CN1300323A - 重组α－L－艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法 - Google Patents

重组α－L－艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法 Download PDF

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Publication number
CN1300323A
CN1300323A CN99806064A CN99806064A CN1300323A CN 1300323 A CN1300323 A CN 1300323A CN 99806064 A CN99806064 A CN 99806064A CN 99806064 A CN99806064 A CN 99806064A CN 1300323 A CN1300323 A CN 1300323A
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China
Prior art keywords
iduronidase
enzyme
disease
carrier
transfectional cell
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Pending
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CN99806064A
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English (en)
Chinese (zh)
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E·D·卡基斯
B·塔纳马奇
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HARBOR-UCLA INST OF UNIV OF CALIFORNIA
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HARBOR-UCLA INST OF UNIV OF CALIFORNIA
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Publication of CN1300323A publication Critical patent/CN1300323A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
CN99806064A 1998-05-13 1999-05-07 重组α－L－艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法 Pending CN1300323A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7820998A 1998-05-13 1998-05-13
US09/078,209 1998-05-13
US17097798A 1998-10-13 1998-10-13
US09/170,977 1998-10-13

Publications (1)

Publication Number Publication Date
CN1300323A true CN1300323A (zh) 2001-06-20

Family

ID=26760239

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99806064A Pending CN1300323A (zh) 1998-05-13 1999-05-07 重组α－L－艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法

Country Status (8)

Country Link
EP (1) EP1078075A2 (ja)
JP (1) JP2002514429A (ja)
CN (1) CN1300323A (ja)
AU (1) AU4072499A (ja)
BR (1) BR9910323A (ja)
CA (1) CA2328518A1 (ja)
IL (1) IL139616A0 (ja)
WO (1) WO1999058691A2 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103487414A (zh) * 2012-06-14 2014-01-01 北京和信非凡生物技术有限公司 一种α-L-艾杜糖醛酸酶活性检测方法、底物和试剂
CN107699590A (zh) * 2017-10-13 2018-02-16 成都中医药大学 一种制备重组人α‑L‑艾杜糖醛酸酶的方法
CN114181318A (zh) * 2021-11-08 2022-03-15 四川大学 一种高效组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585971B1 (en) * 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
US6569661B1 (en) * 1999-11-12 2003-05-27 Biomarin Pharmaceutical Inc. Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6426208B1 (en) * 1999-11-12 2002-07-30 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
EP2767291B1 (en) 2000-07-18 2016-09-14 Duke University Treatment of glycogen storage disease type II
US7442372B2 (en) * 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
EP2630241B1 (en) * 2010-10-22 2018-10-17 CuRNA, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
DK2984166T3 (da) 2013-03-15 2020-07-20 Univ Pennsylvania Sammensætninger til behandling af mpsi
KR20180121899A (ko) 2016-02-03 2018-11-09 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 I형 점액다당류증을 치료하기 위한 유전자 요법
IL268076B1 (en) * 2017-01-31 2024-06-01 Regenxbio Inc Treatment of mucopolysaccharidoses I with human iduronidase L (IDUA) and full human glycosylations
BR112020000063A2 (pt) 2017-07-06 2020-07-14 The Trustees Of The University Of Pennsylvania terapia gênica mediada por aav9 para tratamento de mucopolissacaridose tipo i
CN115109790A (zh) * 2021-03-23 2022-09-27 北京据德医药科技有限公司 一种重组a-L-艾杜糖醛酸普酶及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2099503C (en) * 1991-11-14 2007-10-09 Hamish Steele Scott Synthetic alpha-l-iduronidase and genetic sequences encoding same
ES2326705T3 (es) * 1995-09-14 2009-10-16 Virginia Tech Intellectual Properties, Inc. Produccion de enzimas lisosomicas en sistemas de expresion basados en plantas.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103487414A (zh) * 2012-06-14 2014-01-01 北京和信非凡生物技术有限公司 一种α-L-艾杜糖醛酸酶活性检测方法、底物和试剂
CN107699590A (zh) * 2017-10-13 2018-02-16 成都中医药大学 一种制备重组人α‑L‑艾杜糖醛酸酶的方法
CN114181318A (zh) * 2021-11-08 2022-03-15 四川大学 一种高效组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用

Also Published As

Publication number Publication date
WO1999058691A3 (en) 2000-02-17
AU4072499A (en) 1999-11-29
WO1999058691A2 (en) 1999-11-18
EP1078075A2 (en) 2001-02-28
IL139616A0 (en) 2002-02-10
JP2002514429A (ja) 2002-05-21
BR9910323A (pt) 2001-01-30
CA2328518A1 (en) 1999-11-18

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