CN102106915B - Liniment for treating psoriasis and preparation method thereof - Google Patents

Abstract

The invention provides liniment for treating psoriasis and a preparation method thereof. The preparation method comprises the following steps of: grinding lightyellow sophora root, gentian root, rhubarb and root-bark of ditlany into powder, and soaking the powder in mature vinegar for one week to prepare filtrate (1); completely dissolving benzoic acid, salicylic acid, camphors and borneols in 75 percent ethanol to prepare solution (2); and mixing the filtrate (1) and the solution (2), and sealing the mixed solution to prepare the liniment. The liniment has the effects of clearing away heat and eliminating dampness, expelling pathogenic wind and relieving itching, killing bacteria and relieving itching and dissolving aging skin, can be used for treating psoriasis and has the characteristics of quick response, low side effect and relapse prevention; and according to clinical observation, the curing rate is 78.1 percent.

Description

A kind of psoriatic liniment and preparation method thereof that is used for the treatment of

Technical field

The present invention relates to a kind of psoriatic external used medicine that is used for the treatment of, particularly relating to a kind of is the psoriatic liniment of treatment of feedstock production with the Chinese medicine and western medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Psoriasis has another name called psoriasis, is a kind of common erythema unicorn bits property chronic inflammatory disease dermatoses.Outbreak repeatedly, its skin lesion can general whole body, is more common in head, extremity are stretched face, the back, and skin lesion shows as the pale red maculopapule, with the normal skin clear-cut margin, surface coverage has silvery white squama, scrapes off squama, can expose semi-transparent film, scrape off the visible little petechia of this film, illing skin has pruritus in various degree, and men and women, old and young all can fall ill, and is a kind of skin class difficult miscellaneous diseases.At present, clinically this sick external medication is adopted more medicines such as glucocorticoid, tretinoin cream, this type of drug side effect is big, DeGrain, easily repeatedly.

Summary of the invention

The purpose of this invention is to provide a kind of psoriatic liniment that is used for the treatment of, this medicine by Chinese medicine and western medicine form have heat clearing and damp drying, wind dispelling is antipruritic, the effect of sterilizing and itch-relieving, dissolving cutin, can play little, repeatedly the purpose not of instant effect, side effect to psoriatic treatment.

Simultaneously, another object of the present invention provides the preparation method of liniment of the present invention.

Medicine of the present invention is that crude drug prepares by following parts of medicines by weight:

Radix Sophorae Flavescentis 50～70 Radix Gentianaes 90～110

Favus skin 20～40 Radix Et Rhizoma Rhei 50～70

Camphora 9～11 Borneolum Syntheticums 5～7

Benzoic acid 10～30 salicylic acid 9～11.

The traditional Chinese medical science thinks that the primary disease cause of disease is comparatively complicated, and its pathogenesis is at blood, and endogenous cause of ill mostly is damaged by excess of seven emotions, or eating and drinking without temperance, has a liking for food delicious food savoury etc., so that aquatic weeds heat is in blood, and exopathogenic factor mostly is to experience ailment said due to cold or exposure or hold under the arm and scorchingly injures skin and fall ill.The Therapeutic Principle should be heat clearing away, the wind dispelling of invigorating blood circulation, bacterio static itching-relieving.The Radix Sophorae Flavescentis heat clearing and damp drying; Wind dispelling insecticide; The Radix Gentianae heat clearing and damp drying; Radix Et Rhizoma Rhei clearing away damp-heat, removing heat from blood, blood stasis dispelling, detoxifcation; Favus skin heat clearing and damp drying, the detoxifcation of dispeling the wind; Benzoic acid, salicylic acid sterilizing and itch-relieving, dissolving cutin; Camphora removing damp to relieve itching, warming and odynolysis; Borneolum Syntheticum clearing away heat to alleviate pain, the transdermal of having one's ideas straightened out.All medicines share, heat-clearing and toxic substances removing, and the wind dispelling of invigorating blood circulation, the transdermal of having one's ideas straightened out, bacterio static itching-relieving is used for psoriatic treatment, has little, repeatedly the characteristics not of instant effect, side effect.

