:
Embodiment 1: the medicine for external use component of treatment acne is as follows, is weight portion:
75 parts of 7 parts of Radix Sophorae Flavescentiss of Realgar
20 parts of 60 portions of Herba Schizonepetae of Radix Scutellariae
80 parts of 80 parts of Porias of the Radix Angelicae Dahuricae
60 parts of 80 portions of Radix Gentianaes of Herba Taraxaci
60 parts of 30 parts of Radix Et Rhizoma Rhei of Radix Saposhnikoviae
3 parts of 65 parts of Radix Platycodoniss of Radix Sanguisorbae.
Preparation method is as follows:
(1) takes by weighing the Chinese medicine of formula ratio, except that Realgar, other Chinese medicines lump together common 610kg, add water 2500L, till just flooding, 40 ℃ were soaked 2 hours, extrude the about 2000L of filtrate with 60～80 order filter clothes then, the residue medicinal residues add water 2000L again to just flooding, and soak a hour post-heating and boil, keep boiling 0.5 hour, leach the about 1100L of liquid; Filtering residue adds water 1500L again, soaks 1 hour post-heating and boils, and keeps boiling 0.5 hour, extrudes filtrate 900L, and filtering residue is abandoned it;
(2) three times filtrate merges 4000L altogether, and adding edible ethanol to alcohol concentration in the filtrate that merges is 30%, constantly stirs simultaneously; Room temperature leaves standstill avales, or at 5～12 ℃ of following Cryoprecipitation, filters to get filtrate;
(3) ethanol evaporation in the filtrate is concentrated into heavy 4 times of medicinal liquid raw material, promptly during 2400L, to the medical activated carbon adsorption bleaching that wherein adds 1% weight 1 hour, filtrate got achromatism and clarity filtrate; And then be concentrated into 2 times of medicinal liquid weight, add 0.2% active carbon again and stir decolouring 1 hour, clear and bright colourless solution 1200L;
(4) take by weighing formula ratio Realgar 7kg, porphyrize adds in the medicinal liquid of above-mentioned preparation, adds the hydroxyl methyl formate again, at 5～12 ℃ of following Cryoprecipitation, gets clear and bright supernatant, all the other filtrations, and filtrate and supernatant merge, fill.
(5) product is through 100 ℃ of boiling sterilizations.
Product is put does not for a long time have precipitation, and liquid medicine is clear and bright with atomic yellow.
Embodiment 2:
Herba Taraxaci in embodiment 1 formula constituent used instead be Rhizoma Saururi (Herba Saururi), amount with, preparation method is with embodiment 1.
Treat the observation of 191 routine acne patient's curative effects.
Case is selected: selected patient is colleges and universities and middle school students.Age 17-26 year.17 years old 2 people, 18-19 year 18 people, 20-24 year 141 people, 25-28 year 30 people.Boy student 96 people wherein, schoolgirl 95 people.Differential diagnosis in tcm is inflammation lung-wind syndrome type patient.
Administrated method:
This medicinal liquid is a medicine for external use.Adopt point behind the cotton excellent dip in liquid medicine, wiping, be coated with (or spray) method, abandon it after using up, touch without hands.The band medicine time was no less than 6h (coating immediately after washing face) after daytime, point was wiped.Be mainly used in the dispersive patient of face acne.Smear medicinal liquid before sleeping evening, the band medicine time is no less than 6h.Be mainly used in face large tracts of land acne patient is arranged.
Diagnostic criteria:
1, occurs, be defined as the large tracts of land patient in zone (before, nose and nose both sides, lower jaw etc. are located) 5 square centimeters, having 5 above comedos to concentrate as forehead, ear.Other disperse the patient for acne.
Criterion of therapeutical effect:
Acne detumescences is risen, does head, is moved back redly after the medication, gradually stepping back degradation and being the normal colour of skin.Becoming the normal colour of skin after curative effect is subsided a swelling with acne is statistical standard, is called anti-acne.To the produce effects effect that disappears after the medication as invalid statistics.
