WO1999024017A1 - Novel oral dosage form for carvedilol - Google Patents
Novel oral dosage form for carvedilol Download PDFInfo
- Publication number
- WO1999024017A1 WO1999024017A1 PCT/US1998/024102 US9824102W WO9924017A1 WO 1999024017 A1 WO1999024017 A1 WO 1999024017A1 US 9824102 W US9824102 W US 9824102W WO 9924017 A1 WO9924017 A1 WO 9924017A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carvedilol
- formulation
- release
- coating
- matrix
- Prior art date
Links
- OGHNVEJMJSYVRP-UHFFFAOYSA-N COc(cccc1)c1OCCNCC(COc1c(c2ccccc2[nH]2)c2ccc1)O Chemical compound COc(cccc1)c1OCCNCC(COc1c(c2ccccc2[nH]2)c2ccc1)O OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000520110A JP2001522794A (en) | 1997-11-12 | 1998-11-12 | New oral dosage form of carvedilol |
KR1020007005059A KR20010031952A (en) | 1997-11-12 | 1998-11-12 | Novel Oral Dosage Form for Carvedilol |
BR9814127-9A BR9814127A (en) | 1997-11-12 | 1998-11-12 | New oral dosage form for carvedilol |
NZ504418A NZ504418A (en) | 1997-11-12 | 1998-11-12 | Delayed release oral dosage form of carvedilol |
IL13602898A IL136028A0 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form for carvedilol |
EP98958546A EP1030651A4 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form for carvedilol |
HU0004345A HUP0004345A3 (en) | 1997-11-12 | 1998-11-12 | Novel oral pharmaceutical compositions containing from carvedilol |
AU14569/99A AU751117B2 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form for carvedilol |
PL98340456A PL340456A1 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form of carvedilol |
CA002309542A CA2309542A1 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form for carvedilol |
NO20002439A NO20002439L (en) | 1997-11-12 | 2000-05-11 | New oral dosage forms for carvediol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6545697P | 1997-11-12 | 1997-11-12 | |
US60/065,456 | 1997-11-12 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09554307 A-371-Of-International | 2000-05-11 | ||
US09/974,460 Continuation US20020054911A1 (en) | 1997-11-12 | 2001-10-09 | Novel oral dosage form for carvedilol |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999024017A1 true WO1999024017A1 (en) | 1999-05-20 |
Family
ID=22062830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/024102 WO1999024017A1 (en) | 1997-11-12 | 1998-11-12 | Novel oral dosage form for carvedilol |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1030651A4 (en) |
JP (1) | JP2001522794A (en) |
KR (1) | KR20010031952A (en) |
CN (1) | CN1285738A (en) |
AU (1) | AU751117B2 (en) |
BR (1) | BR9814127A (en) |
CA (1) | CA2309542A1 (en) |
HU (1) | HUP0004345A3 (en) |
IL (1) | IL136028A0 (en) |
NO (1) | NO20002439L (en) |
NZ (1) | NZ504418A (en) |
PL (1) | PL340456A1 (en) |
TR (1) | TR200001362T2 (en) |
WO (1) | WO1999024017A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004056336A2 (en) * | 2002-12-20 | 2004-07-08 | Ranbaxy Laboratories Limited | Controlled release, multiple unit drug delivery systems |
EP1691789A4 (en) * | 2003-11-25 | 2012-08-08 | Smithkline Beecham Cork Ltd | Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
US8449914B2 (en) | 2002-11-08 | 2013-05-28 | Egalet Ltd. | Controlled release carvedilol compositions |
US9629808B2 (en) | 2010-02-22 | 2017-04-25 | Daiichi Sankyo Company, Limited | Sustained-release solid preparation for oral use |
KR20170093589A (en) * | 2016-02-05 | 2017-08-16 | 삼진제약주식회사 | Carvedilol immediate release formulation having improved madescent |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050169994A1 (en) * | 2003-11-25 | 2005-08-04 | Burke Matthew D. | Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
JP5349290B2 (en) * | 2006-04-03 | 2013-11-20 | オディディ,イサ | Drug delivery composition, pharmaceutical comprising the same, and method for producing the same |
TWI415604B (en) * | 2009-09-29 | 2013-11-21 | Tsh Biopharm Corp Ltd | Controlled release carvediolol formulation |
WO2011102505A1 (en) * | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | Sustained-release solid preparation for oral use |
TW201200165A (en) * | 2010-02-22 | 2012-01-01 | Daiichi Sankyo Co Ltd | Oral solid extended release dosage form |
CN104768552A (en) | 2012-09-03 | 2015-07-08 | 第一三共株式会社 | Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition |
