CN1292698A - 甘氨酸传递抑制剂 - Google Patents
甘氨酸传递抑制剂 Download PDFInfo
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- CN1292698A CN1292698A CN998036471A CN99803647A CN1292698A CN 1292698 A CN1292698 A CN 1292698A CN 998036471 A CN998036471 A CN 998036471A CN 99803647 A CN99803647 A CN 99803647A CN 1292698 A CN1292698 A CN 1292698A
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- 239000000203 mixture Substances 0.000 claims description 28
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pain & Pain Management (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98200701 | 1998-03-06 | ||
| EP98200701.5 | 1998-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1292698A true CN1292698A (zh) | 2001-04-25 |
Family
ID=8233444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN998036471A Pending CN1292698A (zh) | 1998-03-06 | 1999-02-26 | 甘氨酸传递抑制剂 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1059922A2 (xx) |
| JP (1) | JP2002505277A (xx) |
| KR (1) | KR20010032968A (xx) |
| CN (1) | CN1292698A (xx) |
| AU (1) | AU3408999A (xx) |
| BG (1) | BG104685A (xx) |
| BR (1) | BR9907951A (xx) |
| CA (1) | CA2322164A1 (xx) |
| EE (1) | EE200000482A (xx) |
| HR (1) | HRP20000523A2 (xx) |
| HU (1) | HUP0101048A2 (xx) |
| IL (1) | IL138228A0 (xx) |
| NO (1) | NO20004431L (xx) |
| PL (1) | PL343435A1 (xx) |
| SK (1) | SK13082000A3 (xx) |
| TR (1) | TR200002567T2 (xx) |
| WO (1) | WO1999044596A2 (xx) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100341871C (zh) * | 2005-06-03 | 2007-10-10 | 复旦大学 | 含哌啶结构的有机硫化合物，制备方法和应用 |
| CN101072762B (zh) * | 2004-12-09 | 2010-06-23 | 弗·哈夫曼-拉罗切有限公司 | 苯基-哌嗪甲酮衍生物 |
| CN101137363B (zh) * | 2005-01-07 | 2010-09-15 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的[4-(杂芳基)哌嗪-1-基]-(2,5-取代的-苯基)甲酮衍生物 |
| CN101141959B (zh) * | 2005-01-18 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的2,5-二取代的苯甲酮衍生物 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60033859T2 (de) * | 1999-06-28 | 2007-11-08 | Janssen Pharmaceutica N.V. | Hemmer des Respiratorischen Syncytial Virus |
| UA73749C2 (en) * | 1999-11-01 | 2005-09-15 | Diarylenines | |
| WO2001081308A2 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| AU2001288896A1 (en) | 2000-09-08 | 2002-03-22 | Gliatech, Inc. | Substituted hydrazine derivatives |
| EP1324986A1 (en) | 2000-09-14 | 2003-07-09 | Gliatech, Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
| AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
| US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| NZ545454A (en) | 2003-09-09 | 2009-11-27 | Hoffmann La Roche | 1-(2-amino-benzoyl)-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
| NZ545613A (en) * | 2003-09-09 | 2009-11-27 | Hoffmann La Roche | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
| WO2005058885A2 (en) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Piperidine derivatives and their use as glycine transporter inhibitors |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| NZ555476A (en) * | 2004-12-15 | 2009-09-25 | Hoffmann La Roche | Bi- and tricyclic substituted phenyl methanones as glycine transporter I (GLYT-1) inhibitors for the treatment of alzheimerÆs disease |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
| EP1836178A1 (en) * | 2005-01-06 | 2007-09-26 | F. Hoffmann-Roche AG | Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders |
| RU2007126951A (ru) | 2005-01-26 | 2009-03-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные фенилметанона и их применение в качестве ингибиторов переносчика глицина 1 |
| CA2596636C (en) * | 2005-02-07 | 2016-04-12 | F. Hoffmann-La Roche Ag | Heterocyclyl substituted phenyl methanones as inhibitors of the glycine transporter 1 |
| WO2007110449A1 (en) | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| US8791264B2 (en) | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| TW200812963A (en) | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
| WO2008053352A2 (en) * | 2006-11-01 | 2008-05-08 | Purdue Pharma L.P. | Phenylpropionamide compounds and the use thereof |
| FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910320B1 (fr) * | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| WO2008124118A1 (en) | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
| WO2009040659A2 (en) | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| AU2008335788B2 (en) * | 2007-12-12 | 2012-11-29 | Amgen Inc. | Glycine transporter-1 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
| CA1140119A (en) * | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
| AU1041599A (en) * | 1997-11-13 | 1999-06-07 | Jose Luis Castro Pineiro | Therapeutic uses of triazolo-pyridazine derivatives |
-
1999
- 1999-02-26 CA CA002322164A patent/CA2322164A1/en not_active Abandoned
- 1999-02-26 PL PL99343435A patent/PL343435A1/xx not_active Application Discontinuation
- 1999-02-26 SK SK1308-2000A patent/SK13082000A3/sk unknown
- 1999-02-26 EP EP99915541A patent/EP1059922A2/en not_active Withdrawn
- 1999-02-26 BR BR9907951-8A patent/BR9907951A/pt not_active Application Discontinuation
- 1999-02-26 IL IL13822899A patent/IL138228A0/xx unknown
- 1999-02-26 WO PCT/EP1999/001309 patent/WO1999044596A2/en not_active Application Discontinuation
- 1999-02-26 KR KR1020007006315A patent/KR20010032968A/ko not_active Application Discontinuation
- 1999-02-26 JP JP2000534198A patent/JP2002505277A/ja not_active Withdrawn
- 1999-02-26 TR TR2000/02567T patent/TR200002567T2/xx unknown
- 1999-02-26 EE EEP200000482A patent/EE200000482A/xx unknown
- 1999-02-26 CN CN998036471A patent/CN1292698A/zh active Pending
- 1999-02-26 HU HU0101048A patent/HUP0101048A2/hu unknown
- 1999-02-26 AU AU34089/99A patent/AU3408999A/en not_active Abandoned
-
2000
- 2000-08-02 HR HR20000523A patent/HRP20000523A2/hr not_active Application Discontinuation
- 2000-08-11 BG BG104685A patent/BG104685A/xx unknown
- 2000-09-05 NO NO20004431A patent/NO20004431L/no not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101072762B (zh) * | 2004-12-09 | 2010-06-23 | 弗·哈夫曼-拉罗切有限公司 | 苯基-哌嗪甲酮衍生物 |
| CN101137363B (zh) * | 2005-01-07 | 2010-09-15 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的[4-(杂芳基)哌嗪-1-基]-(2,5-取代的-苯基)甲酮衍生物 |
| CN101141959B (zh) * | 2005-01-18 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的2,5-二取代的苯甲酮衍生物 |
| CN100341871C (zh) * | 2005-06-03 | 2007-10-10 | 复旦大学 | 含哌啶结构的有机硫化合物，制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101048A2 (hu) | 2001-10-28 |
| NO20004431D0 (no) | 2000-09-05 |
| BG104685A (en) | 2001-04-30 |
| AU3408999A (en) | 1999-09-20 |
| WO1999044596A3 (en) | 2000-02-17 |
| EP1059922A2 (en) | 2000-12-20 |
| CA2322164A1 (en) | 1999-09-10 |
| HRP20000523A2 (en) | 2001-02-28 |
| PL343435A1 (en) | 2001-08-13 |
| WO1999044596A2 (en) | 1999-09-10 |
| EE200000482A (et) | 2002-02-15 |
| IL138228A0 (en) | 2001-10-31 |
| BR9907951A (pt) | 2001-01-30 |
| TR200002567T2 (tr) | 2000-11-21 |
| KR20010032968A (ko) | 2001-04-25 |
| JP2002505277A (ja) | 2002-02-19 |
| SK13082000A3 (sk) | 2001-03-12 |
| NO20004431L (no) | 2000-10-30 |
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