HUP0004345A2 - Novel oral pharmaceutical compositions containing from carvedilol - Google Patents

Novel oral pharmaceutical compositions containing from carvedilol

Info

Publication number
HUP0004345A2
HUP0004345A2 HU0004345A HUP0004345A HUP0004345A2 HU P0004345 A2 HUP0004345 A2 HU P0004345A2 HU 0004345 A HU0004345 A HU 0004345A HU P0004345 A HUP0004345 A HU P0004345A HU P0004345 A2 HUP0004345 A2 HU P0004345A2
Authority
HU
Hungary
Prior art keywords
carvedilol
pharmaceutical compositions
compositions containing
oral pharmaceutical
novel oral
Prior art date
Application number
HU0004345A
Other languages
Hungarian (hu)
Inventor
Choon K. Oh
Original Assignee
Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited Partnership No. 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited Partnership No. 1 filed Critical Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited Partnership No. 1
Publication of HUP0004345A2 publication Critical patent/HUP0004345A2/en
Publication of HUP0004345A3 publication Critical patent/HUP0004345A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány (I) képletű karvedilolt, azaz 1-[(4-karbazolil)-oxi]-3-{[2-(2-metoxi-fenoxi)-etil]-amino}-2- pro- panolt vagy a karvedilolnakegy gyógyászatilag elfogadható sóját tartalmazó új, szabályozotthatóanyag-felszabadítású vagy késleltetett hatóanyag-felszabadításúkészítményekre, valamint a készítmények bizonyos rendellenességek,például hipertenzió, angina vagy szívszélhűdés kezelésében és/vagymegelőzésében történő alkalmazására vonatkozik. ÓThe invention relates to carvedilol of formula (I), i.e. 1-[(4-carbazolyl)oxy]-3-{[2-(2-methoxyphenoxy)ethyl]amino}-2-propanol, or carvedilol has a medicinal applies to new, controlled-release or delayed-release preparations containing an acceptable salt, as well as the use of the preparations in the treatment and/or prevention of certain disorders, such as hypertension, angina or angina pectoris. HE

HU0004345A 1997-11-12 1998-11-12 Novel oral pharmaceutical compositions containing from carvedilol HUP0004345A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6545697P 1997-11-12 1997-11-12
PCT/US1998/024102 WO1999024017A1 (en) 1997-11-12 1998-11-12 Novel oral dosage form for carvedilol

Publications (2)

Publication Number Publication Date
HUP0004345A2 true HUP0004345A2 (en) 2001-06-28
HUP0004345A3 HUP0004345A3 (en) 2001-10-29

Family

ID=22062830

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004345A HUP0004345A3 (en) 1997-11-12 1998-11-12 Novel oral pharmaceutical compositions containing from carvedilol

Country Status (14)

Country Link
EP (1) EP1030651A4 (en)
JP (1) JP2001522794A (en)
KR (1) KR20010031952A (en)
CN (1) CN1285738A (en)
AU (1) AU751117B2 (en)
BR (1) BR9814127A (en)
CA (1) CA2309542A1 (en)
HU (1) HUP0004345A3 (en)
IL (1) IL136028A0 (en)
NO (1) NO20002439D0 (en)
NZ (1) NZ504418A (en)
PL (1) PL340456A1 (en)
TR (1) TR200001362T2 (en)
WO (1) WO1999024017A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1562552A1 (en) 2002-11-08 2005-08-17 Egalet A/S Controlled release carvedilol compositions
WO2004056336A2 (en) * 2002-12-20 2004-07-08 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
EP1686967A4 (en) * 2003-11-25 2012-08-08 Smithkline Beecham Cork Ltd Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
US8734850B2 (en) * 2003-11-25 2014-05-27 Flamel Technologies Oral medicinal product with modified release of at least one active principle in multimicrocapsular form
CA2648278C (en) * 2006-04-03 2019-05-28 Isa Odidi Drug delivery composition
TWI415604B (en) * 2009-09-29 2013-11-21 Tsh Biopharm Corp Ltd Controlled release carvediolol formulation
WO2011102506A1 (en) * 2010-02-22 2011-08-25 第一三共株式会社 Sustained-release solid preparation for oral use
ES2706880T3 (en) 2010-02-22 2019-04-01 Daiichi Sankyo Co Ltd Sustained-release solid preparation for oral use
EP2540317A4 (en) * 2010-02-22 2014-04-16 Daiichi Sankyo Co Ltd Sustained-release solid preparation for oral use
ES2706994T3 (en) 2012-09-03 2019-04-02 Daiichi Sankyo Co Ltd Orally extended-release pharmaceutical composition containing hydromorphone hydrochloride
KR102158339B1 (en) * 2016-02-05 2020-09-21 삼진제약주식회사 Carvedilol immediate release formulation having improved madescent
KR102525298B1 (en) 2020-12-30 2023-04-25 단국대학교 천안캠퍼스 산학협력단 Carvedilol loaded solid dispersion with increased oral bioavailability and methods for their preparation
KR102492147B1 (en) 2020-12-30 2023-01-26 단국대학교 천안캠퍼스 산학협력단 Carvedilol loaded solid oral compositions using self-nanoemulsifying drug delivery system and methods for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (en) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh NEW CARBAZOLYL- (4) -OXY-PROPANOLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
US5403067A (en) * 1990-10-23 1995-04-04 Davband Pty. Limited Back support for a chair or seat
US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
DE19637082A1 (en) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets

Also Published As

Publication number Publication date
NZ504418A (en) 2003-02-28
CA2309542A1 (en) 1999-05-20
IL136028A0 (en) 2001-05-20
EP1030651A4 (en) 2006-05-31
HUP0004345A3 (en) 2001-10-29
PL340456A1 (en) 2001-02-12
KR20010031952A (en) 2001-04-16
CN1285738A (en) 2001-02-28
NO20002439L (en) 2000-05-11
BR9814127A (en) 2000-10-03
NO20002439D0 (en) 2000-05-11
AU751117B2 (en) 2002-08-08
EP1030651A1 (en) 2000-08-30
AU1456999A (en) 1999-05-31
WO1999024017A1 (en) 1999-05-20
TR200001362T2 (en) 2000-09-21
JP2001522794A (en) 2001-11-20

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