AU753268B2 - Heterocyclic topoisomerase poisons - Google Patents
Heterocyclic topoisomerase poisons Download PDFInfo
- Publication number
- AU753268B2 AU753268B2 AU20220/99A AU2022099A AU753268B2 AU 753268 B2 AU753268 B2 AU 753268B2 AU 20220/99 A AU20220/99 A AU 20220/99A AU 2022099 A AU2022099 A AU 2022099A AU 753268 B2 AU753268 B2 AU 753268B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- alkyl
- halo
- hydroxy
- taken together
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7028797P | 1997-12-31 | 1997-12-31 | |
| US60/070287 | 1997-12-31 | ||
| PCT/US1998/027822 WO1999033824A1 (en) | 1997-12-31 | 1998-12-30 | Heterocyclic topoisomerase poisons |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2022099A AU2022099A (en) | 1999-07-19 |
| AU753268B2 true AU753268B2 (en) | 2002-10-10 |
Family
ID=22094368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU20220/99A Ceased AU753268B2 (en) | 1997-12-31 | 1998-12-30 | Heterocyclic topoisomerase poisons |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6667302B2 (https=) |
| EP (1) | EP1044199B1 (https=) |
| JP (1) | JP2002509858A (https=) |
| CN (1) | CN1299358A (https=) |
| AT (1) | ATE402168T1 (https=) |
| AU (1) | AU753268B2 (https=) |
| CA (1) | CA2316221A1 (https=) |
| DE (1) | DE69839781D1 (https=) |
| IL (1) | IL136911A0 (https=) |
| PL (1) | PL341539A1 (https=) |
| WO (1) | WO1999033824A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002509858A (ja) * | 1997-12-31 | 2002-04-02 | ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー | 複素環式トポイソメラーゼ毒化合物 |
| CA2534649A1 (en) * | 2003-08-01 | 2005-02-10 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against flaviviridae |
| ZA200705872B (en) * | 2005-01-14 | 2008-09-25 | Genelabs Tecnologies Inc | Indole derivatives for treating viral infections |
| AU2006218403A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP1910385B1 (en) | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| WO2008073451A2 (en) * | 2006-12-11 | 2008-06-19 | Sirtris Pharmaceuticals, Inc. | Benzoimidazole derivatives as sirtuin (sir) modulating compounds |
| TW200916472A (en) | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| EP2376502B1 (en) | 2008-12-19 | 2015-06-17 | GlaxoSmithKline LLC | Thiazolopyridine sirtuin modulating compounds |
| JP6898255B2 (ja) | 2015-05-28 | 2021-07-07 | エコラボ ユーエスエー インコーポレイティド | ２−置換イミダゾール及びベンズイミダゾール腐食抑制剤 |
| CA2987248C (en) | 2015-05-28 | 2023-09-26 | Ecolab Usa Inc. | Novel corrosion inhibitors |
| EP3314038B1 (en) | 2015-05-28 | 2021-12-29 | Ecolab Usa Inc. | Purine-based corrosion inhibitors |
| AU2016267611B2 (en) | 2015-05-28 | 2021-12-09 | Ecolab Usa Inc. | Water-soluble pyrazole derivatives as corrosion inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036612A1 (en) * | 1995-05-17 | 1996-11-21 | Rutgers, The State University Of New Jersey | Tribenzimidazoles useful as topoisomerase i inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE26065E (en) | 1966-07-19 | Folybenzimidazoles and their preparation | ||
| US26065A (en) | 1859-11-08 | Improvement in cotton-gins | ||
| US2985661A (en) | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
| CH420044A (de) | 1964-09-01 | 1967-03-15 | Ciba Geigy | Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien |
| DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| SU1530628A1 (ru) | 1987-11-20 | 1989-12-23 | Ленинградский Технологический Институт Им.Ленсовета | Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК |
| JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| US5106863A (en) | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| US5767142A (en) | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| US5807874A (en) | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| US5770617A (en) * | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| JP2002509858A (ja) * | 1997-12-31 | 2002-04-02 | ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー | 複素環式トポイソメラーゼ毒化合物 |
| US6063801A (en) * | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
-
1998
- 1998-12-30 JP JP2000526506A patent/JP2002509858A/ja active Pending
- 1998-12-30 CN CN98813818A patent/CN1299358A/zh active Pending
- 1998-12-30 DE DE69839781T patent/DE69839781D1/de not_active Expired - Lifetime
- 1998-12-30 AU AU20220/99A patent/AU753268B2/en not_active Ceased
- 1998-12-30 AT AT98965021T patent/ATE402168T1/de not_active IP Right Cessation
- 1998-12-30 CA CA002316221A patent/CA2316221A1/en not_active Abandoned
- 1998-12-30 WO PCT/US1998/027822 patent/WO1999033824A1/en not_active Ceased
- 1998-12-30 EP EP98965021A patent/EP1044199B1/en not_active Expired - Lifetime
- 1998-12-30 IL IL13691198A patent/IL136911A0/xx unknown
- 1998-12-30 PL PL98341539A patent/PL341539A1/xx unknown
-
2001
- 2001-06-13 US US09/869,141 patent/US6667302B2/en not_active Expired - Lifetime
-
2003
- 2003-10-21 US US10/690,800 patent/US6995154B2/en not_active Expired - Fee Related
-
2006
- 2006-01-25 US US11/339,006 patent/US20080004280A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036612A1 (en) * | 1995-05-17 | 1996-11-21 | Rutgers, The State University Of New Jersey | Tribenzimidazoles useful as topoisomerase i inhibitors |
Non-Patent Citations (2)
| Title |
|---|
| BIOCHEMISTRY, 1997, 36, 6488-6494 * |
| J. MED. CHEM., 1977, 40, 2818-2824 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2316221A1 (en) | 1999-07-08 |
| US20040082637A1 (en) | 2004-04-29 |
| WO1999033824A1 (en) | 1999-07-08 |
| EP1044199B1 (en) | 2008-07-23 |
| CN1299358A (zh) | 2001-06-13 |
| JP2002509858A (ja) | 2002-04-02 |
| IL136911A0 (en) | 2001-06-14 |
| ATE402168T1 (de) | 2008-08-15 |
| US6667302B2 (en) | 2003-12-23 |
| PL341539A1 (en) | 2001-04-23 |
| US6995154B2 (en) | 2006-02-07 |
| US20080004280A1 (en) | 2008-01-03 |
| DE69839781D1 (en) | 2008-09-04 |
| US20020151575A1 (en) | 2002-10-17 |
| EP1044199A1 (en) | 2000-10-18 |
| AU2022099A (en) | 1999-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |