CN1294948C - 一种益气健脾滋补肝肾的药物及其制备方法 - Google Patents
一种益气健脾滋补肝肾的药物及其制备方法 Download PDFInfo
- Publication number
- CN1294948C CN1294948C CNB2004100216290A CN200410021629A CN1294948C CN 1294948 C CN1294948 C CN 1294948C CN B2004100216290 A CNB2004100216290 A CN B2004100216290A CN 200410021629 A CN200410021629 A CN 200410021629A CN 1294948 C CN1294948 C CN 1294948C
- Authority
- CN
- China
- Prior art keywords
- parts
- kidney
- portions
- medicine
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 44
- 210000000952 spleen Anatomy 0.000 title claims abstract description 27
- 210000003734 kidney Anatomy 0.000 title claims abstract description 23
- 210000004185 liver Anatomy 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 229940079593 drug Drugs 0.000 title claims description 22
- 238000005728 strengthening Methods 0.000 title 1
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 241000208340 Araliaceae Species 0.000 claims abstract description 18
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 18
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 18
- 235000008434 ginseng Nutrition 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 241000756943 Codonopsis Species 0.000 claims description 13
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000012567 medical material Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Chemical class 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical class O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Chemical class 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000001913 cellulose Chemical class 0.000 claims description 2
- 229920002678 cellulose Chemical class 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000007812 deficiency Effects 0.000 abstract description 12
- 210000004072 lung Anatomy 0.000 abstract description 11
- 239000002994 raw material Substances 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 6
- 208000002173 dizziness Diseases 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 5
- 230000036528 appetite Effects 0.000 abstract description 4
- 235000019789 appetite Nutrition 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract description 3
- 206010022437 insomnia Diseases 0.000 abstract description 3
- 210000003127 knee Anatomy 0.000 abstract description 3
- 208000009205 Tinnitus Diseases 0.000 abstract description 2
- 230000002269 spontaneous effect Effects 0.000 abstract description 2
- 231100000886 tinnitus Toxicity 0.000 abstract description 2
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000006545 Ziziphus mauritiana Nutrition 0.000 abstract 2
- 244000126002 Ziziphus vulgaris Species 0.000 abstract 2
- 235000008529 Ziziphus vulgaris Nutrition 0.000 abstract 2
- 229940107666 astragalus root Drugs 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 239000008492 tangshen Substances 0.000 abstract 2
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 208000008454 Hyperhidrosis Diseases 0.000 abstract 1
- 206010033557 Palpitations Diseases 0.000 abstract 1
- 208000026500 emaciation Diseases 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000035900 sweating Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 13
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000013558 reference substance Substances 0.000 description 6
- 230000036039 immunity Effects 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 description 3
- 210000000629 knee joint Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 241000216654 Armillaria Species 0.000 description 1
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 241000272184 Falconiformes Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- DLUOMMXONAIKQD-UHFFFAOYSA-N OC=O.ClC(Cl)Cl.CCOC(C)=O Chemical compound OC=O.ClC(Cl)Cl.CCOC(C)=O DLUOMMXONAIKQD-UHFFFAOYSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 241001088563 Trichotoma Species 0.000 description 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- SIHHLZPXQLFPMC-UHFFFAOYSA-N chloroform;methanol;hydrate Chemical compound O.OC.ClC(Cl)Cl SIHHLZPXQLFPMC-UHFFFAOYSA-N 0.000 description 1