KR102525298B1 (en) | 2020-12-30 | 2023-04-25 | 단국대학교 천안캠퍼스 산학협력단 | Carvedilol loaded solid dispersion with increased oral bioavailability and methods for their preparation |
KR102492147B1 (en) | 2020-12-30 | 2023-01-26 | 단국대학교 천안캠퍼스 산학협력단 | Carvedilol loaded solid oral compositions using self-nanoemulsifying drug delivery system and methods for their preparation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4287221A (en) * | 1979-01-16 | 1981-09-01 | Shin-Etsu Chemical Co., Ltd. | Method for providing enteric coating on solid dosage forms |
US4343789A (en) * | 1979-07-05 | 1982-08-10 | Yamanouchi Pharmaceutical Co., Ltd. | Sustained release pharmaceutical composition of solid medical material |
US4503067A (en) * | 1978-04-13 | 1985-03-05 | Boehringer Mannheim Gmbh | Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions |
US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006622A1 (en) * | 1990-10-23 | 1992-04-30 | Davband Pty. Limited | Back support for a chair or seat |
US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
DE19637082A1 (en) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Rapidly disintegrating pellets |
-
1998
- 1998-11-12 BR BR9814127-9A patent/BR9814127A/en not_active IP Right Cessation
- 1998-11-12 IL IL13602898A patent/IL136028A0/en not_active IP Right Cessation
- 1998-11-12 HU HU0004345A patent/HUP0004345A3/en unknown
- 1998-11-12 CA CA002309542A patent/CA2309542A1/en not_active Abandoned
- 1998-11-12 WO PCT/US1998/024102 patent/WO1999024017A1/en not_active Application Discontinuation
- 1998-11-12 TR TR2000/01362T patent/TR200001362T2/en unknown
- 1998-11-12 PL PL98340456A patent/PL340456A1/en unknown
- 1998-11-12 KR KR1020007005059A patent/KR20010031952A/en not_active Application Discontinuation
- 1998-11-12 EP EP98958546A patent/EP1030651A4/en not_active Withdrawn
- 1998-11-12 NZ NZ504418A patent/NZ504418A/en unknown
- 1998-11-12 AU AU14569/99A patent/AU751117B2/en not_active Ceased
- 1998-11-12 CN CN98813082A patent/CN1285738A/en active Pending
- 1998-11-12 JP JP2000520110A patent/JP2001522794A/en active Pending
-
2000
- 2000-05-11 NO NO20002439A patent/NO20002439L/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4503067A (en) * | 1978-04-13 | 1985-03-05 | Boehringer Mannheim Gmbh | Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions |
US4287221A (en) * | 1979-01-16 | 1981-09-01 | Shin-Etsu Chemical Co., Ltd. | Method for providing enteric coating on solid dosage forms |
US4343789A (en) * | 1979-07-05 | 1982-08-10 | Yamanouchi Pharmaceutical Co., Ltd. | Sustained release pharmaceutical composition of solid medical material |
US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
Non-Patent Citations (1)
Title |
---|
See also references of EP1030651A4 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8449914B2 (en) | 2002-11-08 | 2013-05-28 | Egalet Ltd. | Controlled release carvedilol compositions |
WO2004056336A2 (en) * | 2002-12-20 | 2004-07-08 | Ranbaxy Laboratories Limited | Controlled release, multiple unit drug delivery systems |
WO2004056336A3 (en) * | 2002-12-20 | 2004-09-10 | Ranbaxy Lab Ltd | Controlled release, multiple unit drug delivery systems |
EP1691789A4 (en) * | 2003-11-25 | 2012-08-08 | Smithkline Beecham Cork Ltd | Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
USRE47084E1 (en) | 2003-11-25 | 2018-10-16 | Flamel Ireland Limited | Oral medicinal product with modified release of at least one active principle in multimicrocapsular form |
US9629808B2 (en) | 2010-02-22 | 2017-04-25 | Daiichi Sankyo Company, Limited | Sustained-release solid preparation for oral use |
KR20170093589A (en) * | 2016-02-05 | 2017-08-16 | 삼진제약주식회사 | Carvedilol immediate release formulation having improved madescent |
Also Published As
Publication number | Publication date |
---|---|
EP1030651A1 (en) | 2000-08-30 |
CA2309542A1 (en) | 1999-05-20 |
HUP0004345A3 (en) | 2001-10-29 |
AU751117B2 (en) | 2002-08-08 |
EP1030651A4 (en) | 2006-05-31 |
AU1456999A (en) | 1999-05-31 |
BR9814127A (en) | 2000-10-03 |
PL340456A1 (en) | 2001-02-12 |
IL136028A0 (en) | 2001-05-20 |
TR200001362T2 (en) | 2000-09-21 |
NZ504418A (en) | 2003-02-28 |
KR20010031952A (en) | 2001-04-16 |
JP2001522794A (en) | 2001-11-20 |
HUP0004345A2 (en) | 2001-06-28 |
NO20002439D0 (en) | 2000-05-11 |
CN1285738A (en) | 2001-02-28 |
NO20002439L (en) | 2000-05-11 |
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