Observe and the result:
We select the part patient (experiment is mainly carried out) in university, middle school in school institute of Shandong Normal University.Comedo number, name in the investigation statistics class of elder generation, divide into groups.The student that selection is ready to treat illustrates using method as experimental subject, and allow he (she) note impression and effect behind the recording medicine separately.Everyone of seminar is responsible for the student patient below 10.The every 24h of laboratory technician observes once the patient.At first facial comedo is disperseed classmate's experiment, divide three groups, every group 42 people.Every group of patient men and women half and half.First group, a dip in liquid medicine point wiping on daytime, second group, evening, point was wiped, and the 3rd group, all put the liquid of applying medicinal lotion or ointment in daytime and evening, be as the criterion with anti-acne.Found that daytime, apply medicinal lotion or ointment the 3rd day anti-acne person of patient of liquid of point accounted for 52%, all the other anti-acne persons at second and four day individually at first day and the 5th day.Second group of second day effect preferably accounts for and accounted for 26%, the three group of second day anti-acne person in 66%, the three day and account for 83%.Second and the 3rd group of anti-acne person got final product anti-acne on the 3rd day, and was best with the 3rd group.Illustrate all to put in daytime and evening to wipe to be better than to put an evening to wipe and be better than some wiping on daytime.This may with wash one's face daytime often, perspiration is many, medicinal liquid easily removes, and metabolism is vigorous relevant.And time ratio was more lasting after point was wiped before sleeping evening.The body metabolism rate is also lower.
To men and women's therapeutic effect zero difference
| First group of 42 people | Two group of 42 people | Three group of 42 people | |
| First day | 1(2％) | 3(7％) | 5(12％) |
| Second day | 10(24％) | 28(66％) | 35(83％) |
| The 3rd day | 22(52％) | 11(26％) | 2(5％) |
| The 4th day | 8(19％) | 0 | 0 |
| The 5th day | 1(2％) | 0 | 0 |
According to this result, we have the people of large tracts of land comedo to adopt to embrocate to face evening is main, is the method for assisting in conjunction with some wiping on daytime.Wherein there are large tracts of land comedo person 4 people at the cheekbone place, the forehead person of having 29 people, the chin person of having 11 people, forehead and chin all have large tracts of land distribution person 9 people, the person of having 5 people before the ear, nose and the nose two side persons of having 7 people are totally 65 people, wherein male 33 people, women 32 people, anti-acne person accounted for 13% in second day, anti-acne person accounted for 84%, the four day anti-acne person 3% in the 3rd day.Shown that this external medicinal liquid has efficient quick-acting effect.Men and women's patient treatment effect no significant difference, treatment back preventing from scar.We and medication patient 24h keep in touch, and find allergy, and discomfort is not seen other side effect yet.But suggestion is except that using continuously in 1 week.Discontinuous life-time service.
Claims (3)
1, a kind of external medicinal liquid for the treatment of acne is characterized in that, it is as follows to prepare its raw materials of effective components, is weight portion:
60～100 parts of 30～90 parts of Porias of Radix Scutellariae
30～90 parts of 20～50 portions of Radix Gentianaes of Radix Saposhnikoviae
60～100 parts of 30～100 parts of Herba Taraxacis of Radix Sanguisorbae or Rhizoma Saururi (Herba Saururi)s
3～6 parts of 50～100 parts of Radix Platycodoniss of Radix Sophorae Flavescentis
5～10 parts of 10～30 portions of Realgars of Herba Schizonepetae
30～90 parts of 60～100 parts of Radix Et Rhizoma Rhei of the Radix Angelicae Dahuricae.
