EP1030651A4 - Novel oral dosage form for carvedilol - Google Patents

Novel oral dosage form for carvedilol

Info

Publication number
EP1030651A4
EP1030651A4 EP98958546A EP98958546A EP1030651A4 EP 1030651 A4 EP1030651 A4 EP 1030651A4 EP 98958546 A EP98958546 A EP 98958546A EP 98958546 A EP98958546 A EP 98958546A EP 1030651 A4 EP1030651 A4 EP 1030651A4
Authority
EP
European Patent Office
Prior art keywords
carvedilol
dosage form
oral dosage
novel oral
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98958546A
Other languages
German (de)
French (fr)
Other versions
EP1030651A1 (en
Inventor
Choon K Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Roche Diagnostics Corp
Original Assignee
BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Boehringer Mannheim Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP, Boehringer Mannheim Pharmaceuticals Corp filed Critical BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Publication of EP1030651A1 publication Critical patent/EP1030651A1/en
Publication of EP1030651A4 publication Critical patent/EP1030651A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
EP98958546A 1997-11-12 1998-11-12 Novel oral dosage form for carvedilol Withdrawn EP1030651A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6545697P 1997-11-12 1997-11-12
US65456P 1997-11-12
PCT/US1998/024102 WO1999024017A1 (en) 1997-11-12 1998-11-12 Novel oral dosage form for carvedilol

Publications (2)

Publication Number Publication Date
EP1030651A1 EP1030651A1 (en) 2000-08-30
EP1030651A4 true EP1030651A4 (en) 2006-05-31

Family

ID=22062830

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98958546A Withdrawn EP1030651A4 (en) 1997-11-12 1998-11-12 Novel oral dosage form for carvedilol

Country Status (14)

Country Link
EP (1) EP1030651A4 (en)
JP (1) JP2001522794A (en)
KR (1) KR20010031952A (en)
CN (1) CN1285738A (en)
AU (1) AU751117B2 (en)
BR (1) BR9814127A (en)
CA (1) CA2309542A1 (en)
HU (1) HUP0004345A3 (en)
IL (1) IL136028A0 (en)
NO (1) NO20002439D0 (en)
NZ (1) NZ504418A (en)
PL (1) PL340456A1 (en)
TR (1) TR200001362T2 (en)
WO (1) WO1999024017A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
AU2003288608A1 (en) * 2002-12-20 2004-07-14 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
JP2007512350A (en) * 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド Carvedilol composition treatment and delivery methods
US8734850B2 (en) * 2003-11-25 2014-05-27 Flamel Technologies Oral medicinal product with modified release of at least one active principle in multimicrocapsular form
CA2648278C (en) * 2006-04-03 2019-05-28 Isa Odidi Drug delivery composition
TWI415604B (en) * 2009-09-29 2013-11-21 Tsh Biopharm Corp Ltd Controlled release carvediolol formulation
ES2706880T3 (en) * 2010-02-22 2019-04-01 Daiichi Sankyo Co Ltd Sustained-release solid preparation for oral use
WO2011102505A1 (en) * 2010-02-22 2011-08-25 第一三共株式会社 Sustained-release solid preparation for oral use
WO2011102506A1 (en) * 2010-02-22 2011-08-25 第一三共株式会社 Sustained-release solid preparation for oral use
BR112015004190A2 (en) 2012-09-03 2017-07-04 Daiichi Sankyo Co Ltd sustained release pharmaceutical composition, and method for producing a sustained release pharmaceutical composition
KR102158339B1 (en) * 2016-02-05 2020-09-21 삼진제약주식회사 Carvedilol immediate release formulation having improved madescent
KR102492147B1 (en) 2020-12-30 2023-01-26 단국대학교 천안캠퍼스 산학협력단 Carvedilol loaded solid oral compositions using self-nanoemulsifying drug delivery system and methods for their preparation
KR102525298B1 (en) 2020-12-30 2023-04-25 단국대학교 천안캠퍼스 산학협력단 Carvedilol loaded solid dispersion with increased oral bioavailability and methods for their preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010754A1 (en) * 1996-09-12 1998-03-19 Roche Diagnostics Gmbh Fast decomposing pellets
US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (en) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh NEW CARBAZOLYL- (4) -OXY-PROPANOLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
DK0554306T3 (en) * 1990-10-23 1996-03-18 Davband Pty Ltd Backrest for a chair or seat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
WO1998010754A1 (en) * 1996-09-12 1998-03-19 Roche Diagnostics Gmbh Fast decomposing pellets

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROTE LISTE SERVICE GMBH: "Rote Liste 1997", 1997, ECV - EDITIO CANTOR, AULENDORF, GERMANY, XP002352847 *
See also references of WO9924017A1 *

Also Published As

Publication number Publication date
NO20002439L (en) 2000-05-11
NZ504418A (en) 2003-02-28
HUP0004345A3 (en) 2001-10-29
KR20010031952A (en) 2001-04-16
TR200001362T2 (en) 2000-09-21
AU751117B2 (en) 2002-08-08
PL340456A1 (en) 2001-02-12
IL136028A0 (en) 2001-05-20
WO1999024017A1 (en) 1999-05-20
JP2001522794A (en) 2001-11-20
CA2309542A1 (en) 1999-05-20
HUP0004345A2 (en) 2001-06-28
AU1456999A (en) 1999-05-31
EP1030651A1 (en) 2000-08-30
CN1285738A (en) 2001-02-28
NO20002439D0 (en) 2000-05-11
BR9814127A (en) 2000-10-03

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Legal Events

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Effective date: 20070301