PT1545553E - Utilização de alquilfosfocolinas em combinação com medicamentos antitumorais - Google Patents

Utilização de alquilfosfocolinas em combinação com medicamentos antitumorais Download PDF

Info

Publication number
PT1545553E
PT1545553E PT03766336T PT03766336T PT1545553E PT 1545553 E PT1545553 E PT 1545553E PT 03766336 T PT03766336 T PT 03766336T PT 03766336 T PT03766336 T PT 03766336T PT 1545553 E PT1545553 E PT 1545553E
Authority
PT
Portugal
Prior art keywords
combination
antitumor medicaments
alkyl phosphocholines
phosphocholines
alkyl
Prior art date
Application number
PT03766336T
Other languages
English (en)
Portuguese (pt)
Inventor
Eckhard Guenther
Juergen Engel
Herbert Sindermann
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of PT1545553E publication Critical patent/PT1545553E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT03766336T 2002-07-30 2003-07-29 Utilização de alquilfosfocolinas em combinação com medicamentos antitumorais PT1545553E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39961502P 2002-07-30 2002-07-30

Publications (1)

Publication Number Publication Date
PT1545553E true PT1545553E (pt) 2011-09-12

Family

ID=31495746

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03766336T PT1545553E (pt) 2002-07-30 2003-07-29 Utilização de alquilfosfocolinas em combinação com medicamentos antitumorais

Country Status (26)

Country Link
US (3) US8389497B2 (cg-RX-API-DMAC10.html)
EP (2) EP1545553B1 (cg-RX-API-DMAC10.html)
JP (1) JP2005535688A (cg-RX-API-DMAC10.html)
KR (3) KR101066804B1 (cg-RX-API-DMAC10.html)
CN (1) CN1302780C (cg-RX-API-DMAC10.html)
AR (1) AR040717A1 (cg-RX-API-DMAC10.html)
AT (1) ATE516036T1 (cg-RX-API-DMAC10.html)
AU (2) AU2003253350B2 (cg-RX-API-DMAC10.html)
BR (1) BR0313048A (cg-RX-API-DMAC10.html)
CA (1) CA2493023C (cg-RX-API-DMAC10.html)
CY (1) CY1111902T1 (cg-RX-API-DMAC10.html)
DK (1) DK1545553T3 (cg-RX-API-DMAC10.html)
ES (1) ES2369535T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20050184B1 (cg-RX-API-DMAC10.html)
IL (1) IL166329A (cg-RX-API-DMAC10.html)
MX (1) MXPA05001203A (cg-RX-API-DMAC10.html)
NO (1) NO335196B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ538428A (cg-RX-API-DMAC10.html)
PL (1) PL375493A1 (cg-RX-API-DMAC10.html)
PT (1) PT1545553E (cg-RX-API-DMAC10.html)
RU (1) RU2005105693A (cg-RX-API-DMAC10.html)
SI (1) SI1545553T1 (cg-RX-API-DMAC10.html)
TW (1) TWI332007B (cg-RX-API-DMAC10.html)
UA (1) UA82322C2 (cg-RX-API-DMAC10.html)
WO (1) WO2004012744A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200500453B (cg-RX-API-DMAC10.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
UA82322C2 (uk) 2002-07-30 2008-04-10 Центаріс Гмбх Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
DE10324911B4 (de) 2003-05-30 2005-08-18 Siemens Ag Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen
WO2006081452A2 (en) * 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
EP1962862B1 (en) * 2005-12-19 2013-09-04 Æterna Zentaris GmbH Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
US20070167408A1 (en) * 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
CN103479604B (zh) * 2007-07-30 2016-08-10 阿迪生物科学公司 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法
AU2009324464B2 (en) * 2008-12-11 2016-05-05 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US8383607B2 (en) 2010-03-31 2013-02-26 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2086026T3 (es) * 1991-07-04 1996-06-16 Asta Medica Ag Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion.
US5942639A (en) * 1991-07-04 1999-08-24 Asta Medica Aktiengesellschaft Process for the preparation of alkylphosphocholines and the production thereof in pure form
US6172050B1 (en) * 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
JP3079993B2 (ja) * 1996-03-27 2000-08-21 日本電気株式会社 真空マイクロデバイスおよびその製造方法
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
CA2318260C (en) 1998-01-22 2006-11-21 Asta Medica Ag Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
JP2002531534A (ja) * 1998-12-04 2002-09-24 マックス−デルブルック−セントラム フュール モレクラーレ メディツィン タモキシフェン含有リポソーム系腫瘍治療剤
US6583127B1 (en) 1998-12-21 2003-06-24 Inkeysa. Sa Use of etherlysophospholipids as antiinflammatory agents
CN1551767A (zh) * 2001-02-19 2004-12-01 ��˹��ŵ�� 癌症的治疗
ATE450265T1 (de) * 2001-03-23 2009-12-15 Shire Canada Inc Pharmazeutische mischung zur behandlung von krebs,die dioxolan nukleosidanalogen enthält
WO2003005522A1 (es) 2001-07-04 2003-01-16 Acuna Arturo Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica.
DE60210329T2 (de) * 2002-01-02 2006-11-30 Nerviano Medical Sciences S.R.L., Nerviano Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren
UA82322C2 (uk) 2002-07-30 2008-04-10 Центаріс Гмбх Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
WO2005000318A2 (en) * 2003-06-23 2005-01-06 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
WO2006081452A2 (en) 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
US20070167408A1 (en) 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
US8383607B2 (en) 2010-03-31 2013-02-26 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Also Published As

Publication number Publication date
ZA200500453B (en) 2005-08-31
CA2493023C (en) 2012-01-31
EP1545553A1 (de) 2005-06-29
HRP20050184B1 (hr) 2014-04-11
SI1545553T1 (sl) 2011-09-30
US20100190738A1 (en) 2010-07-29
NZ538428A (en) 2006-09-29
CY1111902T1 (el) 2015-11-04
RU2005105693A (ru) 2005-07-10
PL375493A1 (en) 2005-11-28
UA82322C2 (uk) 2008-04-10
US8507710B2 (en) 2013-08-13
JP2005535688A (ja) 2005-11-24
AU2008203060B2 (en) 2011-04-21
KR20130016413A (ko) 2013-02-14
AU2003253350B2 (en) 2008-06-26
NO335196B1 (no) 2014-10-20
HK1080751A1 (en) 2006-05-04
DK1545553T3 (da) 2011-09-12
TWI332007B (en) 2010-10-21
AR040717A1 (es) 2005-04-20
EP1545553B1 (de) 2011-07-13
KR101066804B1 (ko) 2011-09-22
US8389497B2 (en) 2013-03-05
BR0313048A (pt) 2005-06-14
NO20051040L (no) 2005-02-25
CN1671397A (zh) 2005-09-21
ATE516036T1 (de) 2011-07-15
HRP20050184A2 (en) 2005-04-30
US20100189784A1 (en) 2010-07-29
IL166329A (en) 2012-08-30
TW200404073A (en) 2004-03-16
US8551977B2 (en) 2013-10-08
AU2008203060A1 (en) 2008-07-31
MXPA05001203A (es) 2005-06-08
KR20050026028A (ko) 2005-03-14
AU2003253350A1 (en) 2004-02-23
WO2004012744A1 (de) 2004-02-12
KR20110102485A (ko) 2011-09-16
CA2493023A1 (en) 2004-02-12
EP2301551A1 (de) 2011-03-30
US20040097470A1 (en) 2004-05-20
IL166329A0 (en) 2006-01-15
CN1302780C (zh) 2007-03-07
ES2369535T3 (es) 2011-12-01

Similar Documents

Publication Publication Date Title
SI1583542T1 (sl) Sestavki in postopki za kombinacijsko antivirusnoterapijo
IL154761A0 (en) Improved paclitaxel-based antitumor formulation
IL187528A0 (en) Use of pyrimidine compounds in the manufacture of medicaments
IL150240A (en) Infant formula supplemented with phospholipids
IL166156A0 (en) Boroproline compound combination therapy
IL169112A0 (en) Phosphonooxy quinazoline derivatives and their pharmaceuitical use
GB0321911D0 (en) Improvements in or relating to medical devices
GB0324761D0 (en) Use of compounds in therapy
PL370866A1 (en) Use of antitumor indolopyrrolocarbazole derivative and other anticancer agent in combination
HRP20050631A2 (en) Aryl alkyl carbamate derivatives production and use thereof in therapy
AU2003287666A8 (en) Systemic delivery of antiviral agents
IL166329A0 (en) Use of alkyl phosphocholines in combination with antitumor medicaments
GB0223437D0 (en) Improvements in or relating to targeting systems
GB2410209B (en) Improvements in or relating to devices
AU2003264796A8 (en) Three-dimensional display
IL169692A0 (en) Acylated aminopropanediols and analogues and therapeutic uses thereof
TWI339582B (en) Use of alkylphosphocholines in the preventive application of protozoal diseases
EP1507542A4 (en) ANTICANCER PREPARATION
GB2400225B (en) Improvements in and relating to display devices
GB0215773D0 (en) Compunds and their therapeutic use
GB0305969D0 (en) Improvements in the formulation of medicaments
GB0313836D0 (en) Improvements in and relating to the dispensing of medicaments
GB0204909D0 (en) Improvements in or relating to antimalarial agents
GB0312845D0 (en) Use of componds in medicine
GB0226788D0 (en) Improvements in and relating to display devices