2, a kind of external medicinal liquid for the treatment of acne as claimed in claim 1 is characterized in that it is as follows to prepare its raw materials of effective components, is weight portion:
75 parts of 7 parts of Radix Sophorae Flavescentiss of Realgar
20 parts of 60 portions of Herba Schizonepetae of Radix Scutellariae
80 parts of 80 parts of Porias of the Radix Angelicae Dahuricae
60 parts of 80 portions of Radix Gentianaes of Herba Taraxaci or Rhizoma Saururi (Herba Saururi)
60 parts of 30 parts of Radix Et Rhizoma Rhei of Radix Saposhnikoviae
3～6 parts of 65 parts of Radix Platycodoniss of Radix Sanguisorbae.
3, a kind of external medicinal liquid for the treatment of acne as claimed in claim 1 is characterized in that its preparation method is as follows:
(1) takes by weighing the Chinese medicine of formula ratio, except that Realgar, other Chinese medicines lump together, decocting 3 times, perhaps add water to just flooded till, 40 ℃ were soaked 2～3 hours, leached soak, and the residue medicinal residues add water to just and flood, soaking 1 hour post-heating boils, keep boiling 0.5 hour, leach liquid, filtering residue adds water again to be done once equally;
(2) three times filtrate merges, and adding edible ethanol to alcohol concentration in the filtrate that merges is 30～85%, and natural room temperature leaves standstill and avales or at 5～12 ℃ of following Cryoprecipitation, filter to get filtrate;
(3) ethanol evaporation in the filtrate is concentrated into heavy 4 times of medicinal liquid raw material, to the medical activated carbon adsorption bleaching that wherein adds 1% weight, stirred 1 hour, filter to get filtrate, the filtrate achromatism and clarity, and then be concentrated into 2 times of medicinal liquid weight, and adding 0.2% active carbon again and stir decolouring 1 hour, medicinal liquid is clear and bright;
(4) take by weighing the formula ratio Realgar, porphyrize joins and boils off 1～10mg/kg in the alcoholic acid medicinal liquid, at 5～12 ℃ of following Cryoprecipitation, gets clear and bright supernatant, all the other filtrations, and filtrate and supernatant merge, fill;
(5) product is through 100 ℃ of boiling sterilizations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100450377A CN1302788C (en) | 2005-11-04 | 2005-11-04 | Externally applied medicine liquid for treating acne and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100450377A CN1302788C (en) | 2005-11-04 | 2005-11-04 | Externally applied medicine liquid for treating acne and its prepn |
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| Publication Number | Publication Date |
|---|---|
| CN1772076A CN1772076A (en) | 2006-05-17 |
| CN1302788C true CN1302788C (en) | 2007-03-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100450377A Expired - Fee Related CN1302788C (en) | 2005-11-04 | 2005-11-04 | Externally applied medicine liquid for treating acne and its prepn |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103585342B (en) * | 2009-08-14 | 2016-09-28 | 株式会社爱茉莉太平洋 | Compositions containing natural extract |
| CN102106915B (en) * | 2011-02-23 | 2011-11-30 | 徐海彬 | Liniment for treating psoriasis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259382A (en) * | 1999-12-16 | 2000-07-12 | 傅广和 | Dissolvable granula prepn. prepd. from forgythia fruit and honeysuckle |
| CN1331984A (en) * | 2001-07-12 | 2002-01-23 | 刘本维 | External-use trauma treating ointment |
| CN1418674A (en) * | 2002-11-01 | 2003-05-21 | 北京天衡药物研究院 | Medicine compositions for treating acne, and its prepn. method |
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2005
- 2005-11-04 CN CNB2005100450377A patent/CN1302788C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259382A (en) * | 1999-12-16 | 2000-07-12 | 傅广和 | Dissolvable granula prepn. prepd. from forgythia fruit and honeysuckle |
| CN1331984A (en) * | 2001-07-12 | 2002-01-23 | 刘本维 | External-use trauma treating ointment |
| CN1418674A (en) * | 2002-11-01 | 2003-05-21 | 北京天衡药物研究院 | Medicine compositions for treating acne, and its prepn. method |
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| Publication number | Publication date |
|---|---|
| CN1772076A (en) | 2006-05-17 |
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