The preparation method of liniment of the present invention comprises the following steps:

1) 50～70 parts of Radix Sophorae Flavescentiss, 90～110 parts of Radix Gentianaes, 20～40 parts of favus skins, Radix Et Rhizoma Rhei are ground into 100-120 order powder for 50～70 parts, soak a week in the mature vinegar of 1.5-2.5 times of weight of adding drug powder, filter and obtain filtrate 1;

2) 10～30 parts in benzoic acid, 9～11 parts of salicylic acid, 9～11 parts of Camphoras, 5～7 parts of Borneolum Syntheticums, above material is dissolved in 75% alcoholic solution of medicine 3.5-4.5 times weight fully, makes solution 2;

3) filtrate 1 is mixed with solution 2, is sealed and obtain liniment.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 94 routine psoriatics that the curative effect of medicine of the present invention has been carried out clinical observation.

94 routine cases are divided into two groups at random, and 64 people are organized in treatment, matched group 30 people.All case is diagnosed as psoriasis all according to the diagnostic criteria of " new Chinese medicine clinical research guideline (the 3rd volume) ".

Therapeutic Method

Matched group adopts PIKANGWANG, every day 2 times, smears the affected part.The treatment group adopts the liniment of medicine of the present invention to treat, and every day 1 time, smears the affected part.40 days is a course of treatment, uses 2 courses of treatment altogether.

Criterion of therapeutical effect

According to the criterion of therapeutical effect of " new Chinese medicine clinical research guideline (the 3rd volume) ", recovery from illness: skin lesion all disappears, or only residual several unconspicuous fritter skin lesion.Effectively: skin lesion disappears more than 30%.Invalid: skin lesion disappears below 30%, or skin lesion no change or skin lesion increase the weight of.

Two groups of case treatment back curative effect comparative results see Table 1.

Table 1 liang group case treatment back curative effect relatively

Group	The example number	Recovery from illness n(%)	Effective n(%)	Invalid n(%)	Total effective rate n(%)
						Matched group	30	21（70）	6（20）	3（10）	27（90）
The treatment group	64	50（78.1）	14（21.9）	0（0）	64（100）

Statistical result showed, treatment group curative effect obviously is better than matched group, and two group differences are remarkable, P＜0.05.

The specific embodiment

Embodiment 1

Get Radix Sophorae Flavescentis 60g, Radix Gentianae 100g, Radix Et Rhizoma Rhei 60g, the favus skin 30g that selected, clear water cleans and be ground into 100 purpose medicated powder, add in 500 milliliters in the mature vinegar and soak a week, make filtrate 1;

Get benzoic acid 20g, salicylic acid 10g, Camphora 10g, Borneolum Syntheticum 6g, above medicine selected, that clear water is cleaned and be dissolved in 75% ethanol fully, make 200 ml solns 2;

Filtrate 1 mixes with solution 2, seal and make liniment product of the present invention.

Embodiment 2

Get Radix Sophorae Flavescentis 50g, Radix Gentianae 110g, Radix Et Rhizoma Rhei 50g, favus skin 40g selected, that clear water is cleaned and be ground into 120 purpose medicated powder, add mature vinegar and soak a week for 625 milliliters, make filtrate 1;

Get selected, that clear water is cleaned benzoic acid 30g, salicylic acid 5g, Camphora 5g, Borneolum Syntheticum 6g, add 75% ethanol, make 200 ml solns 2;

Filtrate 1 mixes with solution 2, seal and make liniment product of the present invention.

Claims (2)

1. one kind is used for the treatment of psoriatic liniment, is that crude drug prepares by the medicine of following portions by weight:

Radix Sophorae Flavescentis 50～70 Radix Gentianaes 90～110

Favus skin 20～40 Radix Et Rhizoma Rhei 50～70

Camphora 9～11 Borneolum Syntheticums 5～7

Benzoic acid 10～30 salicylic acid 9～11.

2. the described preparation method that is used for the treatment of psoriatic liniment of claim 1 may further comprise the steps:

1) 50～70 parts of Radix Sophorae Flavescentiss, 90～110 parts of Radix Gentianaes, 20～40 parts of favus skins, Radix Et Rhizoma Rhei are ground into 100-120 order powder for 50～70 parts, soak a week in the mature vinegar of 1.5-2.5 times of weight of adding drug powder, filter and obtain filtrate 1;

2) 10～30 parts in benzoic acid, 9～11 parts of salicylic acid, 9～11 parts of Camphoras, 5～7 parts of Borneolum Syntheticums, above material is dissolved in 75% alcoholic solution of medicine 3.5-4.5 times weight fully, makes solution 2;

3) filtrate 1 is mixed with solution 2, is sealed and obtain liniment.