CN1302780C - 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 - Google Patents

烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 Download PDF

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Publication number
CN1302780C
CN1302780C CNB038181010A CN03818101A CN1302780C CN 1302780 C CN1302780 C CN 1302780C CN B038181010 A CNB038181010 A CN B038181010A CN 03818101 A CN03818101 A CN 03818101A CN 1302780 C CN1302780 C CN 1302780C
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preparation
application
treatment
alkyl
benign
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Expired - Fee Related
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CNB038181010A
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English (en)
Chinese (zh)
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CN1671397A (zh
Inventor
J·恩格尔
E·京特
H·辛德曼恩
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Aeterna Zentaris GmbH
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Zentaris AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB038181010A 2002-07-30 2003-07-29 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 Expired - Fee Related CN1302780C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39961502P 2002-07-30 2002-07-30
US60/399,615 2002-07-30

Publications (2)

Publication Number Publication Date
CN1671397A CN1671397A (zh) 2005-09-21
CN1302780C true CN1302780C (zh) 2007-03-07

Family

ID=31495746

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038181010A Expired - Fee Related CN1302780C (zh) 2002-07-30 2003-07-29 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用

Country Status (26)

Country Link
US (3) US8389497B2 (cg-RX-API-DMAC10.html)
EP (2) EP1545553B1 (cg-RX-API-DMAC10.html)
JP (1) JP2005535688A (cg-RX-API-DMAC10.html)
KR (3) KR101066804B1 (cg-RX-API-DMAC10.html)
CN (1) CN1302780C (cg-RX-API-DMAC10.html)
AR (1) AR040717A1 (cg-RX-API-DMAC10.html)
AT (1) ATE516036T1 (cg-RX-API-DMAC10.html)
AU (2) AU2003253350B2 (cg-RX-API-DMAC10.html)
BR (1) BR0313048A (cg-RX-API-DMAC10.html)
CA (1) CA2493023C (cg-RX-API-DMAC10.html)
CY (1) CY1111902T1 (cg-RX-API-DMAC10.html)
DK (1) DK1545553T3 (cg-RX-API-DMAC10.html)
ES (1) ES2369535T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20050184B1 (cg-RX-API-DMAC10.html)
IL (1) IL166329A (cg-RX-API-DMAC10.html)
MX (1) MXPA05001203A (cg-RX-API-DMAC10.html)
NO (1) NO335196B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ538428A (cg-RX-API-DMAC10.html)
PL (1) PL375493A1 (cg-RX-API-DMAC10.html)
PT (1) PT1545553E (cg-RX-API-DMAC10.html)
RU (1) RU2005105693A (cg-RX-API-DMAC10.html)
SI (1) SI1545553T1 (cg-RX-API-DMAC10.html)
TW (1) TWI332007B (cg-RX-API-DMAC10.html)
UA (1) UA82322C2 (cg-RX-API-DMAC10.html)
WO (1) WO2004012744A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200500453B (cg-RX-API-DMAC10.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
UA82322C2 (uk) 2002-07-30 2008-04-10 Центаріс Гмбх Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
DE10324911B4 (de) 2003-05-30 2005-08-18 Siemens Ag Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen
WO2006081452A2 (en) * 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
EP1962862B1 (en) * 2005-12-19 2013-09-04 Æterna Zentaris GmbH Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
US20070167408A1 (en) * 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
CN103479604B (zh) * 2007-07-30 2016-08-10 阿迪生物科学公司 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法
AU2009324464B2 (en) * 2008-12-11 2016-05-05 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US8383607B2 (en) 2010-03-31 2013-02-26 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2086026T3 (es) * 1991-07-04 1996-06-16 Asta Medica Ag Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion.
US5942639A (en) * 1991-07-04 1999-08-24 Asta Medica Aktiengesellschaft Process for the preparation of alkylphosphocholines and the production thereof in pure form
US6172050B1 (en) * 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
JP3079993B2 (ja) * 1996-03-27 2000-08-21 日本電気株式会社 真空マイクロデバイスおよびその製造方法
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
CA2318260C (en) 1998-01-22 2006-11-21 Asta Medica Ag Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
JP2002531534A (ja) * 1998-12-04 2002-09-24 マックス−デルブルック−セントラム フュール モレクラーレ メディツィン タモキシフェン含有リポソーム系腫瘍治療剤
US6583127B1 (en) 1998-12-21 2003-06-24 Inkeysa. Sa Use of etherlysophospholipids as antiinflammatory agents
CN1551767A (zh) * 2001-02-19 2004-12-01 ��˹��ŵ�� 癌症的治疗
ATE450265T1 (de) * 2001-03-23 2009-12-15 Shire Canada Inc Pharmazeutische mischung zur behandlung von krebs,die dioxolan nukleosidanalogen enthält
WO2003005522A1 (es) 2001-07-04 2003-01-16 Acuna Arturo Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica.
DE60210329T2 (de) * 2002-01-02 2006-11-30 Nerviano Medical Sciences S.R.L., Nerviano Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren
UA82322C2 (uk) 2002-07-30 2008-04-10 Центаріс Гмбх Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
WO2005000318A2 (en) * 2003-06-23 2005-01-06 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
WO2006081452A2 (en) 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
US20070167408A1 (en) 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
US8383607B2 (en) 2010-03-31 2013-02-26 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Also Published As

Publication number Publication date
ZA200500453B (en) 2005-08-31
CA2493023C (en) 2012-01-31
EP1545553A1 (de) 2005-06-29
HRP20050184B1 (hr) 2014-04-11
SI1545553T1 (sl) 2011-09-30
US20100190738A1 (en) 2010-07-29
NZ538428A (en) 2006-09-29
CY1111902T1 (el) 2015-11-04
RU2005105693A (ru) 2005-07-10
PL375493A1 (en) 2005-11-28
UA82322C2 (uk) 2008-04-10
US8507710B2 (en) 2013-08-13
JP2005535688A (ja) 2005-11-24
AU2008203060B2 (en) 2011-04-21
KR20130016413A (ko) 2013-02-14
AU2003253350B2 (en) 2008-06-26
NO335196B1 (no) 2014-10-20
HK1080751A1 (en) 2006-05-04
DK1545553T3 (da) 2011-09-12
TWI332007B (en) 2010-10-21
AR040717A1 (es) 2005-04-20
EP1545553B1 (de) 2011-07-13
PT1545553E (pt) 2011-09-12
KR101066804B1 (ko) 2011-09-22
US8389497B2 (en) 2013-03-05
BR0313048A (pt) 2005-06-14
NO20051040L (no) 2005-02-25
CN1671397A (zh) 2005-09-21
ATE516036T1 (de) 2011-07-15
HRP20050184A2 (en) 2005-04-30
US20100189784A1 (en) 2010-07-29
IL166329A (en) 2012-08-30
TW200404073A (en) 2004-03-16
US8551977B2 (en) 2013-10-08
AU2008203060A1 (en) 2008-07-31
MXPA05001203A (es) 2005-06-08
KR20050026028A (ko) 2005-03-14
AU2003253350A1 (en) 2004-02-23
WO2004012744A1 (de) 2004-02-12
KR20110102485A (ko) 2011-09-16
CA2493023A1 (en) 2004-02-12
EP2301551A1 (de) 2011-03-30
US20040097470A1 (en) 2004-05-20
IL166329A0 (en) 2006-01-15
ES2369535T3 (es) 2011-12-01

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