CN1299358A - 杂环拓扑异构酶毒性剂 - Google Patents

杂环拓扑异构酶毒性剂 Download PDF

Info

Publication number
CN1299358A
CN1299358A CN98813818A CN98813818A CN1299358A CN 1299358 A CN1299358 A CN 1299358A CN 98813818 A CN98813818 A CN 98813818A CN 98813818 A CN98813818 A CN 98813818A CN 1299358 A CN1299358 A CN 1299358A
Authority
CN
China
Prior art keywords
alkyl
compound
cycloalkyl
halo
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98813818A
Other languages
English (en)
Chinese (zh)
Inventor
E·J·拉沃伊
J·S·金
L·F·刘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of CN1299358A publication Critical patent/CN1299358A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN98813818A 1997-12-31 1998-12-30 杂环拓扑异构酶毒性剂 Pending CN1299358A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7028797P 1997-12-31 1997-12-31
US60/070287 1997-12-31

Publications (1)

Publication Number Publication Date
CN1299358A true CN1299358A (zh) 2001-06-13

Family

ID=22094368

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98813818A Pending CN1299358A (zh) 1997-12-31 1998-12-30 杂环拓扑异构酶毒性剂

Country Status (11)

Country Link
US (3) US6667302B2 (https=)
EP (1) EP1044199B1 (https=)
JP (1) JP2002509858A (https=)
CN (1) CN1299358A (https=)
AT (1) ATE402168T1 (https=)
AU (1) AU753268B2 (https=)
CA (1) CA2316221A1 (https=)
DE (1) DE69839781D1 (https=)
IL (1) IL136911A0 (https=)
PL (1) PL341539A1 (https=)
WO (1) WO1999033824A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002509858A (ja) * 1997-12-31 2002-04-02 ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー 複素環式トポイソメラーゼ毒化合物
CA2534649A1 (en) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
ZA200705872B (en) * 2005-01-14 2008-09-25 Genelabs Tecnologies Inc Indole derivatives for treating viral infections
AU2006218403A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP1910385B1 (en) 2005-08-04 2013-07-24 Sirtris Pharmaceuticals, Inc. Benzothiazoles and thiazolopyridines as sirtuin modulators
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2008073451A2 (en) * 2006-12-11 2008-06-19 Sirtris Pharmaceuticals, Inc. Benzoimidazole derivatives as sirtuin (sir) modulating compounds
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
EP2376502B1 (en) 2008-12-19 2015-06-17 GlaxoSmithKline LLC Thiazolopyridine sirtuin modulating compounds
JP6898255B2 (ja) 2015-05-28 2021-07-07 エコラボ ユーエスエー インコーポレイティド ２−置換イミダゾール及びベンズイミダゾール腐食抑制剤
CA2987248C (en) 2015-05-28 2023-09-26 Ecolab Usa Inc. Novel corrosion inhibitors
EP3314038B1 (en) 2015-05-28 2021-12-29 Ecolab Usa Inc. Purine-based corrosion inhibitors
AU2016267611B2 (en) 2015-05-28 2021-12-09 Ecolab Usa Inc. Water-soluble pyrazole derivatives as corrosion inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26065E (en) 1966-07-19 Folybenzimidazoles and their preparation
US26065A (en) 1859-11-08 Improvement in cotton-gins
US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
CH420044A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
JP2700475B2 (ja) 1988-07-30 1998-01-21 コニカ株式会社 非線形光学材料および非線形光学素子
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
NZ307959A (en) * 1995-05-17 1998-08-26 Univ Rutgers Substituted tribenzimidazole derivatives where the substituent can be aryl or heteroaryl and medicaments
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
JP2002509858A (ja) * 1997-12-31 2002-04-02 ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー 複素環式トポイソメラーゼ毒化合物
US6063801A (en) * 1998-02-12 2000-05-16 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons

Also Published As

Publication number Publication date
AU753268B2 (en) 2002-10-10
CA2316221A1 (en) 1999-07-08
US20040082637A1 (en) 2004-04-29
WO1999033824A1 (en) 1999-07-08
EP1044199B1 (en) 2008-07-23
JP2002509858A (ja) 2002-04-02
IL136911A0 (en) 2001-06-14
ATE402168T1 (de) 2008-08-15
US6667302B2 (en) 2003-12-23
PL341539A1 (en) 2001-04-23
US6995154B2 (en) 2006-02-07
US20080004280A1 (en) 2008-01-03
DE69839781D1 (en) 2008-09-04
US20020151575A1 (en) 2002-10-17
EP1044199A1 (en) 2000-10-18
AU2022099A (en) 1999-07-19

Similar Documents

Publication Publication Date Title
CN1111409C (zh) 胞嘧啶衍生物在制备用于治疗肿瘤的药物中用途
CN1299358A (zh) 杂环拓扑异构酶毒性剂
JP5337104B2 (ja) 可溶化トポイソメラーゼ毒
CA2316223A1 (en) Hydrophilic coating for an intracorporeal medical device
US6992088B2 (en) Nitro and amino substituted heterocycles as topoisomerase I targeting agents
JP6929903B2 (ja) 抗癌剤およびその調製方法
JPH05508619A (ja) ヒト結腸直腸癌の有効な抑制剤であるカンプトセシンアナローグ
CN1195514C (zh) 海鞘素 743的代谢物
JPH05222048A (ja) 水溶性カンプトテシン誘導体
CN103228655A (zh) 咔唑和咔啉衍生物，及其制备方法和治疗应用
CN1089838A (zh) 一种防治运动病综合征的药物组合物
US5364858A (en) Camptothecin analogs as potent inhibitors of topoisomerase I
US7858627B2 (en) Topoisomerase-targeting agents
EP2268644B1 (en) Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
JP2002508359A (ja) 複素環式細胞毒性剤
US20050010046A1 (en) Topoisomerase poison agents
CN1221554C (zh) 治疗胃肠疾病的吡喃并[2,3－c]咪唑并[－1,2－a]吡啶衍生物及药物组合物
WO1994025466A1 (en) Water soluble derivatives of camptothecin and their use as antitumor agents
CN1324354A (zh) 玻璃状己知缓激肽拮抗剂
EP1611889A1 (en) Antibacterial agent and anticancer agent
JP3068175B2 (ja) イソチアゾロ〔５，４―ｂ〕ピリジン誘導体
JPH1160484A (ja) Ｔｎｆ産生阻害剤
CN101062925A (zh) 紫杉醇衍生物、其制备方法和其药物组合物与用途
WO2024112932A1 (en) Immunomodulators and immunomodulator conjugates
EP0365176A1 (en) Ellipticine glycoside derivatives

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication