CN1285738A - 卡维地洛的新的口服剂型 - Google Patents

卡维地洛的新的口服剂型 Download PDF

Info

Publication number
CN1285738A
CN1285738A CN98813082A CN98813082A CN1285738A CN 1285738 A CN1285738 A CN 1285738A CN 98813082 A CN98813082 A CN 98813082A CN 98813082 A CN98813082 A CN 98813082A CN 1285738 A CN1285738 A CN 1285738A
Authority
CN
China
Prior art keywords
carvedilol
preparation
coating
label
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98813082A
Other languages
English (en)
Chinese (zh)
Inventor
C·K·沃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Mannheim Pharmaceuticals Corp- Smithkline Bechman Corp Ltd Partner
Original Assignee
Boehringer Mannheim Pharmaceuticals Corp- Smithkline Bechman Corp Ltd Partner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Pharmaceuticals Corp- Smithkline Bechman Corp Ltd Partner filed Critical Boehringer Mannheim Pharmaceuticals Corp- Smithkline Bechman Corp Ltd Partner
Publication of CN1285738A publication Critical patent/CN1285738A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
CN98813082A 1997-11-12 1998-11-12 卡维地洛的新的口服剂型 Pending CN1285738A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6545697P 1997-11-12 1997-11-12
US60/065,456 1997-11-12

Publications (1)

Publication Number Publication Date
CN1285738A true CN1285738A (zh) 2001-02-28

Family

ID=22062830

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98813082A Pending CN1285738A (zh) 1997-11-12 1998-11-12 卡维地洛的新的口服剂型

Country Status (14)

Country Link
EP (1) EP1030651A4 (hu)
JP (1) JP2001522794A (hu)
KR (1) KR20010031952A (hu)
CN (1) CN1285738A (hu)
AU (1) AU751117B2 (hu)
BR (1) BR9814127A (hu)
CA (1) CA2309542A1 (hu)
HU (1) HUP0004345A3 (hu)
IL (1) IL136028A0 (hu)
NO (1) NO20002439L (hu)
NZ (1) NZ504418A (hu)
PL (1) PL340456A1 (hu)
TR (1) TR200001362T2 (hu)
WO (1) WO1999024017A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011038683A1 (zh) * 2009-09-29 2011-04-07 台湾东洋药品工业股份有限公司 卡维地洛控释剂

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
WO2004056336A2 (en) * 2002-12-20 2004-07-08 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
WO2005051325A2 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Carvedilol compositions methods of treatment and delivery
WO2005051322A2 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts
CA2648278C (en) * 2006-04-03 2019-05-28 Isa Odidi Drug delivery composition
EP2540318B1 (en) 2010-02-22 2018-10-24 Daiichi Sankyo Company, Limited Sustained-release solid preparation for oral use
EP2540317A4 (en) * 2010-02-22 2014-04-16 Daiichi Sankyo Co Ltd SOLID PREPARATION WITH DELAYED RELEASE FOR ORAL ADMINISTRATION
EP2540294B1 (en) * 2010-02-22 2016-08-03 Daiichi Sankyo Company, Limited Sustained-release solid preparation for oral use
RU2665372C2 (ru) 2012-09-03 2018-08-29 Дайити Санкио Компани, Лимитед Пероральная фармацевтическая композиция замедленного высвобождения, содержащая гидрохлорид гидроморфона
KR102158339B1 (ko) * 2016-02-05 2020-09-21 삼진제약주식회사 인습성이 개선된 카르베딜롤 속방성 제제
KR102492147B1 (ko) 2020-12-30 2023-01-26 단국대학교 천안캠퍼스 산학협력단 자가나노유화 약물전달 시스템을 이용한 카베디롤 함유 경구용 고형제제 조성물 및 이의 제조방법
KR102525298B1 (ko) 2020-12-30 2023-04-25 단국대학교 천안캠퍼스 산학협력단 경구 생체이용률이 증가된 주석산을 포함하는 카베디롤 함유 고체분산체 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
CA2094716C (en) * 1990-10-23 1999-03-23 Kumar Rajaratnam Back support for a chair or seat
US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
DE19637082A1 (de) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Schnellzerfallende Pellets

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011038683A1 (zh) * 2009-09-29 2011-04-07 台湾东洋药品工业股份有限公司 卡维地洛控释剂
CN102740838A (zh) * 2009-09-29 2012-10-17 东生华制药股份有限公司 卡维地洛控释剂
TWI415604B (zh) * 2009-09-29 2013-11-21 Tsh Biopharm Corp Ltd 調控釋放卡菲蒂羅劑型
US8883207B2 (en) 2009-09-29 2014-11-11 Tsh Biopharm Corporation Ltd. Controlled release carvedilol formulation
CN102740838B (zh) * 2009-09-29 2015-07-01 东生华制药股份有限公司 卡维地洛控释剂

Also Published As

Publication number Publication date
TR200001362T2 (tr) 2000-09-21
HUP0004345A2 (hu) 2001-06-28
PL340456A1 (en) 2001-02-12
CA2309542A1 (en) 1999-05-20
KR20010031952A (ko) 2001-04-16
NO20002439D0 (no) 2000-05-11
WO1999024017A1 (en) 1999-05-20
HUP0004345A3 (en) 2001-10-29
EP1030651A1 (en) 2000-08-30
JP2001522794A (ja) 2001-11-20
NO20002439L (no) 2000-05-11
EP1030651A4 (en) 2006-05-31
NZ504418A (en) 2003-02-28
AU751117B2 (en) 2002-08-08
AU1456999A (en) 1999-05-31
BR9814127A (pt) 2000-10-03
IL136028A0 (en) 2001-05-20

Similar Documents

Publication Publication Date Title
CN1298317C (zh) 坦洛新片剂
CN1303998C (zh) 含有达非那新的药物制剂
CN1023293C (zh) 一种含有美多心安盐的控制释放制剂的制备方法
CN1195499C (zh) 肠溶衣药用片剂及其生产方法
CN1151844C (zh) 药学活性颗粒的制备
CN1040061C (zh) 控释药物制剂的制备方法
CN1104891C (zh) 缓释制剂
CN1142780C (zh) 药用组合物
CN1134108A (zh) 用于控释的新颗粒及含有该颗粒的药物制剂
CN1886119A (zh) 泮托拉唑多颗粒制剂
CN1184971C (zh) 药物组合制剂
CN1080169A (zh) 含有水溶性药物的控释片
CN101374505A (zh) 多单元型持续释放口服制剂及其制备方法
CN1321088A (zh) 雷诺嗪持续释放制剂
CN1285738A (zh) 卡维地洛的新的口服剂型
CN1626093A (zh) 奥卡西平包膜片剂
CN1747723A (zh) 含活性成分混合物的组合物及其制备方法
CN1744889A (zh) 坦洛新的控释药物组合物
CN1161112C (zh) 含氯雷他定和伪麻黄碱的药物胶囊组合物
CN1207672A (zh) 含有5-asa的控释口服药物组合物及其治疗肠道疾病的方法
CN1272785A (zh) 微渗透药物控释系统
JP3910939B2 (ja) 単一物質球形粒、それらを用いた食品、医薬及びそれらの製法
CN1634116A (zh) 司他夫定缓释片剂及其制备方法
CN1946376A (zh) 包衣片剂组合物及其制法
CN1529587A (zh) 含有粪便软化剂泊洛沙姆和包有肠溶衣的比沙可定颗粒的药物组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication