CN1297566C - 编码新rg1多肽的dna - Google Patents

编码新rg1多肽的dna Download PDF

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Publication number
CN1297566C
CN1297566C CNB008190518A CN00819051A CN1297566C CN 1297566 C CN1297566 C CN 1297566C CN B008190518 A CNB008190518 A CN B008190518A CN 00819051 A CN00819051 A CN 00819051A CN 1297566 C CN1297566 C CN 1297566C
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CN
China
Prior art keywords
polypeptide
sequence
seq
amino acids
antibody
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Expired - Fee Related
Application number
CNB008190518A
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English (en)
Chinese (zh)
Other versions
CN1434832A (zh
Inventor
理查德·哈金斯
底波拉·帕克斯
戈登·帕里
道格拉斯·W·施奈德
雷娜特·施泰因布雷歇尔
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Bayer Pharma AG
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Schering AG
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Publication of CN1434832A publication Critical patent/CN1434832A/zh
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Publication of CN1297566C publication Critical patent/CN1297566C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CNB008190518A 1999-12-16 2000-12-15 编码新rg1多肽的dna Expired - Fee Related CN1297566C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17237099P 1999-12-16 1999-12-16
US60/172,370 1999-12-16
US09/732,357 US6682902B2 (en) 1999-12-16 2000-12-07 DNA encoding a novel RG1 polypeptide
US09/732,357 2000-12-07

Publications (2)

Publication Number Publication Date
CN1434832A CN1434832A (zh) 2003-08-06
CN1297566C true CN1297566C (zh) 2007-01-31

Family

ID=26868022

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008190518A Expired - Fee Related CN1297566C (zh) 1999-12-16 2000-12-15 编码新rg1多肽的dna

Country Status (32)

Country Link
US (5) US6682902B2 (enExample)
EP (2) EP1237915B1 (enExample)
JP (1) JP4979867B2 (enExample)
KR (1) KR100752434B1 (enExample)
CN (1) CN1297566C (enExample)
AT (1) ATE440862T1 (enExample)
AU (1) AU784674B2 (enExample)
BG (1) BG65898B1 (enExample)
BR (1) BR0017022A (enExample)
CA (1) CA2394574A1 (enExample)
CZ (1) CZ299232B6 (enExample)
DE (1) DE60042836D1 (enExample)
DK (1) DK1237915T3 (enExample)
EE (1) EE05293B1 (enExample)
ES (1) ES2331106T3 (enExample)
HR (1) HRP20020549B1 (enExample)
HU (1) HU229001B1 (enExample)
IL (2) IL150115A0 (enExample)
LT (1) LT5046B (enExample)
ME (1) MEP37808A (enExample)
MX (1) MXPA02005914A (enExample)
NO (1) NO330924B1 (enExample)
NZ (1) NZ519598A (enExample)
PL (1) PL207634B1 (enExample)
PT (1) PT1237915E (enExample)
RO (1) RO122543B1 (enExample)
RS (1) RS50831B (enExample)
RU (1) RU2283130C2 (enExample)
SI (2) SI1237915T1 (enExample)
SK (2) SK288147B6 (enExample)
WO (1) WO2001044291A2 (enExample)
ZA (1) ZA200205638B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1251139A3 (en) * 1998-04-08 2002-12-18 Genentech, Inc. Human mindin-like protein and nucleic acids encoding it
US20020161199A1 (en) * 1998-04-08 2002-10-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US6960433B1 (en) 1998-10-19 2005-11-01 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
US20070031901A1 (en) * 1999-03-08 2007-02-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US6682902B2 (en) * 1999-12-16 2004-01-27 Schering Aktiengesellschaft DNA encoding a novel RG1 polypeptide
MXPA06000798A (es) 2003-07-22 2006-04-07 Schering Ag Anticuerpos de rg1 y usos de los mismos.
US7294704B2 (en) 2003-08-15 2007-11-13 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
TWI494319B (zh) * 2007-02-21 2015-08-01 Oncotherapy Science Inc 表現腫瘤相關抗原之癌症的胜肽疫苗
US20110020329A1 (en) * 2007-11-30 2011-01-27 Bristol-Myers Squibb Company Conjugates of anti-rg-1 antibodies
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
CN102346184B (zh) * 2010-08-03 2014-03-26 中国人民解放军军事医学科学院生物工程研究所 Spon2的新用途
DE102012016127A1 (de) 2011-08-31 2013-02-28 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels

Citations (3)

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US5781969A (en) * 1996-06-06 1998-07-21 Ykk Corporation Molded surface fastener
WO1998045442A2 (en) * 1997-04-10 1998-10-15 Zymogenetics, Inc. Secreted f-spondin homologs
WO1998050073A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Integrin ligand, human mindin

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US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US6150584A (en) * 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
WO1993023057A1 (en) 1992-05-14 1993-11-25 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting cancer development
US5871969A (en) 1996-02-12 1999-02-16 Human Genome Sciences, Inc. Nucleic acids encoding human neuronal attachment factor-1
US6287777B1 (en) * 1996-05-10 2001-09-11 Beth Israel Deaconess Medical Center NPG-1 gene that is differentially expressed in prostate tumors
US5804382A (en) 1996-05-10 1998-09-08 Beth Israel Deaconess Medical Center, Inc. Methods for identifying differentially expressed genes and differences between genomic nucleic acid sequences
US6177244B1 (en) 1996-05-10 2001-01-23 Beth Israel Deaconess Medical Center Inc. NPG-1 gene that is differentially expressed in prostate tumors
CA2263895C (en) * 1996-08-26 2012-06-26 University Of Washington Therapeutic and diagnostic applications of perlecan domain i splice variants
EP0981625A2 (en) * 1997-05-06 2000-03-01 Human Genome Sciences, Inc. $i(ENTEROCOCCUS FAECALIS) POLYNUCLEOTIDES AND POLYPEPTIDES
DK1490386T3 (da) 1998-03-10 2008-12-15 Genentech Inc Nyt polypeptid og nukleinsyrer kodende for dette
US6166176A (en) * 1998-03-17 2000-12-26 Immvarx, Inc. Cancer marker protein and peptides thereof
JP2002527757A (ja) * 1998-10-19 2002-08-27 ダイアデクスアス・インコーポレーテッド 前立腺癌を診断、監視、病期分類、イメージング及び治療する方法
US6960433B1 (en) * 1998-10-19 2005-11-01 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
EE05627B1 (et) * 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US6682902B2 (en) 1999-12-16 2004-01-27 Schering Aktiengesellschaft DNA encoding a novel RG1 polypeptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5781969A (en) * 1996-06-06 1998-07-21 Ykk Corporation Molded surface fastener
WO1998045442A2 (en) * 1997-04-10 1998-10-15 Zymogenetics, Inc. Secreted f-spondin homologs
WO1998050073A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Integrin ligand, human mindin

Also Published As

Publication number Publication date
MXPA02005914A (es) 2003-02-27
JP2003521244A (ja) 2003-07-15
EP2048157B1 (en) 2012-10-10
SI1237915T1 (sl) 2009-12-31
SK8482002A3 (en) 2003-02-04
EP1237915A2 (en) 2002-09-11
ATE440862T1 (de) 2009-09-15
US20020004047A1 (en) 2002-01-10
DK1237915T3 (da) 2009-11-16
SK288147B6 (sk) 2013-12-02
RU2002119208A (ru) 2004-02-27
CN1434832A (zh) 2003-08-06
IL150115A0 (en) 2002-12-01
WO2001044291A3 (en) 2002-01-17
YU44602A (sh) 2005-06-10
US6682902B2 (en) 2004-01-27
AU3074601A (en) 2001-06-25
CZ299232B6 (cs) 2008-05-21
SI21140A (sl) 2003-08-31
AU784674B2 (en) 2006-05-25
PL356220A1 (en) 2004-06-28
US20090292112A1 (en) 2009-11-26
DE60042836D1 (de) 2009-10-08
NO20022836L (no) 2002-08-15
EE05293B1 (et) 2010-04-15
ES2331106T3 (es) 2009-12-22
BG65898B1 (bg) 2010-04-30
EP2048157A1 (en) 2009-04-15
PL207634B1 (pl) 2011-01-31
HRP20020549A2 (en) 2004-04-30
MEP37808A (en) 2011-05-10
US20040023307A1 (en) 2004-02-05
JP4979867B2 (ja) 2012-07-18
IL150115A (en) 2013-11-28
EE200200323A (et) 2003-10-15
US20040152139A1 (en) 2004-08-05
HU229001B1 (en) 2013-07-29
HUP0204224A3 (en) 2004-12-28
US7307154B2 (en) 2007-12-11
PT1237915E (pt) 2009-11-04
RS50831B (sr) 2010-08-31
ZA200205638B (en) 2003-10-15
RO122543B1 (ro) 2009-08-28
RU2283130C2 (ru) 2006-09-10
WO2001044291A2 (en) 2001-06-21
LT2002070A (en) 2003-04-25
LT5046B (lt) 2003-08-25
CA2394574A1 (en) 2001-06-21
HUP0204224A2 (hu) 2003-03-28
BG106823A (bg) 2003-04-30
US7893217B2 (en) 2011-02-22
KR20020065575A (ko) 2002-08-13
HRP20020549B1 (hr) 2013-09-30
NO20022836D0 (no) 2002-06-14
NO330924B1 (no) 2011-08-22
US7887804B2 (en) 2011-02-15
BR0017022A (pt) 2002-11-05
KR100752434B1 (ko) 2007-08-27
SK286384B6 (sk) 2008-08-05
NZ519598A (en) 2004-03-26
US20090214422A1 (en) 2009-08-27
EP1237915B1 (en) 2009-08-26

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