- 229960003290 cortisone acetate Drugs 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 description 1
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
项目 | 治疗前 | 治疗后 | ||
正常 | 异常 | 正常 | 异常 | |
血常规 | 140 | 0 | 140 | 0 |
尿常规 | 118 | 22 | 131 | 12 |
大便常规 | 140 | 0 | 140 | 0 |
肝功 | 140 | 0 | 140 | 0 |
肾功 | 140 | 0 | 140 | 0 |
免疫 | 134 | 6 | 140 | 0 |
症状 | 组别 | 例数 | 治愈 | 显效 | 有效 | 无效 | 有效率(%) | P值 |
活动 | 试验组 | 29 | 12 | 5 | 10 | 2 | 93.1 | X2=1.69 |
对照组 | 10 | 2 | 3 | 4 | 1 | 90.0 | P>0.05 | |
精神 | 试验组 | 30 | 10 | 3 | 15 | 2 | 93.3 | X2=5.41 |
对照组 | 10 | 2 | 6 | 2 | 80.0 | P>0.05 | ||
食欲 | 试验组 | 30 | 8 | 8 | 11 | 3 | 90.0 | X2=3.73 |
对照组 | 10 | 4 | 4 | 2 | 80.0 | P>0.05 | ||
腰膝 | 试验组 | 28 | 7 | 5 | 14 | 2 | 92.9 | X2=4.13 |
对照组 | 10 | 1 | 4 | 3 | 2 | 80.0 | P>0.05 | |
头昏 | 试验组 | 28 | 4 | 7 | 14 | 3 | 89.3 | X2=6.20 |
对照组 | 10 | 5 | 2 | 3 | 70.0 | P>0.05 | ||
头晕 | 试验组 | 25 | 6 | 7 | 7 | 5 | 80.0 | X2=3.68 |
对照组 | 9 | 5 | 2 | 2 | 77.8 | P>0.05 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100216290A CN1294948C (zh) | 2004-01-05 | 2004-01-05 | 一种益气健脾滋补肝肾的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100216290A CN1294948C (zh) | 2004-01-05 | 2004-01-05 | 一种益气健脾滋补肝肾的药物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1555872A CN1555872A (zh) | 2004-12-22 |
CN1294948C true CN1294948C (zh) | 2007-01-17 |
Family
ID=34351957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100216290A Expired - Fee Related CN1294948C (zh) | 2004-01-05 | 2004-01-05 | 一种益气健脾滋补肝肾的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1294948C (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102423481B (zh) * | 2011-12-30 | 2013-05-22 | 陈绍珣 | 治疗糖尿病的药物及制备方法 |
CN102960724A (zh) * | 2012-11-21 | 2013-03-13 | 绍兴市古煌酿酒有限公司 | 一种四季养生五补酒 |
CN108096374A (zh) * | 2017-12-28 | 2018-06-01 | 长春广禾生物科技有限公司 | 一种保健饮品及其制备方法 |
CN112655850A (zh) * | 2021-01-08 | 2021-04-16 | 刘冬健 | 一种康复饮品 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1224057A (zh) * | 1998-08-24 | 1999-07-28 | 刘广东 | 一种保健养生酒 |
-
2004
- 2004-01-05 CN CNB2004100216290A patent/CN1294948C/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1224057A (zh) * | 1998-08-24 | 1999-07-28 | 刘广东 | 一种保健养生酒 |
Also Published As
Publication number | Publication date |
---|---|
CN1555872A (zh) | 2004-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1857690A (zh) | 妇科病制剂及新的制备方法 | |
CN1299742C (zh) | 一种治疗糖尿病的药物及其制备方法 | |
CN1923256A (zh) | 一种药物组合物及其制备方法和质量控制方法 | |
CN102671178B (zh) | 一种治疗肾病综合症及尿毒症的中药组合物配制方法及应用 | |
CN1887330A (zh) | 一种中药组合物及其制备方法和质量控制方法 | |
CN103006989B (zh) | 一种治疗糖尿病肾病的药物组合物 | |
CN1887324B (zh) | 一种治疗肝肾不足的中药组合物及其制备方法和分析方法 | |
CN100341547C (zh) | 一种具有调节血脂作用的药物组合物及其制备方法和用途 | |
CN1294948C (zh) | 一种益气健脾滋补肝肾的药物及其制备方法 | |
CN102652774B (zh) | 一种治疗放化疗引起的白细胞减少症、免疫功能低下药物组合物、制备方法与质量检测方法 | |
CN1931233B (zh) | 一种用于治疗心脑血管疾病的丹参和淫羊藿的药用组合物 | |
CN1927324A (zh) | 用于治疗妇女月经不调中药制剂的制备方法 | |
CN105250989A (zh) | 一种用于抗疲劳的阿胶小肽组合物 | |
CN101919985A (zh) | 一种治疗脂肪肝的药物及其制备方法和用途 | |
CN113304235B (zh) | 一种中药组合物及其制备方法和应用 | |
CN103110100A (zh) | 一种朝医保健食品组合物及其制备方法和用途 | |
CN100493522C (zh) | 一种苦参素和多糖的药物组合物 | |
CN1107711A (zh) | 复方降糖胶囊 | |
CN103393938B (zh) | 一种降血糖的中药组合物 | |
CN102949681B (zh) | 一种预防或治疗感冒的组合物及其制备方法 | |
CN1272047C (zh) | 一种补益肝肾治疗肠燥便秘的药物 | |
CN1977888B (zh) | 一种由黄芩苷、灵芝和丹参制成的药物组合物 | |
CN1182862C (zh) | 一种治疗冠心病心绞痛的中药制剂及其制备方法 | |
CN111388584A (zh) | 一种治疗阳痿的组合物及其制备方法 | |
CN103263581A (zh) | 用于降血糖的双参胶囊 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: YUNNAN PAIYAO GROUP CORP., LTD. Free format text: FORMER OWNER: TIANZIHONG PHARMACEUTICAL CO., LTD., YUNNAN BAIYAO GROUP Effective date: 20070420 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20070420 Address after: 650118 No. 222 West Second Ring Road, Yunnan, Kunming Patentee after: Yunnan Baiyao Group Co.,Ltd. Address before: 650228 Yunnan city of Kunming province old Geng Lu Ma SA Ying No. 130 Patentee before: Yunnan Baiyao Group Tianzihong Pharmaceutical Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070117 |